Standout Papers
Citation Impact
Citing Papers
Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis
2012
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
2012 StandoutScienceNobel
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
2015 Science
A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans
2020
The Structure of an Open Form of an E. coli Mechanosensitive Channel at 3.45 Å Resolution
2008 Science
Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension
2015
Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca2+ flickers
2019
Piezo1 ion channel pore properties are dictated by C-terminal region
2015 StandoutNobel
A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel
2018
Dynamic regulation of TREK1 gating by Polycystin 2 via a Filamin A-mediated cytoskeletal Mechanism
2017
Localized force application reveals mechanically sensitive domains of Piezo1
2016
Piezo1 Channels Are Inherently Mechanosensitive
2016 StandoutNobel
Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons
2015
Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
2017
Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
2016
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
The Primary cilium calcium channels and their role in flow sensing
2014
The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration
2019 StandoutNobel
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
The Structure of a Conserved Piezo Channel Domain Reveals a Topologically Distinct β Sandwich Fold
2014
Cationic channels activated by extracellular atp in rat sensory neurons
1988
Thermodynamics of Heat Activation of Single Capsaicin Ion Channels VR1
2003
C. elegans TRP Family Protein TRP-4 Is a Pore-Forming Subunit of a Native Mechanotransduction Channel
2010
Mechano-Gated Ion Channels in Sensory Systems
2013
Cl- flux through a non-selective, stretch-sensitive conductance influences the outer hair cell motor of the guinea-pig
2003
Inactivation Kinetics and Mechanical Gating of Piezo1 Ion Channels Depend on Subdomains within the Cap
2020
The mechano-gated K2P channel TREK-1
2008
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
‘Feeling the pressure’: structural insights into a gated mechanosensitive channel
1999
Molecular mechanisms of nociception
2001 StandoutNatureNobel
The Combined Effect of Hydrophobic Mismatch and Bilayer Local Bending on the Regulation of Mechanosensitive Ion Channels
2016
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels
2016
Stretch sensitivity of the lateral wall of the auditory outer hair cell from the guinea pig
1991
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Evidence for a protein tether involved in somatic touch
2010
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Structure of the mechanosensitive OSCA channels
2018
Mechanosensory hair cells express two molecularly distinct mechanotransduction channels
2016 StandoutNobel
Mechanotransduction gone awry
2008
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
2019 Nature
Structure and mechanism in prokaryotic mechanosensitive channels
2003
Force-induced conformational changes in PIEZO1
2019 NatureNobel
Spectator no more, the role of the membrane in regulating ion channel function
2016
piezo2bRegulates Vertebrate Light Touch Response
2013
Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force
2010
Analysis of Single-Molecule FRET Trajectories Using Hidden Markov Modeling
2006
Piezo2 is required for Merkel-cell mechanotransduction
2014 StandoutNatureNobel
K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site
2017 Nature
Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix
2017
Open channel structure of MscL and the gating mechanism of mechanosensitive channels
2002 Nature
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
The Purified Mechanosensitive Channel TREK-1 Is Directly Sensitive to Membrane Tension
2013
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Cochlear Outer Hair Cell Motility
2008
Voltage-sensor activation with a tarantula toxin as cargo
2005 Nature
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
2010 Nature
Structure and mechanogating of the mammalian tactile channel PIEZO2
2019 Nature
Mechanosensitive ion channels
1990
Common evolutionary origins of mechanosensitive ion channels in Archaea, Bacteria and cell‐walled Eukarya
2001
Improved Hidden Markov Models for Molecular Motors, Part 1: Basic Theory
2010
Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch
2014
Sensory mechanotransduction at membrane-matrix interfaces
2014
Gating of the Large Mechanosensitive Channel In Situ: Estimation of the Spatial Scale of the Transition from Channel Population Responses
2004
Kinetic properties of mechanically activated currents in spinal sensory neurons
2009
Definition of the Readily Releasable Pool of Vesicles at Hippocampal Synapses
1996
The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation
2009
A fast dynamic mode of the EF‐G‐bound ribosome
2009
Extracellular Proteins Needed for C. elegans Mechanosensation
1996 StandoutNobel
TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel
1999
TREK-2, a New Member of the Mechanosensitive Tandem-pore K+ Channel Family
2000
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Voltage-Gated Channel Mechanosensitivity: Fact or Friction?
