Standout Papers
Citation Impact
Citing Papers
Antibody Class Switching Mediated by Yeast Endonuclease-Generated DNA Breaks
2006 Science
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
2014
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
Trans-splicing as a possible molecular mechanism for the multiple isotype expression of the immunoglobulin gene.
1991 StandoutNobel
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
Linking class-switch recombination with somatic hypermutation
2001 StandoutNobel
The biochemistry of activation-induced deaminase and its physiological functions
2012
A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis
1991
The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching
1996
Mechanism and Regulation of Immunoglobulin Isotype Switching
1993
Somatic Hypermutation of Immunoglobulin Genes Is Linked to Transcription Initiation
1996
The Igκ 3′ Enhancer Influences the Ratio of Igκ versus Igλ B Lymphocytes
1996
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination
2012 StandoutNobel
The V(D)J recombination activating gene, RAG-1
1989 Nobel
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair
2004
Stable expression of immunoglobulin gene V(D)J recombinase activity by gene transfer into 3T3 fibroblasts
1988 Nobel
A DNA Aptamer That Binds Adenosine and ATP
1995 StandoutNobel
Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution
1993
Separate domains of AID are required for somatic hypermutation and class-switch recombination
2004 StandoutNobel
Structure of the recA protein–ADP complex
1992 StandoutNatureNobel
Elevated recombination rates in transcriptionally active DNA
1989 Standout
Transcription-targeted DNA deamination by the AID antibody diversification enzyme
2003 Nature
Activation-induced cytidine deaminase structure and functions: A species comparative view
2011
Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation
2001 Nature
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
1993 StandoutNatureNobel
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
2001 StandoutNatureNobel
A DNA metalloenzyme with DNA ligase activity
1995 StandoutNatureNobel
The influence of transcriptional orientation on endogenous switch region function
2003
RNA folding: beyond Watson–Crick pairs
2000
Isotype switching of an immunoglobulin heavy chain transgene occurs by DNA recombination between different chromosomes
1990
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Elements regulating somatic hypermutation of an immunoglobulin κ gene: Critical role for the intron enhancer/matrix attachment region
1994 Nobel
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
1992 Standout
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
The AID Dilemma
2012 StandoutNobel
Transgenic Mice and Analysis of B-Cell Tolerance
1992
Somatic hypermutagenesis in immunoglobulin genes
1992
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Double-strand breaks at an initiation site for meiotic gene conversion
1989 StandoutNatureNobel
Germline transcripts of the immunoglobulin heavy-chain and T cell receptor genes in a murine hematopoietic stem cell line LyD9 and its derivative cell lines
1991 Nobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The locus of sequence-directed and protein-induced DNA bending
1984 StandoutNature
Generation of Lymphohematopoietic Cells from Embryonic Stem Cells in Culture
1994 StandoutScienceNobel
Somatic generation of antibody diversity.
1976 StandoutNobel
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
1986
Somatic diversification of immunoglobulins.
1984
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
2000 StandoutScienceNobel
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
1989 StandoutScienceNobel
Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.
1991 StandoutNobel
Developmental stage specificity of the lymphoid V(D)J recombination activity.
1987
Multiple Immunoglobulin Heavy-Chain Gene Transcripts in Abelson Murine Leukemia Virus-Transformed Lymphoid Cell Lines
1982 Nobel
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
Monoclonal Antibodies Reveal the Structural Basis of Antibody Diversity
1983 Science
Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin.
1991 StandoutNobel
AID Binds Cooperatively with UNG and Msh2-Msh6 to Ig Switch Regions Dependent upon the AID C Terminus
2011
DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
2007
V(D)J recombination: a functional definition of the joining signals.
1989
Mini-F plasmid genes that couple host cell division to plasmid proliferation.
1983
A hyperconversion mechanism generates the chicken light chain preimmune repertoire
1987
Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals
1987
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice
1998
Immunoglobulin heavy chain switch region recombination within a retroviral vector in murine pre-B cells.
