Citation Impact
Citing Papers
Titanium(IV )‐Catalyzed Dynamic Kinetic Asymmetric Transformation of Alcohols, Silyl Ethers, and Acetals under Carbon Allylation
2004
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone
2003
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox
2003 StandoutNobel
The Intermolecular Pauson–Khand Reaction
2005
The tachykinin NK1 receptor. Part I: Ligands and mechanisms of cellular activation
1997
Comprehensive survey of combinatorial libraries with undisclosed biological activity: 1992–1997
1998
Potential of Substance P Antagonists as Antiemetics
2000
Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist
1998
Visible light driven room temperature Pauson–Khand reaction
2009 StandoutNobel
In Vivo Regulation of Glycogen Synthase Kinase-3β (GSK3β) by Serotonergic Activity in Mouse Brain
2004
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Copper‐Catalyzed Intramolecular Oxidative 6‐exo‐trig Cyclization of 1,6‐Enynes with H2O and O2
2011
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Chemotherapy-Induced Nausea and Vomiting
2008 Standout
New Developments in the Pauson-Khand Reaction
1998
Phosphoramidites: Privileged Ligands in Asymmetric Catalysis
2010 StandoutNobel
The ??2-Agonist Controversy
1994
The search for orally active medications through combinatorial chemistry
1998
Angiotensin II Receptor Antagonists: An Emerging New Class of Cardiovascular Therapeutics.
1999
Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products
2010 Standout
Can a Ketone Be More Reactive than an Aldehyde? Catalytic Asymmetric Synthesis of Substituted Tetrahydrofurans
2018 StandoutNobel
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Catalytic Pauson−Khand Reaction in Super Critical Fluids
1997
Fluorine in medicinal chemistry
2007 Standout
Preparation of an amine N-oxide on solid phase: an efficient promoter of the Pauson–Khand reaction
1999
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Multicomponent Reactions with Isocyanides
2000 Standout
The chemistry of the carbon–transition metal double and triple bond: annual survey covering the year 1999
2001
Rate Enhancement of the Pauson–Khand Reaction by Primary Amines
1997
Natural Product Synthesis Using Multicomponent Reaction Strategies
2009 Standout
Methodologies for Generating Solution-Phase Combinatorial Libraries
2000
Synthesis of Heterocycles via Electrophilic Cyclization of Alkynes Containing Heteroatom
2011 Standout
The in silico world of virtual libraries
2000
New Approaches to Olefin Cross-Metathesis
1999 StandoutNobel
Chiral tertiary amine N-oxides in asymmetric epoxidation of α,β-unsaturated ketones
2008
Intramolecular cyclization reactions of unsaturated amino Fischer chromium carbenes forming indoles and quinolines
2003
Oligosaccharide Mimetics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded Glycopeptide Libraries
1998 StandoutNobel
Nucleophilic Aromatic Substitution Reactions of Novel 5-(2-Methoxyphenyl)tetrazole Derivatives with Organolithium Reagents
1999
Trifluoroacetic acid: Uses and recent applications in organic synthesis
2013
Dynamic kinetic resolution
2003
Synthetic Aspects of the Di-π-methane Rearrangement
1996
Strong and Confined Acids Catalyze Asymmetric Intramolecular Hydroarylations of Unactivated Olefins with Indoles
2021 StandoutNobel
Synthesis of Pyridine and Dihydropyridine Derivatives by Regio- and Stereoselective Addition toN-Activated Pyridines
2012 Standout
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
A practical synthesis of 5-substituted tetrazoles
1995
An Efficient and Cost-Effective Synthesis of 2-Phenyl-3-aminopyridine
2001
Combinatorial Synthesis of Small Organic Molecules
1996
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Iodine-mediated electrophilic cyclization of 2-alkynylbenzaldoximes leading to the formation of iodoisoquinoline N-oxides
2008
Current methods for the synthesis of 2-substituted azoles
2004
Elucidating the mechanism of the photochemical Pauson–Khand reaction: matrix photochemistry of phenylacetylenehexacarbonyldicobalt
1998
The Current Status of Heterocyclic Combinatorial Libraries
1997
Advances in the Chemistry of Tetrahydroquinolines
2011 Standout
Homogeneous Catalysis in Supercritical Fluids
1999 StandoutNobel
Annulation reactions of chromium carbene complexes: scope, selectivity and recent developments
1999
Ground- and Excited-State Reactions of Norbornene and Isomers: A CASSCF Study and Comparison with Femtosecond Experiments
1999 StandoutNobel
Selected Patented Cross-Coupling Reaction Technologies
2006 Standout
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Asymmetric Pauson–Khand reaction with chiral, electron-deficient mono- and bis-phosphine ligands
2004
The chemistry of the carbon-transition metal double and triple bond: annual survey covering the year 1997
1999
Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
2014 Standout
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox
2003 StandoutNobel
2(S)-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3(S)-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine (1): A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist
1996
About Dendrimers: Structure, Physical Properties, and Applications
1999 Standout
Microwave-Assisted Synthesis in Water as Solvent
2007 Standout
Titan(IV )‐katalysierte dynamisch‐kinetische asymmetrische Umwandlung von Alkoholen, Silylethern und Acetalen unter Kohlenstoff‐Allylierung
2004
Aerobic Copper-Catalyzed Organic Reactions
2013 Standout
Theoretical Studies of Some Transition-Metal-Mediated Reactions of Industrial and Synthetic Importance
2000
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Recent advances in siloxane-based aryl–aryl coupling reactions: focus on heteroaromatic systems
