Standout Papers
- A Gene Cluster for Biosynthesis of the Sesquiterpenoid Antibiotic Pentalenolactone inStreptomyces avermitilis (2006)
- Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis (2006)
- Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlH, A Non-Heme Iron Dioxygenase of Streptomyces avermitilis (2006)
- Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism (2010)
- Synthesis of racemic .alpha.-trans- and .beta.-trans-bergamotene (1971)
- Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis (2007)
- Controlled hydroxymethylation of ketones (1971)
- Synthesis of olefins from .beta.-hydroxy phosphonamides. Stereochemistry and extension to the formation of conjugated dienes (1969)
- EngineeredStreptomyces avermitilisHost for Heterologous Expression of Biosynthetic Gene Cluster for Secondary Metabolites (2013)
- Terpene synthases are widely distributed in bacteria (2014)
- Pentalenolactone biosynthesis: Molecular cloning and assignment of biochemical function to PtlF, a short-chain dehydrogenase from Streptomyces avermitilis, and identification of a new biosynthetic intermediate (2006)
- Extension of carbon chains by .gamma.-alkylation of metalated .alpha.,.beta.-ynamines (1970)
Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
2012 StandoutScienceNobel
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
An Engineered Microbial Platform for Direct Biofuel Production from Brown Macroalgae
2012 StandoutScienceNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Genome sequence of an industrial microorganism Streptomyces avermitilis : Deducing the ability of producing secondary metabolites
2001 StandoutNobel
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol
2008 StandoutNobel
Stereochemical Uniformity in Marine Polyether Ladders—Implications for the Biosynthesis and Structure of Maitotoxin
2006
The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition
2016
Crystal Structure of Cytochrome P450 (CYP105P2) from Streptomyces peucetius and Its Conformational Changes in Response to Substrate Binding
2016
Microbial engineering for the production of advanced biofuels
2012 Nature
Crystal Structure of Human Squalene Synthase
2000
Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector
1992
Conserved Amino Acid Residues Correlating With Ketoreductase Stereospecificity in Modular Polyketide Synthases
2003
Cation–π interactions in ligand recognition and catalysis
2002
A Tylosin Ketoreductase Reveals How Chirality Is Determined in Polyketides
2007
Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity
2004
De Novo Prediction of Three-dimensional Structures for Major Protein Families
2002 StandoutNobel
The development of mechanistic enzymology in the 20th century
2001
Combinatorial Biosynthesis of Non-bacterial and Unnatural Flavonoids, Stilbenoids and Curcuminoids by Microorganisms
2008
Structural basis for macrolactonization by the pikromycin thioesterase
2006
Biosynthesis of polyketide synthase extender units
2008
Crystal structure of the surfactin synthetase-activating enzyme Sfp: a prototype of the 4'-phosphopantetheinyl transferase superfamily
1999
Intramolecular cyclizations of polyketide biosynthesis: mining for a “Diels–Alderase”?
2008
The chalcone synthase superfamily of type III polyketide synthases
2002
Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus
2009
Aristolochene Synthase‐Catalyzed Cyclization of 2‐Fluorofarnesyl‐Diphosphate to 2‐Fluorogermacrene A
2007
Novel Intermolecular Iterative Mechanism for Biosynthesis of Mycoketide Catalyzed by a Bimodular Polyketide Synthase
2008
Enhancement and Selective Production of Phoslactomycin B, a Protein Phosphatase IIa Inhibitor, through Identification and Engineering of the Corresponding Biosynthetic Gene Cluster
2003
A chain initiation factor common to both modular and aromatic polyketide synthases
1999 Nature
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Mining and engineering natural-product biosynthetic pathways
2007
Identification of a cyclohexylcarbonyl CoA biosynthetic gene cluster and application in the production of doramectin
2000
Conformational analysis of (+)-germacrene A by variable-temperature NMR and NOE spectroscopy
2007
Complex organization of the Streptomyces avermitilis genes encoding the avermectin polyketide synthase
1992
Sesquiterpene synthases: Passive catalysts or active players?
2011
High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase
2013 StandoutNobel
Type I polyketide biosynthesis in bacteria (Part A — erythromycin biosynthesis) (1994 to 2000)
2001
Directed Mutagenesis Alters the Stereochemistry of Catalysis by Isolated Ketoreductase Domains from the Erythromycin Polyketide Synthase
2006
CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
2012 Standout
Designed divergent evolution of enzyme function
2006 Nature
Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism
1998
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase
2003
Combinatorial biosynthesis of reduced polyketides
2005
Tailoring new enzyme functions by rational redesign
2000
6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase
2009
A New Substrate Specificity for Acyl Transferase Domains of the Ascomycin Polyketide Synthase in Streptomyces hygroscopicus
2002
High-Throughput Mutagenesis to Evaluate Models of Stereochemical Control in Ketoreductase Domains from the Erythromycin Polyketide Synthase
2006
POLYKETIDE SYNTHESIS: Prospects for Hybrid Antibiotics
1993
Biocatalysts for the formation of three- to six-membered carbo- and heterocycles
2015
Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
2003
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Enzymatic total synthesis of enterocin polyketides
2007
Biosynthetic origin of the carbon skeleton and oxygen atoms of the LL-F28249.ALPHA., apoent antiparasitic macrolide.
