Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Activating Mutations in PIK3CB Confer Resistance to PI3K Inhibition and Define a Novel Oncogenic Role for p110β
2016
T cell metabolism drives immunity
2015
A Vascular Targeted Pan Phosphoinositide 3-Kinase Inhibitor Prodrug, SF1126, with Antitumor and Antiangiogenic Activity
2008
Restoration of β-Adrenergic Receptor Signaling and Contractile Function in Heart Failure by Disruption of the βARK1/Phosphoinositide 3-Kinase Complex
2005
Combined Inhibition of Both p110α and p110β Isoforms of Phosphatidylinositol 3-Kinase Is Required for Sustained Therapeutic Effect in PTEN-Deficient, ER+ Breast Cancer
2016
Bruton Tyrosine Kinase–Dependent Immune Cell Cross-talk Drives Pancreas Cancer
2015
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer
2016
AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules
2015
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
A Dual Phosphoinositide-3-Kinase α/mTOR Inhibitor Cooperates with Blockade of Epidermal Growth Factor Receptor in PTEN -Mutant Glioma
2007
Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors
2010
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
2006 StandoutNobel
A monomeric red fluorescent protein
2002 StandoutNobel
Regulation of phosphoinositide 3-kinase expression in health and disease
2009
Antiviral Activity of the Long Chain Pentraxin PTX3 against Influenza Viruses
2008
MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Diffraction-unlimited all-optical imaging and writing with a photochromic GFP
2011 StandoutNatureNobel
The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions
2010
Molecular genetics of implantation in the mouse
1997
Role of the phosphoinositide 3‐kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation
2007
PI3Kδ and primary immunodeficiencies
2016
Genetic Evidence for Selective Transport of Opsin and Arrestin by Kinesin-II in Mammalian Photoreceptors
2000
A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
2010
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
2013
PI3K signalling in inflammation
2014
Combining immunotherapy and targeted therapies in cancer treatment
2012
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ
2000
Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils
2002
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Class I PI3K in oncogenic cellular transformation
2008
TLRs in the Gut.IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction
2007
Signaling to migration in neutrophils: importance of localized pathways
2003
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
2004
Synergy in activating class I PI3Ks
2015
Roles of PI3Ks in leukocyte chemotaxis and phagocytosis
2002
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass
2002
PI3K pathway alterations in cancer: variations on a theme
2008
The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
2007
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
PI3K in lymphocyte development, differentiation and activation
2003
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
2005
Do phosphoinositide 3-kinases direct lymphocyte navigation?
2003
Leukocytes navigate by compass: roles of PI3Kγ and its lipid products
2000
Stem Cells
2000
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
2014
Phosphoinositide 3‐kinases in cell migration
2008
Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism
2011
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
2014 Nature
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Lipid signalling in disease
2008
PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes
2017
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
2004 Nature
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
2015
Eukaryotic Chemotaxis: Distinctions between Directional Sensing and Polarization
2003
Signalling by PI3K isoforms: insights from gene-targeted mice
2005
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
2014
The emerging mechanisms of isoform-specific PI3K signalling
2010
Hyaluronan-dependent pericellular matrix☆
2007
EMT: 2016
2016 Standout
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
2006
Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention
2017
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
2007 StandoutNatureNobel
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
2014
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1
2006 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Metabolism, migration and memory in cytotoxic T cells
2011
AKT/PKB Signaling: Navigating the Network
2017 Standout
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
2014
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
2010
The PI3K Pathway in Human Disease
2017 Standout
Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients
2002
Spatial and Temporal Regulation of 3-Phosphoinositides by PI 3-Kinase and PTEN Mediates Chemotaxis
2002
Cancer-related inflammation
2008 StandoutNature
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension
2005
A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
2006
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
2016
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
2012
Cardiac specific expression of the green fluorescent protein during early murine embryonic development
1998
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
2012
The plant immune system
2006 StandoutNature
Chemotaxis: signalling modules join hands at front and tail
2004
Osp/Claudin-11 Forms a Complex with a Novel Member of the Tetraspanin Super Family and β1 Integrin and Regulates Proliferation and Migration of Oligodendrocytes
2001
Circular permutation and receptor insertion within green fluorescent proteins
1999 StandoutNobel
Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms
2015
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Stimulated emission depletion (STED) nanoscopy of a fluorescent protein-labeled organelle inside a living cell
2008 StandoutNobel
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development
2010
THE GREEN FLUORESCENT PROTEIN
1998 StandoutNobel
PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
2014
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
2010
Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene
2001 StandoutNobel
Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex
2002
Plant Immunity: The Origami of Receptor Activation
2004
Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral
2000 StandoutNobel
The structure of the chromophore within DsRed, a red fluorescent protein from coral
2000 StandoutNobel
Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction
2010
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Illuminating Single Molecules in Condensed Matter
1999 StandoutScienceNobel
Macrophages and iron trafficking at the birth and death of red cells
2015
Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides
2018
Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN +/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase
2005
Conditional Deletion of Focal Adhesion Kinase Leads to Defects in Ventricular Septation and Outflow Tract Alignment
2007 StandoutNobel
Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways
2016
Vav Activation and Function as a Rac Guanine Nucleotide Exchange Factor in Macrophage Colony-Stimulating Factor-Induced Macrophage Chemotaxis
