Standout Papers

K-Ras(G12C) inhibitors allosteri... 1989 2026 2001 2013 1.6k
  1. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions (2013)
    J.M. Ostrem, Ulf Peters et al. Nature
  2. A Hot Spot of Binding Energy in a Hormone-Receptor Interface (1995)
    Tim Clackson, James A. Wells Science
  3. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces (2007)
    James A. Wells, Christopher L. McClendon Nature
  4. Small-molecule inhibitors of protein–protein interactions: progressing towards the dream (2004)
    Michelle R. Arkin, James A. Wells Nature Reviews Drug Discovery
  5. High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis (1989)
    Brian C. Cunningham, James A. Wells Science
  6. Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality (2014)
    Michelle R. Arkin, Yinyan Tang et al. Chemistry & Biology
  7. Dimerization of the Extracellular Domain of the Human Growth Hormone Receptor by a Single Hormone Molecule (1991)
    Brian C. Cunningham, Mark Ultsch et al. Science
  8. Caspases and their substrates (2017)
    Olivier Julien, James A. Wells Cell Death and Differentiation
  9. Convergent Solutions to Binding at a Protein-Protein Interface (2000)
    Warren L. DeLano, Mark Ultsch et al. Science
  10. Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis (2014)
    Alban Ordureau, Shireen A. Sarraf et al. Molecular Cell
  11. Rational Design of Potent Antagonists to the Human Growth Hormone Receptor (1992)
    Germaine Fuh, Brian C. Cunningham et al. Science
  12. Sexually Dimorphic Neurons in the Ventromedial Hypothalamus Govern Mating in Both Sexes and Aggression in Males (2013)
    Cindy F. Yang, Michael C. Chiang et al. Cell
  13. Redox-based reagents for chemoselective methionine bioconjugation (2017)
    Shixian Lin, Xiaoyu Yang et al. Science
  14. Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 (2021)
    Adam D. Cotton, Duy Nguyen et al. Journal of the American Chemical Society
  15. Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins (2022)
    Katarina Pance, Josef A. Gramespacher et al. Nature Biotechnology

Immediate Impact

27 by Nobel laureates 56 from Science/Nature 76 standout
Sub-graph 1 of 21

Citing Papers

Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition
2020 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
8 intermediate papers

Works of James A. Wells being referenced

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Crystal Structure at 1.7 Å Resolution of VEGF in Complex with Domain 2 of the Flt-1 Receptor
1997

Author Peers

Author Last Decade Papers Cites
James A. Wells 24201 6145 5363 294 34.1k
Raymond C. Stevens 31931 5563 2371 358 42.2k
Tom L. Blundell 33473 1866 3474 499 44.6k
Richard A. Lerner 22023 10408 2462 412 37.9k
John Kuriyan 28440 3143 6973 230 38.2k
Steven A. Carr 31123 1668 5287 365 43.3k
Pedro Cuatrecasas 22643 2529 2336 354 34.9k
David Richardson 38369 2129 4013 155 53.5k
John A. Katzenellenbogen 11909 4900 5696 624 33.4k
Gerhard Wagner 29479 3718 3000 520 41.3k
J. Deisenhofer 19294 2560 1688 131 27.2k

All Works

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2026