Standout Papers
Citation Impact
Citing Papers
The Hepatitis C Virus NS3 Protein: A Model RNA Helicase and Potential Drug Target
2007
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity
2005
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis
2016 StandoutNobel
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target.
2007
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
The Metal Binding Site of the Hepatitis C Virus NS3 Protease
1998
Challenges and successes in developing new therapies for hepatitis C
2005 Nature
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
1998
Inhibition of transcription by platinum antitumor compounds
2009
Automation of measurements and data evaluation in biomolecular NMR screening
2001
Diazido Mixed‐Amine Platinum(IV) Anticancer Complexes Activatable by Visible‐Light Form Novel DNA Adducts
2013
Fragment-based lead discovery
2004
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
2006
Determination of a high-quality nuclear magnetic resonance solution structure of the bovine pancreatic trypsin inhibitor and comparison with three crystal structures
1992 StandoutNobel
Mechanism of autoproteolysis at the NS2–NS3 junction of the hepatitis C virus polyprotein
1998
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
NMR-based screening technologies
2003
Treatment triumphs
2014 StandoutNatureNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Pharmacological inhibitors of MAPK pathways
2002
The solution structure of the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein provides new insights into its activation and catalytic mechanism
1999
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
“Strong reasons make strong actions” — The antiviral efficacy of NS3/4A protease inhibitors†
2005
Approaching a new era for hepatitis C virus therapy: inhibitors of the NS3-4A serine protease and the NS5B RNA-dependent RNA polymerase
2003
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase
1999
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
1999
Structural studies of interactions between anticancer platinum drugs and DNA
1996
DNA Modifications by antitumor platinum and ruthenium compounds: Their recognition and repair
2002
Internal Processing of Hepatitis C Virus NS3 Protein
1999
The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding
2002
Nonclassical Platinum Antitumor Agents: Perspectives for Design and Development of New Drugs Complementary to Cisplatin
1993
Dynamics of the Dihydrofolate Reductase-Folate Complex: Catalytic Sites and Regions Known To Undergo Conformational Change Exhibit Diverse Dynamical Features
1995
Structural and Biological Identification of Residues on the Surface of NS3 Helicase Required for Optimal Replication of the Hepatitis C Virus
2005
In Vitro Characterization of a Purified NS2/3 Protease Variant of Hepatitis C Virus
2001
Structure and Function of the Hepatitis C Virus NS3-NS4A Serine Proteinase
2000
Clicking class B GPCR ligands
2011
Molecular Determinants of TRIF Proteolysis Mediated by the Hepatitis C Virus NS3/4A Protease
2005
Inhibition of protein synthesis by the nonstructural proteins NS4A and NS4B of hepatitis C virus
2002
Complex Formation of NS5B with NS3 and NS4A Proteins of Hepatitis C Virus
1998
Molecular Characterization of Hepatitis C Virus
1998 StandoutNobel
Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease
1998
Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form
1998
Binding of Different Divalent Cations to the Active Site of Avian Sarcoma Virus Integrase and Their Effects on Enzymatic Activity
1997
The NMR solution conformation of unligated human cyclophilin A 1 1Edited by P. E. Wright
1997 StandoutNobel
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)
2000
A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus
2006
Recent Developments in Fragment-Based Drug Discovery
2008
The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor
1998
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
1999
Transforming fragments into candidates: small becomes big in medicinal chemistry
2009
Protein–protein interaction through β-strand addition
2006
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
2013
A novel recombinant single‐chain hepatitis C virus ns3‐ns4a protein with improved helicase activity
1999
Structure of the hepatitis C virus RNA helicase domain
1997
Recent progress in fragment-based lead discovery
2009
Recognition of cisplatin adducts by cellular proteins
2001
From Structure to Function: New Insights into Hepatitis C Virus RNA Replication
2005
A reporter cell line for rapid and sensitive evaluation of hepatitis C virus infectivity and replication
2009
Identification of compounds with binding affinity to proteins via magnetization transfer from bulk water*
2000
Structural biology of hepatitis C virus
2004
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand
2003
Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER
2012
Replacement of an NH3by an Iminoether in Transplatin Makes an Antitumor Drug from an Inactive Compound
2000
