Standout Papers
Citation Impact
Citing Papers
Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity
2013 StandoutNobel
The Ser/Thr protein kinase AfsK regulates polar growth and hyphal branching in the filamentous bacteria Streptomyces
2012
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
2010
Subpolar addition of new cell wall is directed by DivIVA in mycobacteria
2014 StandoutNobel
Modeling the expansion of virtual screening libraries
2023
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Quantifying biogenic bias in screening libraries
2009
Enantioselective synthesis of pyrrolo[2,1-a]isoquinolones via stereocontrolled N-acyliminium ion cyclisations
2001
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Fragment-based lead discovery
2004
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Rethinking amide bond synthesis
2011 StandoutNature
Mapping the surface of Escherichia coli peptide deformylase by NMR with organic solvents
2002
NMR-based screening technologies
2003
Acquisition of Sensitivity of Stress-activated Protein Kinases to the p38 Inhibitor, SB 203580, by Alteration of One or More Amino Acids within the ATP Binding Pocket
1998
Voyages to the (un)known: adaptive design of bioactive compounds
2008
Pharmacological inhibitors of MAPK pathways
2002
High-throughput crystallography for lead discovery in drug design
2002
The consequences of translational and rotational entropy lost by small molecules on binding to proteins
2002
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
2011
MAP kinase pathways activated by stress: The p38 MAPK pathway
2000
An Expanded Set of Amino Acid Analogs for the Ribosomal Translation of Unnatural Peptides
2007 StandoutNobel
Effect of SB 203580 on the activity of c-Raf in vitro and in vivo
1999
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Protein kinase inhibition: natural and synthetic variations on a theme
1997
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
De Novo Drug Design
2010
The impact of informatics and computational chemistry on synthesis and screening
2001
A Panel of Cytochrome P450 BM3 Variants to Produce Drug Metabolites and Diversify Lead Compounds
2009 StandoutNobel
The biochemistry of apoptosis
2000 StandoutNature
Designing antimicrobial peptides: form follows function
2011 Standout
Nanoscale synthesis and affinity ranking
2018 Nature
The growing impact of click chemistry on drug discovery
2003 StandoutNobel
Chemical remodelling of cell surfaces in living animals
2004 StandoutNatureNobel
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice
1999
Antagonists of protein–protein interactions
2000
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
Pharmacological Modulation of Cytokine Action and Production through Signaling Pathways
1998
Chemogenomic approaches to drug discovery
2001
Chemistry challenges in lead optimization: silicon isosteres in drug discovery
2003
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
1998
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Crystal Structure of Hck in Complex with a Src Family–Selective Tyrosine Kinase Inhibitor
1999
Features and development of Coot
2010 Standout
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
2000
Mammalian MAP kinase signalling cascades
2001 StandoutNature
Structural basis of inhibitor selectivity in MAP kinases
1998
Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water*
2000
New directions in library design and analysis
2008
New Insights into the Control of MAP Kinase Pathways
1999
Thousands of chemical starting points for antimalarial lead identification
2010 Nature
The role of senescent cells in ageing
2014 StandoutNature
Specificity and mechanism of action of some commonly used protein kinase inhibitors
2000 Standout
The Hallmarks of Aging
2013 Standout
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase
1998
Inhibition of p38 MAP kinase as a therapeutic strategy
2000
The Extracytoplasmic Domain of the Mycobacterium tuberculosis Ser/Thr Kinase PknB Binds Specific Muropeptides and Is Required for PknB Localization
2011
Fragment-based lead discovery: leads by design
2005
Computer-based de novo design of drug-like molecules
2005
Nmr in drug discovery
2002 StandoutNobel
Copper(I)-Catalyzed Synthesis of Azoles. DFT Study Predicts Unprecedented Reactivity and Intermediates
2004 StandoutNobel
Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans
2000
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
Ribosomal Synthesis of N-Methyl Peptides
2008 StandoutNobel
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
Stereoselective Synthesis of An Isoquinolinopyrrolidinone by Acyliminium Ion Cyclization of Chiral Hydroxylactams
