Standout Papers
- A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. (1986)
- Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review (2000)
- The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect (2010)
- The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo (2012)
- The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting (2001)
- Exploiting the enhanced permeability and retention effect for tumor targeting (2006)
- Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology (2013)
- Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity (2015)
- Polymeric drugs for efficient tumor-targeted drug delivery based on EPR-effect (2008)
- Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects (2010)
- Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS (2001)
- Macromolecular therapeutics in cancer treatment: The EPR effect and beyond (2012)
- Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers (2020)
- Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.bul.NO (nitric oxide) through a radical reaction (1993)
Immediate Impact
5 by Nobel laureates 6 from Science/Nature 310 standout
Citing Papers
Biomedicine Meets Fenton Chemistry
2021 Standout
Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1
2019 Standout
Works of Hiroshi Maeda being referenced
The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
2001 Standout
Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth
1999
Author Peers
| Author | Last Decade | Papers | Cites | ||||
|---|---|---|---|---|---|---|---|
| Hiroshi Maeda | 14227 | 18599 | 3478 | 15511 | 241 | 36.7k | |
| Ick Chan Kwon | 12467 | 14739 | 3774 | 13537 | 441 | 33.2k | |
| Omid C. Farokhzad | 24450 | 28771 | 4113 | 28044 | 218 | 61.1k | |
| Vladimir P. Torchilin | 16709 | 15503 | 3208 | 9619 | 181 | 30.9k | |
| Samir Mitragotri | 13489 | 13187 | 3556 | 16135 | 352 | 46.7k | |
| Gert Storm | 12910 | 12299 | 1850 | 9698 | 437 | 30.0k | |
| Zhen Gu | 13415 | 10095 | 1894 | 17236 | 379 | 37.8k | |
| Kwangmeyung Kim | 9811 | 11011 | 2193 | 11859 | 376 | 25.2k | |
| Yasuhiro Matsumura | 8600 | 11341 | 2282 | 7983 | 255 | 22.8k | |
| Patrick Couvreur | 15868 | 21951 | 6722 | 15729 | 573 | 54.9k | |
| Xing‐Jie Liang | 12353 | 9738 | 2340 | 15186 | 459 | 32.1k |
All Works
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