Citation Impact
Citing Papers
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation
2003 StandoutNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons
2008 StandoutScience
Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia
2006 StandoutScience
Loss of C9 ORF 72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death
2016
Modulation of extracellular glutamate concentration in rat brain slices by cystine‐glutamate exchange
1999
First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
2019
Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster
2012
The DNA-damage response in human biology and disease
2009 StandoutNature
Influence of the oestrous cycle on L-glutamate and l-aspartate transport in rat brain synaptosomes
1999
EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex
1998
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
1997 StandoutNature
Altered glutamatergic transmission in neurological disorders: From high extracellular glutamate to excessive synaptic efficacy
1997
Apoptosis in the nervous system
2000 StandoutNature
Quantitative autoradiography of Na+-dependent [3H]l-aspartate binding to l-glutamate transporters in rat brain: structure-activity studies using l-trans-pyrrolidine-2,4-dicarboxylate (l-t-PDC) and 2-(carboxycyclopropyl)-glycine (CCG)
2000
Aspartate 338 contributes to the cationic specificity and to driver-amino acid coupling in the insect cotransporter KAAT1
2004
Glutamate transport in cultures from developing avian cerebellum: Presence of GLT-1 immunoreactivity in Purkinje neurons
1998
Neurotransmitter Transporters: Molecular Biology, Function, and Regulation
1995
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Transient expression of the glial glutamate transporters GLAST and GLT in hippocampal neurons in primary culture
2000
4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake
1997
Differential distribution of the glutamate transporters GLT1 and rEAAC1 in rat cerebral cortex and thalamus: an in situ hybridization analysis
1997
Chemical Technologies for Probing Glycans
2006 StandoutNobel
Deficits of NMDA receptors and glutamate uptake sites in the frontal cortex in AIDS
1999
4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
1997
Arachidonic acid elicits a substrate-gated proton current associated with the glutamate transporter EAAT4
1998
The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms
2000
Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn‐superoxide dismutase mutant mice
2006
Glutamate uptake
2001 Standout
Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis
2013
Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration
1997
Glutamate transporter EAAC1 is expressed in neurons and glial cells in the rat nervous system
1999
Oxygen radicals diminish dopamine transporter function in rat striatum
1997
Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis
1998
Astrocytes are required for the oscillatory activity in cultured hippocampal neurons
1999
The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study
1998
Stress–inducible responses and heat shock proteins: New pharmacologic targets for cytoprotection
1998
Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice
2005
C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD
2016
Sequential changes in glutamate transporter protein levels during Fe3+-induced epileptogenesis
2000
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
2006
Free Radicals and Glutamate Uptake in the Retina*
1998
Increase in External Glutamate and NMDA Receptor Activation Contribute to H2O2‐Induced Neuronal Apoptosis
1999
ER stress and neurodegenerative diseases
2006
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
2015
The high affinity uptake system for excitatory amino acids in the brain
1994
Methylmercury alters glutamate transport in astrocytes
2000
Arachidonic Acid Activates a Proton Current in the Rat Glutamate Transporter EAAT4
1998
Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis
2002
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
2002
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
2016
Cloning and Characterization of aDrosophila melanogastercDNA Encoding a Glutamate Transporter
1999
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
Activation of the Adenylate Cyclase-dependent Protein Kinase Pathway Increases High Affinity Glutamate Uptake Into Rat Striatal Synaptosomes
1996
Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
2015
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
2009 StandoutNature
Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration
1999
High Affinity Glutamate Transporters: Regulation of Expression and Activity
1997
Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry
1995
Decoding ALS: from genes to mechanism
2016 StandoutNature
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
2005 StandoutNature
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
2015 Nature
Mitochondria, Oxidants, and Aging
2005 Standout
