Standout Papers
Citation Impact
Citing Papers
Molecular Architecture of a Eukaryotic Translational Initiation Complex
2013 ScienceNobel
Active Site Tightness and Substrate Fit in DNA Replication
2002
Formation of the First Peptide Bond: The Structure of EF-P Bound to the 70 S Ribosome
2009 StandoutScienceNobel
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
Structure of the large ribosomal subunit from human mitochondria
2014 ScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
Protein stability promotes evolvability
2006 StandoutNobel
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
2009 StandoutNobel
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
A structural view on the mechanism of the ribosome-catalyzed peptide bond formation
2009 StandoutNobel
The Structure and Function of the Eukaryotic Ribosome
2012
Synthesis and Properties of Aminopropyl Nucleic Acids
2005
EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics
2014 StandoutNobel
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Hibernating Bears, Antibiotics, and the Evolving Ribosome (Nobel Lecture)
2010 Nobel
Atomic structures of the eukaryotic ribosome
2012
Rethinking amide bond synthesis
2011 StandoutNature
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Novel mutations in Moloney Murine Leukemia Virus reverse transcriptase increase thermostability through tighter binding to template-primer
2008
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
Structural aspects of translation termination on the ribosome
2011
Evolving strategies for enzyme engineering
2005 StandoutNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Advances in laboratory evolution of enzymes
2008
The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
2010
Structure and Dynamics of the Mammalian Ribosomal Pretranslocation Complex
2011
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Unraveling the Structure of the Ribosome (Nobel Lecture)
2010 Nobel
Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency
2016
Directed evolution of enzymes: Library screening strategies
2009
Single-Molecule Fluorescence Measurements of Ribosomal Translocation Dynamics
2011
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Stoichiometry of MutS and MutL at unrepaired mismatches in vivo suggests a mechanism of repair
2012
High fidelity TNA synthesis by Therminator polymerase
2005
Selection of tRNA by the Ribosome Requires a Transition from an Open to a Closed Form
2002 StandoutNobel
Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination
2012
Synthetically modified DNAs as substrates for polymerases
2000
Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu
2009 StandoutNobel
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide
2010
Rates of evolutionary change in viruses: patterns and determinants
2008
High-throughput screens and selections of enzyme-encoding genes
2005
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å Resolution
2014
Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA
2005
Termination and post-termination events in eukaryotic translation
2012
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
Simple yet functional phosphate-loop proteins
2018 StandoutNobel
Computational Design of an α-Gliadin Peptidase
2012 StandoutNobel
Kinetic Analysis of an Efficient DNA-Dependent TNA Polymerase
2005 StandoutNobel
Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
2009 StandoutScienceNobel
The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other functionals
2007 Standout
Structural characterization of mRNA-tRNA translocation intermediates
2012 StandoutNobel
Converting structural information into an allosteric-energy-based picture for elongation factor Tu activation by the ribosome
2011 StandoutNobel
Complexation of Polyoxometalates with Cyclodextrins
2015 StandoutNobel
Integrity of the P-site is probed during maturation of the 60S ribosomal subunit
2012 StandoutNobel
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Structural basis for mRNA surveillance by archaeal Pelota and GTP-bound EF1α complex
2010
N2′→P3′ Phosphoramidate Glycerol Nucleic Acid as a Potential Alternative Genetic System
2009 StandoutNobel
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
2021 StandoutNobel
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Electrostatic origin of the mechanochemical rotary mechanism and the catalytic dwell of F1-ATPase
2011 StandoutNobel
How Should We Think About the Ribosome?
2012
Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA
1999
Supramolecular systems chemistry
2015
Trajectories of the ribosome as a Brownian nanomachine
2014 StandoutNobel
Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3
2011 Nobel
Computer simulations of protein functions: Searching for the molecular origin of the replication fidelity of DNA polymerases
2005 StandoutNobel
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State
2009 StandoutScienceNobel
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Factors Contributing to Aromatic Stacking in Water: Evaluation in the Context of DNA
2000
Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template
2007 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex
2012 StandoutNobel
Thioamides as Useful Synthons in the Synthesis of Heterocycles
2002 Standout
Cryoelectron microscopy structures of the ribosome complex in intermediate states during tRNA translocation
2011 StandoutNobel
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome
2010
Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside−5′-Phosphorimidazolide Monomers
2009 StandoutNobel
Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit
2016 StandoutNobel
Structure, Energetics, and Dynamics of the Nucleic Acid Base Pairs: NonempiricalAb InitioCalculations
1999
Simulating the pulling of stalled elongated peptide from the ribosome by the translocon
2013 StandoutNobel
Transient Tertiary Structure Formation within the Ribosome Exit Port
2010
Pyrrolo-dC and pyrrolo-C: fluorescent analogs of cytidine and 2′-deoxycytidine for the study of oligonucleotides
2004
Nucleophilic Reactivities of Hydrazines and Amines: The Futile Search for the α-Effect in Hydrazine Reactivities
2012
Works of David Loakes being referenced
Darwinian chemistry: towards the synthesis of a simple cell
2009
Molecular breeding of polymerases for amplification of ancient DNA
2007 StandoutNobel
Stability and structure of DNA oligonucleotides containing non-specific base analogues
1997
Roles of the polymerase and BRCT domains of Rev1 protein in translesion DNA synthesis in yeast in vivo
2005
Directed Evolution of DNA Polymerase, RNA Polymerase and Reverse Transcriptase Activity in a Single Polypeptide
2006
3-Nitropyrrole and 5-nitroindole as universal bases in primers for DNA sequencing and PCR
1995
A thymine-like base analogue forms wobble pairs with adenine in a Z-DNA duplex
1998
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome
2009 StandoutNobel
5-Nitroindole as an universal base analogue
1994
Anti-malarial activity of N6-modified purine analogues
2007
SURVEY AND SUMMARY: The applications of universal DNA base analogues
2001
Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)
2010
The role of deoxycytidyl transferase activity of yeast Rev1 protein in the bypass of abasic sites
2002
Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution
2004
Synthesis of reactive γ-lactams related to penicillins and cephalosporins 1
1999
Synthesis and Polymerase Incorporation Properties of a Tricyclic Pyrrolopyrimidine Related to N6-Hydroxy-2′-deoxyadenosine
1999
Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release
2010 Nobel
Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue
2007
An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside
1995
Saturation of DNA Mismatch Repair and Error Catastrophe by a Base Analogue in Escherichia coli
2002
Synthesis and Some Biochemical Properties of a Novel 5,6,7,8‐Tetrahydropyrimido[4,5‐c]pyridazine Nucleoside
2003
Synthesis and enzymatic incorporation of a novel, bicyclic pyrimidine nucleoside: a thymidine mimic
2003