Standout Papers

Neurogenesis in the adult human hippocampus 1996 2026 2006 2016 4.6k
  1. Neurogenesis in the adult human hippocampus (1998)
    Peter S. Eriksson, Thomas Björk‐Eriksson et al. Nature Medicine
  2. In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector (1996)
    Luigi Naldini, Ulrike Blömer et al. Science
  3. Mammalian Neural Stem Cells (2000)
    Fred H. Gage Science
  4. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus (1999)
    Henriette van Praag, Gerd Kempermann et al. Nature Neuroscience
  5. Mechanisms Underlying Inflammation in Neurodegeneration (2010)
    Christopher K. Glass, Kaoru Saijo et al. Cell
  6. More hippocampal neurons in adult mice living in an enriched environment (1997)
    Gerd Kempermann, H. Georg Kuhn et al. Nature
  7. Mechanisms and Functional Implications of Adult Neurogenesis (2008)
    Chunmei Zhao, Wei Deng et al. Cell
  8. Running enhances neurogenesis, learning, and long-term potentiation in mice (1999)
    Henriette van Praag, Brian R. Christie et al. Proceedings of the National Academy of Sciences
  9. Functional neurogenesis in the adult hippocampus (2002)
    Henriette van Praag, Alejandro F. Schinder et al. Nature
  10. Neural consequences of enviromental enrichment (2000)
    Henriette van Praag, Gerd Kempermann et al. Nature reviews. Neuroscience
  11. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010)
    Wei Deng, James B. Aimone et al. Nature reviews. Neuroscience
  12. Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice (2005)
    Henriette van Praag, Tiffany E. Shubert et al. Journal of Neuroscience
  13. Reactive astrocytes: cellular and molecular cues to biological function (1997)
    Jean‐Luc Ridet, Alain Privat et al. Trends in Neurosciences
  14. Vascular niche for adult hippocampal neurogenesis (2000)
    Theo D. Palmer, Fred H. Gage et al. The Journal of Comparative Neurology
  15. Direct isolation of human central nervous system stem cells (2000)
    Nobuko Uchida, David Buck et al. Proceedings of the National Academy of Sciences
  16. A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation (2009)
    Claire D. Clelland, Minee-Liane Choi et al. Science
  17. Wnt signalling regulates adult hippocampal neurogenesis (2005)
    D. Chichung Lie, Sophia A. Colamarino et al. Nature
  18. In vivo demonstration that α-synuclein oligomers are toxic (2011)
    Beate Winner, Roberto Jappelli et al. Proceedings of the National Academy of Sciences
  19. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. (1996)
    Luigi Naldini, Ulrike Blömer et al. Proceedings of the National Academy of Sciences
  20. Astroglia induce neurogenesis from adult neural stem cells (2002)
    Hongjun Song, Charles F. Stevens et al. Nature
  21. Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus (2006)
    Chunmei Zhao, Robert G. Summers et al. Journal of Neuroscience
  22. An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus (2007)
    Ana Catarina Pereira, Daniel E. Huddleston et al. Proceedings of the National Academy of Sciences
  23. Modelling schizophrenia using human induced pluripotent stem cells (2011)
    Kristen Brennand, Anthony Simone et al. Nature
  24. Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain (1997)
    H. Georg Kuhn, Jürgen Winkler et al. Journal of Neuroscience
  25. A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells (2010)
    Maria C. Marchetto, Cassiano Carromeu et al. Cell
  26. Development of a Self-Inactivating Lentivirus Vector (1998)
    Hiroyuki Miyoshi, Ulrike Blömer et al. Journal of Virology
  27. Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells (2012)
    Mason A. Israel, Shauna H. Yuan et al. Nature
  28. The Adult Rat Hippocampus Contains Primordial Neural Stem Cells (1997)
    Theo D. Palmer, Jun Takahashi et al. Molecular and Cellular Neuroscience
  29. Experience-Induced Neurogenesis in the Senescent Dentate Gyrus (1998)
    Gerd Kempermann, H. Georg Kuhn et al. Journal of Neuroscience
