Standout Papers

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells 2006 2026 2012 2019 3.6k
  1. Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells (2013)
    Ophir Shalem, Neville E. Sanjana et al. Science
  2. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 (2016)
    John G. Doench, Nicolò Fusi et al. Nature Biotechnology
  3. lincRNAs act in the circuitry controlling pluripotency and differentiation (2011)
    Mitchell Guttman, Julie Donaghey et al. Nature
  4. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen (2006)
    Jason Moffat, Dorre A. Grueneberg et al. Cell
  5. Rational design of highly active sgRNAs for CRISPR-Cas9–mediated gene inactivation (2014)
    John G. Doench, Ella Hartenian et al. Nature Biotechnology
  6. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target (2017)
    Robert T. Manguso, Hans W. Pope et al. Nature
  7. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen (2008)
    Benjamin L. Ebert, Jennifer Pretz et al. Nature
  8. KRAS and YAP1 Converge to Regulate EMT and Tumor Survival (2014)
    Diane D. Shao, Wen Xue et al. Cell
  9. ( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible (2013)
    Ryan Looper, Peppi Koivunen et al. Science
  10. Optimized libraries for CRISPR-Cas9 genetic screens with multiple modalities (2018)
    Kendall R Sanson, Ruth E. Hanna et al. Nature Communications
  11. Chronos: a cell population dynamics model of CRISPR experiments that improves inference of gene fitness effects (2021)
    Joshua M. Dempster, Isabella Boyle et al. Genome biology

Immediate Impact

8 by Nobel laureates 43 from Science/Nature 68 standout
Sub-graph 1 of 21

Citing Papers

Gasdermin E suppresses tumour growth by activating anti-tumour immunity
2020 StandoutNature
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
10 intermediate papers

Works of David E. Root being referenced

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
and 2 more

Author Peers

Author Last Decade Papers Cites
David E. Root 16604 911 4071 3562 170 22.8k
Olivier Elemento 16030 882 4103 6290 429 24.8k
Anja‐Katrin Bosserhoff 9594 1049 3532 3487 431 17.0k
Jos Jonkers 13413 325 10011 4045 235 20.9k
Thomas M. Roberts 19460 221 7514 2544 305 28.5k
John D. Pfeifer 12610 239 2186 1680 175 20.5k
Akhilesh Pandey 20546 193 3149 3542 485 31.0k
Steven A. Carr 31123 619 5287 3920 365 43.3k
Nir Hacohen 16330 248 4384 6668 172 24.9k
David C. Ward 16434 262 2784 2479 292 25.8k
Alexey I. Nesvizhskii 19479 206 1657 2319 223 25.9k

All Works

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Rankless by CCL
2026