1989
Asymmetric spiroacetalization catalysed by confined Brønsted acids
2012 StandoutNatureNobel
Interception of the Enzymatic Conversion of Farnesyl Diphosphate to 5‐Epi‐Aristolochene by Using a Fluoro Substrate Analogue: 1‐Fluorogermacrene A from (2E,6Z)‐6‐Fluorofarnesyl Diphosphate
2007
Functional Analysis of the Aureothin Iterative Type I Polyketide Synthase
2005
Comments on Recent Achievements in Biomimetic Organic Synthesis
2003
Accumulation of an E , E , E ‐Triene by the Monensin‐Producing Polyketide Synthase when Oxidative Cyclization is Blocked
2005
Enzymology of acyl chain macrocyclization in natural product biosynthesis
2002
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
1999
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid–type III polyketide synthase
2006
Direct Amino Acid Catalyzed Asymmetric Synthesis of Polyketide Sugars
2004
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
2000
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids
2007
Unusual Cytochrome P450 Enzymes and Reactions
2013
Building-block selectivity of polyketide synthases
2003
Alternative modular polyketide synthase expression controls macrolactone structure
2000 Nature
Metabolic diversity in myxobacteria: identification of the myxalamid and the stigmatellin biosynthetic gene cluster of Stigmatella aurantiaca Sg a15 and a combined polyketide-(poly)peptide gene cluster from the epothilone producing strain Sorangium cellulosum So ce90
1999
The Biosynthesis of the Aromatic Myxobacterial Electron Transport Inhibitor Stigmatellin Is Directed by a Novel Type of Modular Polyketide Synthase
2002
Skipping in a Hybrid Polyketide Synthase
2002
Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic
2008
Asymmetric Organocatalytic Domino Reactions
2007 Standout
Terpenoid synthase structures: a so far incomplete view of complex catalysis
2012
Iterative strategies for the synthesis of deoxypropionates
2010 StandoutNobel
Opportunities and challenges for a sustainable energy future
2012 StandoutNatureNobel
The biosynthesis of C5–C25 terpenoid compounds
2002
Biomimetic synthesis of alkaloids (1980 to 1999)
2000
Analysis of Specific Mutants in the Lasalocid Gene Cluster: Evidence for Enzymatic Catalysis of a Disfavoured Polyether Ring Closure
2008
Characterization of the Azinomycin B Biosynthetic Gene Cluster Revealing a Different Iterative Type I Polyketide Synthase for Naphthoate Biosynthesis
2008
Polyketide Synthase Genes from Marine Dinoflagellates
2003
Synthesis, Biosynthesis, and Absolute Configuration of Vioxanthin
2007
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Control of Avermectin Biosynthesis in Streptomyces avermitilis for the Selective Production of a Useful Component.
1995 StandoutNobel
Molecular breeding of carotenoid biosynthetic pathways
2000 StandoutNobel
Computational design and selections for an engineered, thermostable terpene synthase
2011
The Toxic Dinoflagellate Karenia brevis Encodes Novel Type I-like Polyketide Synthases Containing Discrete Catalytic Domains
2008
Biosynthesis and attachment of novel bacterial polyketide synthase starter units
2001
Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase
2000
Prediction and Manipulation of the Stereochemistry of Enoylreduction in Modular Polyketide Synthases
2008
Polyketide biosynthesis: a millennium review
2001 Standout
Biosynthesis of Natural Products on Modular Peptide Synthetases
2001
Cascade Reactions in Total Synthesis
2006 Standout
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli
2006
Interrogating the Molecular Basis for Multiple Macrolactone Ring Formation by the Pikromycin Polyketide Synthase
2007
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization
2003
A Gene Cluster from a Marine Streptomyces Encoding the Biosynthesis of the Aromatic Spiroketal Polyketide Griseorhodin A
2002
Biosynthesis of the Antibiotic Bacillaene, the Product of a Giant Polyketide Synthase Complex of the trans‐AT Family
2007
Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis
2007
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
2000
Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate
2007
Production of the Tubulin Destabilizer Disorazol in Sorangium cellulosum: Biosynthetic Machinery and Regulatory Genes
2005
Natural sesquiterpenoids
2010
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.
1999
Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15
2001
An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea
1990 Nature
Sesquiterpene Synthases from Grand Fir (Abies grandis)
1998
Iteration as Programmed Event during Polyketide Assembly; Molecular Analysis of the Aureothin Biosynthesis Gene Cluster
2003
Chemoenzymatic preparation of germacrene analogues
2012
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork
2006
Proline-catalysed Mannich reactions of acetaldehyde
2008 StandoutNatureNobel
Evidence for the Role of the monB Genes in Polyether Ring Formation during Monensin Biosynthesis
2006
A Type I/Type III Polyketide Synthase Hybrid Biosynthetic Pathway for the Structurally Unique ansa Compound Kendomycin
2008
Mutasynthesis of Aureonitrile: An Aureothin Derivative with Significantly Improved Cytostatic Effect
2005
Engineering specificity of starter unit selection by the erythromycin‐producing polyketide synthase
2002
The Hidden Steps of Domain Skipping
2002
Engineering Cotton (+)-δ-Cadinene Synthase to an Altered Function: Germacrene D-4-ol Synthase
2006
New Lessons for Combinatorial Biosynthesis from Myxobacteria
1999
The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
2000
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
2008
Leinamycin Biosynthesis Revealing Unprecedented Architectural Complexity for a Hybrid Polyketide Synthase and Nonribosomal Peptide Synthetase
2004
The type I fatty acid and polyketide synthases: a tale of two megasynthases
2007
Biosynthesis of the Off‐Flavor 2‐Methylisoborneol by the Myxobacterium Nannocystis exedens
2007
The Crystal Structure of Yeast Fatty Acid Synthase, a Cellular Machine with Eight Active Sites Working Together
2007 StandoutNobel
Advances in cloning, functional analysis and heterologous expression of fungal polyketide synthase genes
2006
Novel avermectins produced by mutational biosynthesis.
