Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
2014
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
2014
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
An Activating Mutation of AKT2 and Human Hypoglycemia
2011 Science
Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis
2013
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
2013
Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
2013
Nutrient sensing and TOR signaling in yeast and mammals
2017
Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells
2013
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
FYCO1 Contains a C-terminally Extended, LC3A/B-preferring LC3-interacting Region (LIR) Motif Required for Efficient Maturation of Autophagosomes during Basal Autophagy
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
The hVps34‐ SGK 3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC 1 and tumour growth
2016
Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin
2008
Physiological functions of the HECT family of ubiquitin ligases
2009
Mechanisms and function of substrate recruitment by F-box proteins
2013
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
2015
PI3K signaling in cancer: beyond AKT
2017
Autophagy in infection, inflammation and immunity
2013 Standout
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
2011 Nature
The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings
2012
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
2009
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
2011
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Mechanism and medical implications of mammalian autophagy
2018 Standout
Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism
2013
Deubiquitinases in the regulation of NF-κB signaling
2010
Rethinking amide bond synthesis
2011 StandoutNature
The LC3 interactome at a glance
2013
Specificity and Affinity of Natural Product Cyclopentapeptide Inhibitors against A. fumigatus, Human, and Bacterial Chitinases
2005
SNIPERs—Hijacking IAP activity to induce protein degradation
2019
Ubiquitin is phosphorylated by PINK1 to activate parkin
2014 Nature
Molecular and cellular regulation of human glucokinase
2019
Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase
2010
Death by TNF: a road to inflammation
2022
A Ubiquitin Replacement Strategy in Human Cells Reveals Distinct Mechanisms of IKK Activation by TNFα and IL-1β
2009
Intrinsic disorder in scaffold proteins: Getting more from less
2008
TNFR1‐induced activation of the classical NF‐κB pathway
2011
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Select E2 enzymes differentially regulate parkin activation and mitophagy
2014
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
2014
Autophagy in Antimicrobial Immunity
2014
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
2010
Parkin and mitochondrial quality control: toward assembling the puzzle
2014
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells
2009
UPRmt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans
2021
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
2008
Crystal structure of inhibitor of κB kinase β
2011 Nature
The TSC-mTOR pathway regulates macrophage polarization
2013
CD137 (4-1BB) Signalosome: Complexity Is a Matter of TRAFs
2018
Ubiquitin-dependent Regulation of Phospho-AKT Dynamics by the Ubiquitin E3 Ligase, NEDD4-1, in the Insulin-like Growth Factor-1 Response
2012
The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO
2013
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Roles of Autophagy in Elimination of Intracellular Bacterial Pathogens
2013
Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction
2011
The cullin protein family
2011
Covalent protein modification: the current landscape of residue-specific electrophiles
2014
Defining the geometry of the two-component proteasome degron
2011
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
The pyrrolysine translational machinery as a genetic-code expansion tool
2011
Direct activation of protein kinases by unanchored polyubiquitin chains
2009 Nature
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Protein Kinase B Controls Transcriptional Programs that Direct Cytotoxic T Cell Fate but Is Dispensable for T Cell Metabolism
2011
Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo
2007
Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering
2014
Hypomorphic Mutation of PDK1 Suppresses Tumorigenesis in PTEN+/− Mice
2005
Complete subunit architecture of the proteasome regulatory particle
2012 Nature
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
IKK Regulation and Human Genetics
2010
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling
2006
Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense
2017
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization
2016
Linear ubiquitination prevents inflammation and regulates immune signalling
2011 Nature
Cleaning up in the endoplasmic reticulum: ubiquitin in charge
2014
LKB1; linking cell structure and tumor suppression
2008
Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not
2011
Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
2009
Regulation of Endocytic Sorting by ESCRT–DUB-Mediated Deubiquitination
2011
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
2013 Nature
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Metabolism, migration and memory in cytotoxic T cells
2011
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
2011 Nature
UBE2N, UBE2L3 and UBE2D2/3 ubiquitin-conjugating enzymes are essential for parkin-dependent mitophagy
2014
Regulation of proteasome assembly and activity in health and disease
2018
Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome
2011
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis
2014
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
2004
Chemical Methods for Encoding and Decoding of Posttranslational Modifications
2016
Expanding TRAF function: TRAF3 as a tri-faced immune regulator
2011
AKT/PKB Signaling: Navigating the Network
2017 Standout
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
Ubiquitylation in innate and adaptive immunity
2009 Nature
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Cell regulation: determined to signal discrete cooperation
2009
Deubiquitinases as a Signaling Target of Oxidative Stress
2012
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
