Citation Impact
Citing Papers
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
2004 StandoutScience
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
Identification of a Primary Target of Thalidomide Teratogenicity
2010 StandoutScience
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
2004 StandoutScience
Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import
2004
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Dissection of USPcatalytic domains reveals five common insertion points
2009
Suppression of the Deubiquitinating Enzyme USP5 Causes the Accumulation of Unanchored Polyubiquitin and the Activation of p53
2008
Hallmarks of Cancer: The Next Generation
2011 Standout
Hydrogen peroxide sensing, signaling and regulation of transcription factors
2014
The DNA-damage response in human biology and disease
2009 StandoutNature
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin
2014 StandoutNobel
Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges
2012
Metabolism and cancer: the circadian clock connection
2009
Transcriptional regulation by p53: one protein, many possibilities
2006
Complicating the complexity of p53
2005
Inhibition of p53 degradation by Mdm2 acetylation
2004
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Lysine‐63‐linked ubiquitination is required for endolysosomal degradation of class I molecules
2006
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
2012
The ubiquitin-specific protease USP28 is required for MYC stability
2007
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
2008 Nature
E4F1 Is an Atypical Ubiquitin Ligase that Modulates p53 Effector Functions Independently of Degradation
2006
Lysine acetylation and the bromodomain: a new partnership for signaling
2004
A Genomic and Functional Inventory of Deubiquitinating Enzymes
2005 Standout
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
2012
Mdm2-mediated ubiquitylation: p53 and beyond
2009
Transcription-independent pro-apoptotic functions of p53
2005
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Weighing in on ubiquitin: the expanding role of mass-spectrometry-based proteomics
2005
Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey
2006
Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells
2005
Breaking the chains: structure and function of the deubiquitinases
2009 Standout
The P53 pathway: what questions remain to be explored?
2006
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
2009
A coming-of-age story: activation-induced cytidine deaminase turns 10
2009
p53 in health and disease
2007 Standout
A RING Finger Ubiquitin Ligase Is Protected from Autocatalyzed Ubiquitination and Degradation by Binding to Ubiquitin-specific Protease USP7
2004
De novo design of bioactive protein switches
2019 StandoutNatureNobel
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
2007
The hallmarks of cancer
2012 Standout
Origin and physiological roles of inflammation
2008 StandoutNature
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
p53 and stem cells: new developments and new concerns
2010
Targeting ubiquitin specific proteases for drug discovery
2007
USP10 Regulates p53 Localization and Stability by Deubiquitinating p53
2010
β-Arrestin and Mdm2 Mediate IGF-1 Receptor-stimulated ERK Activation and Cell Cycle Progression
2007 StandoutNobel
Targeting the ubiquitin system in cancer therapy
2009 Nature
SIRT1 Regulates Apoptosis and Nanog Expression in Mouse Embryonic Stem Cells by Controlling p53 Subcellular Localization
2008
The Hallmarks of Aging
2013 Standout
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
2004 Standout
Quantitative Profiling of Ubiquitylated Proteins Reveals Proteasome Substrates and the Substrate Repertoire Influenced by the Rpn10 Receptor Pathway
2007
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
2013 StandoutNature
Back to the Future with Ubiquitin
2004
Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4
2006
Global quantification of mammalian gene expression control
2011 StandoutNature
A Deubiquitinating Enzyme Encoded by HSV-1 Belongs to a Family of Cysteine Proteases that Is Conserved across the Family Herpesviridae
2005
Binary switches and modification cassettes in histone biology and beyond
2003 Nature
Reactive oxygen species, cellular redox systems, and apoptosis
2010 Standout
Modes of p53 Regulation
2009
Post-translational modification of p53 in tumorigenesis
2004
Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications
2008
Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications
2004
SIRT1 Regulates HIV Transcription via Tat Deacetylation
2005
Transient Protein-Protein Interactions: Structural, Functional, and Network Properties
2010
Regulation of death receptor signaling by the ubiquitin system
2009
Mechanisms, biology and inhibitors of deubiquitinating enzymes
2007
Mammalian SIRT1 Represses Forkhead Transcription Factors
2004
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
2003
Protein partners of deubiquitinating enzymes
2008
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
p53 and Ceramide as Collaborators in the Stress Response
2013
Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling
2007 Science
Adoptive cell transfer as personalized immunotherapy for human cancer
2015 StandoutScience
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Getting into position: the catalytic mechanisms of protein ubiquitylation
2004
Deracemization of α-Aryl Hydrocoumarins via Catalytic Asymmetric Protonation of Ketene Dithioacetals
2012 StandoutNobel
Acetylation of the C Terminus of Ku70 by CBP and PCAF Controls Bax-Mediated Apoptosis
2004
Deubiquitinating Enzymes as Novel Anticancer Targets
2007
Targeting Mdm2 and Mdmx in Cancer Therapy: Better Living through Medicinal Chemistry?
2009
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Transcriptional control of human p53-regulated genes
2008 Standout
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity
2011
Control of skin cancer by the circadian rhythm
2011 StandoutNobel
RING Domain E3 Ubiquitin Ligases
2009 Standout
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
A comprehensive method for detecting ubiquitinated substrates using TR-TUBE
2015
Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies
2014
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Autophagy and Metabolism
2010 StandoutScience
Sirtuin Functions in Health and Disease
2007
The Ubiquitin Code
2012 Standout
The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
2010
Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3)
2011 StandoutNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
Dynamic FoxO transcription factors
2007
Works of Christopher Brooks being referenced
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
2003
p53 regulation by ubiquitin
2011
Mechanistic Studies of MDM2-mediated Ubiquitination in p53 Regulation
2007
The p53–Mdm2–HAUSP complex is involved in p53 stabilization by HAUSP
2007
p53 Ubiquitination: Mdm2 and Beyond
2006
Acetylation of p53 Inhibits Its Ubiquitination by Mdm2
2002
The impact of acetylation and deacetylation on the p53 pathway
2011
A Dynamic Role of HAUSP in the p53-Mdm2 Pathway
2004
Inactivation of HAUSP in vivo modulates p53 function
2009
How does SIRT1 affect metabolism, senescence and cancer?
2008
Activity of SL-401, a targeted therapy directed to interleukin-3 receptor, in blastic plasmacytoid dendritic cell neoplasm patients
2014
Dynamics of the p53 Acetylation Pathway
2004
Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2
2003 Science
Dynamics in the p53-Mdm2 Ubiquitination Pathway
2004
Monoubiquitination: The Signal for p53 Nuclear Export?
2004