1991
Insights into Polyether Biosynthesis from Analysis of the Nigericin Biosynthetic Gene Cluster in Streptomyces sp. DSM4137
2007
Chain initiation on the soraphen-producing modular polyketide synthase from Sorangium cellulosum
2001
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin
2006
LL-F28249 antibiotic complex: A new family of antiparastic macrocyclic lactones. Isolation, characterization and structures of LL-F28249 .ALPHA., .BETA., .GAMMA., .LAMBDA..
1988
The Biosynthetic Logic of Polyketide Diversity
2009 Standout
Chemistry and Biology of Biosynthetic Diels–Alder Reactions
2003
Albaflavenone, a sesquiterpene ketone with a zizaene skeleton produced by a streptomycete with a new rope morphology.
1994
Evolution of protein function by Domain swapping
2001
Total synthesis and study of 6-deoxyerythronolide B by late-stage C–H oxidation
2009
Unearthing the roots of the terpenome
2008
Evolution of the C 30 Carotenoid Synthase CrtM for Function in a C 40 Pathway
2002 StandoutNobel
Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system
2000
Further studies on the biosynthesis of the avermectins
1989
Synthesis, Biosynthesis, and Absolute Configuration of Vioxanthin
2007
Proline-Catalyzed One-Step Asymmetric Synthesis of 5-Hydroxy-(2E)-hexenal from Acetaldehyde
2001
Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans
2001
Retro-Diels−Alder Femtosecond Reaction Dynamics
1996 StandoutNobel
Identifying functional domains within terpene cyclases using a domain-swapping strategy.
1996
Genetic Contributions to Understanding Polyketide Synthases
1997
Assembly-Line Enzymology for Polyketide and Nonribosomal Peptide Antibiotics: Logic, Machinery, and Mechanisms
2006
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis
2003
cis-Δ2,3-Double Bond of Phoslactomycins Is Generated by a Post-PKS Tailoring Enzyme
2008
A Highly Abbreviated Synthesis of Pentalenene by Means of the Squarate Ester Cascade
2002
Stereocontrolled synthesis of 2,5-linked bistetrahydrofurans via the triepoxide cascade reaction
1986
Cloning and Heterologous Expression of the Macrotetrolide Biosynthetic Gene Cluster Revealed a Novel Polyketide Synthase that Lacks an Acyl Carrier Protein
2001
Übergangsmetallkatalysierte Reaktionen von α‐Diazocarbonylverbindungen – Einfluß der Liganden auf die Chemoselektivität
1994
Evolution of polyketide synthases in bacteria
2008
Organization of the biosynthetic gene cluster for the macrolide concanamycin A in Streptomyces neyagawaensis ATCC 27449
2005
Synthesis of Polyquinane Natural Products: An Update
1997
Biosynthesis of the Antibiotic Bacillaene, the Product of a Giant Polyketide Synthase Complex of the trans‐AT Family
2007
Formal Synthesis of 6-Deoxyerythronolide B
2006
Total synthesis of erythromycin B
2007
Elucidating the Substrate Specificity and Condensation Domain Activity of FkbP, the FK520 Pipecolate-Incorporating Enzyme
2005
Characterization of Hydrogen Bonding in a Continuum Solvent Model
2000
Modular Polyketide Synthases and cis Double Bond Formation: Establishment of Activated cis-3-Cyclohexylpropenoic Acid as the Diketide Intermediate in Phoslactomycin Biosynthesis
2007
A Case Study in Biomimetic Total Synthesis: Polyolefin Carbocyclizations to Terpenes and Steroids
2005
Identification of Sesquiterpene Synthases fromNostoc punctiformePCC 73102 andNostocsp. Strain PCC 7120
2008
Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities
2016
Mutasynthese von Aureonitril, einem Aureothin‐Derivat mit signifikant verbesserter zytostatischer Aktivität
2005
Selective Perhydroxylation of Squalene: Taming the Arithmetic Demon
1993 StandoutScienceNobel
Natural Metabolic Diversity Encoded by the Enterocin Biosynthesis Gene Cluster
2000
Chemie und Biologie natürlicher Diels‐Alder‐Reaktionen
2003
Selective Formation of Six-Membered Cyclic Sulfones and Sulfonates by C−H Insertion
2006
Combinatorial Biosynthesis of Natural Products
2008
Diversifying Carotenoid Biosynthetic Pathways by Directed Evolution
2005 StandoutNobel
Probing Eudesmane Cation−π Interactions in Catalysis by Aristolochene Synthase with Non-canonical Amino Acids
2011
Harnessing the Biosynthetic Potential of Modular Polyketide Synthases
1997
Radical catalysis
2007 StandoutNatureNobel
Elucidation of the Kijanimicin Gene Cluster: Insights into the Biosynthesis of Spirotetronate Antibiotics and Nitrosugars
2007
Rhodium acetate catalyzes the addition of carbenoids α- to ether oxygens
1989
Biosynthesis of the avermectins by Streptomyces avermitilis. Incorporation of labeled precursors.
