Citation Impact
Citing Papers
The Clinical Effect of the Dual-Targeting Strategy Involving PI3K/AKT/mTOR and RAS/MEK/ERK Pathways in Patients with Advanced Cancer
2012
High Frequency of PIK3R1 and PIK3R2 Mutations in Endometrial Cancer Elucidates a Novel Mechanism for Regulation of PTEN Protein Stability
2011
PIK3CA Mutation H1047R Is Associated with Response to PI3K/AKT/mTOR Signaling Pathway Inhibitors in Early-Phase Clinical Trials
2012
Tumor Genetic Analyses of Patients with Metastatic Renal Cell Carcinoma and Extended Benefit from mTOR Inhibitor Therapy
2014
Loss of Integrin α1β1 Ameliorates Kras-Induced Lung Cancer
2008
Alpelisib for PIK3CA -Mutated, Hormone Receptor–Positive Advanced Breast Cancer
2019 Standout
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
2010 Standout
A Multicenter Phase I Trial of PX-866, an Oral Irreversible Phosphatidylinositol 3-Kinase Inhibitor, in Patients with Advanced Solid Tumors
2012
Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
2009
Targeting bile-acid signalling for metabolic diseases
2008
Guidelines for the welfare and use of animals in cancer research
2010 Standout
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Targeting the PI3K signaling pathway in cancer
2009
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
2012 Standout
Phase I safety, pharmacokinetic, and pharmacodynamic study of the oral phosphatidylinositol-3-kinase and mTOR inhibitor BGT226 in patients with advanced solid tumors
2012
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Integrins in cancer: biological implications and therapeutic opportunities
2009 Standout
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
2013
Posttranslational regulation of Akt in human cancer
2014
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
The Tumor Suppressor Par-4 Activates an Extrinsic Pathway for Apoptosis
2009
Ovarian cancer
2014 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
mTOR and cancer: many loops in one pathway
2009
Therapeutic Strategies for Targeting Ras Proteins
2011
Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future
2017 Standout
Cancer drug resistance: an evolving paradigm
2013 Standout
Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer
2010
The biology and function of fibroblasts in cancer
2016 Standout
Oxidative stress and cancer: An overview
2012
GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects
2010 Standout
The Cancer Genome Atlas Pan-Cancer analysis project
2013 Standout
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
2010 StandoutNature
Analyzing real-time PCR data by the comparative CT method
2008 Standout
Autophagy: Renovation of Cells and Tissues
2011 Standout
Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug
2010
Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ
2014
Pancreatic Adenocarcinoma
2014 Standout
TLR4 links innate immunity and fatty acid–induced insulin resistance
2006 Standout
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
Pancreatic cancers require autophagy for tumor growth
2011
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
2009
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet
2008
Regulation of cancer cell metabolism
2011 Standout
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Targeting apoptosis in cancer therapy
2020 Standout
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes
2005
Autophagy in Human Health and Disease
2013 Standout
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
2013 Standout
Autophagy and cancer therapy
2011
Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer
2013 Standout
Alteration of Ceramide Synthase 6/C16-Ceramide Induces Activating Transcription Factor 6-mediated Endoplasmic Reticulum (ER) Stress and Apoptosis via Perturbation of Cellular Ca2+ and ER/Golgi Membrane Network
2011
Activation of Nuclear Factor (Erythroid-2 Like) Factor 2 by Toxic Bile Acids Provokes Adaptive Defense Responses to Enhance Cell Survival at the Emergence of Oxidative Stress
2007
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
2014 Standout
PI3K and MEK inhibitor combinations: examining the evidence in selected tumor types
2013
DNA repair dysregulation from cancer driver to therapeutic target
2012
A2B adenosine receptor blockade inhibits growth of prostate cancer cells
2013
Autophagy as a target for anticancer therapy
2011
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Bile acids as regulatory molecules
2009
Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers
2013
AKT/PKB Signaling: Navigating the Network
2017 Standout
Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans
2015 StandoutNobel
The PI3K Pathway in Human Disease
2017 Standout
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
LncRNA Khps1 Regulates Expression of the Proto-oncogene SPHK1 via Triplex-Mediated Changes in Chromatin Structure
2015
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Autophagy and Cancer Therapy
2014
Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer
2018 Standout
Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms
2015
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction
2006 Standout
Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women
2010
Ring-Strain-Enabled Reaction Discovery: New Heterocycles from Bicyclo[1.1.0]butanes
2015
Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation
2019 Science
Improving Prospects for Targeting RAS
2015
Regulation of Apoptosis by HER2 in Breast Cancer
2013
Recent advances in the synthesis of pyrroles by multicomponent reactions
2014 Standout
A Role of the Bile Salt Receptor FXR in Atherosclerosis
2010
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Phase I, Dose-Escalation Study of BKM120, an Oral Pan-Class I PI3K Inhibitor, in Patients With Advanced Solid Tumors
2011
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Metabolic reprogramming and cancer progression
2020 StandoutScience
Evidence for Pleiotropic Effects of Phosphodiesterase-5 (PDE5) Inhibitors: Emerging Concepts in Cancer and Cardiovascular Medicine
2011
Fibroblast heterogeneity in the cancer wound
2014
Autophagy and Metabolism
2010 StandoutScience
Generation and Detection of Reactive Oxygen Species in Photocatalysis
2017 Standout
Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation
2007
The Double-Edged Sword of Autophagy Modulation in Cancer
2009
Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology
2009
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
2013
Works of Clint Mitchell being referenced
Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+- De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway
2010
Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts
2009
Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
2009
BCL-2 Family Inhibitors Enhance Histone Deacetylase Inhibitor and Sorafenib Lethality via Autophagy and Overcome Blockade of the Extrinsic Pathway to Facilitate Killing
2009
Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via Gαi Signaling
2007
OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells
2006
MDA-7 regulates cell growth and radiosensitivity in vitro of primary (Non-Established) human glioma cells
2004
Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin–sensitive mechanism in murine and human hepatocytes†
2005
Poly(ADP-Ribose) Polymerase 1 Modulates the Lethality of CHK1 Inhibitors in Carcinoma Cells
2010
Sorafenib and Vorinostat Kill Colon Cancer Cells by CD95-Dependent and -Independent Mechanisms
2009
Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo
2010
Radiation-Stimulated ERK1/2 and JNK1/2 Signaling can Promote Cell Cycle Progression in Human Colon Cancer Cells
2005
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
2008
Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes
2004
Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction
2010
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK
2004
17-Allylamino-17-demethoxygeldanamycin enhances the lethality of deoxycholic acid in primary rodent hepatocytes and established cell lines
2007
Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance
2008