Standout Papers
- The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. (1996)
- WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans (1999)
Citation Impact
Citing Papers
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
2012 StandoutScienceNobel
Developmental Decline in Neuronal Regeneration by the Progressive Change of Two Intrinsic Timers
2013 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans
2006
The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans
2002
Gut Reaction to Wnt Signaling in Worms
1997
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Asymmetric and symmetric stem-cell divisions in development and cancer
2006 Nature
How signaling between cells can orient a mitotic spindle
2011
Wnt Signals and Frizzled Activity Orient Anterior-Posterior Axon Outgrowth in C. elegans
2006
A Common Core RNP Structure Shared between the Small Nucleoar Box C/D RNPs and the Spliceosomal U4 snRNP
2000 StandoutNobel
A New Look at TCF and β-Catenin through the Lens of a Divergent C. elegans Wnt Pathway
2009
Involvement of U1 Small Nuclear Ribonucleoproteins (snRNP) in 5′ Splice Site-U1 snRNP Interaction
1996
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity
2013 StandoutNobel
POP-1 and Anterior–Posterior Fate Decisions in C. elegans Embryos
1998
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence
2012 StandoutNatureNobel
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome
1992
Wnt Signaling and the Polarity of the Primary Body Axis
2009
The rde-1 Gene, RNA Interference, and Transposon Silencing in C. elegans
1999 StandoutNobel
U1 snRNP-ASF/SF2 interaction and 5′ splice site recognition: characterization of required elements
1995
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA
2011 StandoutNobel
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
The C-terminal cytoplasmic Lys-Thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling
2000
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Regulation of TCF3 by Wnt-Dependent Phosphorylation during Vertebrate Axis Specification
2010
The Chk2 protein kinase
2004
SRC-1 and Wnt Signaling Act Together to Specify Endoderm and to Control Cleavage Orientation in Early C. elegans Embryos
2002 StandoutNobel
Wnt signaling: a common theme in animal development
1997 Standout
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Functional interaction of a novel 15.5kD [U4/U6middle dotU5] tri-snRNP protein with the 5' stem-loop of U4 snRNA
1999
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
An RNA Switch at the 5′ Splice Site Requires ATP and the DEAD Box Protein Prp28p
1999
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
C. elegans TCF protein, POP-1, converts from repressor to activator as a result of Wnt-induced lowering of nuclear levels
2005
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Wnt signaling controls temporal identities of seam cells in Caenorhabditis elegans
2010
C. elegans LIN-18 Is a Ryk Ortholog and Functions in Parallel to LIN-17/Frizzled in Wnt Signaling
2004
SR proteins can compensate for the loss of U1 snRNP functions in vitro.
1994
Cell–cell signalling: Wingless lands at last
1996
SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation
2010
Notch signaling in the C. elegans embryo
2005
Armadillo and dTCF: a marriage made in the nucleus
1997 Standout
kin-19/casein kinase Iαhas dual functions in regulating asymmetric division and terminal differentiation inC. elegansepidermal stem cells
2010
Dynamics of a Developmental Switch: Recursive Intracellular and Intranuclear Redistribution of Caenorhabditis elegans POP-1 Parallels Wnt-Inhibited Transcriptional Repression
2002
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
2007
High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain
2001 StandoutNobel
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans
2002 StandoutNobel
Cotranscriptional Spliceosome Assembly Dynamics and the Role of U1 snRNA:5′ss Base Pairing in Yeast
2005 StandoutNobel
The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans
2002 StandoutNobel
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
Distinct β-catenins mediate adhesion and signalling functions in C. elegans
2000 Nature
Phosphorylation by the β-Catenin/MAPK Complex Promotes 14-3-3-Mediated Nuclear Export of TCF/POP-1 in Signal-Responsive Cells in C. elegans
2004
Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.
1992
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Meiotic recombination in Caenorhabditis elegans
2007
Revealing the world of RNA interference
2004 StandoutNatureNobel
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
Characterization of U4 and U6 interactions with the 5′ splice site using a S. cerevisiae in vitro trans-splicing system
2001
Disruption of base pairing between the 5′ splice site and the 5′ end of U1 snRNA is required for spliceosome assembly
1993
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
Multiple Wnt Signaling Pathways Converge to Orient the Mitotic Spindle in Early C. elegans Embryos
2004
Wnt signaling drives WRM-1/β-catenin asymmetries in early C. elegans embryos
2005 StandoutNobel
C. elegans AP-2 and Retromer Control Wnt Signaling by Regulating MIG-14/Wntless
2007
MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Caenorhabditis elegans as a model for stem cell biology
2010
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division
2000
Wnt Signaling in Neural Circuit Assembly
2008
Four yeast spliceosomal proteins (PRP5, PRP9, PRP11, and PRP21) interact to promote U2 snRNP binding to pre-mRNA.