1986
Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement
1993
Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
2014 Standout
Biomimetische organische Synthesen: Anmerkungen zu jüngeren Ergebnissen
2003
The Effect of Acetylene Substituents on a PdII‐Catalyzed Cycloisomerization. Total Synthesis of (–)‐Sterepolide and Assignment of Absolute Stereochemistry
1989
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
2011
Accumulation of an E,E,E‐Triene by the Monensin‐Producing Polyketide Synthase when Oxidative Cyclization is Blocked
2005
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units
2006
Directed Evolution of Protein Catalysts
2018
Engineered Biosynthesis of Regioselectively Modified Aromatic Polyketides Using Bimodular Polyketide Synthases
2004
Organocatalysis In a Synthetic Receptor with an Inwardly Directed Carboxylic Acid
2008
Avermectin Biosynthesis
1997 StandoutNobel
Click Chemistry: Diverse Chemical Function from a Few Good Reactions
2001 StandoutNobel
Application of Conformation Design in Acyclic Stereoselection: Total Synthesis of Borrelidin as the Crystalline Benzene Solvate
2003
Functional Expression of Genes Involved in the Biosynthesis of the Novel Polyketide Chain Extension Unit, Methoxymalonyl-Acyl Carrier Protein, and Engineered Biosynthesis of 2-Desmethyl-2-Methoxy-6-Deoxyerythronolide B
2002
The Mechanism of the Slippage Approach to Rotaxanes. Origin of the “All-or-Nothing” Substituent Effect
1998 StandoutNobel
Catalytic Carbene Insertion into C−H Bonds
2009 Standout
Biosynthesis of the Enediyne Antitumor Antibiotic C-1027
2002 Science
Genetically Encoded Short Peptide Tags for Orthogonal Protein Labeling by Sfp and AcpS Phosphopantetheinyl Transferases
2007
Enantioselecitve intramolecular CH insertion of α-diazo [β-keto esters catalyzed by homochiral rhodium(II) carboxylates
1990
Enzyme Redesign
2001
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Modeling the Structural Basis of Human CCR5 Chemokine Receptor Function: From Homology Model Building and Molecular Dynamics Validation to Agonist and Antagonist Docking
2006
Direct Amino Acid Catalyzed Asymmetric Synthesis of Polyketide Sugars
2004
Genetic studies of avermectin biosynthesis in Streptomyces avermitilis
1987 StandoutNobel
A Multiproduct Terpene Synthase from Medicago truncatula Generates Cadalane Sesquiterpenes via Two Different Mechanisms
2010
Modification of post-PKS tailoring steps through combinatorial biosynthesis
2002
[C−H···O] Interactions as a Control Element in Supramolecular Complexes: Experimental and Theoretical Evaluation of Receptor Affinities for the Binding of Bipyridinium-Based Guests by Catenated Hosts1
1999 StandoutNobel
A multifunctional polyketide–peptide synthetase essential for albicidin biosynthesis in Xanthomonas albilineans The GenBank accession number for the sequence determined in this work is AF239749.
2001
Biosynthesis and Metabolism of Cyclopropane Rings in Natural Compounds
2003
Biosynthesis of tetronasin: Part 1 introduction and investigation of the diketide and triketide intermediates bound to the polyketide synthase
1994
Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases
2006
Examining the Role of Hydrogen Bonding Interactions in the Substrate Specificity for the Loading Step of Polyketide Synthase Thioesterase Domains
2008
Fast Boundary Element Method for the Linear Poisson−Boltzmann Equation
2002
A Model for the Enzyme−Substrate Complex of DNA Photolyase and Photodamaged DNA
1999
Genome Sequence of the Streptomycin-Producing MicroorganismStreptomyces griseusIFO 13350
2008
Mechanistic Analysis of a Type II Polyketide Synthase. Role of Conserved Residues in the β-Ketoacyl Synthase−Chain Length Factor Heterodimer
2000
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase
2006
A Model of Structure and Catalysis for Ketoreductase Domains in Modular Polyketide Synthases
2002
Iterative Chain Elongation by a Pikromycin Monomodular Polyketide Synthase
2003
Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility
2004 Science
Stereospecific Acyl Transfers on the Erythromycin-Producing Polyketide Synthase
1994 Science
Synthesis of Methoxynor Polyisoprenoid Alcohols by Alkylation of (3-Methoxyallyl)lithium Reagents
2002
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Modular Organization of Genes Required for Complex Polyketide Biosynthesis
1991 Science
Eubacterial Diterpene Cyclase Genes Essential for Production of the Isoprenoid Antibiotic Terpentecin
2001
Biosynthesis of tetronasin: Part 2 identification of the tetraketide intermediate attached to the polyketide synthase
1994
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae
2008
C-O Bond Formation by Polyketide Synthases
2002 Science
Direct catalytic asymmetric cross-aldol reactions in ionic liquid media
2004
Sequential Transformations in Organic Chemistry: A Synthetic Strategy with a Future
1993
Quantum Mechanical Continuum Solvation Models
2005 Standout
Cloning, Sequencing, and Functional Analysis of an Iterative Type I Polyketide Synthase Gene Cluster for Biosynthesis of the Antitumor Chlorinated Polyenone Neocarzilin in “ Streptomyces carzinostaticus ”
