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Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor
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Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis
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Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells
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The p21 ras C-terminus is required for transformation and membrane association
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Identification of a precursor in the biosynthesis of the p21 transforming protein of harvey murine sarcoma virus
1982
In yeast, RAS proteins are controlling elements of adenylate cyclase
1985
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene
1983 Nature
Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.
1992
The primary structure of the alpha 4 subunit of VLA-4: homology to other integrins and a possible cell-cell adhesion function.
1989
Molecular cloning of integrated Gardner-Rasheed feline sarcoma virus: genetic structure of its cell-derived sequence differs from that of other tyrosine kinase-coding onc genes
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Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.
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Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
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Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action
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CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.
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Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas
1982
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1982
Structure of the FBJ murine osteosarcoma virus genome: molecular cloning of its associated helper virus and the cellular homolog of the v-fos gene from mouse and human cells.
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Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T Cells
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Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure
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Nucleotide Sequence of the Oncogene Encoding the p21 Transforming Protein of Kirsten Murine Sarcoma Virus
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1982
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus.
1983
Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.
1993
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumour cells
1983 StandoutNatureNobel
A novel ras-related gene family
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2001
B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.
1991
Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction.
1989 StandoutNobel
Preferential Migration of Activated CD4 + and CD8 + T Cells in Response to MIP-1α and MIP-1β
1993 Science
Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages
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Induction of c-fos gene and protein by growth factors precedes activation of c-myc
1984 Nature
Structural organization and biological activity of molecular clones of the integrated genome of a BALB/c mouse sarcoma virus
1981
A product of yeast RAS2 gene is a guanine nucleotide binding protein.
1984
Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines
1985 Science
Structure and dimorphism of c-rel (turkey), the cellular homolog to the oncogene of reticuloendotheliosis virus strain T
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Differential expression of cellular oncogenes during pre- and postnatal development of the mouse
1982 Nature
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2006
Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus
1982 StandoutNobel
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Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.
1984
Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses.
1982
A novel transforming gene in a human malignant melanoma cell line
1984 Nature
Structure and activation of the human N-ras gene
1983
A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection
1979
Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors
2005
Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28
1991 Science
The ras oncogene product p21 is not a regulatory component of adenylate cyclase
1985 Nature
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2002
Functional homology of mammalian and yeast RAS genes
1985
Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.
1977 StandoutNobel
Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1.
1991
Transformation of NIH 3T3 cells by microinjection of Ha-ras p21 protein
1984 Nature
Perforin-Mediated Cytotoxicity Is Critical for Surveillance of Spontaneous Lymphoma
2000
Gene Product of v- fgr onc : Hybrid Protein Containing a Portion of Actin and a Tyrosine-Specific Protein Kinase
1984 Science
CELLULAR RESPONSES TO INTERFERON-γ
1997 Standout
The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
1986 StandoutNobel
Mechanism of activation of a human oncogene
1982 Nature
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
1997 Standout
Cellular Transforming Genes
1982 Science
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.
1991
Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry
1980
Sequential expression of protooncogenes during lectin-stimulated mitogenesis of normal human lymphocytes.
1986
Regulation of the Chemokine Receptor CXCR4 by Hypoxia
2003
ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae
1983 Nature
CTLA-4 is a second receptor for the B cell activation antigen B7.
1991
Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors.
1987
Genetic analysis of yeast RAS1 and RAS2 genes
1984
Enhancement of Innate Immunity againstMycobacterium aviumInfection by Immunostimulatory DNA Is Mediated by Indoleamine 2,3-Dioxygenase
2001
The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation
2008
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.
1986 StandoutNobel
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene
1982 Nature
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes
1982 Nature
Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus
1982 Nature
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity
1984 Nature
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
2006
Human naive and memory T cells
1988
Inflammatory Chemokine Transport and Presentation in HEV
2001
T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.
1990
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
1985 StandoutScienceNobel
Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein
1992 Science
FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA
1982
Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.
1992 Nobel
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue
1983 Nature
Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist.
1993
Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS
2005 StandoutNobel
The drosophila ras oncogenes: Structure and nucleotide sequence
1984
A Cell Culture Model for T Lymphocyte Clonal Anergy
1990 StandoutScience
Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1
1983 Nature
The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid
1982
Tolerogenic Dendritic Cells
2003 StandoutNobel
In vitro activation of a transcription factor by gamma interferon requires a membrane-associated tyrosine kinase and is mimicked by vanadate.
1993
Oncogenes in solid human tumours
1982 Nature
Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-dalton phosphoprotein
1982
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line.
1983
Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.