2011
Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels
2013 StandoutNobel
Electron cryo-microscopy structure of the mechanotransduction channel NOMPC
2017 Nature
Phosphoinositide Regulation of TRP Channels
2014
Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception
2014
Mechanically Activated Ion Channels
2015 StandoutNobel
Piezos thrive under pressure: mechanically activated ion channels in health and disease
2017 StandoutNobel
Molecular mechanisms of mechanotransduction in mammalian sensory neurons
2011
Rapid Temperature Jump by Infrared Diode Laser Irradiation for Patch-Clamp Studies
2009
Piezo channels: from structure to function
2014
Molecular regulations governing TREK and TRAAK channel functions
2011
Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing
2005
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
2019
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
“Force-from-lipids” gating of mechanosensitive channels modulated by PUFAs
2017
The force-from-lipid (FFL) principle of mechanosensitivity, at large and in elements
2014
Piezo1 is required for outflow tract and aortic valve development.
2020
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
1994 StandoutNature
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
TRP channels as cellular sensors
2003 StandoutNature
The Piezo Mechanosensitive Ion Channels: May the Force Be with You!
2015
Synaptotagmin I functions as a calcium regulator of release probability
2001 StandoutNatureNobel
Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes
2014
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
2019
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Functional morphology of the telson‐uropod stretch receptor in the sand crab Emerita analoga
1990
Structural Models of the MscL Gating Mechanism
2001
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Transmembrane Helix Straightening and Buckling Underlies Activation of Mechanosensitive and Thermosensitive K2P Channels
2014
Regulation of Exocytotic Fusion by Cell Inflation
1998
Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
2018
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension
2002
Capsaicin Activation of the Pain Receptor, VR1: Multiple Open States from Both Partial and Full Binding
2003
Identification of a Gene Encoding a Hyperpolarization-Activated Pacemaker Channel of Brain
1998 StandoutNobel
Integrating the active process of hair cells with cochlear function
2014
A mammalian two pore domain mechano-gated S-like K+ channel
1998
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Epithelial sodium channel related to proteins involved in neurodegeneration
1993 Nature
Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels
2016
Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology
2017
Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile
2018
Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets
2019
Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors
2016
Identification of Two Distinct Hybrid State Intermediates on the Ribosome
2007
Capacitative calcium entry channels
1999
Vanilloid Receptor–Related Osmotically Activated Channel (VR-OAC), a Candidate Vertebrate Osmoreceptor
2000 Standout
Direct recording and molecular identification of the calcium channel of primary cilia
2013 Nature
Touch, Tension, and Transduction – The Function and Regulation of Piezo Ion Channels
2016
Piezo1 plays a role in erythrocyte volume homeostasis
2013
The principle of gating charge movement in a voltage-dependent K+ channel
2003 StandoutNatureNobel
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating
2002
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel
2014 NatureNobel
Structure and mechanogating mechanism of the Piezo1 channel
2018 Nature
Localization of β and γ subunits of ENaC in sensory nerve endings in the rat foot pad
2000
Mechanosensing is critical for axon growth in the developing brain
2016
A possible unifying principle for mechanosensation
2005 Nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain
2010 StandoutNobel
Single‐channel properties of native and cloned rat vanilloid receptors
2002
Directionality of Temperature Activation in Mouse TRPA1 Ion Channel Can Be Inverted by Single-Point Mutations in Ankyrin Repeat Six
2014 StandoutNobel
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
TRPC1 forms the stretch-activated cation channel in vertebrate cells
2005
Disorders of red cell volume regulation
2013
How We Feel: Ion Channel Partnerships that Detect Mechanical Inputs and Give Rise to Touch and Pain Perception
2012
TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells
2020
Caenorhabditis elegans TRPA-1 functions in mechanosensation
2007 StandoutNobel
Identification and Analysis of Putative Homologues of Mechanosensitive Channels in Pathogenic Protozoa
2013
Mechanosensitive ion channels of E. coli activated by amphipaths
1990 Nature
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Architecture of the mammalian mechanosensitive Piezo1 channel
2015 Nature
TRP channels and mechanosensory transduction: insights into the arterial myogenic response
2008
Emerging roles for lipids in shaping membrane-protein function
2009 Nature
Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization
2017 StandoutNobel
The role of lipids in mechanosensation
2015
The neuronal background K2P channels: focus on TREK1
2007
Structure of the hyperosmolality-gated calcium-permeable channel OSCA1.2
2018
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
1998 Standout
Mechanosensitive TRPC1 Channels Promote Calpain Proteolysis of Talin to Regulate Spinal Axon Outgrowth
2013
