Standout Papers
Citation Impact
Citing Papers
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
2007 StandoutScience
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
The emerging biology of RNA post-transcriptional modifications
2016
The Intrinsic Reactivity of ATP and the Catalytic Proficiencies of Kinases Acting on Glucose, N-Acetylgalactosamine, and Homoserine
2009
An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells
2015 StandoutNobel
Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells
2010
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Fragment-based lead discovery
2004
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
DNA-based asymmetric catalysis
2010 StandoutNobel
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
An iminocoumarin–Cu(ii) ensemble-based chemodosimeter toward thiols
2011
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry
2012 StandoutNobel
The orphan COUP-TF nuclear receptors are markers for neurogenesis from cnidarians to vertebrates
2004
Cytochrome P450BM-3 reduces aldehydes to alcohols through a direct hydride transfer
2012
Rhodamine-based fluorogenic probe for imaging biological thiol
2008
Modification of the Nucleotide Cofactor-binding Site of Cytochrome P-450 Reductase to Enhance Turnover with NADH in Vivo
2002
The Spliceosome: Design Principles of a Dynamic RNP Machine
2009 Standout
A fast-response, highly sensitive and specific organoselenium fluorescent probe for thiols and its application in bioimaging
2009
IDH mutations in glioma and acute myeloid leukemia
2010
Computational Enzyme Design
2013 StandoutNobel
Bleomycins: towards better therapeutics
2005
LJP 394 for the prevention of renal flare in patients with systemic lupus erythematosus: Results from a randomized, double‐blind, placebo‐controlled study
2003
Probing the β2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists
2005 StandoutNobel
A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications
2010
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Selective Incorporation of 19F‐Labeled Trp Side Chains for NMR‐Spectroscopy‐Based Ligand–Protein Interaction Studies
2003
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
A fluorescent chemodosimeter specific for cysteine: effective discrimination of cysteine from homocysteine
2009
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor
2012 StandoutNobel
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm
1999 Standout
Fluorescent and colorimetric probes for detection of thiols
2010 Standout
Construction of a FRET-based ratiometric fluorescent thiol probe
2010
Fragment-based lead discovery: a chemical update
2006
Determination of thiols and disulfides via HPLC quantification of 5-thio-2-nitrobenzoic acid
2008
A highly sensitive fluorescent probe for detection of benzenethiols in environmental samples and living cells
2009
Extending the Size of Protein–RNA Complexes Studied by Nuclear Magnetic Resonance Spectroscopy
2005
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Systemic Lupus Erythematosus
2011 Standout
A Highly Selective Fluorescent Probe for Thiophenols
2007
Kemp elimination catalysts by computational enzyme design
2008 StandoutNatureNobel
New G-protein-coupled receptor crystal structures: insights and limitations
2008 StandoutNobel
Simple Biosensor with High Selectivity and Sensitivity: Thiol‐Specific Biomolecular Probing and Intracellular Imaging by AIE Fluorogen on a TLC Plate through a Thiol–Ene Click Mechanism
2010
From words to literature in structural proteomics
2003 Nature
DNA-induced conformational changes are the basis for cooperative dimerization by the DNA binding domain of the retinoid X receptor
1998
Recent advances in chemical proteomics: exploring the post-translational proteome
2008
A Highly Sensitive Fluorescence Probe for Fast Thiol‐Quantification Assay of Glutathione Reductase
2009
Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols
2012
Aggregation-induced emission
2011 Standout
Structure-based development of target-specific compound libraries
2006
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Getting a chemical handle on proteinpost-translational modification
2009
Engineering the third wave of biocatalysis
2012 StandoutNature
Conformational Plasticity and Structure/Function Relationships in Cytochromes P450
2010
Simple yet functional phosphate-loop proteins
2018 StandoutNobel
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Fluorine in medicinal chemistry
2007 Standout
P450 Fingerprinting Method for Rapid Discovery of Terpene Hydroxylating P450 Catalysts with Diversified Regioselectivity
2011
Development of an Indole-Based Boron-Dipyrromethene Fluorescent Probe for Benzenethiols
2010
Colorimetric Detection of Thiols Using a Chromene Molecule
2009
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Orphan Nuclear Receptors: From Gene to Function*
1999
Hepatocyte-Targeting Single Galactose-Appended Naphthalimide: A Tool for Intracellular Thiol Imaging in Vivo
2011
A Rhodamine-Based Fluorescent Probe Containing a Se−N Bond for Detecting Thiols and Its Application in Living Cells
2007
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Luminescent Chemodosimeters for Bioimaging
2012 Standout
Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine
2009
Topoisomerase II−Drug Interaction Domains: Identification of Substituents on Etoposide That Interact with the Enzyme
2007
An NMR-Based Antagonist Induced Dissociation Assay for Targeting the Ligand−Protein and Protein−Protein Interactions in Competition Binding Experiments
2007
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
A Ratiometric Fluorescent Probe for Thiols Based on a Tetrakis(4-hydroxyphenyl)porphyrin–Coumarin Scaffold
2011
Bcl-2-mediated alterations in endoplasmic reticulum Ca 2+ analyzed with an improved genetically encoded fluorescent sensor
2004 StandoutNobel
Extended-Connectivity Fingerprints
2010 Standout
On the Reactivity of Phosphate Monoester Dianions in Aqueous Solution: Brønsted Linear Free-Energy Relationships Do Not Have an Unique Mechanistic Interpretation
1998 StandoutNobel
Modulation of transferrin receptor mRNA by transferrin-gallium in human myeloid HL60 and lymphoid CCRF-CEM leukaemic cells
1993
Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
2014 StandoutNobel
Combinatorial Rosamine Library and Application to in Vivo Glutathione Probe
2007
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
2013 StandoutNobel
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
2005 StandoutNobel
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
Mechanisms of phosphoryl and acyl transfer.
