Citation Impact
Citing Papers
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
2013 StandoutScience
The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells
2009
Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions
2012 StandoutNobel
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
2012 StandoutScienceNobel
Matrix Metalloproteinase-8 Functions as a Metastasis Suppressor through Modulation of Tumor Cell Adhesion and Invasion
2008
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
2006
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
2004 StandoutNobel
Tumour-cell invasion and migration: diversity and escape mechanisms
2003 Standout
Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165
2002
Hallmarks of Cancer: The Next Generation
2011 Standout
Endogenous human microRNAs that suppress breast cancer metastasis
2008 StandoutNature
The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
2008
Direct visualization of protease activity on cells migrating in three-dimensions
2008
Discovery of Chemokine Substrates for Matrix Metalloproteinases by Exosite Scanning: A New Tool for Degradomics
2002
Proteolytic interstitial cell migration: a five-step process
2009
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion
2001
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation
2000
Matrix metalloproteinases and the regulation of tissue remodelling
2007 Standout
Inflammation and cancer
2002 StandoutNature
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion
2001
Genes that mediate breast cancer metastasis to the brain
2009 StandoutNature
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Matrix Metalloproteinase Processing of CXCL11/I-TAC Results in Loss of Chemoattractant Activity and Altered Glycosaminoglycan Binding
2008
Gelatin Zymography and Substrate Cleavage Assays of Matrix Metalloproteinase-2 in Breast Carcinoma Cells Overexpressing Membrane Type-1 Matrix Metalloproteinase
2002
Chemotaxis in cancer
2011
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Dynamic interplay between the collagen scaffold and tumor evolution
2010
Mechanotransduction gone awry
2008
Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1
2001
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor
2019
Gelatinase B/MMP‐9 and neutrophil collagenase/MMP‐8 process the chemokines human GCP‐2/CXCL6, ENA‐78/CXCL5 and mouse GCP‐2/LIX and modulate their physiological activities
2003
Macrophage elastase kills bacteria within murine macrophages
2009 Nature
Glycosaminoglycans: key players in cancer cell biology and treatment
2012
Chlorotoxin Inhibits Glioma Cell Invasion via Matrix Metalloproteinase-2
2003
Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions
2009
Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion
2011
Structural Basis of the Adaptive Molecular Recognition by MMP9
2002 Nobel
Matrix metalloproteinases as modulators of inflammation
2007
Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model
2008
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Quantitative proteome analysis using isotope-coded affinity tags and mass spectrometry
2006
Targeting proteases: successes, failures and future prospects
2006
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
2007
Pattern Recognition Receptors and Inflammation
2010 Standout
Matrix metalloproteinases in inflammation
2014
The many roles of PTK7: A versatile regulator of cell–cell communication
2012
Emerging roles of proteases in tumour suppression
2007
Collagen-based cell migration models in vitro and in vivo
2009
HIV-induced metalloproteinase processing of the chemokine stromal cell derived factor-1 causes neurodegeneration
2003
Strategies for MMP inhibition in cancer: innovations for the post-trial era
2002
Effects of extracellular matrix viscoelasticity on cellular behaviour
2020 StandoutNature
Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury
2002
Catalytic Domain Architecture of Metzincin Metalloproteases
2009
Structural and Enzymatic Characterization of Drosophila Dm2-MMP, a Membrane-bound Matrix Metalloproteinase with Tissue-specific Expression
2002
Gelatinase B: a tuner and amplifier of immune functions
2001
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
2007 StandoutNature
Wnt/β-Catenin and Fgf Signaling Control Collective Cell Migration by Restricting Chemokine Receptor Expression
2008
Human and mouse proteases: a comparative genomic approach
2003
Determinants of leader cells in collective cell migration
2010
Extracellular matrix structure
2015 Standout
Cancer invasion and resistance: interconnected processes of disease progression and therapy failure
2011
Targeting apoptosis in cancer therapy
2020 Standout
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Cellular Activation of MMP-2 (Gelatinase A) by MT2-MMP Occurs via a TIMP-2-independent Pathway
2001
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin
2001
Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination
2010
Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development
2007
Matrix metalloproteinases as modulators of inflammation and innate immunity
2004 Standout
Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression
2010
Collective cell migration in morphogenesis, regeneration and cancer
2009 Standout
Membrane‐type 1 matrix metalloproteinase is required for normal alveolar development
2005
MT1-MMP Initiates Activation of pro-MMP-2 and Integrin αvβ3 Promotes Maturation of MMP-2 in Breast Carcinoma Cells
2001
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
2005
Regulation of matrix metalloproteinase activity in health and disease
2010
Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics
2009
Intraoperative detection and removal of microscopic residual sarcoma using wide‐field imaging
2012 StandoutNobel
Synergistic up‐regulation of MCP‐2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti‐tumoral effects
2009
In vitro models of tumor vessels and matrix: Engineering approaches to investigate transport limitations and drug delivery in cancer
2013
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
2012
Cancer cell motility: lessons from migration in confined spaces
2016
In search of partners: linking extracellular proteases to substrates
2007
Interstitial leukocyte migration and immune function
2008
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
2009 Nobel
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Elastic Moduli of Collagen Gels Can Be Predicted from Two-Dimensional Confocal Microscopy
2009
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
2002
Crystal structures of MMPs in complex with physiological and pharmacological inhibitors
2004
Matrix metalloproteinases in tumor–host cell communication
2002
Rac Activation and Inactivation Control Plasticity of Tumor Cell Movement
2008
Points of control in inflammation
2002 StandoutNature
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Matrix metalloproteinases: they're not just for matrix anymore!
