Citation Impact
Citing Papers
Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax
2008
Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
2011
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Bax assembly into rings and arcs in apoptotic mitochondria is linked to membrane pores
2016
Mcl-1 Is Required for Melanoma Cell Resistance to Anoikis
2009
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
2009
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Tight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusion
2020 StandoutNobel
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
SOX5/6/21 Prevent Oncogene-Driven Transformation of Brain Stem Cells
2017
Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration
2006
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Contribution of Bcl-2 Phosphorylation to Bak Binding and Drug Resistance
2013
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis
2019
2016
Mito-priming as a method to engineer Bcl-2 addiction
2016
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Proapoptotic Bax and Bak Proteins Form Stable Protein-permeable Pores of Tunable Size
2013
Mitochondrial inner membrane permeabilisation enables mt DNA release during apoptosis
2018
Hallmarks of Cancer: The Next Generation
2011 Standout
Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis
2009
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
Emerging Role for Members of the Bcl-2 Family in Mitochondrial Morphogenesis
2009
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
2006
Concomitant loss of proapoptotic BH3‐only Bcl‐2 antagonists Bik and Bim arrests spermatogenesis
2005
Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic
2012
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia
2017
How the Bcl-2 family of proteins interact to regulate apoptosis
2006
BH3‐ligand regulates access of MCL‐1 to its E3 ligase
2005
BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation
2016
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Necroptosis and its role in inflammation
2015 StandoutNature
Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria
2004
Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
2009
Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation
2013
Regulation of apoptosis: uncovering the binding determinants
2005
BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX
2010
Diagnosing and exploiting cancer's addiction to blocks in apoptosis
2008
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
2010
A Stapled BID BH3 Helix Directly Binds and Activates BAX
2006
×Phosphorylation of Bax Ser184 by Akt Regulates Its Activity and Apoptosis in Neutrophils
2004
In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute
2008
The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation
2016
BID-induced structural changes in BAK promote apoptosis
2013
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis
2007
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
2006 Standout
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
2006
BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines
2018
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Structural Plasticity Underpins Promiscuous Binding of the Prosurvival Protein A1
2008
Rescuing the function of mutant p53
2001
Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival
2011
Caspase activation and apoptosis in response to proteasome inhibitors
2005
Intrinsic Instability of BOK Enables Membrane Permeabilization in Apoptosis
2018
Helicobacter pylori Vacuolating Cytotoxin Induces Activation of the Proapoptotic Proteins Bax and Bak, Leading to Cytochrome c Release and Cell Death, Independent of Vacuolation
2006
A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection
2017
BCL-2 family proteins: changing partners in the dance towards death
2017
BCL-2 family antagonists for cancer therapy
2008
Proteasome Inhibitor PS-341 Induces Apoptosis in Cisplatin-resistant Squamous Cell Carcinoma Cells by Induction of Noxa
2006
Flow cytometric analysis of apoptotic subpopulations with a combination of Annexin V-FITC, propidium iodide, and SYTO 17
2001
Autophagy: Renovation of Cells and Tissues
2011 Standout
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
2007
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Mitochondria: In Sickness and in Health
2012 Standout
Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX
2010
Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis
2016
Apoptosis: embedded in membranes
2010
Effect of scaffold morphology and cell co-culture on tenogenic differentiation of HADMSC on centrifugal melt electrospun poly (L‑lactic acid) fibrous meshes
2017
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
BAX activation is initiated at a novel interaction site
2008 Nature
Blinded by the Light: The Growing Complexity of p53
2009 Standout
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers
2010
Bcl‐2 changes conformation to inhibit Bax oligomerization
2006
BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response
2013
Protein folding and misfolding
2003 StandoutNature
The development of allergic inflammation
2008 StandoutNature
Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes
2010
Autophagy in the Pathogenesis of Disease
2008 Standout
Mutation to Bax beyond the BH3 Domain Disrupts Interactions with Pro-survival Proteins and Promotes Apoptosis
2011
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
2006
Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus BHRF1
2010
An interconnected hierarchical model of cell death regulation by the BCL-2 family
2015
Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist
2007
Autophagy in Human Health and Disease
2013 Standout
Programmed Anuclear Cell Death Delimits Platelet Life Span
2007
Bax Forms an Oligomer via Separate, Yet Interdependent, Surfaces
2010
A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak
2007
A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria
2011
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
Functional characterization of the Bcl-2 gene family in the zebrafish
2006
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics
2011
Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion
2017
Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation
2019
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
2008
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance
2007
DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa
2012
Expanding perspectives on the significance of mitophagy in cancer
2017
Pore-forming toxins: ancient, but never really out of fashion
2015
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
2012
Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol
2011
Small-molecule allosteric inhibitors of BAX
2019
AKT/PKB Signaling: Navigating the Network
2017 Standout
Mitochondria as multifaceted regulators of cell death
2019 Standout
The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest
2007
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
The Hallmarks of Aging
2013 Standout
