Citation Impact
Citing Papers
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
2017 Science
High burden and pervasive positive selection of somatic mutations in normal human skin
2015 StandoutScience
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Machine learning predicts new anti-CRISPR proteins
2020 StandoutNobel
Meta-hallmarks of aging and cancer
2023
Reading Frame Correction by Targeted Genome Editing Restores Dystrophin Expression in Cells From Duchenne Muscular Dystrophy Patients
2013
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
International regulatory landscape and integration of corrective genome editing into in vitro fertilization
2014
Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase
2016 StandoutNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
2022
Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes
2017
Isolation of single-base genome-edited human iPS cells without antibiotic selection
2014
Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor
2012
Autophagosomes form at ER–mitochondria contact sites
2013 StandoutNature
A guide to genome engineering with programmable nucleases
2014 Standout
Mutant mice with small amounts of BubR1 display accelerated age-related gliosis
2006
A view on drug resistance in cancer
2019 StandoutNature
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome
2019
Efficient and Allele-Specific Genome Editing of Disease Loci in Human iPSCs
2014
The genetics of ageing
2010 StandoutNature
Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
2010
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice
2014
Hallmarks of aging: An expanding universe
2023 Standout
Nuclear lamins and laminopathies
2011
Metabolic Control of Longevity
2016
Cellular Senescence in Cancer and Aging
2007 Standout
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering
2013 Standout
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Somatic genomic changes in single Alzheimer’s disease neurons
2022 Nature
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
The changing landscape of atherosclerosis
2021 StandoutNature
Stability of Zinc Finger Nuclease Protein Is Enhanced by the Proteasome Inhibitor MG132
2013
Seamless genome editing in human pluripotent stem cells using custom endonuclease–based gene targeting and the piggyBac transposon
2013
Emerging roles of proteases in tumour suppression
2007
Autophagy: Renovation of Cells and Tissues
2011 Standout
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
2013 Standout
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells
2013 StandoutNobel
Human and mouse proteases: a comparative genomic approach
2003
Metazoan MicroRNAs
2018 Standout
Blinded by the Light: The Growing Complexity of p53
2009 Standout
DNA Damage, Aging, and Cancer
2009 Standout
Progeria: A Paradigm for Translational Medicine
2014
Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies
2018
Age to survive: DNA damage and aging
2008
FLASH assembly of TALENs for high-throughput genome editing
2012
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
2009
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
Advances in targeted genome editing
2012
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
2008
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
2012
Two faces of p53: aging and tumor suppression
2007
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
The effects of p53 on whole organism longevity are mediated by autophagy
2008
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1
2009
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
2019
Accelerating progress in induced pluripotent stem cell research for neurological diseases
2012
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity
2009
Delayed ageing through damage protection by the Arf/p53 pathway
2007 Nature
CRISPR/Cas9 for genome editing: progress, implications and challenges
2014
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The role of senescent cells in ageing
2014 StandoutNature
Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming
2014
The Hallmarks of Aging
2013 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
The PI3K Pathway in Human Disease
2017 Standout
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
The Human Condition—A Molecular Approach
2014 StandoutNobel
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
2008
p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
2013
Genome-editing Technologies for Gene and Cell Therapy
2016
Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”
2018
Genome Engineering with Targetable Nucleases
2014
Gene Editing in Human Pluripotent Stem Cells: Choosing the Correct Path.
2015
iPSC Disease Modeling
2012 Science
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
2015
Pivoting the Plant Immune System from Dissection to Deployment
2013 StandoutScience
Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy
2013
The Posttranslational Processing of Prelamin A and Disease
2009
Molecular Pathology of Laminopathies
2021
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
TALENs: a widely applicable technology for targeted genome editing
2012
Progress and trends in the development of therapies for Hutchinson–Gilford progeria syndrome
2020
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Genome Engineering at the Dawn of the Golden Age
2013
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria
2021
Spermidine in health and disease
2018 StandoutScience
Four faces of cellular senescence
2011 Standout
Adopt a moratorium on heritable genome editing
2019 StandoutNatureNobel
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression
2013
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes
2015 Standout
LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes
2022
Mouse Models to Disentangle the Hallmarks of Human Aging
2018
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
The Arf/p53 Pathway in Cancer and Aging
2008
Works of Ignacio Varela being referenced
Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
2008
Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions
2006
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging
2008
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
2011 Nature
Somatic structural rearrangements in genetically engineered mouse mammary tumors
2010
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
2005 Nature
Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis
2015
Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis
2018
Nuclear envelope alterations generate an aging‐like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
2010
Aging and chronic DNA damage response activate a regulatory pathway involving miR‐29 and p53
2011
Tumor Functional Heterogeneity Unraveled by scRNA-seq Technologies
2020
Role of SWI/SNF chromatin remodeling genes in lung cancer development
2022
Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging
2011
Premature aging in mice activates a systemic metabolic response involving autophagy induction
2008
Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans
2003