Standout Papers
- UNC93B1 Mediates Host Resistance to Infection with Toxoplasma gondii (2010)
- Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2 (1999)
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (2010)
Citation Impact
Citing Papers
MyD88 Primes Macrophages for Full-Scale Activation by Interferon-γ yet Mediates Few Responses to Mycobacterium tuberculosis
2003
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
2006
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
2003
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
2005
Inflammasome is a central player in the induction of obesity and insulin resistance
2011
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis
2004
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
2006
TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis
2005
Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9
2007
HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
2009 Science
Response to Staphylococcus aureus requires CD36-mediated phagocytosis triggered by the COOH-terminal cytoplasmic domain
2005
K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling
2015
Critical Role of Apoptotic Speck Protein Containing a Caspase Recruitment Domain (ASC) and NLRP3 in Causing Necrosis and ASC Speck Formation Induced by Porphyromonas gingivalis in Human Cells
2009
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Acylation State of the Phosphatidylinositol Hexamannosides from Mycobacterium bovis Bacillus Calmette Guérin and Mycobacterium tuberculosis H37Rv and Its Implication in Toll-like Receptor Response
2003
Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
2008 StandoutNobel
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
2005
Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin
2001
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction
2005 Nature
Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors
2004
Dendritic cell lineage, plasticity and cross-regulation
2001
A Toll-like receptor recognizes bacterial DNA
2000 StandoutNature
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
2008 Nature
Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis
2013
LPS-Induced Upregulation of SHIP Is Essential for Endotoxin Tolerance
2004
MD-2 Binds to Bacterial Lipopolysaccharide
2001
Innate immune sensing and its roots: the story of endotoxin
2003 StandoutNobel
The sweetness of the DNA backbone drives Toll-like receptor 9
2008
Toll receptors and pathogen resistance
2003
Acylation Determines the Toll-like receptor (TLR)-dependent Positive Versus TLR2-, Mannose Receptor-, and SIGNR1-independent Negative Regulation of Pro-inflammatory Cytokines by Mycobacterial Lipomannan
2007
Development of immunoadjuvants for immunotherapy of cancer
2001
Toll-like receptors as adjuvant receptors
2002
The Forward Genetic Dissection of Afferent Innate Immunity
2008 StandoutNobel
Necroptosis and its role in inflammation
2015 StandoutNature
Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran
2007
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
2013
IKKε and TBK1 are essential components of the IRF3 signaling pathway
2003 Standout
Innate recognition of lipopolysaccharide by CD14 and toll-like receptor 4-MD-2: unique roles for MD-2
2003
Human Toll-like receptor 4 recognizes host-specific LPS modifications
2002
Toll-like receptor pathways in the immune responses to mycobacteria
2004
Toll‐Like Receptor 2–Deficient Mice Are Highly Susceptible toStreptococcus pneumoniaeMeningitis because of Reduced Bacterial Clearing and Enhanced Inflammation
2002
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction
2003
Toll-like receptors in neurodegeneration
2008
Silica Crystals and Aluminum Salts Regulate the Production of Prostaglandin in Macrophages via NALP3 Inflammasome-Independent Mechanisms
2011
Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway
2000
Differential recognition of structural details of bacterial lipopeptides by toll-like receptors
2002
Death by TNF: a road to inflammation
2022
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
2002
Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages
2013
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
Tlr4: central component of the sole mammalian LPS sensor
2000 StandoutNobel
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
2011 Standout
Toll signaling pathways in the innate immune response
2000
Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
2011
Macrophages in the Pathogenesis of Atherosclerosis
2011 Standout
Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
2001 Standout
Peptidoglycan Recognition Proteins
2001
CD14 is required for MyD88-independent LPS signaling
2005 StandoutNobel
Endotoxin recognition and signal transduction by the TLR4/MD2-complex
2004
Extracellular Toll-Like Receptor 2 Region Containing Ser40-Ile64 but Not Cys30-Ser39 Is Critical for the Recognition ofStaphylococcus aureus Peptidoglycan
2001
Bacterial RNA is recognized by different sets of immunoreceptors
2009
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
2005
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
2006 StandoutNobel
The roles of TLRs, RLRs and NLRs in pathogen recognition
2009
Atherosclerosis: current pathogenesis and therapeutic options
2011 Standout
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
1999 Nature
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
2006 Standout
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
2007
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
2008 Standout
