Citation Impact
Citing Papers
The Genetic Basis for Bacterial Mercury Methylation
2013 StandoutScience
Structural and Kinetic Evidence for an Extended Hydrogen-bonding Network in Catalysis of Methyl Group Transfer
2006
Mutational Analysis of Trp-229 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase (RT) Identifies This Amino Acid Residue as a Prime Target for the Rational Design of New Non-Nucleoside RT Inhibitors
2000
Magnesium-cationic Dummy Atom Molecules Enhance Representation of DNA Polymerase β in Molecular Dynamics Simulations: Improved Accuracy in Studies of Structural Features and Mutational Effects
2006 StandoutNobel
Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance
2005 StandoutNobel
Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase
2000
The group II intron ribonucleoprotein precursor is a large, loosely packed structure
2010 StandoutNobel
Domain structure and three-dimensional model of a group II intron-encoded reverse transcriptase
2004
Use of organic cosmotropic solutes to crystallize flexible proteins: application to T7 RNA polymerase and its complex with the inhibitor T7 lysozyme
1997 StandoutNobel
Crystal Structures of the Bacillus stearothermophilus CCA-Adding Enzyme and Its Complexes with ATP or CTP
2002 StandoutNobel
Crystal Structures of 8-Cl and 9-Cl TIBO Complexed with Wild-type HIV-1 RT and 8-Cl TIBO Complexed with the Tyr181Cys HIV-1 RT Drug-resistant Mutant
1996
Allosteric Inhibitor Development Targeting HIV‐1 Integrase
2011
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69
1997 StandoutNobel
The Structures of Four Macrolide Antibiotics Bound to the Large Ribosomal Subunit
2002 StandoutNobel
Structure of unliganded HIV-1 reverse transcriptase at 2.7 å resolution: implications of conformational changes for polymerization and inhibition mechanisms
1996
Structure of the Replicating Complex of a Pol α Family DNA Polymerase
2001 StandoutNobel
Structural Mechanisms of HIV Drug Resistance
1996
Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain
2001 StandoutNobel
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
Yeast RNA Polymerase II at 5 Å Resolution
1999 StandoutNobel
Drugs, their targets and the nature and number of drug targets
2006
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase
2000
RIBEYE, a Component of Synaptic Ribbons
2000 StandoutNobel
Multiple protein sequence alignment from tertiary structure comparison: Assignment of global and residue confidence levels
1992
Interaction of Retroviral Reverse Transcriptase with Template–Primer Duplexes during Replication
1997
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance 1 1Edited by J. Karn
1998
Aptamer Displacement Identifies Alternative Small-Molecule Target Sites that Escape Viral Resistance
2007
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B‐family polymerases
2007 StandoutNobel
Relating the Structure ofHIV-1 Reverse Transcriptaseto Its Processing Step
2000
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors 1 1Edited by J. Karn
2001
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase
1995
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
1995
The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design
1995
Structure of T7 RNA polymerase complexed to the transcriptional inhibitor T7 lysozyme
1998 StandoutNobel
Polyalanine Reconstruction from Cα Positions Using the ProgramCALPHACan Aid Initial Phasing of Data by Molecular Replacement Procedures
1997
Structure of Taq polymerase with DNA at the polymerase active site
1996 StandoutNatureNobel
Insights into Strand Displacement and Processivity from the Crystal Structure of the Protein-Primed DNA Polymerase of Bacteriophage φ29
2004 StandoutNobel
Crystal structure of a thermostable Bacillus DNA polymerase l large fragment at 2.1 Å resolution
1997
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
Role of Residues in the Tryptophan Repeat Motif for HIV-1 Reverse Transcriptase Dimerization
2003
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
Structure and mechanism of DNA polymerases
2005
Structures of DNA and RNA polymerases and their interactions with nucleic acid substrates
1995
MolProbity: all-atom structure validation for macromolecular crystallography
2009 Standout
Leprosy
2004 Standout
An open and closed case for all polymerases
1999
Phenylethylthiazolylthiourea (PETT) Non-nucleoside Inhibitors of HIV-1 and HIV-2 Reverse Transcriptases
2000
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
Features and development of Coot
2010 Standout