Learning Rates and States from Biophysical Time Series: A Bayesian Approach to Model Selection and Single-Molecule FRET Data
2009
Neurosensory mechanotransduction
2008 StandoutNobel
Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel
1999
How the ear's works work
1989 StandoutNature
The RSC chromatin remodelling ATPase translocates DNA with high force and small step size
2011
Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution
1993
Sensing pressure with ion channels
2012
Integrins as mechanochemical transducers
1991
Transduction without Tip Links in Cochlear Hair Cells Is Mediated by Ion Channels with Permeation Properties Distinct from Those of the Mechano-Electrical Transducer Channel
2014
Stretch-Activation and Stretch-Inactivation of Shaker-IR, a Voltage-Gated K+ Channel
2001
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Evidence of fast serotonin transmission in frog slowly adapting type 1 responses
2010
The emerging role of forces in axonal elongation
2011
On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL
2003
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
Inward current channels activated by intracellular Ca in cultured cardiac cells
1981 StandoutNatureNobel
MEC-2 and MEC-6 in the Caenorhabditis elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable Channel Activity
2008
Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS
2012
Novel mechanisms of PIEZO1 dysfunction in hereditary xerocytosis
2017
The mechanosensitive Piezo1 channel is required for bone formation
2019
Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells
2013
Piezo1 links mechanical forces to red blood cell volume
2015 StandoutNobel
Eukaryotic Mechanosensitive Channels
2010 Nobel
Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides
2015
A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels
1989
Single-molecule observation of helix staggering, sliding, and coiled coil misfolding
2012
Pressure-sensitive ion channel in Escherichia coli.
1987
Mechanosensitive Ion Channels in Cultured Sensory Neurons of Neonatal Rats
2002
Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance
2008
A speed limit for conformational change of an allosteric membrane protein
2004
A Structural Mechanism for MscS Gating in Lipid Bilayers
2008 Science
Spontaneous formation of the unlocked state of the ribosome is a multistep process
2009
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
2020
Piezo1 mediates angiogenesis through activation of MT1-MMP signaling
2018
Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes
2017
A study of stretch‐activated channels in the membrane of frog oocytes: interactions with Ca2+ ions.
1988
Membrane-Protein Interactions in Mechanosensitive Channels
2004
A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification
2003
A Mechanosensitive Ion Channel in the Yeast Plasma Membrane
1988 Science
Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes
1987 Nature
TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons
2011
Bacterial Mechanosensors
2017
Molecular Background of Leak K+Currents: Two-Pore Domain Potassium Channels
2010
Conductance and block of hair-cell mechanotransducer channels in transmembrane channel–like protein mutants
2014
Yoda1 analogue (D ooku1) which antagonizes Y oda1‐evoked activation of P iezo1 and aortic relaxation
2018
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
2013 StandoutNobel
Structure-guided examination of the mechanogating mechanism of PIEZO2
2019
Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K + channels
2014 Nobel
Permeation of both cations and anions through a single class of ATP-activated ion channels in developing chick skeletal muscle.
1990
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Polycystins and partners: proposed role in mechanosensitivity
2014
Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis
2019
Acetylcholine receptor: Modification of synaptic gating mechanism after treatment with a disulfide bond reducing agent
1975
Reversible inhibition of voltage-dependent outer hair cell motility and capacitance
1991
A nonselective cation channel in rat liver cells is activated by membrane stretch
1990
Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels
2014
Molecular Basis of Mechanotransduction in Living Cells
2001
The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding
2014
Feeling the hidden mechanical forces in lipid bilayer is an original sense
2014
United in Diversity: Mechanosensitive Ion Channels in Plants
2014
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
2006
Mechanisms of Mechanotransduction
2006
INDUCED MEMBRANE HYPO/HYPER-MECHANOSENSITIVITY:A Limitation of Patch-Clamp Recording
1997
Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins
2018
The actions of calcium on the mechano‐electrical transducer current of turtle hair cells.
1991
Mechanosensitive ion channel Piezo2 is inhibited by D-GsMTx4
2017
Coupling of voltage-dependent gating and Ba++ block in the high-conductance, Ca++-activated K+ channel.
1987
Mammalian TRP ion channels are insensitive to membrane stretch
2019
Asymmetric mechanosensitivity in a eukaryotic ion channel
2017
Tarantula Toxins Interact with Voltage Sensors within Lipid Membranes
2007
Molecular and electrophysiological characterization of a mechanosensitive channel expressed in the chloroplasts of Chlamydomonas
2007
Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
2014
Assessment of Potential Stimuli for Mechano-Dependent Gating of MscL: Effects of Pressure, Tension, and Lipid Headgroups
2005
The transduction channel of hair cells from the bull‐frog characterized by noise analysis.
