Citation Impact
Citing Papers
Mitochondrial dysfunction in Parkinson's disease
2016
Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness
2015 Science
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
2015 StandoutScience
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
In vivo aspects of protein folding and quality control
2016 Science
Development of P assive I mmunotherapies for S ynucleinopathies
2015
The Implications of Autophagy in Alzheimer’s Disease
2018
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
2016
Sorting out release, uptake and processing of alpha‐synuclein during prion‐like spread of pathology
2015
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
2014
Limelight on Alpha-Synuclein: Pathological and Mechanistic Implications in Neurodegeneration
2013
Spreading of α-synuclein in the face of axonal transport deficits in Parkinson's disease: A speculative synthesis
2014
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
2011
The Role of Autophagy in Parkinson's Disease
2012
Parkinson disease
2017 Standout
p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
1999
Neuropathology underlying clinical variability in patients with synucleinopathies
2011
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?
2009
Pathological roles of α-synuclein in neurological disorders
2011
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
The role of autophagy in neurodegenerative disease
2013 Standout
Unbiased Approaches to Biomarker Discovery in Neurodegenerative Diseases
2014
Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells
2016
Glucocerebrosidase is shaking up the synucleinopathies
2014
Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model
2012
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
2010
Reprogramming of human somatic cells to pluripotency with defined factors
2007 StandoutNature
Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy
2013
Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97
2014
Exosomes in the Diseased Brain: First Insights from In vivo Studies
2017
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
2013 Nature
VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
2015
Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex
2010
Exosomes in the Pathology of Neurodegenerative Diseases
2016
Zinc-finger proteins in health and disease
2017
Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives
2014
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
2010
Spreading of pathology in neurodegenerative diseases: a focus on human studies
2015
Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders
2017
Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease
2020
Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice
2011
Hsc70 Protein Interaction with Soluble and Fibrillar α-Synuclein
2011
Haematopoietic stem cells require a highly regulated protein synthesis rate
2014 Nature
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
2010
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
2011
Mdm2-mediated ubiquitylation: p53 and beyond
2009
MDM2 — master regulator of the p53 tumor suppressor protein
2000
Autophagy: Renovation of Cells and Tissues
2011 Standout
Ageing, neurodegeneration and brain rejuvenation
2016 Nature
A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP
2013
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Prion-like transmission of protein aggregates in neurodegenerative diseases
2010
Decoding ALS: from genes to mechanism
2016 StandoutNature
Immune attack: the role of inflammation in Alzheimer disease
2015 Standout
The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels
2010
Lysosomal Dysfunction in a Mouse Model of Sandhoff Disease Leads to Accumulation of Ganglioside-Bound Amyloid-β Peptide
2012
Macroautophagy Is Not Directly Involved in the Metabolism of Amyloid Precursor Protein
2010
Exploring the link between glucocerebrosidase mutations and parkinsonism
2011
Autophagy gone awry in neurodegenerative diseases
2010
Autophagy failure in Alzheimer's disease—locating the primary defect
2011
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
2015
HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration
2002
Regulation of the p53 Tumor Suppressor Protein
1999
Autophagy in Human Health and Disease
2013 Standout
Immunohistochemical evidence for macroautophagy in neurones and endothelial cells in Alzheimer's disease
2010
Depletion of Beclin-1 due to proteolytic cleavage by caspases in the Alzheimer's disease brain
2010
Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau
2010
The propagation of prion-like protein inclusions in neurodegenerative diseases
2010
Autophagy modulation as a potential therapeutic target for diverse diseases
2012 Standout
Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
2014
Autophagy and Aging
2011 Standout
Distinct RolesIn Vivofor the Ubiquitin–Proteasome System and the Autophagy–Lysosomal Pathway in the Degradation of α-Synuclein
2011
Basic mechanisms of neurodegeneration: a critical update
2010
Non-motor features of Parkinson disease
2017 Standout
Regulation of proteasome assembly and activity in health and disease
2018
Accelerating progress in induced pluripotent stem cell research for neurological diseases
2012
Molecular and clinical prodrome of Parkinson disease: implications for treatment
2010
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
2012
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
2012
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
PP2A blockade inhibits autophagy and causes intraneuronal accumulation of ubiquitinated proteins
2012
Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship
2012
Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
2014
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
2011
Linking pathways in the developing and aging brain with neurodegeneration
2014
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014
Glia and alpha-synuclein in neurodegeneration: A complex interaction
2015
The Hallmarks of Aging
2013 Standout
Proteolytic Degradation of Amyloid -Protein
2012
The epigenetics of aging and neurodegeneration
2015
Calcium and Parkinson's disease
2016
Autophagy and Neuronal Cell Death in Neurological Disorders
2012
Deep sequencing and miRNA profiles in alcohol-induced neuroinflammation and the TLR4 response in mice cerebral cortex
2018
The Aging Stress Response
2010
Are synucleinopathies prion-like disorders?