1993
Regulation of Neurotrophin-3 Expression by Epithelial-Mesenchymal Interactions: The Role of Wnt Factors
1999 StandoutScienceNobel
Cell polarity and gastrulation inC. elegans
2002
A general two-metal-ion mechanism for catalytic RNA.
1993 StandoutNobel
Mutations in U6 snRNA that Alter Splice Site Specificity: Implications for the Active Site
1993 Science
A U1/U4/U5 snRNP Complex Induced by a 2′- O -Methyl-Oligoribonucleotide Complementary to U5 snRNA
1996 Science
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Caenorhabditis elegans cog-1 Locus Encodes GTX/Nkx6.1 Homeodomain Proteins and Regulates Multiple Aspects of Reproductive System Development
2002
A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans
1999
Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13
2008
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors
1997
Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of β-catenin/Arm and stimulation of target gene expression
2008
The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons
1999 StandoutNobel
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Corin, a Mosaic Transmembrane Serine Protease Encoded by a Novel cDNA from Human Heart
1999
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position
1996
The sys-1 and sys-3 Genes Cooperate With Wnt Signaling to Establish the Proximal-Distal Axis of the Caenorhabditis elegans Gonad
2004
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
1998 Standout
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
2015 StandoutNobel
An antagonistic role for theC. elegansSchnurri homolog SMA-9 in modulating TGFβ signaling during mesodermal patterning
2006 StandoutNobel
Extensive interactions of PRP8 protein with the 5′ and 3′ splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA.
1995
Involvement of U6 snRNA in 5′ Splice Site Selection
1993 Science
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity
2001
Interactions of Small Nuclear RNA's with Precursor Messenger RNA During in Vitro Splicing
1992 Science
Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans
2000
TheC. elegansCBFβ homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal
2007
The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome.
1996
A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing.
1995
RNAi in C. elegans : Soaking in the Genome Sequence
1998 StandoutScienceNobel
Cell shape and Wnt signaling redundantly control the division axis ofC. elegansepithelial stem cells
2011
Wnt signaling controls the stem cell-like asymmetric division of the epithelial seam cells during C. elegans larval development
2010
Protein components specifically associated with prespliceosome and spliceosome complexes.
1992
Works of Hitoshi Sawa being referenced
β-Catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions
2008
Cortical β-Catenin and APC Regulate Asymmetric Nuclear β-Catenin Localization during Asymmetric Cell Division in C. elegans
2007
Wnt Signaling and a Hox Protein Cooperatively Regulate PSA-3/Meis to Determine Daughter Cell Fate after Asymmetric Cell Division in C. elegans
2006
Wnt Regulates Spindle Asymmetry to Generate Asymmetric Nuclear β-Catenin in C. elegans
2011
Two βs or not two βs: regulation of asymmetric division by β-catenin
2007
Components of the SWI/SNF Complex Are Required for Asymmetric Cell Division in C. elegans
2000
Asymmetric cortical and nuclear localizations of WRM-1/β-catenin during asymmetric cell division in C. elegans
2005
The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell
2005
Control of Cell Polarity and Asymmetric Division in C. elegans
2012
A β-Catenin Identified by Functional Rather Than Sequence Criteria and Its Role in Wnt/MAPK Signaling
2005
Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development
2011
Wnt Signals Can Function as Positional Cues in Establishing Cell Polarity
2006
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans
2003
The HumanMusashi Homolog 1(MSI1) Gene Encoding the Homologue of Musashi/Nrp-1, a Neural RNA-Binding Protein Putatively Expressed in CNS Stem Cells and Neural Progenitor Cells
1998
Multiple Wnts Redundantly Control Polarity Orientation in Caenorhabditis elegans Epithelial Stem Cells
2011
Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryo
2010
Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast.
1992
Critical Role of Caenorhabditis elegansHomologs of Cds1 (Chk2)-Related Kinases in Meiotic Recombination
2001
Components of the transcriptional Mediator complex are required for asymmetric cell division inC. elegans
2005
Complex Network of Wnt Signaling Regulates Neuronal Migrations DuringCaenorhabditis elegansDevelopment
2008
Association of U6 snRNA with the 5'-splice site region of pre-mRNA in the spliceosome.
1992
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.
1996 StandoutNobel