1986
Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion
2015
Piezo’s membrane footprint and its contribution to mechanosensitivity
2018 Nobel
A structural model of the acetylcholine receptor channel based on partition energy and helix packing calculations
1984
Stiffened lipid platforms at molecular force foci
2013
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
1988 StandoutNatureNobel
Chemical activation of the mechanotransduction channel Piezo1
2015 StandoutNobel
Structure-based membrane dome mechanism for Piezo mechanosensitivity
2017 Nobel
OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels
2018 StandoutNobel
Patch clamp measurements onXenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels
1986 StandoutNobel
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones
1982 StandoutNatureNobel
The Physiology of Mechanoelectrical Transduction Channels in Hearing
2014
Single-channel currents recorded from membrane of denervated frog muscle fibres
1976 StandoutNatureNobel
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2
2015
Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K + channels
2012 Nobel
Flow-mediated endothelial mechanotransduction
1995 Standout
Mechanics in Neuronal Development and Repair
2013
Highly Anisotropic Stability and Folding Kinetics of a Single Coiled Coil Protein under Mechanical Tension
2011
TRP Channels as Sensors of Chemically-Induced Changes in Cell Membrane Mechanical Properties
2019
Shear force sensing of epithelial Na + channel (ENaC) relies on N -glycosylated asparagines in the palm and knuckle domains of αENaC
2019
Works of Frederick Sachs being referenced
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage
2014
Baroreceptor mechanisms at the cellular level.
1987
Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
2016
Identification of a Peptide Toxin fromGrammostola spatulataSpider Venom That Blocks Cation-Selective Stretch-Activated Channels
2000
Cholesterol Depletion Facilitates Recovery from Hypotonic Cell Swelling in CHO Cells
2011
Mechanical stress activates NMDA receptors in the absence of agonists
2017
Mechanosensitivity of Na v 1.5, a voltage-sensitive sodium channel
2010
Molecular force transduction by ion channels – diversity and unifying principles
2012
Effects of GsMTx4 on Bacterial Mechanosensitive Channels in Inside-Out Patches from Giant Spheroplasts
2010
Quantitative video microscopy of patch clamped membranes stress, strain, capacitance, and stretch channel activation
1991
Hypoxia Activates a Ca2+-Permeable Cation Conductance Sensitive to Carbon Monoxide and to GsMTx-4 in Human and Mouse Sickle Erythrocytes
2010
Stretch induced endothelin-1 secretion by adult rat astrocytes involves calcium influx via stretch-activated ion channels (SACs)
2011
Mechanosensitive ion channels in nonspecialized cells
2005
Mechanosensitive channel properties and membrane mechanics in mouse dystrophic myotubes
2007
Revisiting TRPC1 and TRPC6 mechanosensitivity
2007
Ionic Selectivity and Permeation Properties of Human PIEZO1 Channels
2015
Biophysics and Structure of the Patch and the Gigaseal
2009
Extracting Dwell Time Sequences from Processive Molecular Motor Data
2006
Polycystin-1 and -2 Dosage Regulates Pressure Sensing
2009
Voltage-induced membrane movement
2001 Nature
Free Volume in Membranes: Viscosity or Tension?