2010
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?
2012
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Subcellular targeting strategies for drug design and delivery
2009
Autophagy in immunity and inflammation
2011 StandoutNature
Exosomes, an Unmasked Culprit in Neurodegenerative Diseases
2017
Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors
2015
The autophagy effector Beclin 1: a novel BH3-only protein
2008
Autophagy Protects the Retina from Light-induced Degeneration
2013
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
Neuropathology in transplants in Parkinson's disease
2012
Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier
2019 StandoutNobel
First‐in‐human assessment of PRX002, an anti–α‐synuclein monoclonal antibody, in healthy volunteers
2016
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy
2012
Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging
2011 Science
Therapeutic prospects for Parkinson disease
2013
α‐Synuclein: The Long Distance Runner
2013
Immunotherapy in Parkinson’s Disease: Micromanaging Alpha-Synuclein Aggregation
2015
Targeting Receptor-Mediated Transport for Delivery of Biologics Across the Blood-Brain Barrier
2014
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
2010
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Functional Collaboration between Different Cyclin-Dependent Kinase Inhibitors Suppresses Tumor Growth with Distinct Tissue Specificity
2000
Endoplasmic Reticulum Stress in Immunity
2014
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Do prions cause Parkinson disease?: The evidence accumulates
2014
Ion-dependent protein–surface interactions from intrinsic solvent response
2021 StandoutNobel
Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis
2001
Autophagy in Idiopathic Pulmonary Fibrosis
2012
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Basic science breaks through: New therapeutic advances in Parkinson's disease
2015
The Synaptic Function of α-Synuclein
2015
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys
2013
Atg13 HORMA domain recruits Atg9 vesicles during autophagosome formation
2015 StandoutNobel
Surfing the p53 network
2000 StandoutNature
Regulation of p53 stability
1999
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
2013
The Biology of Proteostasis in Aging and Disease
2015
Review: The future of cell therapies and brain repair: P arkinson's disease leads the way
2013
Mutual exacerbation of peroxisome proliferator‐activated receptor γ coactivator 1α deregulation and α‐synuclein oligomerization
2014
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
2013
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
2011
Prion-like spread of protein aggregates in neurodegeneration
2012
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease
2011
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics
2010 StandoutNobel
Nondestructive nanostraw intracellular sampling for longitudinal cell monitoring
2017
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein
2015 Science
Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative Stress
2020
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
1998
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Brian Spencer being referenced
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
2009
Cell-to-Cell Transmission of α-Synuclein Aggregates
2012
α-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1
2012
α-Synuclein Sequesters Dnmt1 from the Nucleus
2011
Immunotherapy for Alzheimer’s disease: past, present and future
2014
Neuropeptide Y Fragments Derived from Neprilysin Processing Are Neuroprotective in a Transgenic Model of Alzheimer's Disease
2009
Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease
2013
Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy
2012
Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
2008
Peripheral Delivery of a CNS Targeted, Metalo-Protease Reduces Aβ Toxicity in a Mouse Model of Alzheimer's Disease
2011
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
2010
Increased proteasome activity in human embryonic stem cells is regulated by PSMD11
2012 Nature
Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease
2012
Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
2014
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease
2016
Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
2014
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice
2008
Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases
2009
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
1997
Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
2015
Targeted delivery of proteins across the blood–brain barrier
2007
2013
HSV-1 Vector-Delivered FGF2 to the Retina Is Neuroprotective but Does Not Preserve Functional Responses
2001
Widespread microRNA dysregulation in multiple system atrophy – disease‐related alteration in miR‐96
2013