Standout Papers
Citation Impact
Citing Papers
Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells
2005
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol
2003
Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 + T Lymphocytes
2008 StandoutScienceNobel
A Salmonella protein causes macrophage cell death by inducing autophagy
2003
Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines.
2002
p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice
1998
Autoimmune lymphoproliferative syndrome: molecular basis of disease and clinical phenotype
2006
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
Identification and Characterization of a Ligand-independent Oligomerization Domain in the Extracellular Region of the CD95 Death Receptor
1999
Hallmarks of Cancer: The Next Generation
2011 Standout
The Apoptosome: Heart and Soul of the Cell Death Machine
1999
Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437
2001
Fas Ligand-independent, FADD-mediated Activation of the Fas Death Pathway by Anticancer Drugs
1999
Identification and Characterization of an IκB Kinase
1997
Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B
1998
T cell defined tumor antigens
1997
The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
2002
Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal
1998
Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand
1997
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
2011 Nature
RIP3, a Novel Apoptosis-inducing Kinase
1999
NMR structure and mutagenesis of the FADD (Mort1) death-effector domain
1998 Nature
ICEBERG
2000
Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis
1997 Nobel
Bcl-xL Functions Downstream of Caspase-8 to Inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced Apoptosis of MCF7 Breast Carcinoma Cells
1998
Target Protease Specificity of the Viral Serpin CrmA
1997
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
1998 Standout
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death
1996 Standout
An Induced Proximity Model for Caspase-8 Activation
1998
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Apoptotic Pathways
2000
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
1998
Caspases: their intracellular localization and translocation during apoptosis
1999
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunity
2000
Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells
2000
Granzyme B Induces BID-mediated Cytochrome c Release and Mitochondrial Permeability Transition
2001
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Molecules involved in cell death and peripheral tolerance
1997
RAIDD is a new 'death' adaptor molecule
1997 Nature
Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL
1997
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
2001
From bench to clinic with apoptosis-based therapeutic agents
2000 Nature
Death by TNF: a road to inflammation
2022
Casper Is a FADD- and Caspase-Related Inducer of Apoptosis
1997
Chemotherapy: targeting the mitochondrial cell death pathway
2002
Differential regulation of TRAIL and CD95 ligand in transformed cells of the T and B lymphocyte lineage
1998
Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents
2004
NMR structure of the death domain of the p75 neurotrophin receptor
1997
Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling
1999
Virus Inhibition of RIP3-Dependent Necrosis
2010
Resistance of cultured peripheral T cells towards activation‐induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death‐inducing signaling complex
1997
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
1998 Nature
Apoptosis by Death Factor
1997 Standout
Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development
2000
Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?
2003
Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death
1999
Granzyme B-Induced Apoptosis Requires Both Direct Caspase Activation and Relief of Caspase Inhibition
2003
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4
1997
Phosphorylation of Bid by Casein Kinases I and II Regulates Its Cleavage by Caspase 8
2001
Identification of a ligand for the death-domain-containing receptor Apo3
1998
Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system
1997
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
2006
X-linked IAP is a direct inhibitor of cell-death proteases
1997 StandoutNature
Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
1999
The Large Subunit of the DNA Replication Complex C (DSEB/RF-C140) Cleaved and Inactivated by Caspase-3 (CPP32/YAMA) during Fas-induced Apoptosis
1997
The Structural Basis for the Recognition of Diverse Receptor Sequences by TRAF2
1999
An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9
1999 Standout
TNF, Apoptosis and Autoimmunity: A Common Thread?
1998 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
2002
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
2000 Standout
The Apaf-1 apoptosome: a large caspase-activating complex
2002
Cell Death
2004 Standout
Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
1999 Nature
Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: optimal caspase substrates are not necessarily optimal inhibitors
1999
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
Bcl-2 family proteins
1998
The biochemistry of apoptosis
2000 StandoutNature
BCL-2 family members and the mitochondria in apoptosis
1999 Standout
Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells
1999
The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis
2001
Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts
2003
Mechanisms of Ischemic Injury Are Different in the Steatotic and Normal Rat Liver
2000
Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator
2000
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
2002
Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors
1998
Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
1998
Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8
2001
Mitochondrial control of cell death
2000 Standout
TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL
1997
Caspase activity is required for commitment to Fas-mediated apoptosis
1997
More than one way to die: apoptosis, necrosis and reactive oxygen damage
1999
Death receptors in chemotherapy and cancer
2004
The modular nature of apoptotic signaling proteins
1999
Cell Death in Development
1999
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
1998
Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade
1998
Intrinsic tumour suppression
2004 Nature
Characterization of two receptors for TRAIL1
1997
Apoptotic Pathways
1998
Caspase structure, proteolytic substrates, and function during apoptotic cell death
1999
Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c
1999
A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c
2001
The immune response of Drosophila
2003 StandoutNatureNobel
