Citation Impact
Citing Papers
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
2004 Standout
Variable phenotype of familial adenomatous polyposis in pedigrees with 3′ mutation in the APC gene
1998
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
2005 StandoutNobel
Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.
1996
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis
1999
HIF Hydroxylase Pathways in Cardiovascular Physiology and Medicine
2015 StandoutNobel
Hypoxia-Inducible Factor Linked to Differential Kidney Cancer Risk Seen with Type 2A and Type 2B VHL Mutations
2007 StandoutNobel
Apc1638N: A mouse model for familial adenomatous polyposis–associated desmoid tumors and cutaneous cysts
1998
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Base-excision repair of oxidative DNA damage
2007 StandoutNature
Caught up in a Wnt storm: Wnt signaling in cancer
2003
Germline mutations in the von Hippel-Lindau (VHL) gene in patients from Poland: disease presentation in patients with deletions of the entire VHL gene
2002
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2
2007 StandoutNobel
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
Heterozygous HIF‐1α deficiency impairs carotid body‐mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
2006 StandoutNobel
Germline Mutations of the APC Gene in Patients with Familial Adenomatous Polyposis-Associated Thyroid Carcinoma: Results from a European Cooperative Study1
2000
Genetics of hereditary colorectal cancer
2005
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
VHL and p53: Tumor Suppressors Team Up to Prevent Cancer
2006 StandoutNobel
Von Hippel‐Lindau disease
2003
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
Lessons from Hereditary Colorectal Cancer
1996 Standout
Colorectal cancer
2013 Standout
Osteoporosis: now and the future
2011 Standout
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
2007 StandoutNobel
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
2002 StandoutNobel
Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers
2008 StandoutNobel
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
2003 Standout
von Hippel-Lindau disease
2003 Standout
Levels of Hypoxia-Inducible Factor-1 During Breast Carcinogenesis
2001 StandoutNobel
OS-9 Interacts with Hypoxia-Inducible Factor 1α and Prolyl Hydroxylases to Promote Oxygen-Dependent Degradation of HIF-1α
2005 StandoutNobel
The ABC of APC
2001
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation
1996
Failure to prolyl hydroxylate hypoxia‐inducible factor α phenocopies VHL inactivation in vivo
2006 StandoutNobel
Heterogeneous Effects of Direct Hypoxia Pathway Activation in Kidney Cancer
2015 StandoutNobel
Hereditary Colorectal Cancer
2003 Standout
LKB1; linking cell structure and tumor suppression
2008
Pancreatic involvement in von Hippel–Lindau disease
2000
The adenomatous polyposis coli (APC) tumor suppressor
1997
Neuroblastoma
2007 Standout
Pancreatic cancer biology and genetics
2002
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
LKB1, a protein kinase regulating cell proliferation and polarity
2003
Wnt signalling in stem cells and cancer
2005 StandoutNature
FIH-1: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
2001 StandoutNobel
The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
2000
LKB1 — A master tumour suppressor of the small intestine and beyond
2002
Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation
2011
Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease
2000
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein
1996
β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds
2002 Standout
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer.
2003
Severe Gardner syndrome in families with mutations restricted to a specific region of the APC gene.
1995
Mutations in the VHL gene in sporadic apparently congenital polycythemia
2003
Inherited Susceptibility to Colorectal Cancer
2005
The HIF Pathway and Erythrocytosis
2011
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
2001 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Retinal hemangioblastoma in von Hippel-Lindau disease: a clinical and molecular study.
2002
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
1997 StandoutScience
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
1999 Standout
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Expression of hypoxia-inducible factor 1? in brain tumors
2000 StandoutNobel
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
2012 StandoutNobel
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
2004
A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor.
2002
Genetic Testing for Cancer Predisposition
2001
Works of Cécile Boisson being referenced
Germline mutation profile of the VHL gene in von Hippel‐Lindau disease and in sporadic hemangioblastoma
1998
Germline mutation profile of theVHL gene in von Hippel-Lindau disease and in sporadic hemangioblastoma
1998
Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444
1995
Heterogeneity of mesothelioma cell lines as defined by altered genomic structure and expression of theNF2 gene
1998
MSH2 in contrast to MLH1 and MSH6 is frequently inactivated by exonic and promoter rearrangements in hereditary nonpolyposis colorectal cancer.
2002
Peutz-Jeghers families unlinked toSTK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma
2001