1987
Molecular Mechanism of Class Switch Recombination: Linkage with Somatic Hypermutation
2002 StandoutNobel
Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.
1989
Purification of genomic sequences from bacteriophage libraries by recombination and selectionin vivo
1983
Developmentally controlled and tissue-specific expression of unrearranged VH gene segments
1985
Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins.
1981
Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA
1981 StandoutNatureNobel
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
An Evolutionary View of the Mechanism for Immune and Genome Diversity
2012 StandoutNobel
Immunoglobulin Structure-Function Correlates: Antigen Binding and Idiotypes
1983
Deletions in immunoglobulin mu chains.
1982 StandoutNobel
Expression Levels of B Cell Surface Immunoglobulin Regulate Efficiency of Allelic Exclusion and Size of Autoreactive B-1 Cell Compartment
1999 StandoutNobel
The connection between transcription and genomic instability
2002
Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences
1984 StandoutNatureNobel
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Structure of the 5' ends of immunoglobulin genes: a novel conserved sequence.
1984
Cis‐acting sequences that affect somatic hypermutation of Ig genes
1998
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.
1986
Recombination of exogenous interleukin 2 receptor gene flanked by immunoglobulin recombination signal sequences in a pre-B cell line and transgenic mice.
1991 StandoutNobel
SOMATIC HYPERMUTATION OF IMMUNOGLOBULIN GENES
1996
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.
1982
Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
1981
An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development
1982
Chromosome Translocation, B Cell Lymphoma, and Activation-Induced Cytidine Deaminase
2012
An optimized potential function for the calculation of nucleic acid interaction energies I. Base stacking
1978
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.
1989
Non-B right-handed DNA conformations of homopurine.homopyrimidine sequences in the murine immunoglobulin C alpha switch region.
1988
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
A general method for site-directed mutagenesis in prokaryotes
1981 StandoutNatureNobel
Regulation of the Assembly and Expression of Variable-Region Genes
1986
The Transcriptional Promoter Regulates Hypermutation of the Antibody Heavy Chain Locus
1997
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone
1984 StandoutNatureNobel
Analysis of somatic mutation and class switching in naive and memory B cells generating adoptive primary and secondary responses
1987
Immunoglobulin Genes
1983 StandoutNobel
Recombined flanks of the variable and joining segments of immunoglobulin genes.
1982
Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.
1990
B Lineage—Specific Interactions of an Immunoglobulin Enhancer with Cellular Factors in Vivo
1985 StandoutScienceNobel
APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination
2007
Molecular Characterization of the Lymphoid V(D) J Recombination Activity
1989
Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.
1991 Nobel
Unusual association of V, J and C regions in a mouse immunoglobulin λ chain
1982 Nature
Mechanism and Regulation of Class Switch Recombination
2008
Construction of artificial chromosomes in yeast
1983 StandoutNatureNobel
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
Regulation of Genome Rearrangement Events during Lymphocyte Differentiation
1986
Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
2012 StandoutNobel
Dual expression of λ genes in the MOPC-315 plasmacytoma
1981 NatureNobel
High-salt d(CpGpCpG), a left-handed Z′ DNA double helix
1980 Nature
RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene.
1981
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains.
1984 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region
2002 StandoutNobel
Stabilities of nearest‐neighbor doublets in double‐helical DNA determined by fitting calculated melting profiles to observed profiles
1981
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes
1983
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.
1983 StandoutNobel
Somatic hypermutation
1995 Nobel
Role of RecA protein spiral filaments in genetic recombination
1984 Nature
RNA structure
1977
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch Recombination
2013
Mechanism of R-Loop Formation at Immunoglobulin Class Switch Sequences
2007
Recombination-stimulating sequences in yeast ribosomal DNA correspond to sequences regulating transcription by RNA polymerase I
1987
Restricted association of V and J-C gene segments for mouse lambda chains.