Different Subcellular Distribution of Caspase-3 and Caspase-7 following Fas-induced Apoptosis in Mouse Liver
1998
BID regulation by p53 contributes to chemosensitivity
2002
T cell life and death signalling via TNF-receptor family members
2000
TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)
1997
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
1998
Proteasome activation as a critical event of thymocyte apoptosis
2000
A License to Kill
1996
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations
1999
I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis
1997
Caspase-14 Is a Novel Developmentally Regulated Protease
1998
Proteases to die for
1998
Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish
2000
Transducing signals of life and death
1997
Inhibition of Fas death signals by FLIPs
1998
Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death
1999
Regulation of apoptosis by endoplasmic reticulum pathways
2003
Induction of apoptosis and chemosensitization of mesothelioma cells by Bcl‐2 and Bcl‐xL antisense treatment
2003
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
1998 Standout
Characterization of seven murine caspase family members
1997
Death and anti-death: tumour resistance to apoptosis
2002 Standout
Caspases: killer proteases
1997 Standout
Apoptosis in the development and maintenance of the immune system
2003
Bile acid-induced rat hepatocyte apoptosis is inhibited by antioxidants and blockers of the mitochondrial permeability transition
2001
Redundant cell death mechanisms as relics and backups
2005
The atomic-resolution structure of human caspase-8, a key activator of apoptosis
1999
Spontaneous apoptosis in primary cultures of human and rat hepatocytes: molecular mechanisms and regulation by dexamethasone
2002
DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis
1997 Standout
Molecular characterization of mitochondrial apoptosis-inducing factor
1999 StandoutNature
Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology
2003
Apoptosis Induction by Caspase-8 Is Amplified through the Mitochondrial Release of Cytochrome c
1998
Mitochondriotoxic compounds for cancer therapy
2006
Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis
1997
The central executioners of apoptosis: caspases or mitochondria?
1998
Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes
2003 Standout
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1998 StandoutNature
Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB
1996
An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis
2002
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response
2002
A Unified Model for Apical Caspase Activation
2003
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
2000 Standout
Mitochondrial permeability transition induced DNA-fragmentation in the rat hippocampus following hypoglycemia
1999
Errors of homeostasis and deregulated apoptosis
1997
Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II
1999
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
1997
A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila
1999 StandoutNobel
Death-inducing functions of ligands of the tumor necrosis factor family: a Sanhedrin verdict
1998
Escaping Cell Death: Survival Proteins in Cancer
1999
BI-1 Regulates an Apoptosis Pathway Linked to Endoplasmic Reticulum Stress
2004 StandoutNobel
Autoproteolytic Activation of Pro-Caspases by Oligomerization
1998 Nobel
FLICE Induced Apoptosis in a Cell-free System
1997
Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling
1997
Neisserial PorB is translocated to the mitochondria of HeLa cells infected with Neisseria meningitidis and protects cells from apoptosis
2003
The TNF and TNF Receptor Superfamilies
2001 Standout
Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway
1997
RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis
1998
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways
2001
Autoimmunity and Apoptosis
2001 StandoutNobel
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
TNF-Induced Signaling in Apoptosis
1999
Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling
2006
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Apoptotic and necrotic cell death induced by death domain receptors
2001
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis
1999
NF-κB at the crossroads of life and death
2002 Standout
Kaposi's Sarcoma
2000 Standout
Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria
2002
Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
2002 StandoutNobel
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
1997
Cytotoxic T lymphocytes: all roads lead to death
2002
Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases
1999
Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling
1999
Caspase-9 Can Be Activated without Proteolytic Processing
1999
Toso, a Cell Surface, Specific Regulator of Fas-Induced Apoptosis in T Cells
1998
CD95's deadly mission in the immune system
2000 Nature
E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways
1999
Pro-caspase-8 Is Predominantly Localized in Mitochondria and Released into Cytoplasm upon Apoptotic Stimulation
2001
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
2001 StandoutScience
Cif (Cytochrome c Efflux-Inducing Factor) Activity Is Regulated by Bcl-2 and Caspases and Correlates with the Activation of Bid
1999
Transition from Caspase-dependent to Caspase-independent Mechanisms at the Onset of Apoptotic Execution
1998
BNIP3 and Genetic Control of Necrosis-Like Cell Death through the Mitochondrial Permeability Transition Pore
2000
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore
2000
Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis
1999
NF-κB Signals Induce the Expression of c-FLIP
2001
The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling
1998
Molecular biology of Bax and Bak activation and action
2010
Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway
1997 Science
Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia
2005
Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt
1997
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Bcl-2 Inhibitors Sensitize Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis by Uncoupling of Mitochondrial Respiration in Human Leukemic CEM Cells
2004
dFADD, a Novel Death Domain-containing Adapter Protein for theDrosophila Caspase DREDD
2000
Apoptosis: A Review of Programmed Cell Death
2007 Standout
A Role of the Mitochondrial Apoptosis-Inducing Factor in Granulysin-Induced Apoptosis
2001
Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.
1996
Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor
1998
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
1998
Induction of Necrotic-Like Cell Death by Tumor Necrosis Factor Alpha and Caspase Inhibitors: Novel Mechanism for Killing Virus-Infected Cells
2000
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
2000
Lamin proteolysis facilitates nuclear events during apoptosis.