The serine protease inhibitor antithrombin III inhibits LPS‐mediated NF‐κB activation by TLR‐4
2001
Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex
2001
Membrane Sorting of Toll-like Receptor (TLR)-2/6 and TLR2/1 Heterodimers at the Cell Surface Determines Heterotypic Associations with CD36 and Intracellular Targeting
2006
Toll-like receptors in systemic autoimmune disease
2006
Toll-like receptors in innate immunity
2004 Standout
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
2007 Nature
Gram-negative Bacteria-binding Protein, a Pattern Recognition Receptor for Lipopolysaccharide and β-1,3-Glucan That Mediates the Signaling for the Induction of Innate Immune Genes in Drosophila melanogaster Cells
2000
Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
2003 StandoutNobel
Bacterial Lipopolysaccharide Activates NF-κB through Toll-like Receptor 4 (TLR-4) in Cultured Human Dermal Endothelial Cells
2000
Intracellular Toll-like Receptors
2010 StandoutNobel
EMERGING PARADIGM
2006
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
2002
Recognition of Double-stranded RNA by Human Toll-like Receptor 3 and Downstream Receptor Signaling Requires Multimerization and an Acidic pH
2005
Development of TLR9 agonists for cancer therapy
2007
Divergence of Bacterial Lipopolysaccharide Pro-apoptotic Signaling Downstream of IRAK-1
2002
Toll-like receptors as potential therapeutic targets for multiple diseases
2002
Poxvirus Protein N1L Targets the I-κB Kinase Complex, Inhibits Signaling to NF-κB by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-κB and IRF3 Signaling by Toll-like Receptors
2004
IFNs activate toll-like receptor gene expression in viral infections
2001
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
Mechanisms of inflammasome activation: recent advances and novel insights
2015
The apoptotic signaling pathway activated by Toll-like receptor-2
2000
The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3
2006
Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation
2001
Toll-like receptor signalling
2004 Standout
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
Discrimination of bacterial lipoproteins by Toll-like receptor 6
2001 Standout
The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
2008 Nature
Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4
2004
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
NOD2 and Toll-Like Receptors Are Nonredundant Recognition Systems of Mycobacterium tuberculosis
2005
The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation
2008
TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β
2003
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
2007
Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition
2001
The immune response of Drosophila
2003 StandoutNatureNobel
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
2004 StandoutNature
The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol
2001
3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome
2013
The expression of toll‐like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll‐like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
2005
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway
2009
Heat Shock Protein gp96 Is a Master Chaperone for Toll-like Receptors and Is Important in the Innate Function of Macrophages
2007
Streptococcal β-hemolysins: genetics and role in disease pathogenesis
2002
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
2008
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
1999 Standout
Toll receptors in innate immunity
2001 StandoutNobel
Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity
2006
Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
2001
The Functional Effects of Physical Interactions among Toll-like Receptors 7, 8, and 9
2006
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
2004
MIF regulates innate immune responses through modulation of Toll-like receptor 4
2001 Nature
A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression
2005
Viral recognition by Toll-like receptors
2007
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
2014
Toll‐like receptor 6‐independent signaling by diacylated lipopeptides
2004
The Role of Toll-like Receptors (TLRs) in Bacteria-induced Maturation of Murine Dendritic Cells (DCs)
2001
Tehao functions in the Toll pathway in Drosophila melanogaster : possible roles in development and innate immunity
2001
Mammalian Peptidoglycan Recognition Protein Binds Peptidoglycan with High Affinity, Is Expressed in Neutrophils, and Inhibits Bacterial Growth
2000
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling
2004
Sterile inflammation: sensing and reacting to damage
2010 Standout
TLR3 and TLR7 Are Targeted to the Same Intracellular Compartments by Distinct Regulatory Elements
2005
Toll-Like Receptor 3 Is a Potent Negative Regulator of Axonal Growth in Mammals
2007
Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors
2007
Role of the Toll/interleukin‐1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites
2004
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
2012 Nature
Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages
2003
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Toll-like receptors: critical proteins linking innate and acquired immunity
2001 Standout
Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved
2003
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal Transduction
2003
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
2006 StandoutNobel
Recognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2
