Standout Papers
Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis
2006
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
2007
Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans
2009 Science
Oxygen-Regulated β 2 -Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL
2009 StandoutNobel
Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate
2005
Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways.
2003 StandoutNobel
Hypoxia Inducible Factor Prolyl 4-Hydroxylase Enzymes: Center Stage in the Battle Against Hypoxia, Metabolic Compromise and Oxidative Stress
2007
Persistent induction of HIF‐1α and ‐2α in cardiomyocytes and stromal cells of ischemic myocardium
2004
Regulation of HIF prolyl hydroxylases by hypoxia‐inducible factors
2004
Prolyl Hydroxylases 2 and 3 Act in Gliomas as Protective Negative Feedback Regulators of Hypoxia-Inducible Factors
2009
Role of ETS Transcription Factors in the Hypoxia-Inducible Factor-2 Target Gene Selection
2006
RGS5, a Hypoxia-inducible Apoptotic Stimulator in Endothelial Cells
2009
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
2005 StandoutNobel
Inhibitory PAS Domain Protein (IPAS) Is a Hypoxia-inducible Splicing Variant of the Hypoxia-inducible Factor-3α Locus
2002
Induction of ID2 Expression by Hypoxia-inducible Factor-1
2004
MCM Proteins Are Negative Regulators of Hypoxia-Inducible Factor 1
2011 StandoutNobel
Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury
2010
HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels
2003 StandoutNobel
The Transcriptional Activation Function of the HIF-like Factor Requires Phosphorylation at a Conserved Threonine
2002
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
2002 StandoutNobel
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
2005 StandoutNobel
Hypoxia Increases Sirtuin 1 Expression in a Hypoxia-inducible Factor-dependent Manner
2011
Increased Prolyl 4-Hydroxylase Domain Proteins Compensate for Decreased Oxygen Levels
2006
Impaired Oxygen-dependent Reduction of HIF-1α and -2α Proteins in Pre-eclamptic Placentae
2003
Tight Control of Hypoxia-inducible Factor-α Transient Dynamics Is Essential for Cell Survival in Hypoxia
2014
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
Structural and Mechanistic Studies on the Inhibition of the Hypoxia-inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates
2006
Induction of HIF-2α is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line
2008
Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
2010 StandoutNobel
HLF/HIF-2α is a key factor in retinopathy of prematurity in association with erythropoietin
2003
Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells
2010
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
2003
Sequence Determinants in Hypoxia-inducible Factor-1α for Hydroxylation by the Prolyl Hydroxylases PHD1, PHD2, and PHD3
2002
Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor
2003
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Complex Regulation of the Transactivation Function of Hypoxia-inducible Factor-1α by Direct Interaction with Two Distinct Domains of the CREB-binding Protein/p300
2009
Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing
2008
Cardiopulmonary function in two human disorders of the hypoxia‐inducible factor (HIF) pathway: von Hippel‐Lindau disease and HIF‐2α gain‐of‐function mutation
2011 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor α Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2
2006
The Hypoxia-Inducible Factor 2α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo
2007 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Biology of hypoxia-inducible factor-2α in development and disease
2008
Hypoxia Requires Notch Signaling to Maintain the Undifferentiated Cell State
2005
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
Calcium signaling stimulates translation of HIF‐α during hypoxia
2006
Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
2010
Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain
2015 StandoutNobel
The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen
2003
Regulation and Destabilization of HIF-1α by ARD1-Mediated Acetylation
2002
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells
2015 StandoutNobel
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway
2002
Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases
2003 StandoutNobel
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase
2009 StandoutNobel
Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production
2010
Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases
2007
The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma
2002
The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF
2008
Preconditional Activation of Hypoxia-Inducible Factors Ameliorates Ischemic Acute Renal Failure
2006
Substrate Requirements of the Oxygen-sensing Asparaginyl Hydroxylase Factor-inhibiting Hypoxia-inducible Factor
2004
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Hypoxia Up-regulates Prolyl Hydroxylase Activity
2003
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
2002 Standout
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
2006 Standout
Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1)
2009
Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation
2008
HIF-1 and tumor progression: pathophysiology and therapeutics
2002 StandoutNobel
The Length of Peptide Substrates Has a Marked Effect on Hydroxylation by the Hypoxia-inducible Factor Prolyl 4-Hydroxylases
2006
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
2011 StandoutNobel
Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α
2003
Structural Basis for Binding of Hypoxia-Inducible Factor to the Oxygen-Sensing Prolyl Hydroxylases
2009
Roles of individual prolyl‐4‐hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice
2012 StandoutNobel
Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
2011 StandoutNobel
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Many Amino Acid Substitutions in a Hypoxia-inducible Transcription Factor (HIF)-1α-like Peptide Cause Only Minor Changes in Its Hydroxylation by the HIF Prolyl 4-Hydroxylases
2004
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
2006
Suppression of Hypoxia-inducible Factor 1α (HIF-1α) Transcriptional Activity by the HIF Prolyl Hydroxylase EGLN1
2005
Inhibition of 2-oxoglutarate dependent oxygenases
2011
Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia‐inducible factor 1
2006 StandoutNobel
Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide
2001
Prolyl 4-hydroxylase activity-responsive transcription factors: From hydroxylation to gene expression and neuroprotection
2007
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells
2004
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia
2010
Role of Iron (II)-2-Oxoglutarate-dependent Dioxygenases in the Generation of Hypoxia-induced Phosphatidic Acid through HIF-1/2 and von Hippel-Lindau-independent Mechanisms
2004
Divergent roles of reactive oxygen species in the responses of perinatal adrenal chromaffin cells to hypoxic challenges
2010
Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
2007 StandoutNobel
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity
2012 StandoutNobel
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
2010
Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates
2006
Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors
2002
Non-heme iron oxygenases
2002
Hypoxia-inducible Factor and Its Biomedical Relevance
2003
Cyclosporin A Prevents the Hypoxic Adaptation by Activating Hypoxia-inducible Factor-1α Pro-564 Hydroxylation
2003
Prolyl hydroxylase inhibitor treatment confers whole‐animal hypoxia tolerance
2007
Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1
2005
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
2010
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
2006
EGLN3 Prolyl Hydroxylase Regulates Skeletal Muscle Differentiation and Myogenin Protein Stability
2007
HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond
2015
Hypoxic Induction of the Regulator of G-Protein Signalling 4 Gene Is Mediated by the Hypoxia-Inducible Factor Pathway
2012
JmjC-domain-containing proteins and histone demethylation
2006
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
Mammalian EGLN genes have distinct patterns of mRNA expression and regulation
2002
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
2005
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
2003
Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor
2003
Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction
2010
How oxygen makes its presence felt: Figure 1.