2004
Stereochemische Uniformität bei marinen Polyetherleitern: Folgerungen für Biosynthese und Struktur des Maitotoxins
2006
Dynamic Control of Chiral Space in a Catalytic Asymmetric Reaction Using a Molecular Motor
2011 StandoutScienceNobel
Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint ( Mentha x piperita , L.) that produces the aphid alarm pheromone ( E )-β-farnesene
1997
Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications
2001
Asymmetric Enamine Catalysis
2007 StandoutNobel
Abietadiene synthase catalysis: Mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement
2002
Pre-Steady-State Study of Recombinant Sesquiterpene Cyclases
1997
(+)-Germacrene A Biosynthesis
1998
Cyclic Carbopalladation. A Versatile Synthetic Methodology for the Construction of Cyclic Organic Compounds
1996 StandoutNobel
Proline-catalyzed asymmetric assembly reactions: enzyme-like assembly of carbohydrates and polyketides from three aldehyde substrates
2002
Manipulation of Modular Polyketide Synthases
1997
Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase
1997 Science
Trichodiene Synthase: Synthesis and Inhibition Kinetics of 12‐Fluoro‐farnesylphosphonophosphate for Sesquiterpene Cyclases
2006
Cloning and Functional Expression of cDNA Encoding Aphidicolan-16β-ol Synthase: A Key Enzyme Responsible for Formation of an Unusual Diterpene Skeleton in Biosynthesis of Aphidicolin
2001
Genetics of Zwittermicin A Production by Bacillus cereus
2004
Direct Organocatalytic Asymmetric Heterodomino Reactions: The Knoevenagel/Diels−Alder/Epimerization Sequence for the Highly Diastereoselective Synthesis of Symmetrical and Nonsymmetrical Synthons of Benzoannelated Centropolyquinanes
2004
Studies in biomimetic polyether synthesis: Construction of an ABCD-ring subunit of etheromycin using polyepoxide cascade cyclisations.
1993
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis
1999
Inverse electron demand Diels-Alder reactions of heterocyclic azadienes: formal total synthesis of streptonigrin
1985
Supramolecular Self-Assembly of Dendronized Polymers: Reversible Control of the Polymer Architectures through Acid−Base Reactions
2006 StandoutNobel
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Insertion reactions of electrophilic iron carbene complexes with organosilanes: a synthetic and mechanistic study
1995
Sequentielle Transformationen in der Organischen Chemie eine Synthesestrategie mit Zukunft
1993
Works of David E. Cane being referenced
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channel
2001
The 2.7-Å crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase
2006
Isoprenoids including carotenoids and steroids
1999
X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis
2008
Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor A3(2)
2008
Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme
2007
Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition—elimination reactions
1991
Amorpha-4,11-diene synthase: Mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate
2005
Studies of the cryptic allylic pyrophosphate isomerase activity of trichodiene synthase using the anomalous substrate 6,7-dihydrofarnesyl pyrophosphate
1990
Pentalenene Synthase. Purification, Molecular Cloning, Sequencing, and High-Level Expression in Escherichia coli of a Terpenoid Cyclase from Streptomyces UC5319
1994
Geosmin Biosynthesis in Streptomyces avermitilis. Molecular Cloning, Expression, and Mechanistic Study of the Germacradienol/Geosmin Synthase
2006
Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site
2009
Molecular recognition of diketide substrates by a β-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase
1997
Overproduction of Soluble Trichodiene Synthase from Fusarium sporotrichioides in Escherichia coli
1993
Chain Elongation, Macrolactonization, and Hydrolysis of Natural and Reduced Hexaketide Substrates by the Picromycin/Methymycin Polyketide Synthase
2005
Exploring biosynthetic diversity with trichodiene synthase
2007
Enhancing the Atom Economy of Polyketide Biosynthetic Processes through Metabolic Engineering
2001
Trichodiene synthase: Mechanism-based inhibition of a sesquiterpene cyclase
1999
Trichodiene Synthase. Identification of Active Site Residues by Site-Directed Mutagenesis
1995
Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis
2010
Crystallization and preliminary X‐ray diffraction analysis of recombinant pentalenene synthase
1995
Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
1995 Nature
Structural and mechanistic analysis of trichodiene synthase using site-directed mutagenesis: Probing the catalytic function of tyrosine-295 and the asparagine-225/serine-229/glutamate-233–Mg 2 + B
2007
Crystal Structure Determination of Aristolochene Synthase from the Blue Cheese Mold, Penicillium roqueforti*
2000
Identification of NanE as the Thioesterase for Polyether Chain Release in Nanchangmycin Biosynthesis
2006
Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis.