  30. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor (1987)
    Walter Fischer, Klas Wictorin et al. Nature
  31. An in vivo model of functional and vascularized human brain organoids (2018)
    Abed AlFatah Mansour, J. Tiago Gonçalves et al. Nature Biotechnology
  32. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. (1995)
    Fred H. Gage, Penelope W. Coates et al. Proceedings of the National Academy of Sciences
  33. Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice (2002)
    Gerd Kempermann, Daniela Gast et al. Development
  34. Therapeutic interventions after spinal cord injury (2006)
    Sandrine Thuret, Lawrence Moon et al. Nature reviews. Neuroscience
  35. Adult hippocampal neurogenesis and its role in Alzheimer's disease (2011)
    Yangling Mu, Fred H. Gage Molecular Neurodegeneration
  36. Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior (2016)
    J. Tiago Gonçalves, Simon T. Schafer et al. Cell
  37. An environment-dependent transcriptional network specifies human microglia identity (2017)
    David Gosselin, Dylan Skola et al. Science
  38. A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death (2009)
    Kaoru Saijo, Beate Winner et al. Cell
  39. Adult brain neurogenesis and psychiatry: a novel theory of depression (2000)
    Barry L. Jacobs, Henriette van Praag et al. Molecular Psychiatry
  40. Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS (1999)
    Theo D. Palmer, Eleni A. Markakis et al. Journal of Neuroscience
  41. Hippocampal connections and spatial discrimination (1978)
    David S. Olton, John Walker et al. Brain Research
  42. Human embryonic stem cells express an immunogenic nonhuman sialic acid (2005)
    Maria J. Martin, Alysson R. Muotri et al. Nature Medicine
  43. Neurogenesis in the Adult Hippocampus (2015)
    Gerd Kempermann, Hongjun Song et al. Cold Spring Harbor Perspectives in Biology
  44. Retrograde Viral Delivery of IGF-1 Prolongs Survival in a Mouse ALS Model (2003)
    Brian K. Kaspar, Jerònia Lladó et al. Science
  45. Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment (2002)
    Gerd Kempermann, Daniela Gast et al. Annals of Neurology
  46. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition (2005)
    Alysson R. Muotri, Vi Chu et al. Nature
  47. Isolation, Characterization, and use of Stem Cells from the CNS (1995)
    Fred H. Gage, J Ray et al. Annual Review of Neuroscience
  48. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo (2004)
    Jennifer Farmer, Xinyu Zhao et al. Neuroscience
  49. Stem and Progenitor Cells: Origins, Phenotypes, Lineage Commitments, and Transdifferentiations (2001)
    Irving L. Weissman, David J. Anderson et al. Annual Review of Cell and Developmental Biology
  50. Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo (2002)
    Karen Lai, Brian K. Kaspar et al. Nature Neuroscience
  51. Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord (2000)
    Philip J. Horner, Ann E. Power et al. Journal of Neuroscience
  52. Regenerating the damaged central nervous system (2000)
    Philip J. Horner, Fred H. Gage Nature
  53. L1 retrotransposition in human neural progenitor cells (2009)
    Nicole G. Coufal, José L. García-Pérez et al. Nature
  54. Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis (2003)
    Jason P. Brown, Christiana M. Cooper‐Kuhn et al. European Journal of Neuroscience
  55. In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2+ Neural Stem Cells in the Adult Hippocampus (2007)
    Hoonkyo Suh, Antonella Consiglio et al. Cell stem cell
  56. Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector (1997)
    Ulrike Blömer, Luigi Naldini et al. Journal of Virology
  57. Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells (2004)
    Jenny Hsieh, Kinichi Nakashima et al. Proceedings of the National Academy of Sciences
  58. Multipotent progenitor cells in the adult dentate gyrus (1998)
    Fred H. Gage, Gerd Kempermann et al. Journal of Neurobiology
  59. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model (2018)