Differential Effects of Corticostriatal and Thalamostriatal Deafferentation on Expression of the Glutamate Transporter GLT1 in the Rat Striatum
2000
Distribution of the glutamate transporters GLAST and GLT-1 in rat circumventricular organs, meninges, and dorsal root ganglia
2000
Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes
2000
Mitochondrial fragmentation in neurodegeneration
2008
HIV Decreases Glutamate Transport in Sk-N-Mc Neuroblastoma Cells
1998
Pre-incubation of synaptosomes with arachidonic acid potentiates inhibition of [3H]D-aspartate transport
1995
Sulfation of N-Acetylglucosamine by Chondroitin 6-Sulfotransferase 2 (GST-5)
2000 StandoutNobel
Reactive oxygen species trigger motoneuron death in non-cell-autonomous models of ALS through activation of c-Abl signaling
2015
Effects of PKA and PKC modulators on high affinity glutamate uptake in primary neuronal cell cultures from rat cerebral cortex
1999
MOLECULAR PHARMACOLOGY AND PHYSIOLOGY OF GLUTAMATE TRANSPORTERS IN THE CENTRAL NERVOUS SYSTEM
1998
Neurodegenerative disorders: the role of peroxynitrite
1999
Stimulation of glutamate uptake and Na, K-ATPase activity in rat astrocytes exposed to ischemia-like insults
1997
Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters
2005 StandoutNature
Oxidative damage to protein in sporadic motor neuron disease spinal cord
1995
Inherited Defects of Sodium-dependent Glutamate Transport Mediated by Glutamate/Aspartate Transporter in Canine Red Cells Due to a Decreased Level of Transporter Protein Expression
2000
Heterogeneity and Functional Properties of Subtypes of Sodium-Dependent Glutamate Transporters in the Mammalian Central Nervous System
1996
Differential Modulation of Human Glutamate Transporter Subtypes by Arachidonic Acid
1995
Molecular cloning and expression of human chondroitin 6-sulfotransferase
1998
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Characterization of a Functional Bacterial Homologue of Sodium-dependent Neurotransmitter Transporters
2003
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
2000 StandoutNature
Studies of the coding region of the neuronal glutamate transporter gene in amyotrophic lateral sclerosis
1995
Alzheimer's Disease
2010 Standout
Differentiation of Substrate and Nonsubstrate Inhibitors of the High-Affinity, Sodium-Dependent Glutamate Transporters
1999
A role for tumor necrosis factor-α in ischemia and ischemic preconditioning
2011
Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis
2005
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses
2003 StandoutNobel
Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia
2000
Differential Developmental Expression of the Two Rat Brain Glutamate Transporter Proteins GLAST and GLT
1997
Molecular signaling in the regulation of mucins
2007
Is High Extracellular Glutamate the Key to Excitotoxicity in Traumatic Brain Injury?
1997
Cellular Distribution and Kinetic Properties of High-Affinity Glutamate Transporters
1998
Structural Selectivity and Molecular Nature ofl-Glutamate Transport in Cultured Human Fibroblasts
1998
Interindividual differences in the levels of the glutamate transporters GLAST and GLT, but no clear correlation with Alzheimer's disease
1999
17?-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron
1997
Arachidonic acid inhibits uptake of amino acids and potentiates PKC effects on glutamate, but not GABA, exocytosis in isolated hippocampal nerve terminals
1997
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
2004
Nontransportable Inhibitors Attenuate Reversal of Glutamate Uptake in Synaptosomes Following a Metabolic Insult
1999
Excitatory Amino Acids as a Final Common Pathway for Neurologic Disorders
1994 Standout
Venom phospholipase A2-induced impairment of glutamate uptake: An indirect and nonselective effect related to phospholipid hydrolysis
1998
Metabolism, Cell Surface Organization, and Disease
2009
Mitochondrial DNA damage and repair in neurodegenerative disorders
2008
Chapter 3 Properties and localization of glutamate transporters
1998
Flux coupling in a neuronal glutamate transporter
1996 Nature
Glutamate Release Monitored with Astrocyte Transporter Currents during LTP
1998
Membrane trafficking of neurotransmitter transporters in the regulation of synaptic transmission
1999
Toxic PR Poly-Dipeptides Encoded by the C9orf72 Repeat Expansion Target LC Domain Polymers
2016
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
2006
HIV‐1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid
1997
Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration
2015
Reversible Activation of Glutamate Transport in Rat Brain Glia by Protein Kinase C and an Okadaic Acid-Sensitive Phosphoprotein Phosphatase
1999
Cytokine Effects on Glutamate Uptake by Human Astrocytes
2000
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
1998 Nature
Mediators of Injury in Neurotrauma: Intracellular Signal Transduction and Gene Expression
1995
Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS
2014
Amyotrophic Lateral Sclerosis