2002 StandoutNobel
An Endoplasmic Reticulum Transmembrane Prolyl 4-Hydroxylase Is Induced by Hypoxia and Acts on Hypoxia-inducible Factor α
2007
Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia
2002 StandoutNobel
HIF‐1α induces cell cycle arrest by functionally counteracting Myc
2004
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
2003
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
2005 Standout
Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors
2011 StandoutNobel
Crystal structure of a clavaminate synthase–Fe(II)–2‐oxoglutarate–substrate–NO complex: evidence for metal centred rearrangements
2002
Molecular Pathways in Renal Cell Carcinoma—Rationale for Targeted Treatment
2006
Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana
2002
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Siah2 Regulates Stability of Prolyl-Hydroxylases, Controls HIF1α Abundance, and Modulates Physiological Responses to Hypoxia
2004
A Ratiometric Sensor Based on Plant N-Terminal Degrons Able to Report Oxygen Dynamics in Saccharomyces cerevisiae
2019
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
HIF-1 and hypoxic response: the plot thickens
2003
Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor
2004 StandoutNobel
Hypoxia-inducible Factor 1 Activation by Aerobic Glycolysis Implicates the Warburg Effect in Carcinogenesis
2002
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Levels of Hypoxia-Inducible Factor-1 During Breast Carcinogenesis
2001 StandoutNobel
OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α
2005 StandoutNobel
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Hypoxia inducible factor (HIF)‐2α is required for the development of the catecholaminergic phenotype of sympathoadrenal cells
2009
The use of dioxygen by HIF prolyl hydroxylase (PHD1)
2002 StandoutNobel
A role for hypoxia and hypoxia-inducible transcription factors in tumor physiology
2002
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
2005
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
2005
Hypoxia signalling in cancer and approaches to enforce tumour regression
2006 Nature
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors
2004
RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α
2007 StandoutNobel
Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant
2005
Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases
2004
SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia
2007
Effects of Iron Supplementation and Depletion on Hypoxic Pulmonary Hypertension
2009 StandoutNobel
The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling
2012
Hypoxic gene expression and metastasis
2004
JunD Reduces Tumor Angiogenesis by Protecting Cells from Oxidative Stress
2004
Hypoxia-inducible Factor (HIF) Asparagine Hydroxylase Is Identical to Factor Inhibiting HIF (FIH) and Is Related to the Cupin Structural Family
2002 StandoutNobel
Genetic Analysis of the Role of the Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-inducible Factor (HIF) in Regulating HIF Transcriptional Target Genes
2004 StandoutNobel
Falkor, a novel cell growth regulator isolated by a functional genetic screen
2002
MAPK Signaling Up-regulates the Activity of Hypoxia-inducible Factors by Its Effects on p300
2003
The human oxygen sensing machinery and its manipulation
2008
The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin
2004 StandoutNobel
Regulation of HIF-1α Stability through S-Nitrosylation
2007
HIF-1α expression regulates the bactericidal capacity of phagocytes
2005
Structure of Human FIH-1 Reveals a Unique Active Site Pocket and Interaction Sites for HIF-1 and von Hippel-Lindau
2003
Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data
2010
Evidence for the slow reaction of hypoxia‐inducible factor prolyl hydroxylase 2 with oxygen
2010
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia
2003 Standout
HIF-1 as a target for drug development
2003
Hypoxia-induced genetic instability—a calculated mechanism underlying tumor progression
2006
Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans
2004 StandoutNobel
Structure of Factor-inhibiting Hypoxia-inducible Factor (HIF) Reveals Mechanism of Oxidative Modification of HIF-1α
2003 StandoutNobel
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
2009 StandoutNobel
The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids
2005
Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor
2001 StandoutNobel
From Polyps to People
2009
Signalling hypoxia by HIF hydroxylases
2005 StandoutNobel
Investigating hypoxic tumor physiology through gene expression patterns
2003
Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis
2003
Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1β and regulates the cellular PDH activity
2014
Hypoxia, gene expression, and metastasis
2007
Leu-574 of HIF-1α Is Essential for the von Hippel-Lindau (VHL)-mediated Degradation Pathway
2002
HIF‐1 and p53: communication of transcription factors under hypoxia
2004
Induction of Hypoxia-Inducible-Factor 1 by Nitric Oxide Is Mediated via the PI 3K Pathway
2000
Oxygen-sensitive reset of hypoxia-inducible factor transactivation response: Prolyl hydroxylases tune the biological normoxic set point
2006
Anaemia in kidney disease: harnessing hypoxia responses for therapy
2015
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
2002 StandoutNobel
Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α
2002
