Citation Impact
Citing Papers
ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation
2004
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans
2006 Science
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G 2 checkpoints
2002
Chk2 Molecular Interaction Map and Rationale for Chk2 Inhibitors
2006 Nobel
Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions
2008 Science
ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1
2005
The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement
2007 StandoutNobel
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
2013
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
2003 Nature
MDC1: The art of keeping things in focus
2010
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
2007 Science
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
Hallmarks of Cancer: The Next Generation
2011 Standout
DNA Damage Induced by Temozolomide Signals to both ATM and ATR: Role of the Mismatch Repair System
2004
Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
2000
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres
2006
Claspin, a Chk1-Regulatory Protein, Monitors DNA Replication on Chromatin Independently of RPA, ATR, and Rad17
2003
Inflammation and cancer
2002 StandoutNature
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
2007
"ATR activation in response to ionizing radiation: still ATM territory"
2006
Stability of Checkpoint Kinase 2 Is Regulated via Phosphorylation at Serine 456
2007
Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
2009
The emerging role of nuclear architecture in DNA repair and genome maintenance
2009
Cell cycle checkpoint signaling through the ATM and ATR kinases
2001 Standout
Distinct modes of ATR activation after replication stress and DNA double‐strand breaks in Caenorhabditis elegans
2005
Identification of potential binding sites for the FHA domain of human Chk2 by in vitro binding studies
2003
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
2009 Nature
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
2007 StandoutNobel
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints
2010
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
H2AX Haploinsufficiency Modifies Genomic Stability and Tumor Susceptibility
2003
Cell-cycle checkpoints and cancer
2004 StandoutNature
Chk1 and Chk2 kinases in checkpoint control and cancer
2003
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
2005
Structural and functional analysis of the Crb2–BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair
2008
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
2006
Intrinsic Kinase Activity and SQ/TQ Domain of Chk2 Kinase as Well as N-terminal Domain of Wip1 Phosphatase Are Required for Regulation of Chk2 by Wip1
2006
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage
2000
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
2004
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
2009
Polo-like Kinase 1 and Chk2 Interact and Co-localize to Centrosomes and the Midbody
2003
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
2007 Nature
Histone H2AX
2003
Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathway
2004
DNA Damage-induced Association of ATM with Its Target Proteins Requires a Protein Interaction Domain in the N Terminus of ATM
2005
Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice
2007
Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
2004
Identification of SMARCAL1 as a Component of the DNA Damage Response
2009
ATM and related protein kinases: safeguarding genome integrity
2003 Standout
ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism
2003
Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice
2003
DNA damage checkpoints in mammals
2005
Role of the Cdc25A phosphatase in human breast cancer
2000
ATR: an essential regulator of genome integrity
2008
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
2008 Nature
MDC1 interacts with Rad51 and facilitates homologous recombination
2005
Rapid activation of ATM on DNA flanking double-strand breaks
2007
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex
2008
Human Xip1 (C2orf13) Is a Novel Regulator of Cellular Responses to DNA Strand Breaks
2007
Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase
2004
Checkpoint Kinase 2 (Chk2) Monomers or Dimers Phosphorylate Cdc25C after DNA Damage Regardless of Threonine 68 Phosphorylation
2002
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
2009
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
The mismatch repair system is required for S-phase checkpoint activation
2002
The Chk2 protein kinase
2004
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
2001
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
2006
Checkpoint Mediators: Relaying Signals from DNA Strand Breaks
2003
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
2008 Nature
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes
2004
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
2009
Trans‐activation of the DNA‐damage signalling protein kinase Chk2 by T‐loop exchange
2006
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
2008
Structure and Activation Mechanism of the CHK2 DNA Damage Checkpoint Kinase
2009
Checking on DNA damage in S phase
2004
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
2002
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
2008 StandoutNobel
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
TTK/hMps1 Participates in the Regulation of DNA Damage Checkpoint Response by Phosphorylating CHK2 on Threonine 68
2004
Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathology
2020
The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase
2006
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Tip60: Connecting chromatin to DNA damage signaling
2010
BRCA1 and its toolbox for the maintenance of genome integrity
2009
BLM is an early responder to DNA double-strand breaks
2006
Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
2009
Chk1 is haploinsufficient for multiple functions critical to tumor suppression
2004
WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
2008 Nature
MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
2005
Adaptation to P Element Transposon Invasion in Drosophila melanogaster
2011
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
Myc and E2F1 induce p53 through p14ARF-independent mechanisms in human fibroblasts
2003
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
2002
UV Irradiation Triggers Ubiquitin-Dependent Degradation of p21WAF1 to Promote DNA Repair
2003
Choreography of the DNA Damage Response
2004
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways
2002
Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair
2008
Chk2 Oligomerization Studied by Phosphopeptide Ligation
2008 StandoutNobel
Structural and Functional Versatility of the FHA Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2
2002
Unwind and slow down: checkpoint activation by helicase and polymerase uncoupling: Figure 1.