2001
Precursor-Directed Biosynthesis
2002
Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase
2001
Genome Mining in Streptomyces clavuligerus: Expression and Biochemical Characterization of Two New Cryptic Sesquiterpene Synthases
2011
Chapter 9 The Enzymology of Polyether Biosynthesis
2009
Erythromycin Biosynthesis. Highly Efficient Incorporation of Polyketide Chain Elongation Intermediates into 6-Deoxyerythronolide B in an Engineered Streptomyces Host.
1995
Aristolochene Synthase: Purification, Molecular Cloning, High-Level Expression in Escherichia coli, and Characterization of the Aspergillus terreus Cyclase
2000
The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
1999
High Level Expression ofRicinus communisCasbene Synthase inEscherichia coliand Characterization of the Recombinant Enzyme
1996
Irreversible Inactivation of Monoterpene Cyclases by a Mechanism-Based Inhibitor
1993
Structure-Based Dissociation of a Type I Polyketide Synthase Module
2007
Overexpression in Escherichia coli of Soluble Aristolochene Synthase from Penicillium roqueforti
1993
Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase
2005
Brushes with sage
2005
A functional chimeric modular polyketide synthase generated via domain replacement
1996
Improved precursor-directed biosynthesis in E. coli via directed evolution
2010
Pre-Steady-State Kinetic Analysis of the Trichodiene Synthase Reaction Pathway
1997
Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit
2001
Probing the interactions of an acyl carrier protein domain from the 6‐deoxyerythronolide B synthase
2011
Understanding Substrate Specificity of Polyketide Synthase Modules by Generating Hybrid Multimodular Synthases
2003
The X-ray crystal structure of pentalenolactone F methyl ester (epi-pentalenolactone F).
1988
Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase
1999
Trichodiene Synthase. Substrate Specificity and Inhibition
1995
Mechanism of Thioesterase-Catalyzed Chain Release in the Biosynthesis of the Polyether Antibiotic Nanchangmycin
2008
Spontaneous Priming of a Downstream Module in 6-Deoxyerythronolide B Synthase Leads to Polyketide Biosynthesis
1998
Biosynthesis of pentalenene and pentalenolactone
1990
Pentalenene Synthase. Histidine-309 Is Not Required for Catalytic Activity
1999
Harnessing the Biosynthetic Code: Combinations, Permutations, and Mutations
1998 Science
Pentalenene Synthase. Analysis of Active Site Residues by Site-Directed Mutagenesis
2002
Trichodiene Synthase. Probing the Role of the Highly Conserved Aspartate-Rich Region by Site-Directed Mutagenesis
1996
6-Deoxyerythronolide B Synthase 1 Is Specifically Acylated by a Diketide Intermediate at the β-Ketoacyl-Acyl Carrier Protein Synthase Domain of Module 2
1996
Gain-of-Function Mutagenesis of a Modular Polyketide Synthase
1997
Trichodiene synthase. Synergistic inhibition by inorganic pyrophosphate and aza analogs of the bisabolyl cation.
1992
Intermodular Communication in Modular Polyketide Synthases: Structural and Mutational Analysis of Linker Mediated Protein−Protein Recognition
2003
Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates
1996
Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase
1997 Science
Dissecting the Role of Acyltransferase Domains of Modular Polyketide Synthases in the Choice and Stereochemical Fate of Extender Units
1999
Enzymic formation of sesquiterpenes
1990
Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates,
2010
Engineered biosynthesis of a triketide lactone from an incomplete modular polyketide synthase
1994
Precursor-Directed Biosynthesis of 16-Membered Macrolides by the Erythromycin Polyketide Synthase
2001
Assessing the Balance between Protein−Protein Interactions and Enzyme−Substrate Interactions in the Channeling of Intermediates between Polyketide Synthase Modules
2001
Dissecting the Evolutionary Relationship between 14-Membered and 16-Membered Macrolides
1998
Analysis of the Molecular Recognition Features of Individual Modules Derived from the Erythromycin Polyketide Synthase
2000
Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate. Anti stereochemistry in a biological SE' reaction
1988
Trichodiene Synthase. Enzymatic Formation of Multiple Sesquiterpenes by Alteration of the Cyclase Active Site
1996
The biosynthesis of streptonigrin. 5. Biosynthesis of streptonigrin from [U-13C6]-D-glucose. Origin of the quinoline quinone
1982
Stereospecificity of Ketoreductase Domains of the 6-Deoxyerythronolide B Synthase
2007
Bergamotene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate
1989
Macrolide biosynthesis. 4. Intact incorporation of a chain-elongation intermediate into erythromycin.
1987
Extender Unit and Acyl Carrier Protein Specificity of Ketosynthase Domains of the 6-Deoxyerythronolide B Synthase
2006
Purification and Characterization of Bimodular and Trimodular Derivatives of the Erythromycin Polyketide Synthase
1997
Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis
2003
Molecular Recognition of the Substrate Diphosphate Group Governs Product Diversity in Trichodiene Synthase Mutants,
2005
Epicubenol Synthase and the Stereochemistry of the Enzymic Cyclization of Farnesyl and Nerolidyl Diphosphate
1995
Macrolide biosynthesis. 5. Intact incorporation of a chain-elongation intermediate into nargenicin
1988
Nargenicin biosynthesis: Late stage oxidations and absolute configuration.