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Prolyl Hydroxylase Inhibitors Depend on Extracellular Glucose and Hypoxia-Inducible Factor (HIF)-2α to Inhibit Cell Death Caused by Nerve Growth Factor (NGF) Deprivation: Evidence that HIF-2α Has a Role in NGF-Promoted Survival of Sympathetic Neurons
2009
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Oxygen and Iron Regulation of Iron Regulatory Protein 2
2003
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel–Lindau tumor suppressor
2002
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity
2003
Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth
2003
Development of novel therapeutic strategies that target HIF-1
2006 StandoutNobel
Differential regulation of HIF-1α prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells
2003
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
2009
Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition
2005
Drosophila Cyclin D/Cdk4 Requires Hif-1 Prolyl Hydroxylase to Drive Cell Growth
2004
The human side of hypoxia‐inducible factor
2008 StandoutNobel
Evaluation of HIF-1 inhibitors as anticancer agents
2007 StandoutNobel
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
2009 StandoutNobel
2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase
2003 StandoutNobel
HIF activation identifies early lesions in VHL kidneys
2002 StandoutNobel
Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2
2011
Immunophilin‐ligands FK506 and CsA inhibit HIF1α expression by a VHL‐ and ubiquitin‐independent mechanism
2006
Hypoxia Inducible Factor Activates the Transforming Growth Factor-α/Epidermal Growth Factor Receptor Growth Stimulatory Pathway in VHL-/- Renal Cell Carcinoma Cells
2003
Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets
2017
Multiple Splice Variants of the Human HIF-3α Locus Are Targets of the von Hippel-Lindau E3 Ubiquitin Ligase Complex
2003
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats
2006
HIF and the Lung
2011 StandoutNobel
Reversion of lethality and growth defects in Fatiga oxygen‐sensor mutant flies by loss of Hypoxia‐Inducible Factor‐α/Sima
2005 StandoutNobel
Iron Homeostasis and Its Interaction with Prolyl Hydroxylases
2009
Life with Oxygen
2007 StandoutScienceNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
2000 StandoutNobel
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the β-carbon of asparagine-803
2002
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
2007 StandoutNobel
A Nontranscriptional Role for HIF-1α as a Direct Inhibitor of DNA Replication
2013 StandoutNobel
Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α
2003 Science
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
Activation of the hypoxia‐inducible factor pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors
2003
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
2002
Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion
2007
Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1.
2003 StandoutNobel
Mitochondria and cellular oxygen sensing in the HIF pathway
2007
HIF‐1 is expressed in normoxic tissue and displays an organ‐specific regulation under systemic hypoxia
2001
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
2009 Science
Control of the Hypoxic Response in Drosophila melanogaster by the Basic Helix-Loop-Helix PAS Protein Similar
2002 StandoutNobel
von Hippel-Lindau Disease
2006 StandoutNobel
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Histone Deacetylase Inhibitors Induce VHL and Ubiquitin-Independent Proteasomal Degradation of Hypoxia-Inducible Factor 1α
2006
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases
2013 StandoutNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Stabilization of HIF-1α is critical to improve wound healing in diabetic mice
2008
Hypoxia-Inducible Factor-1 Is Central to Cardioprotection
2008
Coordinate Regulation of the Oxygen-Dependent Degradation Domains of Hypoxia-Inducible Factor 1α
2005
Mutations in the VHL gene in sporadic apparently congenital polycythemia
2003
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.
2003
Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway
2002 Nobel
Normoxic Stabilization of Hypoxia-Inducible Factor-1α by Modulation of the Labile Iron Pool in Differentiating U937 Macrophages: Effect of Natural Resistance–Associated Macrophage Protein 1
2006 StandoutNobel
PROLINE HYDROXYLATION AND GENE EXPRESSION
2005 StandoutNobel
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
2005
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP
2002
The HIF Pathway and Erythrocytosis
2011
Hypoxic induction of an HIF-1α–dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
2005
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Defective Brain Development in Mice Lacking the Hif-1α Gene in Neural Cells
2003
A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo
2009 StandoutNobel
Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
2004 StandoutNobel
The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α
2006
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
2005
Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
2010
Inhibition of Prolyl Hydroxylase Domain Proteins Promotes Therapeutic Revascularization
2009
Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure
2009
Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level
2004 StandoutNobel
Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis
2002
Phorbol ester stimulates the nonhypoxic induction of a novel hypoxia-inducible factor 1alpha isoform: implications for tumor promotion.