2005
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Mechanisms of Mechanotransduction
2006
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment
2006
Systemic Iron Homeostasis
2013
Role of Phosphatidylinositol 3′ Kinase and a Downstream Pleckstrin Homology Domain–Containing Protein in Controlling Chemotaxis inDictyostelium
2001
Phosphoinositide 3-Kinase : Diverse Roles in Immune Cell Activation
2004
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
2016
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
2003
Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis
2000 Science
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling
2004
An essential role in liver development for transcription factor XBP-1
2000
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
2016
Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8, an Inhibitory Member of the Interleukin-1 Receptor Family
2007
Seeing the Machinery of Live Cells
1998 StandoutScienceNobel
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
2017 Science
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
2016
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells
1998 StandoutScienceNobel
Molecular spectroscopy and dynamics of intrinsically fluorescent proteins: Coral red (dsRed) and yellow (Citrine)
2000 StandoutNobel
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
Dynamic and quantitative Ca 2+ measurements using improved cameleons
1999 StandoutNobel
Works of Emilio Hirsch being referenced
Phosphoinositide 3–kinase γ participates in T cell receptor–induced T cell activation
2007
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K–AKT Signaling at Endosomes
2015
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate–mediated egress
2007
The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions
2011
Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression
2016
PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling
2015
Measurement of PIP3 Levels Reveals an Unexpected Role for p110β in Early Adaptive Responses to p110α-Specific Inhibitors in Luminal Breast Cancer
2014
Involvement of Phosphoinositide 3-Kinase γ, Rac, and PAK Signaling in Chemokine-induced Macrophage Migration
2004
Distinct Roles of the Adaptor Protein Shc and Focal Adhesion Kinase in Integrin Signaling to ERK
2000
Lipids on the move: phosphoinositide 3-kinases in leukocyte function
2000
PI3-Kinase γ Promotes Rap1a-Mediated Activation of Myeloid Cell Integrin α4β1, Leading to Tumor Inflammation and Growth
2013
Phosphoinositide 3-kinase p110γ in immunity
2011
Taming the PI3K team to hold inflammation and cancer at bay
2008
PI3K/AKT signaling pathway and cancer: an updated review
2014
PI3K inhibition in inflammation: Toward tailored therapies for specific diseases
2010
Phosphoinositide 3‐kinase γ controls autonomic regulation of the mouse heart through Gi‐independent downregulation of cAMP level
2004
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
2005
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate
2013 Nature
PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control
2013
αv Integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development
1994
Isoform Selective Phosphoinositide 3-Kinase γ and δ Inhibitors and Their Therapeutic Potential
2008
Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function
2002
PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis
2006
A Single Cis-acting Element in a Short Promoter Segment of the Gene Encoding the Interphotoreceptor Retinoid-binding Protein Confers Tissue-specific Expression
1995
Importance of Phosphoinositide 3-Kinase γ in the Host Defense against Pneumococcal Infection
2007
Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ‐deficient mice
2004
Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1
2003
Genetic analyses of integrin function in mice
1996
Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
2011
Targeting PI3K in Cancer: Any Good News?
2013
Leukocyte transmigration is modulated by chemokine‐mediated PI3Kγ‐dependent phosphorylation of vimentin
2009
PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects
2004
Phosphoinositide 3-Kinases in Health and Disease
2012
PI3K Class II α Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function
2014
Impaired migration but not differentiation of haematopoietic stem cells in the absence of β1 integrins
1996 Nature
Analysis of the murine phosphoinositide 3-kinase γ gene
2000
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy
2013
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
2016
Green fluorescent protein as a reporter of gene expression in transgenic mice
1997
Twice upon a time: PI3K's secret double life exposed
2009
Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
2002 Nature
PI3K in cancer–stroma interactions: bad in seed and ugly in soil
2013
Melusin, a muscle-specific integrin β1–interacting protein, is required to prevent cardiac failure in response to chronic pressure overload
2002
Ablation of Phosphoinositide 3-Kinase-γ Reduces the Severity of Acute Pancreatitis
2004
Airway inflammation: chemokine‐induced neutrophilia and the class I phosphoinositide 3‐kinases
2005
Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling
2011
Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
2007
Phosphoinositide 3-kinase γ: kinase-dependent and -independent activities in cardiovascular function and disease
2004
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer
2007
Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis
2002
Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio
2003
PI3Kγ Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P 3 Pools in Mast Cells
2009
Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ
2005
Genetic evidence for a predominant role of PI3Kβ catalytic activity in ITAM- and integrin-mediated signaling in platelets
2009
Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy
2003
Skin wounds and severed nerves heal normally in mice lacking tenascin-C.
1996
The catalytic PI3K isoforms p110γ and p110δ contribute to B cell development and maintenance, transformation, and proliferation
2010
PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization
2004
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
2007
Neurocan Is Dispensable for Brain Development
2001
Blockade of Phosphatidylinositol 3-Kinase (PI3K)δ or PI3Kγ Reduces IL-17 and Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis
2012
Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation
2000 Science
Crossroads of PI3K and Rac pathways
2015
Dissection of the Interplay between Class I PI3Ks and Rac Signaling in Phagocytic Functions
2010
Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH–dependent sympathetic drive
2014
Essential Role of the p110β Subunit of Phosphoinositide 3-OH Kinase in Male Fertility
2010
Genetic and Pharmacological Targeting of Phosphoinositide 3-Kinase-γ Reduces Atherosclerosis and Favors Plaque Stability by Modulating Inflammatory Processes
2008
Intestinal inflammation in mice deficient in Tir8 , an inhibitory member of the IL-1 receptor family
2004
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase γ
2007
Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase
2005
Resistance to thromboembolism in PI3Kγ‐deficient mice
2001
Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion
2006