2001
Extracellular matrix determinants of proteolytic and non-proteolytic cell migration
2011
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
2010
Genes that mediate breast cancer metastasis to lung
2005 StandoutNature
Conversion of Proepithelin to Epithelins
2002
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency
2002
Global quantification of mammalian gene expression control
2011 StandoutNature
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
2009 Standout
Cancer Dissemination—Lessons from Leukocytes
2010
New functions for the matrix metalloproteinases in cancer progression
2002 Standout
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice
2003
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells
2013
Molecular Determinants of Metalloproteinase Substrate Specificity: Matrix Metalloproteinase Substrate Binding Domains, Modules, and Exosites
2002
Cleavage of Syndecan-1 by Membrane Type Matrix Metalloproteinase-1 Stimulates Cell Migration
2003
Identification of Novel, Functional Genetic Variants in the Human Matrix Metalloproteinase-2 Gene
2001
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
2005
Transmembrane Signaling Proteoglycans
2010
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
2006
Tube Travel: The Role of Proteases in Individual and Collective Cancer Cell Invasion
2008
Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2
2002
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel
2011
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Cell–matrix interactions: focus on proteoglycan–proteinase interplay and pharmacological targeting in cancer
2014
Making the cut: Protease-mediated regulation of angiogenesis
2006
Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation
2004
Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis
2013 StandoutNobel
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
2013
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines
2004
Stromal regulation of vessel stability by MMP14 and TGFβ
2010
Molecular and structural mapping of collagen fibril interactions
2010
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Architecture and function of metallopeptidase catalytic domains
2013
MMP‐2 null mice exhibit an early onset and severe experimental autoimmune encephalomyelitis due to an increase in MMP‐9 expression and activity
2004
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx
2008
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling
2002
The integrin αvβ8 mediates epithelial homeostasis through MT1-MMP–dependent activation of TGF-β1
2002
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation
2015 StandoutNobel
Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation
2006
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
The Role of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Antibody-Induced Arthritis
2002
Protease degradomics: A new challenge for proteomics
2002
Mechanisms of collective cell migration at a glance
2009
Measuring dynamic cell–material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels
2015
Designing Cell-Compatible Hydrogels for Biomedical Applications
2012 StandoutScience
De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor
2019 StandoutNobel
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP
2004
How Matrix Metalloproteinases Regulate Cell Behavior
2001 Standout
Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
2003 Standout
Updated Biological Roles for Matrix Metalloproteinases and New “Intracellular” Substrates Revealed by Degradomics
2009
The Pathobiology of Collagens in Glioma
2013
Plasticity of cell migration: a multiscale tuning model
2009
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited
2009
Macrophage Elastase (Matrix Metalloproteinase-12) Suppresses Growth of Lung Metastases
2006
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
2002
Interstitial guidance of cancer invasion
2011
Chemical Glycoproteomics
2016 StandoutNobel
Works of Eric M. Tam being referenced
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates
2004
The Canonical Methionine 392 of Matrix Metalloproteinase 2 (Gelatinase A) Is Not Required for Catalytic Efficiency or Structural Integrity
2004
Collagen Binding Properties of the Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Hemopexin C Domain
2002
Characterization of the Distinct Collagen Binding, Helicase and Cleavage Mechanisms of Matrix Metalloproteinase 2 and 14 (Gelatinase A and MT1-MMP)
2004
Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors
2004
Domain Interactions in the Gelatinase A·TIMP-2·MT1-MMP Activation Complex
2000
Identification of the TIMP‐2 Binding Site on the Gelatinase A Hemopexin C‐Domain by Site‐Directed Mutagenesis and the Yeast Two‐Hybrid System
1999
Noncompetitive Inhibition of Hepatocyte Growth Factor-dependent Met Signaling by a Phage-derived Peptide
2008
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
2007
Mannose-binding Lectin (MBL) Mutants Are Susceptible to Matrix Metalloproteinase Proteolysis
2002
Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A)
2007
Pharmacoproteomics of a Metalloproteinase Hydroxamate Inhibitor in Breast Cancer Cells: Dynamics of Membrane Type 1 Matrix Metalloproteinase-Mediated Membrane Protein Shedding
2008
Abstract 2491: Engineering and preclinical activity of MM-201, a best-in-class TRAIL receptor agonist
2019
Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3
2000 Science