1985
Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase
1995
Pentalenolactone F,a new metabolite isolated from Streptomyces. Isolation and structure elucidation.
1983
Alcohol Stereochemistry in Polyketide Backbones Is Controlled by the β-Ketoreductase Domains of Modular Polyketide Synthases
1998
Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate. Inversion at C-1 during 11-membered-ring formation
1988
Introduction: Polyketide and Nonribosomal Polypeptide Biosynthesis. From Collie to Coli
1997
Tolerance and Specificity of Polyketide Synthases
1999
Partial purification and characterization of pentalenene synthase
1987
Polyketide Double Bond Biosynthesis. Mechanistic Analysis of the Dehydratase-Containing Module 2 of the Picromycin/Methymycin Polyketide Synthase
2005
Aristolochene Synthase. Mechanism-Based Inhibition of a Terpenoid Cyclase
1994
Macrolide biosynthesis—II
1983
Synthesis and Incorporation of an N-Acetylcysteamine Analogue of Methylmalonyl-CoA by a Modular Polyketide Synthase
1998
Biosynthetic origin of the carbon skeleton and oxygen atoms of the avermectins
1983
The stereochemistry of allylic pyrophosphate metabolism
1980
Synthesis of proposed chain-elongation intermediates of the monensin biosynthetic pathway
1988
Reconstituting Modular Activity from Separated Domains of 6-Deoxyerythronolide B Synthase
2004
Biosynthesis of the Sesquiterpene Botrydial in Botrytis cinerea. Mechanism and Stereochemistry of the Enzymatic Formation of Presilphiperfolan-8β-ol
2009
Isolation and Characterization of the Gene Associated with Geosmin Production in Cyanobacteria
2008
Total synthesis of (±)-epicubenol
1994
Geosmin Biosynthesis. Mechanism of the Fragmentation−Rearrangement in the Conversion of Germacradienol to Geosmin
2007
Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular Polyketide Synthase Using Natural and Unnatural Substrates
1996
Macrolide biosynthesis. Origin of the oxygen atoms in the erythromycins
1981
Aristolochene Synthase: Mechanistic Analysis of Active Site Residues by Site-Directed Mutagenesis
2004
Specificity and versatility in erythromycin biosynthesis
1996
Selective Protein−Protein Interactions Direct Channeling of Intermediates between Polyketide Synthase Modules
2001
Cyclization of farnesyl diphosphate to pentalenene. Orthogonal stereochemistry in an enzyme-catalyzed SE′ reaction
1994
Overproduction and characterization of the erythromycin C-12 hydroxylase, EryK
1995
Biosynthesis of camptothecin. 3. Definition of strictosamide as the penultimate biosynthetic precursor assisted by carbon-13 and deuterium NMR spectroscopy
1979
Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase
1996
Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of E. coli
2001 Science
Isoprenoid biosynthesis. Stereochemistry of the cyclization of allylic pyrophosphates
1985
Expression, Site-Directed Mutagenesis, and Steady State Kinetic Analysis of the Terminal Thioesterase Domain of the Methymycin/Picromycin Polyketide Synthase
2002
Trichodiene biosynthesis and the role of nerolidyl pyrophosphate in the enzymic cyclization of farnesyl pyrophosphate
1988
Stereospecificity of Ketoreductase Domains 1 and 2 of the Tylactone Modular Polyketide Synthase
2008
Enzymatic Formation of Isochamigrene, a Novel Sesquiterpene, by Alteration of the Aspartate-Rich Region of Trichodiene Synthase
1996
Enzymic cyclization of geranyl pyrophosphate to bornyl pyrophosphate. Role of the pyrophosphate moiety
1982
Remarkably Broad Substrate Tolerance of Malonyl-CoA Synthetase, an Enzyme Capable of Intracellular Synthesis of Polyketide Precursors
2001
Functional Orientation of the Acyltransferase Domain in a Module of the Erythromycin Polyketide Synthase
1998
Mechanism of the pyrophosphate migration in the enzymic cyclization of geranyl and linalyl pyrophosphates to (+)- and (-)-bornyl pyrophosphates
1985
Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone in Streptomyces coelicolor. Mechanism and Stereochemistry of the Enzymatic Formation of Epi-isozizaene
2009
Biosynthesis of (+)-epicubenol
1994
Monoterpene cyclization mechanisms and the use of natural abundance deuterium NMR—short cut or primrose path?