2007 StandoutNobel
Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
2013
The evolution and genetics of innate immunity
2001 StandoutNobel
Toll‐like receptors, endogenous ligands, and systemic autoimmune disease
2005
The Extra Domain A of Fibronectin Activates Toll-like Receptor 4
2001
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
2002 Standout
Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
2009
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
2013
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Toll-like receptors and innate immunity
2009
CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium
2000
Host–pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes
2001
Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod
2008
Autoimmunity and Apoptosis
2001 StandoutNobel
Leucine-rich repeats and pathogen recognition in Toll-like receptors
2003
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
2008
Proinflammatory phenotype of vascular smooth muscle cells: role of efficient Toll-like receptor 4 signaling
2005
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
2000
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
2008 Standout
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages
2002
Toll-like receptors control activation of adaptive immune responses
2001
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
2015 Standout
Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling
2003
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Absence of Toll-Like Receptor 4 Explains Endotoxin Hyporesponsiveness in Human Intestinal Epithelium
2001
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
2000
Pathogen Recognition and Innate Immunity
2006 Standout
The Lipopolysaccharide-activated Toll-like Receptor (TLR)-4 Induces Synthesis of the Closely Related Receptor TLR-2 in Adipocytes
2000
Inflammasomes and Metabolic Disorders: Old Genes in Modern Diseases
2014
Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2
2009 StandoutNobel
CD14-dependent clearance of apoptotic cells: relevance to the immune system
2000
Phagosome Maturation Proceeds Independently of Stimulation of Toll-like Receptors 2 and 4
2005
Inflammasomes in health and disease
2012 StandoutNature
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
2013
Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes
2014
Toll-like receptors: key mediators of microbe detection
2002
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Toll-like receptors and innate immunity
2001 Standout
Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice
2011
Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells
2001
Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1β Secretion through the NLRP3 Inflammasome In Vitro
2011
Toll-Like Receptors
2003 Standout
Identification of an N-Terminal Recognition Site in TLR9 That Contributes to CpG-DNA-Mediated Receptor Activation
2009
The efficiency of acute infection of CD4+ T cells is markedly enhanced in the setting of antigen-specific immune activation.
1996 StandoutNobel
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
2011
Involvement of Toll-Like Receptor 4 in Innate Immunity to Respiratory Syncytial Virus
2001
Endotoxin-mimetic effect of antibodies against Toll-like receptor 4
2000 StandoutNobel
Caspase‐8 functions as a key mediator of inflammation and pro‐IL‐1β processing via both canonical and non‐canonical pathways
2015
Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner
2004
An Essential Role of the NF-κB/Toll-Like Receptor Pathway in Induction of Inflammatory and Tissue-Repair Gene Expression by Necrotic Cells
2001
Toll-like receptor 4-mediated activation of murine mast cells
2001
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
2009 StandoutNobel
The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense
2003
Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
2002 Standout
Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
2000
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
2001 Standout
Critical role for calcium mobilization in activation of the NLRP3 inflammasome
2012
Toll-Like Receptor 4 Mediates Innate Immune Responses toHaemophilus influenzaeInfection in Mouse Lung
2002
Gut flora and bacterial translocation in chronic liver disease
2006
IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism
2004
Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
2005
Regulation of Toll-Like Receptor 2 Expression by Macrophages FollowingMycobacterium aviumInfection
2000
Cutting Edge: Gln22 of Mouse MD-2 Is Essential for Species-Specific Lipopolysaccharide Mimetic Action of Taxol
2001
TLR2- and TLR4-Mediated Signals Determine Attenuation or Augmentation of Inflammation by Acute Alcohol in Monocytes
2006
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
2007
The Inflammasome in Atherosclerosis and Type 2 Diabetes
2011
Rapid Chromatin Remodeling of Toll-Like Receptor 2 Promoter During Infection of Macrophages with Mycobacterium avium
2002
Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection withTrypanosoma cruziin Mice Lacking Functional Myeloid Differentiation Factor 88
2004
Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses
2000
Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible toStaphylococcus aureusInfection
2000
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
Cooperation of Toll-Like Receptor 2 and 6 for Cellular Activation by Soluble Tuberculosis Factor andBorrelia burgdorferiOuter Surface Protein A Lipoprotein: Role of Toll-Interacting Protein and IL-1 Receptor Signaling Molecules in Toll-Like Receptor 2 Signaling
