Citation Impact
Citing Papers
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
2013 Standout
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses
2010
The histamine H3 receptor as a therapeutic drug target for CNS disorders
2009
Ketone bodies as signaling metabolites
2013
A Study of the Involvement of Melanin-Concentrating Hormone Receptor 1 (MCHR1) in Murine Models of Depression
2006
Current and Future Drug Targets in Weight Management
2010
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
N-acylethanolamines, anandamide and food intake
2009
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones
2012 Standout
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
2009
HTRF: A Technology Tailored for Drug Discovery - A Review of Theoretical Aspects and Recent Applications
2009
Commensal bacteria make GPCR ligands that mimic human signalling molecules
2017 Nature
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Atherosclerosis: current pathogenesis and therapeutic options
2011 Standout
Association analyses suggest GPR24 as a shared susceptibility gene for bipolar affective disorder and schizophrenia
2006
Gold(I)‐Catalyzed Aminohalogenation of Fluorinated N′‐Aryl‐N‐Propargyl Amidines for the Synthesis of Imidazole Derivatives under Mild Conditions
2012
Nicotinic acid: an old drug with a promising future
2007
PET of Somatostatin Receptor–Positive Tumors Using 64Cu- and 68Ga-Somatostatin Antagonists: The Chelate Makes the Difference
2011
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
GPR119, a novel G protein‐coupled receptor target for the treatment of type 2 diabetes and obesity
2007
Iron‐Catalyzed Asymmetric Olefin cis‐Dihydroxylation with 97 % Enantiomeric Excess
2008
Manganese catalysed asymmetric cis-dihydroxylation with H2O2
2008 StandoutNobel
Efficacy of the MCHR1 Antagonist N-[3-(1-{[4-(3,4-Difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in Mouse Models of Anxiety and Depression following Acute and Chronic Administration Is Independent of Hippocampal Neurogenesis
2007
Novel bioactive glycerol-based lysophospholipids: New data – New insight into their function
2012
The growing impact of click chemistry on drug discovery
2003 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
2-Oleoyl Glycerol Is a GPR119 Agonist and Signals GLP-1 Release in Humans
2011
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
A within-trial cost-effectiveness analysis of primary care referral to a commercial provider for weight loss treatment, relative to standard care—an international randomised controlled trial
2012 Standout
The Catalytic Asymmetric Abramov Reaction
2014 StandoutNobel
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
MCH-R1 antagonists: what is keeping most research programs away from the clinic?
2007
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists
2006
Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
2011
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group
2004
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
Continuous‐Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
2015 Standout
Matching chelators to radiometals for radiopharmaceuticals
2013 Standout
1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes
2010
Continuous‐Flow Synthesis of 1‐Substituted Benzotriazoles from Chloronitrobenzenes and Amines in a CN Bond Formation/Hydrogenation/Diazotization/Cyclization Sequence
2013
β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
2009 StandoutNobel
Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder
2011 Standout
Oxidative Carbonylation Reactions: Organometallic Compounds (RM) or Hydrocarbons (RH) as Nucleophiles
2011
2,5-Disubstituted pyridines as potent GPR119 agonists
2010
Biaryl Phosphane Ligands in Palladium‐Catalyzed Amination
2008 Standout
GPR119 is required for physiological regulation of glucagon-like peptide-1 secretion but not for metabolic homeostasis
2009
Substitution of Two Fluorine Atoms in a Trifluoromethyl Group: Regioselective Synthesis of 3‐Fluoropyrazoles
2012
The molecular neurobiology of depression
2008 StandoutNature
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
2015 Standout
Prediabetes: a high-risk state for diabetes development
2012 Standout
Beyond Directing Groups: Transition‐Metal‐Catalyzed CH Activation of Simple Arenes
2012 Standout
Amyloid as a Depot for the Formulation of Long-Acting Drugs
2008
Solid-Phase Synthesis of Biologically Active Benzoannelated Nitrogen Heterocycles: An Update
2008
Bimodal Inhibition of Caspase-1 by Aryloxymethyl and Acyloxymethyl Ketones
1998
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Role of GPR81 in lactate-mediated reduction of adipose lipolysis
2008
Efficient synthesis of functionalized dihydroquinolines, quinolines and dihydrobenzo[b]azepine via an iron(iii ) chloride-catalyzed intramolecular alkyne–carbonyl metathesis of alkyne tethered 2-amino benzaldehyde/acetophenone derivatives
2014
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Microwave-Assisted Fluorination of 2-Acylpyrroles: Synthesis of Fluorohymenidin
2011
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Non-Peptide Gonadotropin-Releasing Hormone Receptor Antagonists
2008
A Novel Synthesis of Fluorinated Pyrazoles via Gold(I)-Catalyzed Tandem Aminofluorination of Alkynes in the Presence of Selectfluor
2011
Neanderthal ancestry drives evolution of lipid catabolism in contemporary Europeans
2014 StandoutNobel
Recent Developments in the Area of Thionation Methods and Related Synthetic Applications
1992
The Current State of Peptide Drug Discovery: Back to the Future?