1993
Mechanism and Stereochemistry of the Germacradienol/Germacrene D Synthase of Streptomyces coelicolor A3(2)
2004
Polyether biosynthesis. Origin of the oxygen atoms of monensin A
1981
Epicubenol synthase and the enzymic cyclization of farnesyl diphosphate
1993
ChemInform Abstract: Enzymatic Formation of Sesquiterpenes
1991
Crystal Structure of Pentalenene Synthase: Mechanistic Insights on Terpenoid Cyclization Reactions in Biology
1997 Science
X-ray Crystal Structures of D100E Trichodiene Synthase and Its Pyrophosphate Complex Reveal the Basis for Terpene Product Diversity,
2002
Geosmin Biosynthesis. Streptomyces coelicolor Germacradienol/Germacrene D Synthase Converts Farnesyl Diphosphate to Geosmin
2006
Trichodiene Synthase. Stereochemical Studies of the Cryptic Allylic Diphosphate Isomerase Activity Using an Anomalous Substrate
1994
Synthesis of (dl)-pentalenolactones E and F
1984
Enhancing the Modularity of the Modular Polyketide Synthases: Transacylation in Modular Polyketide Synthases Catalyzed by Malonyl-CoA:ACP Transacylase
2003
Sesquiterpene Synthase from the Botrydial Biosynthetic Gene Cluster of the Phytopathogen Botrytis cinerea
2008
The isolation and structural elucidation of pentalenolactone E
1979
Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities
1999
Structure and Mechanism of the 6-Deoxyerythronolide B Synthase
2007
Role of Arginine-304 in the Diphosphate-Triggered Active Site Closure Mechanism of Trichodiene Synthase,
2005
Macrolide biosynthesis. 7. Incorporation of polyketide chain elongation intermediates into methymycin
1993
Chain Elongation, Macrolactonization, and Hydrolysis of Natural and Reduced Hexaketide Substrates by the Picromycin/Methymycin Polyketide Synthase
2005
Synthesis of (+)-5-epi-aristolochene and (+)-1-deoxycapsidiol from capsidiol
1990
Pentalenolactone Biosynthesis. Molecular Cloning and Assignment of Biochemical Function to PtlI, a Cytochrome P450 of Streptomyces avermitilis
2006 StandoutNobel
A Gene Cluster for Biosynthesis of the Sesquiterpenoid Antibiotic Pentalenolactone inStreptomyces avermitilis
2006 StandoutNobel
Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry
2012
Unified stereochemical model of polyether antibiotic structure and biogenesis
1983
Aristolochene biosynthesis and enzymatic cyclization of farnesyl pyrophosphate
1989
Aristolochene Synthase. Elucidation of the Cryptic Germacrene A Synthase Activity Using the Anomalous Substrate Dihydrofarnesyl Diphosphate
1996
Nargenicin biosynthesis. Incorporation of polyketide chain elongation intermediates and support for a proposed intramolecular Diels-Alder cyclization
1993
Genome Mining in Streptomyces. Elucidation of the Role of Baeyer−Villiger Monooxygenases and Non-Heme Iron-Dependent Dehydrogenase/Oxygenases in the Final Steps of the Biosynthesis of Pentalenolactone and Neopentalenolactone
2011
Insights into Channel Architecture and Substrate Specificity from Crystal Structures of Two Macrocycle-Forming Thioesterases of Modular Polyketide Synthases,
2002
Biosynthesis of polyketide antibiotics. Incorporation of a pentaketide chain elongation intermediate into nargenicin
1995
Genome Mining in Streptomyces avermitilis: Cloning and Characterization of SAV_76, the Synthase for a New Sesquiterpene, Avermitilol
2010
X-ray Crystal Structure of Aristolochene Synthase from Aspergillus terreus and Evolution of Templates for the Cyclization of Farnesyl Diphosphate,
2007
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade
2001
Macrolide biosynthesis. 3. Stereochemistry of the chain-elongation steps of erythromycin biosynthesis
1986
Polyether biosynthesis. 2. Origin of the oxygen atoms of monensin A
1982
Dissecting and Exploiting Intermodular Communication in Polyketide Synthases
1999 Science
Biosynthetic origin of the carbon skeleton and oxygen atoms of nargenicin A1
1984
Evidence for Two Catalytically Independent Clusters of Active Sites in a Functional Modular Polyketide Synthase
1996
Quantitative Analysis of Loading and Extender Acyltransferases of Modular Polyketide Synthases
2002
Trichodiene biosynthesis and the stereochemistry of the enzymatic cyclization of farnesyl pyrophosphate
1985
Cyclonerodiol biosynthesis and the enzymic conversion of farnesyl to nerolidyl pyrophosphate
1981
Remarkably broad substrate specificity of a modular polyketide synthase in a cell-free system
1995
Erythromycin Biosynthesis: The β-Ketoreductase Domains Catalyze the Stereospecific Transfer of the 4-pro-SHydride of NADPH
1998
ChemInform Abstract: UNIFIED STEREOCHEMICAL MODEL OF POLYETHER ANTIBIOTIC STRUCTURE AND BIOGENESIS
1983
Stereochemical studies of isoprenoid biosynthesis. Biosynthesis of fomannosin from [1,2-13C2]acetate
1978
Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate
1983
Substrate Specificity of the Loading Didomain of the Erythromycin Polyketide Synthase
2000
Pentalenene biosynthesis and the enzymatic cyclization of farnesyl pyrophosphate: Proof that the cyclization is catalyzed by a single enzyme
1984
Genome Mining in Streptomyces coelicolor: Molecular Cloning and Characterization of a New Sesquiterpene Synthase
2006
Macrolide biosynthesis. 6 Mechanism of polyketide chain elongation
1991
Aristolochene biosynthesis. Stereochemistry of the deprotonation steps in the enzymatic cyclization of farnesyl pyrophosphate
1990
Gain of Function Mutagenesis of the Erythromycin Polyketide Synthase. 2. Engineered Biosynthesis of an Eight-Membered Ring Tetraketide Lactone
1997