2001
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
2003
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
2000
Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3
2008
TLR-Independent Induction of Dendritic Cell Maturation and Adaptive Immunity by Negative-Strand RNA Viruses
2004
MyD88-Dependent but Toll-Like Receptor 2-Independent Innate Immunity to Listeria: No Role for Either in Macrophage Listericidal Activity
2002
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity
2002
A family of peptidoglycan recognition proteins in the fruit flyDrosophila melanogaster
2000
Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells
2001
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
NFκB and Sp1 Elements Are Necessary for Maximal Transcription of Toll-like Receptor 2 Induced byMycobacterium avium
2001
Activation of Toll-Like Receptor-2 by Glycosylphosphatidylinositol Anchors from a Protozoan Parasite
2001
Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine Macrophages
2001
Toll-Like Receptor 4 Expression Is Required to Control ChronicMycobacterium tuberculosisInfection in Mice
2002
Divergent Response to LPS and Bacteria in CD14-Deficient Murine Macrophages
2000
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
2005
Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering
2006
Cathepsins are required for Toll-like receptor 9 responses
2008
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
2000 Standout
TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA
2008
Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease
2000
NF-κB and STAT5 Play Important Roles in the Regulation of Mouse Toll-Like Receptor 2 Gene Expression
2001
Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
2007
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
2002
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Toll-Like Receptor 2 Is Required for Innate, But Not Acquired, Host Defense to Borrelia burgdorferi
2002
Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen, Candida albicans
2014
Cutting Edge: Immune Stimulation by Neisserial Porins Is Toll-Like Receptor 2 and MyD88 Dependent
2002
Yersinia V–Antigen Exploits Toll-like Receptor 2 and CD14 for Interleukin 10–mediated Immunosuppression
2002
Cutting Edge: Repurification of Lipopolysaccharide Eliminates Signaling Through Both Human and Murine Toll-Like Receptor 2
2000
Chlamydia pneumoniae and Chlamydial Heat Shock Protein 60 Stimulate Proliferation of Human Vascular Smooth Muscle Cells via Toll-Like Receptor 4 and p44/p42 Mitogen-Activated Protein Kinase Activation
2001
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
2001
Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo
2001
Expression of Toll-Like Receptor 2 on γδ T Cells Bearing Invariant Vγ6/Vδ1 Induced by Escherichia coli Infection in Mice
2000
Immunobiology of Dendritic Cells
2000 Standout
Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
1999
TLR9 Is Localized in the Endoplasmic Reticulum Prior to Stimulation
2004
Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)–deficient mice
2003
Endosomal Translocation of Vertebrate DNA Activates Dendritic Cells via TLR9-Dependent and -Independent Pathways
2005
Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1β
2001
Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4
2001
Interleukin-10 Upregulates Tumor Necrosis Factor Receptor Type-II (p75) Gene Expression in Endotoxin-Stimulated Human Monocytes
1997
Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ: a molecular basis for priming and synergism with bacterial lipopolysaccharide
2002
Gene Expressions of Toll-Like Receptor 2, But Not Toll-Like Receptor 4, Is Induced by LPS and Inflammatory Cytokines in Mouse Macrophages
2000
Lipopolysaccharide Endotoxins
2002 Standout
The TLR3 signaling complex forms by cooperative receptor dimerization
2008
Inflammasomes and Their Roles in Health and Disease
2012
c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities
1998
Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide
2001
Critical Roles of Myeloid Differentiation Factor 88-Dependent Proinflammatory Cytokine Release in Early Phase Clearance ofListeria monocytogenesin Mice
2002
Flagellin, a Novel Mediator of Salmonella-Induced Epithelial Activation and Systemic Inflammation: IκBα Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction
2001
Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators
2001
Protective Roles of Mast Cells Against Enterobacterial Infection Are Mediated by Toll-Like Receptor 4
2001
Toll-like Receptor 4 Resides in the Golgi Apparatus and Colocalizes with Internalized Lipopolysaccharide in Intestinal Epithelial Cells
2002
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
2006 StandoutNobel
TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
2006
NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease
2005
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes
2004
Activation of NF-κB by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK–IKKα/β–IκBα and MKK3/6–p38 MAP kinase signaling pathways in epithelial cells
2001
Innate Immune Recognition
2002 Standout
Cutting Edge: Protective Cell-Mediated Immunity to Listeria monocytogenes in the Absence of Myeloid Differentiation Factor 88
2003
Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression
2000
Lactobacilli and Streptococci Activate NF-κB and STAT Signaling Pathways in Human Macrophages
2000
In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation
2002