1984
Mice Bearing Late-Stage Tumors Have Normal Functional Systemic T Cell Responses In Vitro and In Vivo
2000
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus
1982 Nature
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus
1983
Immune Therapy for Cancer
2008
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
1984 StandoutNature
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4
2013 StandoutNobel
Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice
1992 Science
Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells
2002
Nucleotide Sequence of the p21 Transforming Protein of Harvey Murine Sarcoma Virus
1982 Science
Form and Function of Retroviral Proviruses
1982 Science
The Function of Gamma Interferon-Inducible GTP-Binding Protein IGTP in Host Resistance toToxoplasma gondiiIs Stat1 Dependent and Requires Expression in Both Hematopoietic and Nonhematopoietic Cellular Compartments
2002
FBR murine osteosarcoma virus I. Molecular analysis and characterization of a 75,000-Da gag-fos fusion product
1984
Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter.
1993
The IFN-Inducible Golgi- and Endoplasmic Reticulum- Associated 47-kDa GTPase IIGP Is Transiently Expressed During Listeriosis
2002
Dual Roles for Immunity in Gastrointestinal Cancers
2010
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Analysis of the transforming potential of the human H-ras gene by random mutagenesis.
1984
Expression of Cellular Oncogenes in Human Malignancies
1984 Science
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
1985 StandoutNatureNobel
Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1
1994 StandoutNobel
Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family
1982
Works of Howard A. Young being referenced
Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Induce Expression of CXCR4 on Human Endothelial Cells
1999
Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor‐mediated activation
1989
Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe
2005
Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus
1979
Divergent effects of dithiocarbamates on AP-1-containing and AP-1-less NFAT sites
1999
Pathogenesis of Ebola Hemorrhagic Fever in Primate Models
2003
Gradual Loss of T-Helper 1 Populations in Spleen of Mice During Progressive Tumor Growth
1995
Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway
1996
A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription
2002
Pathogenesis of Ebola Hemorrhagic Fever in Cynomolgus Macaques
2003
Interferon-γ links ultraviolet radiation to melanomagenesis in mice
2011 Nature
Interaction of NF-κB and NFAT with the Interferon-γ Promoter
1997
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
2000 StandoutNature
Glucocorticoid-receptor interaction and induction of murine mammary tumor virus.
1975
Interleukin-10 and the immune response against cancer: a counterpoint
2005
The p21 src genes of Harvey and Kirsten sarcoma viruses originate from divergent members of a family of normal vertebrate genes
1981 Nature
Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus.
1981
Heteroduplex analysis of cloned rat endogenous replication-defective (30 S) retrovirus and Harvey murine sarcoma virus
1980
Mammary tumor virus induction by glucocorticoids. Characterization of specific transcriptional regulation.
1975
Eotaxin (CCL11) Induces In Vivo Angiogenic Responses by Human CCR3+ Endothelial Cells
2001
Physical map of the Kirsten sarcoma virus genome as determined by fingerprinting RNase T1-resistant oligonucleotides
1978
Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production.
1988
Different rat-derived transforming retroviruses code for an immunologically related intracellular phosphoprotein.
1979
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
1991
Characterization of a class 3 tyrosine kinase.
1992
Interleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.
1990
Rat sarcoma virus: further analysis of individual viral isolates and the gene product
1981
Dual evolutionary origin for the rat genetic sequences of Harvey murine sarcoma virus
1980
Role of interferon-gamma in immune cell regulation.
1995
p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation
1979
Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.
1994
Biochemical and physiological mechanisms in glucocorticoid hormone induction of mouse mammary tumor virus
1976
The c-rel protooncogene product c-Rel but not NF-kappa B binds to the intronic region of the human interferon-gamma gene at a site related to an interferon-stimulable response element.
1992
The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.
1993
Immunoregulation in cancer-bearing hosts. Down-regulation of gene expression and cytotoxic function in CD8+ T cells
1992
Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1
1989 Science
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression
2000
Role of interferon-γ in immune cell regulation
1995
Correction: The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer
2001 Nature
Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation
2000
Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10
2000
Enhanced lymphokine production and lymphokine receptor expression in multiple antibody-stimulated human CD4+ peripheral blood lymphocytes.
1992
Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP
2000
CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.
1989
Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells
2004
Alterations in NF kappa B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy.
1994
Two essential regulatory elements in the human interferon gamma promoter confer activation specific expression in T cells.
1993
Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes
2000
Steroid induction of mouse mammary tumor virus: effect upon synthesis and degradation of viral RNA
1977
CD8+ and CD45RA+ human peripheral blood lymphocytes are potent sources of macrophage inflammatory protein 1α, interleukin‐8 and RANTES
1995
In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses
2008