2003
Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α
2002
Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity
2005
Expression of prolyl-hydroxylase-1 (PHD1/EGLN2) suppresses hypoxia inducible factor-1alpha activation and inhibits tumor growth.
2003
Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
2002 Science
Contrasting effects of ascorbate and iron on the pulmonary vascular response to hypoxia in humans
2014
Cell Type–Specific Regulation of Angiogenic Growth Factor Gene Expression and Induction of Angiogenesis in Nonischemic Tissue by a Constitutively Active Form of Hypoxia-Inducible Factor 1
2003 StandoutNobel
Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor
2007
Gene Expression Profiling of the Hypoxia Signaling Pathway in Hypoxia-Inducible Factor 1α Null Mouse Embryonic Fibroblasts
2003
Angiogenesis Ischemic and Neoplastic Disorders
2003 StandoutNobel
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
2007 StandoutNobel
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay
2006 StandoutNobel
HIF-1 mediates pathogenic inflammatory responses to intestinal ischemia-reperfusion injury
2010 StandoutNobel
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
2013
The Caenorhabditis elegans rhy-1 Gene Inhibits HIF-1 Hypoxia-Inducible Factor Activity in a Negative Feedback Loop That Does Not Include vhl-1
2006
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
2000
The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress
2008
Essential Role for Prolyl Hydroxylase Domain Protein 2 in Oxygen Homeostasis of the Adult Vascular System
2007
HIF and pulmonary vascular responses to hypoxia
2013
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Hypoxia-Inducible Factor-1 Mediates Activation of Cultured Vascular Endothelial Cells by Inducing Multiple Angiogenic Factors
2003
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
2008 StandoutNobel
Endogenous 2-oxoacids differentially regulate expression of oxygen sensors
2004
Hypoxia. 2. Hypoxia regulates cellular metabolism
2010
Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells.
2003 StandoutNobel
Impaired Oxygen-dependent Reduction of HIF-1α and -2α Proteins in Pre-eclamptic Placentae
2003
ASB4 Is a Hydroxylation Substrate of FIH and Promotes Vascular Differentiation via an Oxygen-Dependent Mechanism
2007
Pathways for Oxygen Regulation and Homeostasis
2016 StandoutNobel
von Hippel–Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
2003
Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans
2000
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
2007 StandoutNobel
Hypoxia-Induced Gene Expression Occurs Solely through the Action of Hypoxia-Inducible Factor 1α (HIF-1α): Role of Cytoplasmic Trapping of HIF-2α
2003
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia
2007
Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells
2005
Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro
2006
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
2002
Works of Eric Metzen being referenced
Review: Hypoxia-Inducible Factor-1 (HIF-1): A Novel Transcription Factor in Immune Reactions
2005
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Chelation of Cellular Calcium Modulates Hypoxia-inducible Gene Expression through Activation of Hypoxia-inducible Factor-1α
2004
Hydroxylation of Hypoxia-Inducible Transcription Factors and Chemical Compounds Targeting the HIF-α Hydroxylases
2007
Evidence against a major role for Ca2+ in hypoxia‐induced gene expression in human hepatoma cells (Hep3B)
1999
HIF hydroxylation and cellular oxygen sensing
2004 StandoutNobel
Pericellular PO2 and O2 consumption in monolayer cell cultures
1995
Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1α accumulation—Implications for prolyl hydroxylase activity and iron
2005
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element
2005
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
2005
Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1
1999
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
2001 StandoutNobel
Nitric Oxide Impairs Normoxic Degradation of HIF-1α by Inhibition of Prolyl Hydroxylases
2003
Prolyl Hydroxylase PHD3 Activates Oxygen-dependent Protein Aggregation
2008
Interleukin-1β and Tumor Necrosis Factor- Stimulate DNA Binding of Hypoxia-Inducible Factor-1
1999
Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing
2003
Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases
2004