    Se Hoon Choi, Enjana Bylykbashi et al. Science
  60. Neurons born in the adult dentate gyrus form functional synapses with target cells (2008)
    Nicolas Toni, Diego A. Laplagne et al. Nature Neuroscience
  61. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice (2005)
    B. Cummings, Nobuko Uchida et al. Proceedings of the National Academy of Sciences
  62. Human Adult Neurogenesis: Evidence and Remaining Questions (2018)
    Gerd Kempermann, Fred H. Gage et al. Cell stem cell
  63. Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus (2000)
    Lamya S. Shihabuddin, Philip J. Horner et al. Journal of Neuroscience
  64. FGF-2-Responsive Neuronal Progenitors Reside in Proliferative and Quiescent Regions of the Adult Rodent Brain (1995)
    Theo D. Palmer, J Ray et al. Molecular and Cellular Neuroscience
  65. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats (2009)
    Sebastian Jessberger, Robert E. Clark et al. Learning & Memory
  66. Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury (1997)
    Ray Grill, Keith K. Murai et al. Journal of Neuroscience
  67. Genetic influence on neurogenesis in the dentate gyrus of adult mice (1997)
    Gerd Kempermann, H. Georg Kuhn et al. Proceedings of the National Academy of Sciences
  68. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects (2015)
    Jérôme Mertens, Apuã C.M. Paquola et al. Cell stem cell
  69. Potential role for adult neurogenesis in the encoding of time in new memories (2006)
    James B. Aimone, Janet Wiles et al. Nature Neuroscience
  70. Functional significance of adult neurogenesis (2004)
    Gerd Kempermann, Laurenz Wiskott et al. Current Opinion in Neurobiology
  71. Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis (2009)
    Tomoko Kuwabara, Jenny Hsieh et al. Nature Neuroscience
  72. Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation (2011)
    James B. Aimone, Wei Deng et al. Neuron
  73. Regulation and Function of Adult Neurogenesis: From Genes to Cognition (2014)
    James B. Aimone, Yan Li et al. Physiological Reviews
  74. The role of adult hippocampal neurogenesis in brain health and disease (2018)
    Tomohisa Toda, Sarah Parylak et al. Molecular Psychiatry
  75. Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation (2016)
    Xinde Zheng, Leah Boyer et al. eLife
  76. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS (2015)
    Ana Jovičić, Jérôme Mertens et al. Nature Neuroscience
  77. A regenerative approach to the treatment of multiple sclerosis (2013)
    V. Deshmukh, Virginie Tardif et al. Nature
  78. The role of retrotransposable elements in ageing and age-associated diseases (2021)
    Vera Gorbunova, Andrei Seluanov et al. Nature
  79. A nomenclature consensus for nervous system organoids and assembloids (2022)
    Sergiu P. Pașca, Paola Arlotta et al. Nature
  80. An in vivo neuroimmune organoid model to study human microglia phenotypes (2023)
    Simon T. Schafer, Abed AlFatah Mansour et al. Cell

Immediate Impact

21 by Nobel laureates 64 from Science/Nature 159 standout
Sub-graph 1 of 19

Citing Papers

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7 intermediate papers

Works of Fred H. Gage being referenced

CRISPR interference-based specific and efficient gene inactivation in the brain
2018
Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells
2008
and 9 more

Author Peers

Author Last Decade Papers Cites
Fred H. Gage 53643 61065 58290 742 143.0k
Mark P. Mattson 28661 50681 9846 948 125.5k
Bruce S. McEwen 30956 17365 13988 1.0k 154.3k
Pasko Rakić 25072 26087 19262 360 61.8k
Michael E. Greenberg 26130 57907 7472 249 87.5k
Ben A. Barres 19466 23688 15255 171 61.2k
Hideyuki Okano 14737 31604 12250 1.1k 59.8k
Arturo Álvarez-Buylla 17653 23859 31773 224 51.7k
Carl W. Cotman 33526 27855 10092 659 76.2k
John Q. Trojanowski 31420 45584 4612 1.1k 148.3k
Thomas C. Südhof 40299 64289 4440 584 96.5k

All Works

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2026