2005
Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus Egg Extracts Requires Binding of ATRIP to ATR but Not the Stable DNA-binding or Coiled-coil Domains of ATRIP
2005
53BP1, an activator of ATM in response to DNA damage
2004
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
2006
Identification and Characterization of Human MUS81-MMS4 Structure-specific Endonuclease
2003 StandoutNobel
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
2010
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
2006
ATR activation and replication fork restart are defective in FANCM‐deficient cells
2010
Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA
2009
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
2009
NFBD1/KIAA0170 Is a Chromatin-associated Protein Involved in DNA Damage Signaling Pathways
2003
Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends
2008
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
2007 StandoutNobel
CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?
2007
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
2005 NatureNobel
Early events in the mammalian response to DNA double-strand breaks
2008
Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated Domain
2002
An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication
2003
PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites
2007
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
2008
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Crosstalk between histone modifications during the DNA damage response
2009
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
2002
Human CtIP promotes DNA end resection
2007 Nature
RNF168 Binds and Amplifies Ubiquitin Conjugates on Damaged Chromosomes to Allow Accumulation of Repair Proteins
2009
Colocalization of Sensors Is Sufficient to Activate the DNA Damage Checkpoint in the Absence of Damage
2008
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
2005
Collaboration of Brca1 and Chk2 in tumorigenesis
2004
The Mre11 complex is required for ATM activation and the G2/M checkpoint
2003
The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways
2004
Autophosphorylated Residues Involved in the Regulation of Human Chk2 In Vitro
2008
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
2007 Nature
Mechanisms of Dealing with DNA Damage-Induced Replication Problems
2008
The Stress Kinase MRK Contributes to Regulation of DNA Damage Checkpoints through a p38γ-independent Pathway
2004
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
2007
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
2007
TopBP1 Activates the ATR-ATRIP Complex
2006
The annealing helicase HARP protects stalled replication forks
2009
Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations
2004
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
2005
Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association
2005
The combined status of ATM and p53 link tumor development with therapeutic response
2009
Visualization of Altered Replication Dynamics after DNA Damage in Human Cells
2004
Chapter 2 DNA-PK
2008
Regulation of G2/M events by Cdc25A through phosphorylation-dependent modulation of its stability
2002
Targeting the checkpoint kinases: chemosensitization versus chemoprotection
2004
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
2010
The cellular response to DNA double-strand breaks: defining the sensors and mediators
2003
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability
2010
Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex
2006
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
2002
Requirement of the MRN complex for ATM activation by DNA damage
2003
Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
2008
Nbs1 is required for ATR‐dependent phosphorylation events
2004
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
DNA helicases Sgs1 and BLM promote DNA double-strand break resection
2008
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain
2003
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
2008
A Novel Tel1/ATM N-Terminal Motif, TAN, Is Essential for Telomere Length Maintenance and a DNA Damage Response
2008 StandoutNobel
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex
2004 Science
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach
2002
The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation
2014
Diethylstilbestrol is a potent inhibitor of store-operated channels and capacitative Ca(2+) influx.
