Citation Impact
Citing Papers
Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
2015
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
2010 StandoutNobel
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes
2006 StandoutScience
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
2008
CD8+ T Cell Activation Is Governed by TCR-Peptide/MHC Affinity, Not Dissociation Rate
2007
The Proline-Rich Sequence of CD3ε as an Amplifier of Low-Avidity TCR Signaling
2008
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse
2009
Re-establishing immunological self-tolerance in autoimmune disease
2012 StandoutNobel
Signal perception and transduction: the role of protein kinases
1999
Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε
2011
Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes
2009
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Relating TCR-peptide-MHC affinity to immunogenicity for the design of tumor vaccines
2006
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
2010 Nature
The microbiota in adaptive immune homeostasis and disease
2016 StandoutNature
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
T-cell receptor signal transmission: who gives an ITAM?
2003
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
1999 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Evidence that Structural Rearrangements and/or Flexibility during TCR Binding Can Contribute to T Cell Activation
2003
Pathogenesis and therapy of psoriasis
2007 StandoutNature
Microarrays of cells expressing defined cDNAs
2001 Nature
Suboptimal engagement of the T‐cell receptor by a variety of peptide–MHC ligands triggers T‐cell anergy
2009
Loss of Net as Repressor Leads to Constitutive Increased c-fos Transcription in Cervical Cancer Cells
2004 StandoutNobel
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Central tolerance: learning self-control in the thymus
2005
PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
2000 Nature
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions
2007
Computational analysis of T cell receptor signaling and ligand discrimination – Past, present, and future
2010
A temporal and spatial summation model for T-cell activation: signal integration and antigen decoding
2002
Signaling clusters in the cell membrane
2011
Quantitative challenges in understanding ligand discrimination by αβ T cells
2007
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Missing Pieces in the NF-κB Puzzle
2002 Standout
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
2004
Attenuated T Cell Responses to a High-Potency Ligand In Vivo
2010 StandoutNobel
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
How T cells 'see' antigen
2005
The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2
2007
PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
2004
Mechanisms of immunological tolerance
2015
Osteoclast differentiation and activation
2003 StandoutNature
Alternative Antigen Receptor (TCR) Signaling in T Cells Derived from ZAP-70-deficient Patients Expressing High Levels of Syk
2000
Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
2007
Complete but curtailed T-cell response to very low-affinity antigen
2009 Nature
T‐cell receptor binding affinities and kinetics: impact on T‐cell activity and specificity
2008
Plant recognition of symbiotic bacteria requires two LysM receptor-like kinases
2003 StandoutNature
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Transcriptional repressor Blimp-1 regulates T cell homeostasis and function
2006
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
1999
Programmable Cell Adhesion Encoded by DNA Hybridization
2005 StandoutNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1β
2003 StandoutNobel
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
2008
Altered Peptide Ligands Induce Delayed CD8-T Cell Receptor Interaction—a Role for CD8 in Distinguishing Antigen Quality
2006
Modeling T Cell Antigen Discrimination Based on Feedback Control of Digital ERK Responses
2005
Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator
2002
L-type Voltage-sensitive Ca2+ Channel Activation Regulates c-fos Transcription at Multiple Levels
1995
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
NAK is an IκB kinase-activating kinase
2000 Nature
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
2006 StandoutNature
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation
2001 StandoutNobel
Arachidonic acid induces mobilization of calcium stores and c-jun gene expression: evidence that intracellular calcium release is associated with c-jun activation
1999
Selection of regulatory T cells in the thymus
2012
Quantitative Analysis of the Contribution of TCR/pepMHC Affinity and CD8 to T Cell Activation
2003
Jun N-Terminal Kinase in Rheumatoid Arthritis
1999
Positive and Negative Selection of T Cells
2003
Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities
2004
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation
2001
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
The State of Lipid Rafts: From Model Membranes to Cells
2003
The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor
2013
Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex
2000
Strength of TCR–Peptide/MHC Interactions and In Vivo T Cell Responses
2011 StandoutNobel
Colony Inhibition of Fibroblasts from Chimeric Dogs Mediated by the Dogs' Own Lymphocytes and Specifically Abrogated by Their Serum
1970 StandoutNobel
Suppression of T cell function: a potential role for transcriptional repressor ICER
2000
Thymocyte Sensitivity and Supramolecular Activation Cluster Formation Are Developmentally Regulated: A Partial Role for Sialylation
2003
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
2001 StandoutScience
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
2000 StandoutScience
Stabilization of Interleukin-2 mRNA by the c-Jun NH 2 -Terminal Kinase Pathway
1998 Science
Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
2005 StandoutNobel
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
2010 StandoutNobel
CD4 + CD25 + Foxp3 + regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion
2011
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
2011
Acetylcholinesterase — new roles for an old actor
2001
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
CAR T cell immunotherapy for human cancer
2018 StandoutScience
The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28
2000
Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β
2000
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death
1999
TCR and CD28 Are Coupled Via ZAP-70 to the Activation of the Vav/Rac-1-/PAK-1/p38 MAPK Signaling Pathway
1999
Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase.
1996 StandoutNobel
Stimulation of Elk1 Transcriptional Activity by Mitogen-activated Protein Kinases Is Negatively Regulated by Protein Phosphatase 2B (Calcineurin)
1999
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Works of Guy Werlen being referenced
Cooperation between Syk and Rac1 Leads to Synergistic JNK Activation in T Lymphocytes
1998
Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
2006 Nature
Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes
1998
The Impact of Duration versus Extent of TCR Occupancy on T Cell Activation
2001
A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity
2000 Nature
The T-cell receptor signalosome: a dynamic structure with expanding complexity
2002
Signaling Life and Death in the Thymus: Timing Is Everything
2003 Science
Calcineurin Enhances Acetylcholinesterase mRNA Stability during C2-C12 Muscle Cell Differentiation
1999
Intracellular Ca2+ and the regulation of early response gene expression in HL-60 myeloid leukemia cells
1993