Steric control of DNA interstrand cross-link sites of trans platinum complexes: specificity can be dictated by planar nonleaving groups
2000
Viral and cellular RNA helicases as antiviral targets
2005
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
The molecular virology of hepatitis C
1997
Inhibition of telomerase activity by cisplatin in human testicular cancer cells
1997
DNA-protein cross-linking by trans-[PtCl2(E-iminoether)2]. A concept for activation of the trans geometry in platinum antitumor complexes
2003
Light-Activated Destruction of Cancer Cell Nuclei by Platinum Diazide Complexes
2006
A decade of fragment-based drug design: strategic advances and lessons learned
2007
25 years of interferon-based treatment of chronic hepatitis C: an epoch coming to an end
2013
Nmr in drug discovery
2002 StandoutNobel
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
2003
Replication of hepatitis C virus
2007 StandoutNobel
Polarization transfer by cross-correlated relaxation in solution NMR with very large molecules
1999 StandoutNobel
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Interactions of DNA with a New Platinum(IV) Azide Dipyridine Complex Activated by UVA and Visible Light: Relationship to Toxicity in Tumor Cells
2012
TROSY-type Triple-Resonance Experiments for Sequential NMR Assignments of Large Proteins
1999 StandoutNobel
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
Kinetics and Mechanism of the Oxidation of Guanosine Derivatives by Pt(IV) Complexes
2006
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Replication of hepatitis C virus
2000
Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione
2000
Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2.
1992 StandoutNobel
Mechanism of action of a pestivirus antiviral compound
2000 StandoutNobel
Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein.
1999
Third row transition metals for the treatment of cancer
2015
Viral Proteomics
2007
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
TROSY in triple-resonance experiments: New perspectives for sequential NMR assignment of large proteins
1998 StandoutNobel
Probing the substrate specificity of hepatitis C virus NS3 serine protease by using synthetic peptides
1997
Subcellular Localization, Stability, and trans -Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines
2000 StandoutNobel
Protein‐Templated Fragment Ligations—From Molecular Recognition to Drug Discovery
2017
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity
1997
Mechanistic studies of a novel class of trisubstituted platinum(II) antitumor agents.
1991
Platination Pathways for Reactions of Cisplatin with GG Single‐Stranded and Double‐Stranded Decanucleotides
1995
The Solution Structure of a DNA Duplex Containing the cis ‐Pt(NH3)2[d(‐GTG‐)‐N 7(G), N 7(G)] Adduct, as Determined with High‐Field NMR and Molecular Mechanics/Dynamics
1994
Biochemical and structural analysis of the NS5B RNA‐dependent RNA polymerase of the hepatitis C virus
2000
The Hepatitis C Virus NS3 Proteinase: Structure and Function of a Zinc-Containing Serine Proteinase
1998
Efficient Initiation of HCV RNA Replication in Cell Culture
2000 StandoutScienceNobel
The C Terminus of Hepatitis C Virus NS4A Encodes an Electrostatic Switch That Regulates NS5A Hyperphosphorylation and Viral Replication
2007 StandoutNobel
Chemical Versatility of Transplatin Monofunctional Adducts within Multiple Site-Specifically Platinated DNA
1997
Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
2008
Relationship of Solution and Protein-Bound Structures of DNA Duplexes with the Major Intrastrand Cross-Link Lesions Formed on Cisplatin Binding to DNA
2001
The events that occur when cisplatin encounters cells
1996
Studying Hepatitis C Virus: Making the Best of a Bad Virus
2007 StandoutNobel
Mutations That Affect Dimer Formation and Helicase Activity of the Hepatitis C Virus Helicase
2001 StandoutNobel
Specific Interaction of Hepatitis C Virus Protease/Helicase NS3 with the 3′-Terminal Sequences of Viral Positive- and Negative-Strand RNA
2001
Isotope labeling in solution protein assignment and structural analysis
1994
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
The relevance of hydrogen bonding in the mechanism of action of platinum antitumor compounds
1992
One-Dimensional Relaxation- and Diffusion-Edited NMR Methods for Screening Compounds That Bind to Macromolecules
1997
Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin
2000
Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
2002 StandoutScience
Structure, Recognition, and Processing of Cisplatin−DNA Adducts
1999 Standout
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Characterization of engineered hepatitis C virus NS3 protease inhibitors affinity selected from human pancreatic secretory trypsin inhibitor and minibody repertoires
1997
Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
1997
Cancer Genome Landscapes
2013 StandoutScience
Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
1998 StandoutNobel
DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.