2016
Emerging roles of pseudokinases
2006
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Fluorescence-Based Sensors to Monitor Localization and Functions of Linear and K63-Linked Ubiquitin Chains in Cells
2012
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling
2012
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila
2012 StandoutNobel
Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation
2017
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
2016
TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures
2014
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
The application of targeted mass spectrometry‐based strategies to the detection and localization of post‐translational modifications
2014
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase
2014
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
2013
Organellophagy: Eliminating cellular building blocks via selective autophagy
2014
Selective autophagy
2013
Signalling through Class I PI3Ks in mammalian cells
2006
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins
2014
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
2011 Science
Molecular Mechanism of an Oncogenic Mutation That Alters Membrane Targeting: Glu17Lys Modifies the PIP Lipid Specificity of the AKT1 PH Domain
2008
Developments in the Field of Bioorthogonal Bond Forming Reactions—Past and Present Trends
2014
Chitin metabolism in insects: structure, function and regulation of chitin synthases and chitinases
2003 Standout
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
Cell Signaling in Space and Time: Where Proteins Come Together and When They’re Apart
2009 Science
mir-276a strengthens Drosophila circadian rhythms by regulating timeless expression
2016 StandoutNobel
Rational design of a split-Cas9 enzyme complex
2015 StandoutNobel
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Current Developments in Activity-Based Protein Profiling
2014
Building and remodelling Cullin–RING E3 ubiquitin ligases
2013
Ubiquitin and Parkinson's disease through the looking glass of genetics
2017
Phosphorylated ubiquitin chain is the genuine Parkin receptor
2015
Regulation and function of the RSK family of protein kinases
2011
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Chemically tunable mucin chimeras assembled on living cells
2015 StandoutNobel
Novel TCR-Mediated Mechanisms of Notch Activation and Signaling
2017
Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2
2009
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension
2012
Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation
2016
O2 Regulates Skeletal Muscle Progenitor Differentiation through Phosphatidylinositol 3-Kinase/AKT Signaling
2011
Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65
2014
A kinase-independent function of AKT promotes cancer cell survival
2014
Repositioning of an existing drug for the neglected tropical disease Onchocerciasis
2010
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
2010
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
2009
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Activity-Based Profiling of Proteases
2014
Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity
2014
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
2009
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: Mimicry of carbohydrate substrate
2002 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
2015
Works of David Komander being referenced
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
2013
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
2014
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
2016
Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2
2018
Recognition of Polyubiquitin Isoforms by the Multiple Ubiquitin Binding Modules of Isopeptidase T
2008
OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin
2013
Molecular Basis and Regulation of OTULIN-LUBAC Interaction
2014
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne
2010
Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates
2004
Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages
2012
Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling
2020
LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy
2012
Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase
2010
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network
2009
PDK1, the master regulator of AGC kinase signal transduction
2004
Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase
2014
Regulation of A20 and other OTU deubiquitinases by reversible oxidation
2013
OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis
2013
Mechanism, Specificity and Structure of the Deubiquitinases
2010
OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling
2013
Breaking the chains: structure and function of the deubiquitinases
2009 Standout
The nuts and bolts of AGC protein kinases
2009
The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module
2008
Lining the pockets of kinases and phosphatases
2006
Psammaplin A, a chitinase inhibitor isolated from the fijian marine sponge Aplysinella rhax
2002
Assembly, analysis and architecture of atypical ubiquitin chains
2013
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain
2009
LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB
2017
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
2009
Mechanism of phospho-ubiquitin-induced PARKIN activation
2015 Nature
Structure of the human Parkin ligase domain in an autoinhibited state
2013
Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation
2009
Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains
2009
Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance
2008
Analysis of the LKB1-STRAD-MO25 complex
2004
Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease
2016
Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition
2003
The emerging complexity of protein ubiquitination
2009
OTULIN deficiency in ORAS causes cell type‐specific LUBAC degradation, dysregulated TNF signalling and cell death
2019
On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases
2013
BIMEL, an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation
2011
The Ubiquitin Code
2012 Standout
Structural insights into the catalytic mechanism of a family 18 exo-chitinase
2001
Structure of the A20 OTU domain and mechanistic insights into deubiquitination
2007