1995
The in silico world of virtual libraries
2000
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Eukaryote-Like Serine/Threonine Kinases and Phosphatases in Bacteria
2011
Shaping the Water-Harvesting Behavior of Metal–Organic Frameworks Aided by Fine-Tuned GPT Models
2023 StandoutNobel
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Integrating Fragment Assembly and Biophysical Methods in the Chemical Advancement of Small-Molecule Antagonists of IL-2: An Approach for Inhibiting Protein−Protein Interactions
2004
Interaction of Mycobacterium tuberculosis Elongation Factor Tu with GTP Is Regulated by Phosphorylation
2011
Chemical space as a source for new drugs
2010
ZINC20—A Free Ultralarge-Scale Chemical Database for Ligand Discovery
2020
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation
2000
RECAPRetrosynthetic Combinatorial Analysis Procedure: A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry
1998
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
2002 Standout
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Mechanisms of Mycobacterium tuberculosis Serine/Threonine Protein Kinase Activation
2010
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor
2004 StandoutScience
Stereodivergent Synthesis of Hetero-Fused Isoquinolines by Acyliminium and Metallation Methods
2001
The Mitogen-Activated Protein Kinase p38-2 Is Necessary for the Inhibition of N-Type Calcium Current by Bradykinin
1998
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
2002 StandoutScience
Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression
1999
Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry
2002
Cyclizations of N-Acyliminium Ions
2004 Standout
Molecular Basis for p38 Protein Kinase Inhibitor Specificity
1998
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Cancer Genome Landscapes
2013 StandoutScience
Deficiency of the Stress Kinase P38α Results in Embryonic Lethality
2000
A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria
2012
Molecular Shape Diversity of Combinatorial Libraries: A Prerequisite for Broad Bioactivity
2003
Structural Mechanism for STI-571 Inhibition of Abelson Tyrosine Kinase
2000 StandoutScience
Syntheses of Pyrrolo- and Indoloisoquinolinones by Intramolecular Cyclizations of 1-(2-Arylethyl)-5-benzotriazolylpyrrolidin-2-ones and 3-Benzotriazolyl-2-(2-arylethyl)-1-isoindolinones
2000
Conformational Effects on the Passive Membrane Permeability of Synthetic Macrocycles
2022
Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
1999
Unexpected formation and crystal structure of a spiro[indene-1,7′(6′H)pyrrolo[3,4-b]pyridin]-5′-one
1994
Ruthenium-Catalyzed Cycloaddition of Alkynes and Organic Azides
2005 StandoutNobel
Charting biologically relevant chemical space: A structural classification of natural products (SCONP)
2005
Privileged Molecules for Protein Binding Identified from NMR-Based Screening
2000
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Solar Synthesis: Prospects in Visible Light Photocatalysis
2014 StandoutScience
Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry
2008 StandoutNobel
Tin tetrachloride-induced π-cyclizations of glycine cation equivalents to substituted pipecolic acid derivatives
1991
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Second-Site NMR Screening with a Spin-Labeled First Ligand
2000
Lamin B1 loss is a senescence-associated biomarker
2012
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Acyliminium ion cyclisations to pyrrolo- and pyrido-[1,2-f]phenanthridine and benzo[de]pyrrolo[2,1-a]isoquinoline ring systems
1992
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of Guy W. Bemis being referenced
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
1997
Kinase inhibitors and the case for CH…O hydrogen bonds in protein–ligand binding
2002
The SHAPES strategy: an NMR-based approach for lead generation in drug discovery
1999
Dramatic reversal of diastereoselectivity in an N-acyliminium ion cyclization leading to hexahydropyrrolo[2,1-a]isoquinolines. A case of competing steric interactions
1986
Designing Libraries with CNS Activity
1999
BREED: Generating Novel Inhibitors through Hybridization of Known Ligands. Application to CDK2, P38, and HIV Protease
2004
Properties of Known Drugs. 2. Side Chains
1999
The Properties of Known Drugs. 1. Molecular Frameworks
1996 Standout
Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors
2007
Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzyme
1997
Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases
2010
Inhibitors ofp38 MAP Kinase: TherapeuticIntervention inCytokine-Mediated Diseases
1999