Citation Impact
Citing Papers
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
The DNA-damage response in human biology and disease
2009 StandoutNature
β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase
2005 StandoutNobel
Regulation of p53 stability by Mdm2
1997 StandoutNature
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Inhibition of E6-induced Degradation of its Cellular Substrates by Novel Blocking Peptides
2003
Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
2002
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1992 Standout
Basic mechanisms of high‐risk human papillomavirus‐induced carcinogenesis: Roles of E6 and E7 proteins
2007
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
2009 Standout
Inhibition of shoot branching by new terpenoid plant hormones
2008 StandoutNature
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
1990 Standout
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
p53 tumour suppressor gene polymorphism is associated with recurrent implantation failure
2006
p53: link to the past, bridge to the future
2005
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
1991 StandoutNature
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway
2008
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome
1990 StandoutNature
Isolation, Characterization, and Partial Purification of a Novel Ubiquitin-Protein Ligase, E3
1996 StandoutNobel
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
2007
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1992 Standout
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
The p53 tumour suppressor gene
1991 StandoutNature
Amplification of a gene encoding a p53-associated protein in human sarcomas
1992 StandoutNature
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Human papillomavirus immortalization and transformation functions
2002
Polymorphisms in the p53 pathway
2006
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1992 StandoutNature
Targetting of the N-terminal domain of the human papillomavirus type 16 E6 oncoprotein with monomeric scFvs blocks the E6-mediated degradation of cellular p53
1999
TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes
2007
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
1993 Standout
The Tumor Suppressor Protein p16 and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System
2004 StandoutNobel
Global quantification of mammalian gene expression control
2011 StandoutNature
Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
2002 StandoutNobel
The ubiquitin system
2000 StandoutNobel
siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells
2003
Inhibition of Papillomavirus Protein Function in Cervical Cancer Cells by Intrabody Targeting
2005 StandoutNobel
F-box proteins everywhere
2006 Standout
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
Wild-type p53 binds to the TATA-binding protein and represses transcription.
1992
Mechanisms of Human Papillomavirus-Induced Oncogenesis
2004
p53 Mutations in Human Cancers
1991 StandoutScience
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
1995 StandoutScience
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
2000 StandoutNobel
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
1994 StandoutScience
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
1991
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Binding of human papillomavirus 16 E6 to p53 and E6AP is impaired by monoclonal antibodies directed against the second zinc-binding domain of E6
2005
Craniofacial Dysmorphogenesis Including Cleft Palate in Mice with an Insertional Mutation in the discs large Gene
2001
Deletion of CASK in mice is lethal and impairs synaptic function
2007 StandoutNobel
Global Protein Stability Profiling in Mammalian Cells
2008 Science
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
1990 StandoutScience
Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions
1994
Human Papillomavirus and Cervical Cancer
2003 Standout
p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression.
1988
The retinoblastoma protein and cell cycle control
1995 Standout
Primary structure polymorphism at amino acid residue 72 of human p53.
1987
Isolation of human‐p53‐specific monoclonal antibodies and their use in the studies of human p53 expression
1986
Viruses in Human Cancers
1991 StandoutScienceNobel
Activation of p53 in cervical carcinoma cells by small molecules
2000
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
1994 StandoutNobel
Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene.
1996
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
c-Abl Regulates p53 Levels under Normal and Stress Conditions by Preventing Its Nuclear Export and Ubiquitination
2001 StandoutNobel
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
1990 StandoutScience
Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
1989 StandoutScience
The Arf/p53 Pathway in Cancer and Aging
2008
Mechanisms of p53 loss in human sarcomas.
1990
Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
1990 StandoutScience
Works of David Pim being referenced
HPV-18 E6*I protein modulates the E6-directed degradation of p53 by binding to full-length HPV-18 E6
1999
HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation
2001
The role of the E6-p53 interaction in the molecular pathogenesis of HPV
1999
Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins
2002
Alternatively spliced HPV-18 E6* protein inhibits E6 mediated degradation of p53 and suppresses transformed cell growth
1997
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
2005
HPV E6 targeted degradation of the discs large protein: evidence for the involvement of a novel ubiquitin ligase
2000
Viruses and the 26S proteasome: hacking into destruction
2003
p53 polymorphic variants at codon 72 exert different effects on cell cycle progression
2003
Analysis of human p53 proteins and mRNA levels in normal and transformed cells
1986
Two Polymorphic Variants of Wild-Type p53 Differ Biochemically and Biologically
1999