2017
Rhodium(III)-Catalyzed C–C Coupling of Arenes with 2-Vinyloxiranes: Synthesis of Allylic Alcohols
2014
Lanthanide Luminescence for Biomedical Analyses and Imaging
2010 Standout
The potential for caspases in drug discovery.
2010
A General Strategy for the Synthesis of Amino-Substituted 2-Pyridones Using a Palladium-Catalyzed Amination Reaction
2007
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Recent Natural Products Based Drug Development: A Pharmaceutical Industry Perspective
1998
Mild metal-catalyzed C–H activation: examples and concepts
2016 Standout
Mitsunobu and Related Reactions: Advances and Applications
2009
Recent advances in the synthesis of pyrroles by multicomponent reactions
2014 Standout
Phosphine Organocatalysis
2018 Standout
Oxidative Carbonylierungen: Organometallverbindungen (RM) oder Kohlenwasserstoffe (RH) als Nucleophile
2011
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Structure-Based Design of Functional Amyloid Materials
2014 StandoutNobel
Development and Applications of Disulfonimides in Enantioselective Organocatalysis
2015 StandoutNobel
Chromone: A Valid Scaffold in Medicinal Chemistry
2014 Standout
Substitution of Two Fluorine Atoms in a Trifluoromethyl Group: Regioselective Synthesis of 3‐Fluoropyrazoles
2012
Use of Lawesson's Reagent in Organic Syntheses
2007 Standout
Iron‐Catalyzed Asymmetric Olefin cis‐Dihydroxylation with 97 % Enantiomeric Excess
2008
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles
2013
Remote, Late-Stage Oxidation of Aliphatic C–H Bonds in Amide-Containing Molecules
2017
Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules
2006 Standout
Microwave-Assisted Synthesis in Water as Solvent
2007 Standout
Silyl esters of phosphorous—common intermediates in synthesis
1989
Comprehensive Survey of Combinatorial Library Synthesis: 2005
2006
A combinatorial approach towards 2-acyl-3-amino-indole derivatives
2000
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Continuous‐Flow Synthesis of 1‐Substituted Benzotriazoles from Chloronitrobenzenes and Amines in a CN Bond Formation/Hydrogenation/Diazotization/Cyclization Sequence
2013
From 2000 to Mid-2010: A Fruitful Decade for the Synthesis of Pyrazoles
2011 Standout
GPR119 Is Essential for Oleoylethanolamide-Induced Glucagon-Like Peptide-1 Secretion From the Intestinal Enteroendocrine L-Cell
2009
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
2015 Standout
Works of Graeme Semple being referenced
Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1
2005
International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)
2011
Identification of 4-amino-2-cyclohexylaminoquinazolines as metabolically stable melanin-concentrating hormone receptor 1 antagonists
2006
Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists
2005
Novel H3 receptor antagonists with improved pharmacokinetic profiles
2008
Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1
2005
Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods
2003
Peptidomimetic aminomethylene ketone inhibitors of interleukin-1β-converting enzyme (ICE)
1998
Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans
2008
Nicotinic Acid Receptor Agonists Differentially Activate Downstream Effectors
2007
Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a
2007
Analogues of Acifran: Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b
2007
New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists
2008
A facile large scale synthesis of optically active 3-amino-5-(2-pyridyl)-1,4-benzodiazepin-2-one derivatives
1996
(3R)-N-(1-(tert-Butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H- 1,4-benzodiazepin-3-yl)-N‘-(3-(methylamino)phenyl)urea (YF476): A Potent and Orally Active Gastrin/CCK-B Antagonist
1997
1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b
2006
Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119
2008
Retroinverso endothionopeptides
1989
PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE)
1997
Synthesis of alkylated methylene bisphosphonates via organothallium intermediates
1985
GnRH Antagonists: A New Generation of Long Acting Analogues Incorporatingp-Ureido-phenylalanines at Positions 5 and 6
2000
A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release
2007