2015
Neurite outgrowth from PC12 cells is enhanced by an inhibitor of mechanical channels
2010
Protonation of the Human PIEZO1 Ion Channel Stabilizes Inactivation
2015
Mechanical transduction by membrane ion channels: a mini review
1991
A Direct Optimization Approach to Hidden Markov Modeling for Single Channel Kinetics
2000
Mechanically Activated Currents in Chick Heart Cells
1996
Mechanical transduction by ion channels: A cautionary tale
2015
Piezo1
2012
Stretch-activated ion channels in guinea pig outer hair cells
1991
Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K2P Channels
2012
Regulation of the Mechano‐Gated K2P Channel TREK‐1 by Membrane Phospholipids
2007
Solution Structure of Peptide Toxins That Block Mechanosensitive Ion Channels
2002
Caveolae Regulation of Mechanosensitive Channel Function in Myotubes
2013
Mechanosensation and endothelin in astrocytes—hypothetical roles in CNS pathophysiology
2004
Thermodynamics of mechanosensitivity
2004
Atomic force microscopy analysis of cell volume regulation
2008
The Breakdown of Cell Membranes by Electrical and Mechanical Stress
1998
Effects of Lys to Glu mutations in GsMTx4 on membrane binding, peptide orientation, and self-association propensity, as analyzed by molecular dynamics simulations
2015
Ca2+Influx through Mechanosensitive Channels Inhibits Neurite Outgrowth in Opposition to Other Influx Pathways and Release from Intracellular Stores
2006
Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: History, properties, mechanisms and pharmacology
2006
Mechanotransducing ion channels in astrocytes
1992
Up- and down-regulation of the mechano-gated K2P channel TREK-1 by PIP2 and other membrane phospholipids
2007
Human PIEZO1: Removing Inactivation
2013
A fluorescence energy transfer‐based mechanical stress sensor for specific proteins in situ
2008
Gating the mechanical channel Piezo1
2012
Tarantula peptide inhibits atrial fibrillation
2001 Nature
A simple automated stimulator of mechanically induced arrhythmias in the isolated rat heart
2009
Real Time FRET Based Detection of Mechanical Stress in Cytoskeletal and Extracellular Matrix Proteins
2010
Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events
1996
Stretch-Activated Channels in Heart Cells
1991
Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers
2004 Nature
Effects of stretch‐activated channel blockers on [Ca2+]i and muscle damage in the mdx mouse
2004
Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer
2016
GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels
2017
High-speed pressure clamp
2002
Mechanosensitive Ion Channels as Drug Targets
2004
Maximum Likelihood Estimation of Molecular Motor Kinetics from Staircase Dwell-Time Sequences
2006
Dynamic regulation of mechanosensitive channels: capacitance used to monitor patch tension in real time
2004
Mechanically Induced Calcium Movements in Astrocytes, Bovine Aortic Endothelial Cells and C6 Glioma Cells
2000
Hidden Markov Modeling for Single Channel Kinetics with Filtering and Correlated Noise
2000
cDNA sequence and in vitro folding of GsMTx4, a specific peptide inhibitor of mechanosensitive channels
2003
GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion
2016
Fluorescence-Based Force/Tension Sensors: A Novel Tool to Visualize Mechanical Forces in Structural Proteins in Live Cells
2013
Stretch-activated whole cell currents in adult rat cardiac myocytes
2000
Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels
1992
Is Lipid Bilayer Binding a Common Property of Inhibitor Cysteine Knot Ion-Channel Blockers?
2007
The Peptide GsMTx4 Inhibits the TREK-1 Channel from the Intracellular Side
2009
Desensitization of mechano-gated K 2P channels
2006
The structure and dynamics of patch-clamped membranes: a study using differential interference contrast light microscopy.
1990
Hereditary xerocytosis revisited
2014
Flickering of a nicotinic ion channel to a subconductance state
1983
The automated analysis of data from single ionic channels
1982
A mechanosensitive ion channel regulating cell volume
2010
Biophysics of Mechanoreception
1986
Characterization of stretch‐activated ion channels in Xenopus oocytes.
1990
Stretch-Activated Ion Channels: What Are They?
2010
Energetic and Spatial Parameters for Gating of the Bacterial Large Conductance Mechanosensitive Channel, MscL
1999
The ultrastructure of patch-clamped membranes: a study using high voltage electron microscopy.
1991
Mechanical transduction by ion channels: how forces reach the channel.
1997
Acetylcholine Noise in Tissue Culture Muscle Cells
1973
Mechanotransducer ion channels in chick skeletal muscle: the effects of extracellular pH.
1985
Ca2+ uptake in GH3 cells during hypotonic swelling: the sensory role of stretch-activated ion channels
1996
Maximum likelihood estimation of aggregated Markov processes
1997
Single ionic channels observed in tissue-cultured muscle
1979 Nature
Mechanical perturbation of cultured human endothelial cells causes rapid increases of intracellular calcium
1993
The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4
2011
Block of Stretch-Activated Ion Channels in Xenopus Oocytes by Gadolinium and Calcium Ions
1989 Science
Microfluidic Chip to Produce Temperature Jumps for Electrophysiology
2008
Stretch-induced voltage changes in the isolated beating heart: importance of the timing of stretch and implications for stretch-activated ion channels
1996
Stretch-sensitive ion channels: an update.
1992
[14] Temperature measurement and control of small volumes: Applications for single channel recording
1986
Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1
2013
Mechanical transduction in biological systems.
1988
Single-channel currents from acetylcholine receptors in embryonic chick muscle. Kinetic and conductance properties of gaps within bursts
1984
Stretch‐activated single ion channel currents in tissue‐cultured embryonic chick skeletal muscle.
1984
Gigaseal Mechanics: Creep of the Gigaseal under the Action of Pressure, Adhesion, and Voltage
2014