1993
Synthesis and characterization of a new bile acid and platinum(II) complex with cytostatic activity
1997
Conserved C-Terminal Threonine of Hepatitis C Virus NS3 Regulates Autoproteolysis and Prevents Product Inhibition
2003
A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein
1997
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
The hepatitis C virus NS4A protein: interactions with the NS4B and NS5A proteins
1997
Structure-Based Design of Novel, Urea-Containing FKBP12 Inhibitors
1996
Direct Cellular Responses to Platinum-Induced DNA Damage
2007
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Intrinsically Fluorescent Cytotoxic Cisplatin Analogues as DNA Marker Molecules
2005
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor
2003
In Vitro Anticancer Activity ofcis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands
2012
Conformation of FK506 in X-ray structures of its complexes with human recombinant FKBP12 mutants
1995
Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.
1992
Second-Site NMR Screening with a Spin-Labeled First Ligand
2000
Modulation of Hepatitis C Virus NS5A Hyperphosphorylation by Nonstructural Proteins NS3, NS4A, and NS4B
1999
Multiple Enzymatic Activities Associated with Recombinant NS3 Protein of Hepatitis C Virus
1998
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
The Metal−Ligand Bifunctional Catalysis: A Theoretical Study on the Ruthenium(II)-Catalyzed Hydrogen Transfer between Alcohols and Carbonyl Compounds
2000 StandoutNobel
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication
1997 StandoutNobel
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Christopher A. Lepre being referenced
Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism
2010
Applications of SHAPES Screening in Drug Discovery
2002
Solution structure of FK506 bound to FKBP‐12
1992
Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design
2003
Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer
2007
Synthesis and characterization of trans-diamminedichloroplatinum(II) adducts of d(CCTCGAGTCTCC).cntdot.d(GGAGACTCGAGG)
1990
Solution Structure of FK506 Bound to the R42K, H87V Double Mutant of FKBP-12
1994
Fragment-based drug discovery using the SHAPES method
2007
Dynamic NMR studies of ligand‐receptor interactions: Design and analysis of a rapidly exchanging complex of FKBP‐12/FK506 with a 24 kDa calcineurin fragment
1996
15N NMR Relaxation Studies of the FK506 Binding Protein: Dynamic Effects of Ligand Binding and Implications for Calcineurin Recognition
1994
Synthesis and proton NMR spectroscopic characterization of trans-[Pt(NH3)2[d(ApGpGpCpCpT)-N7-A(1),N7-G(3)]]
1987
Nitrogen-15 NMR relaxation studies of the FK506 binding protein: Backbone dynamics of the uncomplexed receptor
1993
The SHAPES strategy: an NMR-based approach for lead generation in drug discovery
1999
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Nuclear Magnetic Resonance-Based Approaches for Lead Generation in Drug Discovery
2002
Application of NMR Screening in Drug Discovery
2003
Library design for NMR-based screening
2001
High-resolution solution structure of reduced French bean plastocyanin and comparison with the crystal structure of poplar plastocyanin
1991
Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA
1990
Theory and Applications of NMR-Based Screening in Pharmaceutical Research
2004
Dynamics of a receptor-bound ligand by heteronuclear NMR: FK506 bound to FKBP-12
1993
ChemInform Abstract: 195Pt NMR Kinetic and Mechanistic Studies of cis‐ and trans‐Diamminedichloroplatinum(II) Binding to DNA.
1990