Standout Papers
Citation Impact
Citing Papers
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
2010
Triggering a Cell Shape Change by Exploiting Preexisting Actomyosin Contractions
2012 StandoutScienceNobel
The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin
2005
Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix
2006 Standout
Human MicroRNA Targets
2004 Standout
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
Structures of the RNA-guided surveillance complex from a bacterial immune system
2011 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Matrix metalloproteinases and the regulation of tissue remodelling
2007 Standout
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
2009 Standout
Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion
2009
Human Argonaute2 Mediates RNA Cleavage Targeted by miRNAs and siRNAs
2004 Standout
Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2
2007
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
Exploiting the RNA interference pathway to counter hepatitis B virus replication
2005
Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression
2010
Loss of Net as Repressor Leads to Constitutive Increased c-fos Transcription in Cervical Cancer Cells
2004 StandoutNobel
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices
2009
Kinetic analysis of the RNAi enzyme complex
2004
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study
2011
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
2016
TGF-β-induced EMT: mechanisms and implications for fibrotic lung disease
2007 Standout
TRIBE: Hijacking an RNA-Editing Enzyme to Identify Cell-Specific Targets of RNA-Binding Proteins
2016 StandoutNobel
Fibrosis and cancer: Do myofibroblasts come also from epithelial cells via EMT?
2007
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Small C-terminal Domain Phosphatase Enhances Snail Activity through Dephosphorylation
2008
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
2016
Epithelial-Mesenchymal Transition in tumor microenvironment
2011
Stromal myofibroblasts are drivers of invasive cancer growth
2008
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
2008 Nature
Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways
2009
Determinants of targeting by endogenous and exogenous microRNAs and siRNAs
2007
C911: A Bench-Level Control for Sequence Specific siRNA Off-Target Effects
2012
Improving Site‐Directed RNA Editing In Vitro and in Cell Culture by Chemical Modification of the GuideRNA
2014
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Molecular Basis for Target RNA Recognition and Cleavage by Human RISC
2007
Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi
2006 StandoutNobel
Modulation of several waves of gene expression during FGF‐1 induced epithelial‐mesenchymal transition of carcinoma cells
2008
Collective cell guidance by cooperative intercellular forces
2011
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
2011
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein
2009
Cancer as an overhealing wound: an old hypothesis revisited
2008 Standout
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases
2012
Fiji: an open-source platform for biological-image analysis
2012 Standout
TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial–mesenchymal transition
2007
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Argonaute: a scaffold for the function of short regulatory RNAs
2006
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
NIR light controlled photorelease of siRNA and its targeted intracellular delivery based on upconversion nanoparticles
2012
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
2007 Standout
EMT, the cytoskeleton, and cancer cell invasion
2009
Collective cell migration in morphogenesis, regeneration and cancer
2009 Standout
Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis
2008 Standout
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
2018
Lipid‐based nanotherapeutics for siRNA delivery
2009
Capturing complex 3D tissue physiology in vitro
2006 Standout
Sequence characteristics of functional siRNAs
2005 StandoutNobel
Revealing the world of RNA interference
2004 StandoutNatureNobel
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
The basics of epithelial-mesenchymal transition
2009 Standout
Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing
2017
Systems survey of endocytosis by multiparametric image analysis
2010 Nature
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Design of a genome-wide siRNA library using an artificial neural network
2005
Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
2010
Co-evolution of tumor cells and their microenvironment
2008
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
2018
Regulatory networks defining EMT during cancer initiation and progression
2013 Standout
Perspective: machines for RNAi
2005
Defining and Assaying RNAi in Mammalian Cells
2005
NF-κB: linking inflammation and immunity to cancer development and progression
2005 Standout
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
2011 StandoutNobel
Small RNA-mediated regulation of iPS cell generation
2011
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
2014 Standout
RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
2010
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Matrix Metalloproteinases As Novel Biomarker s and Potential Therapeutic Targets in Human Cancer
2009
Molecular Imaging with Theranostic Nanoparticles
2011
Mechanisms of Motility in Metastasizing Cells
2010
Seed Sequence-Matched Controls Reveal Limitations of Small Interfering RNA Knockdown in Functional and Structural Studies of Hepatitis C Virus NS5A-MOBKL1B Interaction
2014 StandoutNobel
The Ins and Outs of the Epithelial to Mesenchymal Transition in Health and Disease
2011
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
Distance constraints between microRNA target sites dictate efficacy and cooperativity
2007
eIF4E, the mRNA cap-binding protein: from basic discovery to translational researchThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process.
2008
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Genomic Screening with RNAi: Results and Challenges
2010
Epithelial-Mesenchymal Interactions in Pulmonary Fibrosis
2011
Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
2008
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Activation of fibroblasts in cancer stroma
2010
The epithelial–mesenchymal transition: new insights in signaling, development, and disease
2006 Standout
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Devin Leake being referenced
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
2005 Nature
Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
2009
Identification of genes that regulate epithelial cell migration using an siRNA screening approach
2008
Biodegradable Nanoparticles With Sustained Release of Functional siRNA in Skin
2010
Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing
2006
Off-target effects by siRNA can induce toxic phenotype
2006
A protocol for designing siRNAs with high functionality and specificity
2007
Rational siRNA design for RNA interference
2004 Standout
Double-stranded regions are essential design components of potent inhibitors of RISC function
2007
Single-Nucleotide-Specific siRNA Targeting in a Dominant-Negative Skin Model
2007
3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
2006
Mechanistic Insights Aid Computational Short Interfering RNA Design
2005
In Vivo Sustained Release of siRNA from Solid Lipid Nanoparticles
2011