2004
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
53BP1: function and mechanisms of focal recruitment
2009
Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
2010
Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins
2007
NFBD1/MDC1 regulates ionizing radiation‐induced focus formation by DNA checkpoint signaling and repair factors
2003
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
2006
An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage
2002
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
2001
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
2005
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
2009
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Chk2 Activation and Phosphorylation-Dependent Oligomerization
2002
p53 Binding Protein 53BP1 Is Required for DNA Damage Responses and Tumor Suppression in Mice
2003
The Basic Cleft of RPA70N Binds Multiple Checkpoint Proteins, Including RAD9, To Regulate ATR Signaling
2008
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
Methylator-induced, Mismatch Repair-dependent G2Arrest Is Activated through Chk1 and Chk2
2005
End-resection at DNA double-strand breaks in the three domains of life
2013
Kinase-Independent Functions of TEL1 in Telomere Maintenance
2009 StandoutNobel
Phospho‐dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
2008
Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation
2002
Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
2008
Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner
2002
Double-Strand Break End Resection and Repair Pathway Choice
2011
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation.
2003
The cellular response to DNA damage: A focus on MDC1 and its interacting proteins
2010
Surviving the Breakup: The DNA Damage Checkpoint
2006
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
2005
Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.
2007
Cdc13 Telomere Capping Decreases Mec1 Association but Does Not Affect Tel1 Association with DNA Ends
2007
The role of the DNA damage response pathways in brain development and microcephaly: Insight from human disorders
2008
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
ATR, Claspin and the Rad9-Rad1-Hus1 Complex Regulate Chk1 and Cdc25A in the Absence of DNA Damage
2004
An Oligomerized 53BP1 Tudor Domain Suffices for Recognition of DNA Double-Strand Breaks
2008
Haploinsufficiency of t e lomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita
2005 StandoutNobel
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
2008 StandoutNobel
Mechanism and Regulation of Class Switch Recombination
2008
Structure and Function of the Phosphothreonine-Specific FHA Domain
2008
Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation
2005
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells
2007
ATR Affecting Cell Radiosensitivity Is Dependent on Homologous Recombination Repair but Independent of Nonhomologous End Joining
2004
Nonperiodic Activity of the Human Anaphase-Promoting Complex–Cdh1 Ubiquitin Ligase Results in Continuous DNA Synthesis Uncoupled from Mitosis
2000
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
DNA Damage Responses: Mechanisms and Roles in Human Disease
2008
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5
2006 StandoutNobel
Regulating mammalian checkpoints through Cdc25 inactivation
2003
Oligomerization of MDC1 Protein Is Important for Proper DNA Damage Response
2011
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Non-homologous end-joining, a sticky affair
2007
Recruitment of DNA Damage Checkpoint Proteins to Damage in Transcribed and Nontranscribed Sequences
2005 StandoutNobel
Works of Jacob Falck being referenced
Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization.
1997
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
2005 Nature
Alternative splicing and mutation status of CHEK2 in stage III breast cancer
2004
Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation
2004
Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention
2004
Chk2 kinase — a busy messenger
2001
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing Radiation
2003
The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways
2002
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
2003
HCLK2 Is Required for Activity of the DNA Damage Response Kinase ATR
2008
MDC1 is required for the intra-S-phase DNA damage checkpoint
2003 Nature
Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
2001
CHEK2 variant I157T may be associated with increased breast cancer risk
2004
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
2003
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
2005
Differential impact of diverse anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathway
2004
The ATM–Chk2–Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
2001 Nature
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
2001
Rapid Destruction of Human Cdc25A in Response to DNA Damage
2000 Science
CDK targeting of NBS1 promotes DNA‐end resection, replication restart and homologous recombination
2012
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin
2008
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology.
2001
Involvement of Myc Activity in a G1/S-Promoting Mechanism Parallel to the pRb/E2F Pathway
2000