1996
Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells
1997
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal
1998
Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction
1999
Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria
2004
The protein structures that shape caspase activity, specificity, activation and inhibition
2004
Activation of the STAT Signaling Pathway Can Cause Expression of Caspase 1 and Apoptosis
1997
Two Adjacent Trimeric Fas Ligands Are Required for Fas Signaling and Formation of a Death-Inducing Signaling Complex
2003
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
Death Receptors: Signaling and Modulation
1998 StandoutScience
Lack of a Role for Jun Kinase and AP-1 in Fas-Induced Apoptosis
1997
Requirement for the CD95 Receptor-Ligand Pathway in c-Myc-Induced Apoptosis
1997 Science
The mitochondrial permeability transition pore and its role in cell death
1999 Standout
Resveratrol, a tumor‐suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl‐2
2001
Biochemical Pathways of Caspase Activation During Apoptosis
1999 Standout
Caspase-10 is an initiator caspase in death receptor signaling
2001
FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis
2001
Adenine Nucleotide Translocase-1, a Component of the Permeability Transition Pore, Can Dominantly Induce Apoptosis
1999
Bcl-w is expressed in a majority of infiltrative gastric adenocarcinomas and suppresses the cancer cell death by blocking stress-activated protein kinase/c-Jun NH2-terminal kinase activation.
2003
Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
1996
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
The Role of Caspases in Development, Immunity, and Apoptotic Signal Transduction
1999
The Incredible Life and Times of Biological Cells
2000 StandoutScienceNobel
E2 of Hepatitis C Virus Inhibits Apoptosis
2005
Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
1997
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
1997
Caspases: the executioners of apoptosis
1997 Standout
Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells
1997
FADD is required for multiple signaling events downstream of the receptor Fas.
1999
FLIP Prevents Apoptosis Induced by Death Receptors But Not by Perforin/Granzyme B, Chemotherapeutic Drugs, and Gamma Irradiation
1998
Mitochondria as Functional Targets of Proteins Coded by Human Tumor Viruses
2005
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
1999
Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance
2004
Bcl-X L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
1998
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Purified Photoproducts of Merocyanine 540 Trigger Cytochrome C Release and Caspase 8-Dependent Apoptosis in Human Leukemia and Melanoma Cells
1999
Caspase-independent Cell Killing by Fas-associated Protein with Death Domain
1998
MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic Environment
1999
Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95
1996 Science
Epstein-Barr Virus Encodes a Novel Homolog of thebcl-2Oncogene That Inhibits Apoptosis and Associates with Bax and Bak
1999
The Receptor for the Cytotoxic Ligand TRAIL
1997 StandoutScience
Newcomers in the process of mitochondrial permeabilization
2005
BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases
1996
The Mitochondrion in Cell Death Control: Certainties and Incognita
2000
The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis
1997
Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia
1999
Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins
2003
A Regulatory Role for TRAF1 in Antigen-induced Apoptosis of T Cells
1997
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Fas Ligand-Induced c-Jun Kinase Activation in Lymphoid Cells Requires Extensive Receptor Aggregation But Is Independent of DAXX, and Fas-Mediated Cell Death Does Not Involve DAXX, RIP, or RAIDD
2000
Peripheral benzodiazepine receptor ligands reverse apoptosis resistance of cancer cells in vitro and in vivo.
2002
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
1998
Apoptosis in Neural Development and Disease
2000
The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.
1999
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells
1997
Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways
1998
p28 Bap31, a Bcl-2/Bcl-XL- and Procaspase-8–associated Protein in the Endoplasmic Reticulum
1997
Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis
1997 Standout
Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis
2000
Altered Cytochrome c Display Precedes Apoptotic Cell Death in Drosophila
1999
Bcl-xLcan inhibit apoptosis in cells that have undergone Fas-induced protease activation
1997
De novo design of protein logic gates
2020 StandoutScienceNobel
Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization
1998
FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis
1998 Science
Apoptosis induction by the photosensitizer verteporfin: identification of mitochondrial adenine nucleotide translocator as a critical target.
2001
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
1996 StandoutScience
The E2F-1 Transcription Factor Promotes Caspase-8 and Bid Expression, and Enhances Fas Signaling in T Cells
2004
Works of Carsten Scaffidi being referenced
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
1997 Nature
Apoptosis signaling in lymphocytes
1999
The Role of c-FLIP in Modulation of CD95-induced Apoptosis
1999
Bcl-xL Acts Downstream of Caspase-8 Activation by the CD95 Death-inducing Signaling Complex
1998
Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells
1999
The Death Receptors
1999
Two CD95 (APO-1/Fas) signaling pathways
1998 Standout
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Activation of the CD95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells
1998
Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid
1998
Cleavage of FLICE (caspase‐8) by granzyme B during cytotoxic T lymphocyte‐induced apoptosis
1997
FLICE Is Predominantly Expressed as Two Functionally Active Isoforms, Caspase-8/a and Caspase-8/b
1997
Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide
2000
Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.
1997
The role of p53 and the CD95 (APO-1/Fas) death system in chemotherapy-induced apoptosis.
1998
Expression of c-FLIPL and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide
2000