Standout Papers

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment 2009 2026 2014 2020 993
  1. The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment (2009)
    Greg M. Delgoffe, Thomas P. Kole et al. Immunity
  2. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2 (2011)
    Greg M. Delgoffe, Kristen Pollizzi et al. Nature Immunology
  3. Metabolic support of tumour-infiltrating regulatory T cells by lactic acid (2021)
    McLane J. Watson, Paolo Vignali et al. Nature
  4. Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion (2016)
    Bertram Bengsch, Andrew L. Johnson et al. Immunity
  5. The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction (2016)
    Nicole E. Scharping, Ashley V. Menk et al. Immunity
  6. Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion (2021)
    Nicole E. Scharping, Dayana B. Rivadeneira et al. Nature Immunology
  7. Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis (2013)
    Greg M. Delgoffe, Seng‐Ryong Woo et al. Nature
  8. Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity (2017)
    Abigail E. Overacre-Delgoffe, Maria Chikina et al. Cell
  9. Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia (2016)
    Nicole E. Scharping, Ashley V. Menk et al. Cancer Immunology Research
  10. Metabolic barriers to cancer immunotherapy (2021)
    Kristin DePeaux, Greg M. Delgoffe Nature reviews. Immunology
  11. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions (2018)
    Ashley V. Menk, Nicole E. Scharping et al. Cell Reports
  12. Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity (2022)
    Paolo Vignali, Kristin DePeaux et al. Nature Immunology
  13. LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity (2024)
    Lawrence P. Andrews, Jian Cui et al. Cell
  14. Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism (2024)
    Ronal M. Peralta, Bingxian Xie et al. Nature Immunology

Immediate Impact

17 by Nobel laureates 23 from Science/Nature 125 standout
Sub-graph 1 of 17

Citing Papers

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67 intermediate papers

Works of Greg M. Delgoffe being referenced

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions
2018 Standout
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8 + T Cell Exhaustion
2016 Standout
and 29 more

Author Peers

Author Last Decade Papers Cites
Greg M. Delgoffe 7474 4104 3673 107 11.3k
Augusto C. Ochoa 10271 4821 3147 127 14.1k
Paulo C. Rodrı́guez 10346 4963 3514 121 14.7k
Ping‐Chih Ho 5028 3186 3770 104 9.4k
Ann Richmond 5381 6193 5009 164 12.7k
Ilona Kryczek 7816 6389 4250 91 13.3k
Karin E. de Visser 5587 5512 3553 79 11.1k
Gerritje J. W. van der Windt 6273 2693 3606 43 10.1k
Paola Zanovello 7231 3516 2973 142 10.8k
Gerhard Müller‐Newen 3860 4562 3790 125 10.0k
David G. DeNardo 8758 8420 4355 108 14.7k

All Works

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2026