2005
Development of intermolecular additive free Pauson–Khand reactions for estrone E-ring extension using microwaves
2008
Hetarynes
1982
Recent Advances in the Pauson–Khand Reaction and Related [2+2+1] Cycloadditions
2000
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
High Oxidation State Multiple Metal−Carbon Bonds
2001 StandoutNobel
The Cinchona Primary Amine-Catalyzed Asymmetric Epoxidation and Hydroperoxidation of α,β-Unsaturated Carbonyl Compounds with Hydrogen Peroxide
2013 StandoutNobel
Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals
2011 Standout
Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction
1998
Efficient, simple procedures for the large‐scale preparation of building blocks for angiotensin (II) receptor antagonists
1995
Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives
2011 Standout
Synthesis of Novel Quinone Boronic Ester Derivatives via a Highly Regioselective Cr-Mediated Benzannulation Reaction and Their Application in Pd-Catalyzed Coupling Processes
2001
IDPi Catalysis
2019 StandoutNobel
Update on the Development of Antagonists of Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTH2). From Lead Optimization to Clinical Proof-of-Concept in Asthma and Allergic Rhinitis
2012
Thioamides as Useful Synthons in the Synthesis of Heterocycles
2002 Standout
Lewis Acid Complexation of Tertiary Amines and Related Compounds: A Strategy for α-Deprotonation and Stereocontrol
1997
Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions
2017 StandoutNobel
Fluorine in medicinal chemistry: A review of anti-cancer agents
2006
Transition-Metal-Catalyzed Addition of Heteroatom−Hydrogen Bonds to Alkynes
2004 Standout
Solution-phase synthesis of a combinatorial monocyclic β-lactam library: Potential protease inhibitors
1997
Transition metal alkyne complexes: the Pauson–Khand reaction
1999
Discovery and Biological Characterization of (2R,4S)-1′-Acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4′-bipiperidine-1-carboxamide as a New Potent and Selective Neurokinin 1 (NK1) Receptor Antagonist Clinical Candidate
2011
1,2-Amino Alcohols and Their Heterocyclic Derivatives as Chiral Auxiliaries in Asymmetric Synthesis
1996
Dynamic kinetic resolution
1995
Asymmetric Cyclopentannulation of Cyclic Enones with a Chiral 1,3‐Dipole Equivalent
1997
Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation
2009 Standout
Strong and Confined Acids Enable a Catalytic Asymmetric Nazarov Cyclization of Simple Divinyl Ketones
2019 StandoutNobel
Synthesis of Chiral Cyclopentenones
2016
Some Typical Advances in the Synthetic Applications of Allenes
2005 Standout
Kilogram Synthesis of a Selective Serotonin Reuptake Inhibitor
2008
Palladium-Catalyzed Reaction of o-Ethynylphenols, o-((Trimethylsilyl)ethynyl)phenyl Acetates, and o-Alkynylphenols with Unsaturated Triflates or Halides: A Route to 2-Substituted-, 2,3-Disubstituted-, and 2-Substituted-3-acylbenzo[b]furans
1996
SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase
1999 StandoutNobel
Isolation and Synthesis of Biologically Active Carbazole Alkaloids
2002 Standout
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist
1998
Applied Hydroformylation
2012 Standout
Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
2002 Standout
Works of David Middlemiss being referenced
Bromobenzofuran-Based Non-peptide Antagonists of Angiotensin II: GR138950, a Potent Antihypertensive Agent with High Oral Bioavailability
1994
Serotonergic targets in depression
2002
Cardiovascular effects of GR117289, a novel angiotensin AT1 receptor antagonist
1994
Discovery of an Orally Bioavailable NK1 Receptor Antagonist, (2S,3S)-(2-Methoxy-5-tetrazol-1-ylbenzyl)(2-phenylpiperidin-3-yl)amine (GR203040), with Potent Antiemetic Activity
1995
Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound
1996
Chiral recognition in the reaction of the enolate derived from [(η5-C5H5)Fe(CO)(PPh3)COCH2OCH2Ph] with 1-phenylethyl bromide
1990
Mild and efficient preparation of alkynepentacarbonyldicobalt complexes containing the chiral (R) -(+) -Glyphos ligand
1996
Enantiospecific synthesis of (+)-(R)-6,7-dimethoxy-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline from (+)-(S)-2-methylamino-1-phenylethanol (halostachine)
1989
Facile Synthesis of Functionalised β-Lactones; Novel Cyclisations of Chromium Carbene Complexes with Propargylic Alcohols
1996
Spiro-piperidine non-peptide neurokinin-1 receptor antagonists
1995
Promotion of the chromium carbene dötz annulation reaction under dry state adsorption conditions
1993
Total synthesis of parvaquone and the serendipitous discovery of a novel chromium-mediated method for β-lactone formation
1997
Absolute configuration of the optical isomers of salbutamol
1971
Highly Efficient Enantioselective Pauson-Khand Reactions
1995
Indole-3-acetic Acid Antagonists of the Prostaglandin D2 Receptor CRTH2
2005
A convenient procedure for the solution phase preparation of 2-aminothiazole combinatorial libraries
1996
Enantioselective Pauson-Khand Reactions Mediated by a Chiral Amine N-Oxide
1995
Tetrahydroisoquinolines. Part 3. Stereoselective synthesis of cis- and trans-1,4-disubstituted N-methyl-1,2,3,4-tetrahydroisoquinolines as their tricarbonylchromium complexes
1987
Promotion of the chromium carbene Dötz annulation reaction under sonochemical and dry state adsorption conditions
1993
1-Phenyl-2,3-diazacycl[3,2,2]azine, a new 10-π electron system. Involvement of 3,5-didehydroimidazo[1,5-a]pyridine?
1980
Chromium-mediated β-lactone synthesis using ultrasonication
1999
Photochemistry of ethenobenzocycloheptenones
1982
A medicinal chemistry case study: An account of an angiotensin II antagonist drug discovery programme
1994