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Role of Toll-Like Receptors in Changes in Gene Expression and NF-κB Activation in Mouse Hepatocytes Stimulated with Lipopolysaccharide
2002
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
2007 StandoutNobel
Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by a Retrovirus
2003
Mycobacterium tuberculosisInhibits Macrophage Responses to IFN-γ through Myeloid Differentiation Factor 88-Dependent and -Independent Mechanisms
2004
Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines
2002
A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding
2011 StandoutNobel
A Critical Role for Human Caspase-4 in Endotoxin Sensitivity
2014
Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2
2003
Signaling through CD14 Attenuates the Inflammatory Response toBorrelia burgdorferi, the Agent of Lyme Disease
2005
Cutting Edge: TLR9 and TLR2 Signaling Together Account for MyD88-Dependent Control of Parasitemia in Trypanosoma cruzi Infection
2006
Maturation of Human Dendritic Cells by Cell Wall Skeleton ofMycobacterium bovisBacillus Calmette-Guerin: Involvement of Toll-Like Receptors
2000
Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
2007
Works of Egil Lien being referenced
Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death
2018 Science
Activation of Human Monocytic Cells by Borrelia burgdorferi and Treponema pallidum Is Facilitated by CD14 and Correlates with Surface Exposure of Spirochetal Lipoproteins
1999
Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome
2010
Cutting Edge: Recognition of Gram-Positive Bacterial Cell Wall Components by the Innate Immune System Occurs Via Toll-Like Receptor 2
1999 Standout
Human Toll-Like Receptors Mediate Cellular Activation by Mycobacterium tuberculosis
1999
Immunohistochemical localization of Toll‐like receptors 2 and 4 in gingival tissue from patients with periodontitis
2003
Lipopolysaccharide Rapidly Traffics to and from the Golgi Apparatus with the Toll-like Receptor 4-MD-2-CD14 Complex in a Process That Is Distinct from the Initiation of Signal Transduction
2002
Involvement of Toll-like Receptor (TLR) 2 and TLR4 in Cell Activation by Mannuronic Acid Polymers
2002
Toll-Like Receptors and Their Function in Innate and Adaptive Immunity
2003
Toll‐like receptor 3 associates with c‐Src tyrosine kinase on endosomes to initiate antiviral signaling
2006
LIPOPOLYSACCHARIDE RECOGNITION, CD14, AND LIPOPOLYSACCHARIDE RECEPTORS
1999
Toll-like Receptor 2 Functions as a Pattern Recognition Receptor for Diverse Bacterial Products
1999
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
2004
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
2000
The NLRP12 Inflammasome Recognizes Yersinia pestis
2012
Tumor necrosis factor-alpha inhibits stem cell factor-induced proliferation of human bone marrow progenitor cells in vitro. Role of p55 and p75 tumor necrosis factor receptors.
1994
Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88
2004
Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
2006
Serum Levels of Tumor Necrosis Factor- (TNF ) and Soluble TNF Receptors in Human Immunodeficiency Virus Type 1 Infection-Correlations to Clinical, Immunologic, and Virologic Parameters
1994
A Novel Synthetic Acyclic Lipid A-like Agonist Activates Cells via the Lipopolysaccharide/Toll-like Receptor 4 Signaling Pathway
2001
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Polymorphonuclear granulocytes enhance lipopolysaccharide‐induced soluble p75 tumor necrosis factor receptor release from mononuclear cells
1995
Enhanced Interleukin‐10 Production in Response toMycobacterium aviumProducts in Mononuclear Cells from Patients with Human Immunodeficiency Virus Infection
1998
Elevated Levels of Serum-Soluble CD14 in Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Correlation to Disease Progression and Clinical Events
1998
Differential expression of Toll-like receptor 2 in human cells
2001
Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice
2004
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
2014
Human Toll-Like Receptor 2 Mediates Monocyte Activation byListeria monocytogenes, But Not by Group B Streptococci or Lipopolysaccharide
2000
Inflammatory Response After Open Heart Surgery
2002
The LPS receptor generates inflammatory signals from the cell surface
2003
Toll-like receptors
2002
Membrane-Associated Proteins of a Lipopolysaccharide-Deficient Mutant ofNeisseria meningitidisActivate the Inflammatory Response through Toll-Like Receptor 2
2001
Hemagglutinin Protein of Wild-Type Measles Virus Activates Toll-Like Receptor 2 Signaling
2002
Toll-like receptors.
2002
The CD14 Ligands Lipoarabinomannan and Lipopolysaccharide Differ in Their Requirement for Toll-Like Receptors
1999
Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line
2001
Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity
2003
Cutting Edge: Cells That Carry A Null Allele for Toll-Like Receptor 2 Are Capable of Responding to Endotoxin
1999
Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling; role of CD14 and CD36
2008
A Mechanism for Neurodegeneration Induced by Group B Streptococci through Activation of the TLR2/MyD88 Pathway in Microglia
2006
Cellular Activation, Phagocytosis, and Bactericidal Activity Against Group B Streptococcus Involve Parallel Myeloid Differentiation Factor 88-Dependent and Independent Signaling Pathways
2002
Induction of Tolerance to Lipopolysaccharide and Mycobacterial Components in Chinese Hamster Ovary/CD14 Cells Is Not Affected by Overexpression of Toll-Like Receptors 2 or 4
2001