1995
Enzymatic Mechanisms of Phosphate and Sulfate Transfer
2006
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy
2019
Intrinsic Disorder and Protein Function
2002
Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins.
2003
Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives
2011 Standout
Substituents on Etoposide That Interact with Human Topoisomerase IIα in the Binary Enzyme−Drug Complex: Contributions to Etoposide Binding and Activity
2008
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Nuclear Magnetic Resonance Structural Studies of a Potassium Channel−Charybdotoxin Complex
2005
The Molecular Biology of Axon Guidance
1996 StandoutScience
Nucleic Acid Recognition by Metal Complexes of Bleomycin
1999
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Direct C−H Transformation via Iron Catalysis
2010 Standout
Ratiometric Detection of Mitochondrial Thiols with a Two-Photon Fluorescent Probe
2011
Activation of DNA Carbon−Hydrogen Bonds by Metal Complexes
2010
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Atomically Precise Clusters of Noble Metals: Emerging Link between Atoms and Nanoparticles
2017 Standout
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Daniel S. Sem being referenced
Geometric relationship between the nicotinamide and isoalloxazine rings in NADPH-cytochrome P-450 oxidoreductase: implications for the classification of evolutionarily and functionally related flavoproteins
1992
Object-oriented approach to drug design enabled by NMR SOLVE: First real-time structural tool for characterizing protein-ligand interactions
2001
13C-Methyl isocyanide as an NMR probe for cytochrome P450 active sites
2009
Structural evidence for a functionally relevant second camphor binding site in P450cam: Model for substrate entry into a P450 active site
2007
Conserved amino acids in each subunit of the heteroligomeric tRNA m 1 A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding
2007
Chemical proteomics from a nuclear magnetic resonance spectroscopy perspective
2004
High-resolution solution structure of the retinoid X receptor DNA-binding domain
1998
Antibody Affinities and Relative Titers in Polyclonal Populations: Surface Plasmon Resonance Analysis of anti-DNA Antibodies
1999
NMR-based structural characterization of large protein-ligand interactions
2002
Interaction with arginine 597 of NADPH-cytochrome P-450 oxidoreductase is a primary source of the uniform binding energy used to discriminate between NADPH and NADH
1993
NMR Spectroscopic Studies of the DNA-binding Domain of the Monomer-binding Nuclear Orphan Receptor, Human Estrogen Related Receptor-2
1997
Kinetic Mechanism for the Model Reaction of NADPH-Cytochrome P450 Oxidoreductase with Cytochrome c
1994
AmineDB: Large scale docking of amines with CYP2D6 and scoring for druglike properties—towards defining the scope of the chemical defense against foreign amines in humans
2007
Systems-Based Design of Bi-Ligand Inhibitors of Oxidoreductases
2004
Phosphorylated aminosugars; synthesis, properties, and reactivity in enzymic reactions
1991
Fluorescence-based detection of thiols in vitro and in vivo using dithiol probes
2006
Phosphorylated thiosugars: synthesis, properties, and reactivity in enzymic reactions
1991
NMR Assignments and Secondary Structure of the Retinoid X Receptor α DNA‐binding Domain
1994
Nmr in drug discovery
2002 StandoutNobel
Systems-Based Design of Bi-Ligand Inhibitors of OxidoreductasesFilling the Chemical Proteomic Toolbox
2004
Intracellular DNA strand scission and growth inhibition of Ehrlich ascites tumor cells by bleomycins.
1990
SEA-TROSY (Solvent Exposed Amides with TROSY): A Method to Resolve the Problem of Spectral Overlap in Very Large Proteins
2001
Inhibition of ribonucleotide reductase by gallium in murine leukemic L1210 cells.
1991