2001 Standout
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
2015
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
1995
Mechanism of glutamate release from rat hippocampal slices during in vitro ischemia
1996
Immunocytochemical Localization of a High‐affinity Glutamate‐Aspartate Transporter, GLAST, in the Rat and Guinea‐pig Cochlea
1997
Tumor Necrosis Factor α Inhibits Glutamate Uptake by Primary Human Astrocytes
1996
Exosomes, an Unmasked Culprit in Neurodegenerative Diseases
2017
4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes
1998
Glutamate uptake is decreased in platelets from Alzheimer's disease patients
2000
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
2006
A Genetic Approach to Mammalian Glycan Function
2003
β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease
1997
Structural Features of the Glutamate Transporter Family
1999
Control of the Molecular Orientation of Membrane-Anchored Biomimetic Glycopolymers
2009 StandoutNobel
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
2002 StandoutNobel
Glutamate Induces Rapid Upregulation of Astrocyte Glutamate Transport and Cell-Surface Expression of GLAST
1999
Elevated Cortical Extracellular Fluid Glutamate in Transgenic Mice Expressing Human Mutant (G93A) Cu/Zn Superoxide Dismutase
2000
EXCITATORY AMINO ACID TRANSPORTERS: A Family in Flux
1999
Brain Glutamate Transporter Proteins Form Homomultimers
1996
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Long-Term Potentiation--A Decade of Progress?
1999 StandoutScience
Expression of a Variant Form of the Glutamate Transporter GLT1 in Neuronal Cultures and in Neurons and Astrocytes in the Rat Brain
2002
Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls
2000
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Inhibition of Astrocyte Glutamate Uptake by Reactive Oxygen Species: Role of Antioxidant Enzymes
1997
ALS-Linked Cu/Zn-SOD Mutation Impairs Cerebral Synaptic Glucose and Glutamate Transport and Exacerbates Ischemic Brain Injury
2000
EIN2, a Bifunctional Transducer of Ethylene and Stress Responses in Arabidopsis
1999 StandoutScience
Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism
2000
Cloning and expression of a neuronal rat brain glutamate transporter
1996
Accumulation of SOD1 Mutants in Postnatal Motoneurons Does Not Cause Motoneuron Pathology or Motoneuron Disease
2002
Arachidonic Acid Stimulates a Novel Cocaine-Sensitive Cation Conductance Associated with the Human Dopamine Transporter
2000
Na+-Dependent High-Affinity Glutamate Transport in Macrophages
2000
Spermidine in health and disease
2018 StandoutScience
Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
2021 StandoutNobel
From Charcot to SOD1
1999
Neurotransmitter Transporters in the Central Nervous System
1999
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin
1999
Mitochondrial damage due to SOD1 deficiency in SH‐SY5Y neuroblastoma cells: a rationale for the redundancy of SOD1
2006
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Glutamate Transporters Contribute to the Time Course of Synaptic Transmission in Cerebellar Granule Cells
1999
Effects of feline immunodeficiency virus on astrocyte glutamate uptake: Implications for lentivirus-induced central nervous system diseases
1998
Optical measurement of synaptic glutamate spillover and reuptake by linker optimized glutamate-sensitive fluorescent reporters
2008 StandoutNobel
Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy
1999
Ischemic Cell Death in Brain Neurons
1999 Standout
A Postsynaptic Excitatory Amino Acid Transporter with Chloride Conductance Functionally Regulated by Neuronal Activity in Cerebellar Purkinje Cells
1997
Acute decrease in net glutamate uptake during energy deprivation
2000
Insights into glutamate transport regulation in human astrocytes: Cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
2003
The Glutamate Transporter EAAT4 in Rat Cerebellar Purkinje Cells: A Glutamate-Gated Chloride Channel Concentrated near the Synapse in Parts of the Dendritic Membrane Facing Astroglia
1998
Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast‐derived iPS cells using zinc‐finger nuclease technology
2015
UNRAVELING THE MECHANISMS INVOLVED IN MOTOR NEURON DEGENERATION IN ALS
2004
Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain
1997 StandoutNobel
Accumulation of acetylcholine receptors is a necessary condition for normal accumulation of acetylcholinesterase during in vitro neuromuscular synaptogenesis
1998
The role of oxidative damage in the neuropathology of organic acidurias: Insights from animal studies
2004
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes
1994
Identification and characterization of an amino acid transporter expressed differentially in liver
2000
Developmental regulation of glutamate transporters and glutamine synthetase activity in astrocyte cultures differentiatedin vitro
1999
EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
1999
Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes.
