Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
A defined structural unit enables de novo design of small-molecule–binding proteins
2020 Science
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
Protein homology model refinement by large-scale energy optimization
2018 StandoutNobel
Crystal structure of the CRISPR RNA–guided surveillance complex from Escherichia coli
2014 Science
Crystal Structure of the Human Two–Pore Domain Potassium Channel K2P1
2012 Science
Structure of the cold- and menthol-sensing ion channel TRPM8
2017 Science
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Structure of the Yeast Mitochondrial Large Ribosomal Subunit
2014 ScienceNobel
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
Structures of the CRISPR genome integration complex
2017 StandoutScienceNobel
Hallucinating symmetric protein assemblies
2022 StandoutScienceNobel
Structural Basis of Wnt Recognition by Frizzled
2012 Science
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN
2024 StandoutNobel
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Structure-Based Optimization Strategies for G Protein-Coupled Receptor (GPCR) Allosteric Modulators: A Case Study from Analyses of New Metabotropic Glutamate Receptor 5 (mGlu 5 ) X-ray Structures
2018
Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF
2021
De novo protein design—From new structures to programmable functions
2024
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Refinement of protein termini in template‐based modeling using conformational space annealing
2011
Precisely patterned nanofibres made from extendable protein multiplexes
2023 StandoutNobel
Correcting pervasive errors in RNA crystallography through enumerative structure prediction
2012
lDDT: a local superposition-free score for comparing protein structures and models using distance difference tests
2013
Structures of the calcium-activated, non-selective cation channel TRPM4
2017 Nature
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Improvements to Robotics-Inspired Conformational Sampling in Rosetta
2013
Pre-fusion structure of a human coronavirus spike protein
2016 Nature
Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
2016 Nature
RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite
2011 StandoutNobel
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2
2018
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions
2014
Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement
2015 StandoutNobel
Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy
2016
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs
2017 Nature
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation
2011
High-Resolution Comparative Modeling with RosettaCM
2013 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
2012 StandoutNobel
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Efficient sampling of protein conformational space using fast loop building and batch minimization on highly parallel computers
2012 StandoutNobel
Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
2014 Nature
A Brief History of De Novo Protein Design: Minimal, Rational, and Computational
2021
Structural basis for human coronavirus attachment to sialic acid receptors
2019
Electron cryo-microscopy structure of the mechanotransduction channel NOMPC
2017 Nature
Towards automated crystallographic structure refinement with phenix.refine
2012 Standout
Recommendations of the wwPDB NMR Validation Task Force
2013
Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
2021
Crystallographic model validation: from diagnosis to healing
2013
Computational design of self-assembling cyclic protein homo-oligomers
2016 StandoutNobel
A New Generation of Crystallographic Validation Tools for the Protein Data Bank
2011
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
2011
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Molecular Basis for the Unique Role of the AAA+ Chaperone ClpV in Type VI Protein Secretion
2011
Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion
2019
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
A Pareto-Optimal Refinement Method for Protein Design Scaffolds
2013 StandoutNobel
The Phenix software for automated determination of macromolecular structures
2011
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein
2020 Standout
Improved low-resolution crystallographic refinement with Phenix and Rosetta
2013 StandoutNobel
Protein structure validation by generalized linear model root‐mean‐square deviation prediction
2011
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
De novo design of a non-local β-sheet protein with high stability and accuracy
2018 StandoutNobel
ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
2018
Human TRPML1 channel structures in open and closed conformations
2017 NatureNobel
X-ray structures define human P2X3 receptor gating cycle and antagonist action
2016 Nature
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel
2014 NatureNobel
Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
2020 Standout
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
2012 Nature
PHENIX: a comprehensive Python-based system for macromolecular structure solution
2010 Standout
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Structure of the F-actin–tropomyosin complex
2014 Nature
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
2018 Nature
The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs
2016
Automatically Fixing Errors in Glycoprotein Structures with Rosetta
2018
Protein sequence design with a learned potential
2022
Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors
2019
New tools provide a second look at HDV ribozyme structure, dynamics and cleavage
2014 StandoutNobel
Scientific Benchmarks for Guiding Macromolecular Energy Function Improvement
2013 StandoutNobel
EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy
2015
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
2017
Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation
2018
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Structure of the mammalian TRPM7, a magnesium channel required during embryonic development
2018
Relaxation of backbone bond geometry improves protein energy landscape modeling
2013 StandoutNobel
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
2017
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
2015 StandoutNobel
Protein NMR Structures Refined with Rosetta Have Higher Accuracy Relative to Corresponding X-ray Crystal Structures
2014 StandoutNobel
Advances, Interactions, and Future Developments in the CNS, Phenix, and Rosetta Structural Biology Software Systems
2013 StandoutNobel
High thermodynamic stability of parametrically designed helical bundles
2014 StandoutScienceNobel
Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion
2017
Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections
2017
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Computational design of environmental sensors for the potent opioid fentanyl
2017 StandoutNobel
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
De novo protein fold design through sequence-independent fragment assembly simulations
2023
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
2015
Protein Structure Refinement through Structure Selection and Averaging from Molecular Dynamics Ensembles
2012
Computational protein structure refinement: almost there, yet still so far to go
2017
Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta
2016
Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin
2015 Science
Assessment of the model refinement category in CASP12
2017
Determination of the Structures of Symmetric Protein Oligomers from NMR Chemical Shifts and Residual Dipolar Couplings
2011 StandoutNobel
Control over overall shape and size in de novo designed proteins
2015 StandoutNobel
Current developments in Coot for macromolecular model building of Electron Cryo‐microscopy and Crystallographic Data
2019
Assessment of refinement of template‐based models in CASP11
2016
The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design
2017 StandoutNobel
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
The human coronavirus HCoV-229E S-protein structure and receptor binding
2019
Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel
2019 Science
RCrane: semi-automated RNA model building
2012
Effective protein model structure refinement by loop modeling and overall relaxation
2015
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Structure of the human lipid-gated cation channel TRPC3
2018
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Works of D.A. Keedy being referenced
Algorithm for backrub motions in protein design
2008
osprey
2013
The other 90% of the protein: Assessment beyond the Cαs for CASP8 template‐based and high‐accuracy models
2009
Autofix for backward-fit sidechains: using MolProbity and real-space refinement to put misfits in their place
2008
Alternate States of Proteins Revealed by Detailed Energy Landscape Mapping
2010 StandoutNobel
MolProbity: all-atom structure validation for macromolecular crystallography
2009 Standout
MolProbity: More and better reference data for improved all‐atom structure validation
2017 Standout
An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering
2018