Bax monomers form dimer units in the membrane that further self-assemble into multiple oligomeric species
2015
Life in the balance: how BH3-only proteins induce apoptosis
2005
Vibrio cholerae Porin OmpU Induces Caspase-independent Programmed Cell Death upon Translocation to the Host Cell Mitochondria
2015
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
2009
The BCL-2 protein family: opposing activities that mediate cell death
2007 Standout
Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane
2016
BIM-Mediated Membrane Insertion of the BAK Pore Domain Is an Essential Requirement for Apoptosis
2013
Molecular Details of Bax Activation, Oligomerization, and Membrane Insertion
2009
Cytochrome c: functions beyond respiration
2008
Mechanisms of Action of Bcl-2 Family Proteins
2013
Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1
2006
Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance
2016
Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands
2009
Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
2021 Nature
Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML
2012
Mitochondria and cell death: outer membrane permeabilization and beyond
2010 Standout
The BCL-2 Family Reunion
2010
NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells
2012
A Plug Release Mechanism for Membrane Permeation by MLKL
2014
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition
2007
Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics
2007
Embryogenesis and Adult Life in the Absence of Intrinsic Apoptosis Effectors BAX, BAK, and BOK
2018
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Structural insights into the degradation of Mcl-1 induced by BH3 domains
2007
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications
2019 Standout
Asthma : Mechanisms of Disease Persistence and Progression
2004
Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease
2013
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
2007 Science
Mcl-1 Integrates the Opposing Actions of Signaling Pathways That Mediate Survival and Apoptosis
2009
BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs
2010
Proteasome Inhibitor PS-341 Induces Apoptosis in Cisplatin-resistant Squamous Cell Carcinoma Cells by Induction of Noxa
2006
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity
2010
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway
2006
α/β-Peptide Foldamers Targeting Intracellular Protein–Protein Interactions with Activity in Living Cells
2015
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-xL Recognition: Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions
2006
Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak
2016
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Direct activation of full-length proapoptotic BAK
2013
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Apoptosis-inducing factor: vital and lethal
2006
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
2005 StandoutNature
Evaluating cytochrome c diffusion in the intermembrane spaces of mitochondria during cytochrome c release
2008
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Inhibiting the Mitochondrial Fission Machinery Does Not Prevent Bax/Bak-Dependent Apoptosis
2006
An intracellular wave of cytochrome c propagates and precedes Bax redistribution during apoptosis
2008
Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
2013
Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis
2014
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
2019
Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization
2012
Reshaping de Novo Protein Switches into Bioresponsive Materials for Biomarker, Toxin, and Viral Detection
2022 StandoutNobel
Visual and functional demonstration of growing Bax-induced pores in mitochondrial outer membranes
2014
Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis
2015
Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
2010
Differential retrotranslocation of mitochondrial Bax and Bak
2014
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
2008
Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain
2011
CASTp 3.0: computed atlas of surface topography of proteins
2018 Standout
Works of Grant Dewson being referenced
Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use
2018
Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies
2016
Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
2015
To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions
2008
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis
2013
Bak Activation for Apoptosis Involves Oligomerization of Dimers via Their α6 Helices
2009
Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
2015
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
2007
Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design
2017
Mitochondrial Release of Pro-apoptotic Proteins
2004
BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association
2019
Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers
2014
Proapoptotic Bak is sequestered by Mcl-1 and Bcl-x L , but not Bcl-2, until displaced by BH3-only proteins
2005
Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis
2015
Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains
2015
Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor
2010
Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function
2012
The Functional Differences between Pro-survival and Pro-apoptotic B Cell Lymphoma 2 (Bcl-2) Proteins Depend on Structural Differences in Their Bcl-2 Homology 3 (BH3) Domains
2014
A comparative study of different methods for the assessment of apoptosis and necrosis in human eosinophils
1998
Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function
2014
Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis
2013
Parkin and mitophagy in cancer
2016
Physiological restraint of Bak by Bcl-x L is essential for cell survival
2016
BCL-2: Long and winding path from discovery to therapeutic target
2017
Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells
2003
Assembly of the Bak Apoptotic Pore
2013
Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins
2011
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
2011
Expression of Bcl-2 and Its Homologues in Human Eosinophils
1999
Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis
2016
A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice
2017
Interleukin-5 inhibits translocation of Bax to the mitochondria, cytochrome c release, and activation of caspases in human eosinophils
2001
Molecular biology of Bax and Bak activation and action
2010
Small, but deadly: small-molecule inhibition of Bcl-2 homologue heterodimerization
2001
Parkin inhibits BAK and BAX apoptotic function by distinct mechanisms during mitophagy
2018
Disordered clusters of Bak dimers rupture mitochondria during apoptosis
2017
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis
2009
Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane
2014
Fas-mediated neutrophil apoptosis is accelerated by Bid, Bak, and Bax and inhibited by Bcl-2 and Mcl-1
2011
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
2010
Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak
2007