Citation Impact
Citing Papers
Soft corrugated channel with synergistic exclusive discrimination gating for CO2 recognition in gas mixture
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Relative Unidirectional Translation in an Artificial Molecular Assembly Fueled by Light
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Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures
2011
Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
2007
Understanding organofluorine chemistry. An introduction to the C–F bond
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Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments
2011
C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation
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Development of a platform for the discovery and practical synthesis of new tetracycline antibiotics
2016
Electron Sharing and Anion–π Recognition in Molecular Triangular Prisms
2013 StandoutNobel
Porous Coordination Polymer with π Lewis Acidic Pore Surfaces, {[Cu3(CN)3{hat(CN)3(OEt)3}]⋅3 THF}n
2006 StandoutNobel
A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions
2003
CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
2012 Standout
Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases
2011
A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKaand binding affinity and evidence for intermolecular C–F⋯CN interactions
2004
PdCl2 and N‐Hydroxyphthalimide Co‐catalyzed CH Hydroxylation by Dioxygen Activation
2013
2‐Iodoxybenzoic Acid—A Simple Oxidant with a Dazzling Array of Potential Applications
2011
The Science of Antibiotic Discovery
2020 Standout
Quantification of Cation–π Interactions in Protein–Ligand Complexes: Crystal‐Structure Analysis of Factor Xa Bound to a Quaternary Ammonium Ion Ligand
2005
Solid-State Characterization and Photoinduced Intramolecular Electron Transfer in a Nanoconfined Octacationic Homo[2]Catenane
2014 StandoutNobel
Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles
2004
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
A Fluorine Scan at the Catalytic Center of Thrombin: CF, COH, and COMe Bioisosterism and Fluorine Effects on pKa and log D Values
2006
Molecular Recognition in Chemical and Biological Systems
2015
New aspects of natural products in drug discovery
2007
Electron Delocalization in a Rigid Cofacial Naphthalene‐1,8:4,5‐bis(dicarboximide) Dimer
2014 StandoutNobel
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Fluorine in medicinal chemistry
2007 Standout
Symbiotic Control in Mechanical Bond Formation
2016 StandoutNobel
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
2016 Standout
A Water-Soluble pH-Triggered Molecular Switch
2013 StandoutNobel
Controlling Switching in Bistable [2]Catenanes by Combining Donor–Acceptor and Radical–Radical Interactions
2012 StandoutNobel
Proline Editing: A General and Practical Approach to the Synthesis of Functionally and Structurally Diverse Peptides. Analysis of Steric versus Stereoelectronic Effects of 4-Substituted Prolines on Conformation within Peptides
2013
Functionalization of Graphene: Covalent and Non-Covalent Approaches, Derivatives and Applications
2012 Standout
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Mild metal-catalyzed C–H activation: examples and concepts
2016 Standout
Sliding-Ring Catenanes
2016 StandoutNobel
Mitsunobu and Related Reactions: Advances and Applications
2009
Phosphine Organocatalysis
2018 Standout
α-Amido Sulfones as Stable Precursors of ReactiveN-Acylimino Derivatives
2005
Additions to Metal-Activated Organonitriles
2002 Standout
Folding of Oligoviologens Induced by Radical–Radical Interactions
2014 StandoutNobel
Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template
2012 StandoutNobel
Redox-Controlled Selective Docking in a [2]Catenane Host
2013 StandoutNobel
Aromatische Ringe in chemischer und biologischer Erkennung: Energien und Strukturen
2011
Metal-Catalyzed Decarboxylative C–H Functionalization
2017 Standout
Two Dimensional Chiral Networks Emerging from the Aryl−F···H Hydrogen-Bond-Driven Self-Assembly of Partially Fluorinated Rigid Molecular Structures
2008 StandoutNobel
Antibiotics for Emerging Pathogens
2009 Science
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Highly Enantioselective Ag(I)-Catalyzed [3 + 2] Cycloaddition of Azomethine Ylides
2002
Synthesis and Antibacterial Activity of Pentacyclines: A Novel Class of Tetracycline Analogs
2011
Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery
2011
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
DNA-Based Asymmetric Catalysis: Sequence-Dependent Rate Acceleration and Enantioselectivity
2008 StandoutNobel
Disulfonimide-Catalyzed Asymmetric Synthesis of β3-Amino Esters Directly from N-Boc-Amino Sulfones
2013 StandoutNobel
Mechanical Bonds and Topological Effects in Radical Dimer Stabilization
2014 StandoutNobel
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Construction of Enantiopure Pyrrolidine Ring System via Asymmetric [3+2]-Cycloaddition of Azomethine Ylides
2006 Standout
Influence of Constitution and Charge on Radical Pairing Interactions in Tris-radical Tricationic Complexes
2016 StandoutNobel
The Halogen Bond
2016 Standout
Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis
2004 Standout
Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity
2009 Standout
Cu(I)-Catalyzed Highly Exo-selective and Enantioselective [3 + 2] Cycloaddition of Azomethine Ylides with Acrylates
2005
Redox Switchable Daisy Chain Rotaxanes Driven by Radical–Radical Interactions
2014 StandoutNobel
Photochromism of Diarylethene Molecules and Crystals: Memories, Switches, and Actuators
2014 Standout
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products
2017
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
Strong and Confined Acids Enable a Catalytic Asymmetric Nazarov Cyclization of Simple Divinyl Ketones
2019 StandoutNobel
Mechanical Bond-Induced Radical Stabilization
2012 StandoutNobel
Multipolar interactions in the D pocket of thrombin: large differences between tricyclic imide and lactam inhibitors
2006
Redox Control of the Binding Modes of an Organic Receptor
2015 StandoutNobel
Radically Enhanced Molecular Switches
2012 StandoutNobel
Wechselwirkungen mit aromatischen Ringen in chemischen und biologischen Erkennungsprozessen
2003
Works of C. Lerner being referenced
Bisubstrate Inhibitors of Catechol O‐Methyltransferase (COMT): the Crucial Role of the Ribose Structural Unit for Inhibitor Binding Affinity
2006
Molecular Recognition at the Active Site of Catechol‐O‐Methyltransferase: Energetically Favorable Replacement of a Water Molecule Imported by a Bisubstrate Inhibitor
2009
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity We thank F. Hoffmann–La Roche for generous support of this work. We are grateful to P. Malherbe for the cloning of COMT, P. Caspers for the expression of COMT, A. Cesura for enzyme purification, B. Wipf for fermentation, and H. W. Lahm for sequencing.
2001
Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity
2002
Molecular Recognition at the Active Site of Catechol‐O‐methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors
2011
Catechol-O-methyltransferase in complex with substituted 3′-deoxyribose bisubstrate inhibitors
2012
A Convergent Enantioselective Route to Structurally Diverse 6-Deoxytetracycline Antibiotics
2005 Science
A Robust Platform for the Synthesis of New Tetracycline Antibiotics
2008
Molekulare Erkennung in der aktiven Tasche der Catechol‐O‐ Methyltransferase: energetisch günstige Verdrängung eines von einem Bisubstratinhibitor importierten Wassermoleküls
2009
Synthesis of Novel Nonpeptidic Thrombin Inhibitors
2000
Bisubstrate Inhibitors for the Enzyme Catechol O‐Methyltransferase (COMT): Dramatic Effects of Ribose Modifications on Binding Affinity and Binding Mode
2003
X-ray Crystal Structure of a Bisubstrate Inhibitor Bound to the Enzyme Catechol-O-methyltransferase: A Dramatic Effect of Inhibitor Preorganization on Binding Affinity
2001