1984 StandoutNobel
Structure of an alternating-B DNA helix and its relationship to A-tract DNA.
1988
A rapid boiling method for the preparation of bacterial plasmids
1981 Standout
Rat kappa-chain J-segment genes: Two recent gene duplications separate rat and mouse
1982
Works of Erik Selsing being referenced
Sequence Dependence of Chromosomal R-Loops at the Immunoglobulin Heavy-Chain Sμ Class Switch Region
2007
Shifts in targeting of class switch recombination sites in mice that lack μ switch region tandem repeats or Msh2
2005
Class Switch Recombination Efficiency and Junction Microhomology Patterns in Msh2-, Mlh1-, and Exo1-Deficient Mice Depend on the Presence of μ Switch Region Tandem Repeats
2009
Activation-Induced Cytidine Deaminase-Dependent DNA Breaks in Class Switch Recombination Occur during G1 Phase of the Cell Cycle and Depend upon Mismatch Repair
2007
Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors
2007 StandoutNobel
Ig class switching: targeting the recombinational mechanism
2006
The Sμ Tandem Repeat Region Is Critical for Ig Isotype Switching in the Absence of Msh2
2003
Antibody Class Switch Recombination: Roles for Switch Sequences and Mismatch Repair Proteins
2005
S-S Synapsis during Class Switch Recombination Is Promoted by Distantly Located Transcriptional Elements and Activation-Induced Deaminase
2007
A rapid microscale technique for isolation of recombinant plasmid DNA suitable for restriction enzyme analysis
1980
Preparation of triple-block DNA polymers using recombinant DNA techniques
1979
Novel κ light-chain gene rearrangements in mouse λ light chain-producing B lymphocytes
1984 Nature
Structural alterations in J regions of mouse immunoglobulin λ genes are associated with differential gene expression
1982 Nature
The conformation of C-DNA
1975
Expression of an anti‐RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN ‐I expression
2013
Analysis of Sequence Transfers Resembling Gene Conversion in a Mouse Antibody Transgene
1994 Science
Evolution of mouse immunoglobulin lambda genes.
1982
The structure of polydeoxyguanylic acid · polydeoxycytidylic acid
1974
Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice.
1989
Somatic mutation of immunoglobulin light-chain variable-region genes
1981
Bent DNA: visualization of a base-paired and stacked A-B conformational junction.
1979
Quantitative analysis of idiotypic mimicry and allelic exclusion in mice with a mu Ig transgene.
1989
Polynucleotide block polymers consisting of a DNA.RNA hybrid joined to a DNA.DNA duplex. Synthesis and characterization of dGn.rCidCk duplexes.
1979
Deletions of kappa chain constant region genes in mouse lambda chain-producing B cells involve intrachromosomal DNA recombinations similar to V-J joining.
1985
Somatic hypermutation of an immunoglobulin mu heavy chain transgene.
1993
Immunoglobulin gene ‘remnant’ DNA - implications for antibody gene recombination
1984
The μ Switch Region Tandem Repeats Are Important, but Not Required, for Antibody Class Switch Recombination
2001
Recombination between immunoglobulin variable region gene segments is enhanced by transcription
1986 Nature
Active lambda and kappa antibody gene rearrangement in Abelson murine leukemia virus-transformed pre-B cell lines.
1987
Models of triple-stranded polynucleotides with optimised stereochemistry
1976
Tissue-specific expression of allogeneic class II MHC molecules induces neither tissue rejection nor clonal inactivation of alloreactive T cells.
1990
Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for “allelic exclusion”
1980
Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene
1981
Rearranged and germline immunoglobulin .kappa. genes: different states of DNase I sensitivity of C.kappa. genes in immunocompetent and nonimmune cells
1981
Mismatch Repair Proteins MSH2, MLH1, and EXO1 Are Important for Class-Switch Recombination Events Occurring in B Cells That Lack Nonhomologous End Joining
2011