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
1995
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
2001
Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver
1998
Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions
1997
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2.8 Å resolution
1998
Crystal structure of a NAD-dependent d-glycerate dehydrogenase at 2·4 Å resolution
1994
The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase
2004 StandoutNobel
Diaminodiphenylsulfone resistance ofMycobacterium lepraedue to mutations in the dihydropteroate synthase gene
1999
The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor
1998
DNA Polymerases: Structural Diversity and Common Mechanisms
1999 StandoutNobel
Insights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III α-Subunit
2008 StandoutNobel
The Gewald multicomponent reaction
2010
Binding of the Second Generation Non-nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding
2000
Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization
2006
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Functional Nucleic Acid Sensors
2009 Standout
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
2002 StandoutNobel
A Water-Based Mechanism of Specificity and Resistance for Lapatinib with ErbB Family Kinases
2012
Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non-Nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modeling Studies
1999
Die Bedeutung der Balance von Wasserstoffbrückenbindungen und hydrophoben Wechselwirkungen im Wirkstoff-Rezeptor-Komplex
1999
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance
1998 StandoutScience
Computer Simulation of the Chemical Catalysis of DNA Polymerases: Discriminating between Alternative Nucleotide Insertion Mechanisms for T7 DNA Polymerase
2003 StandoutNobel
Crystal Structures of HIV-1 Reverse Transcriptase in Complex with Carboxanilide Derivatives,
1998
Getting a grip: polymerases and their substrate complexes
1999
3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
1998
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89
1997
Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates
2008 Science
Dynamic reorganization of the functionally active ribosome explored by normal mode analysis and cryo-electron microscopy
2003 StandoutNobel
The Guanine Nucleotide-Binding Switch in Three Dimensions
2001 StandoutScience
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
2008
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
2007
Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template
2007 StandoutNobel
Activatable Photosensitizers for Imaging and Therapy
2010 Standout
Electrogenerated Chemiluminescence and Its Biorelated Applications
2008 Standout
The small ribosomal subunit from Thermus thermophilus at 4.5 Å resolution: Pattern fittings and the identification of a functional site
1999 StandoutNobel
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
2004 StandoutNobel
Complexes of HIV-1 Reverse Transcriptase with Inhibitors of the HEPT Series Reveal Conformational Changes Relevant to the Design of Potent Non-Nucleoside Inhibitors
1996
A unified statistical framework for sequence comparison and structure comparison
1998 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY
2005 StandoutNobel
Molecular Dynamics Free-Energy Simulations of the Binding Contribution to the Fidelity of T7 DNA Polymerase
2002 StandoutNobel
Structure of importin-β bound to the IBB domain of importin-α
1999 Nature
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Design of MKC-442 (Emivirine) Analogues with Improved Activity Against Drug-Resistant HIV Mutants
1999
Crystal Structures of Zidovudine- or Lamivudine-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptases Containing Mutations at Codons 41, 184, and 215
2002
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor
1997
Works of D.O. Somers being referenced
Continuous and Discontinuous Changes in the Unit Cell of HIV-1 Reverse Transcriptase Crystals on Dehydration
1998
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
1997
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3
2006
Crystals of HIV-1 Reverse Transcriptase Diffracting to 2·2 Å Resolution
1994
High resolution structures of HIV-1 RT from four RT–inhibitor complexes
1995
Sheep 6-phosphogluconate dehydrogenase. Revised protein sequence based upon the sequences of cDNA clones obtained with the polymerase chain reaction
1992 StandoutNobel
The structure of 6-phosphogluconate dehydrogenase refined at 2.5 Å resolution
1991