1993
Restricted Expression of G86R Cu/Zn Superoxide Dismutase in Astrocytes Results in Astrocytosis But Does Not Cause Motoneuron Degeneration
2000
Voltage-Induced Misfolding of Zinc-Replete ALS Mutant Superoxide Dismutase-1
2015
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
Reversing cerebellar long-term depression
2003 StandoutNobel
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
2004 StandoutNobel
Substrate Turnover by Transporters Curtails Synaptic Glutamate Transients
1999
Synaptically Evoked Glutamate Transport Currents May Be Used To Detect the Expression of Long-Term Potentiation in Cerebellar Culture
1998
Neurotransmitter Transporters: Regulators of Function and Functional Regulation
1998
Glial Contribution to Glutamate Uptake at Schaffer Collateral–Commissural Synapses in the Hippocampus
1998
Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit gluR2 in the rat hippocampus
2000
Works of Davide Trotti being referenced
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1
2012
Peroxynitrite Inhibits Glutamate Transporter Subtypes
1996
Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms.
1994
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2
2010
Non‐synaptic Localization of the Glutamate Transporter EAACI in Cultured Hippocampal Neurons
1997
Differential Modulation of the Uptake Currents by Redox Interconversion of Cysteine Residues in the Human Neuronal Glutamate Transporter EAAC1
1997
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
1999
Neuronal and Glial Glutamate Transporters Possess an SH‐based Redox Regulatory Mechanism
1997
Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis
2014
Arachidonic Acid Inhibits a Purified and Reconstituted Glutamate Transporter Directly from the Water Phase and Not via the Phospholipid Membrane
1995
Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD
2016
Regulation of glutamate transporters in health and disease
2001
Caspase-3 Cleaves and Inactivates the Glutamate Transporter EAAT2
2006
The Competitive Transport Inhibitor L‐trans‐pyrrolidine‐2,4‐dicarboxylate Triggers Excitotoxicity in Rat Cortical Neuron‐Astrocyte Co‐cultures via Glutamate Release rather than Uptake Inhibition
1996
Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?
1998
High Sensitivity of Glutamate Uptake to Extracellular Free Arachidonic Acid Levels in Rat Cortical Synaptosomes and Astrocytes
1992
Amyotrophic Lateral Sclerosis-Associated SOD1 Mutant Proteins Bind and Aggregate with Bcl-2 in Spinal Cord Mitochondria
2004
Amyotrophic Lateral Sclerosis-linked Glutamate Transporter Mutant Has Impaired Glutamate Clearance Capacity
2001
A Role for The Arachidonic Acid Cascade In Fast Synaptic Modulation: Ion Channels and Transmitter Uptake Systems As Target Proteins
1992
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
2014
Reactive Oxygen Species Inhibit High‐Affinity Glutamate Uptake: Molecular Mechanism and Neuropathological Implications
1994
Symmetry of H+ Binding to the Intra- and Extracellular Side of the H+-coupled Oligopeptide Cotransporter PepT1
1997
Molecular Characteristics Of Mammalian And Insect Amino Acid Transporters: Implications For Amino Acid Homeostasis
1997
Cloning and characterization of a potassium-coupled amino acid transporter
1998
Inhibiting drug efflux transporters improves efficacy of ALS therapeutics
2014
Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
1994