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Citing Papers
EFECTO ANTIPARASITARIO DE INHIBIDORES DE CISTEIN PROTEASAS IN VITRO E IN VIVO EN LA ENFERMEDAD DE CHAGAS EXPERIMENTAL
1999
Inhibition of Trypanosomal Cysteine Proteinases by Their Propeptides
1998
A Human RNA Viral Cysteine Proteinase That Depends upon a Unique Zn2+-binding Finger Connecting the Two Domains of a Papain-like Fold
1999
Favipiravir, an anti-influenza drug against life-threatening RNA virus infections
2020
The Multiple cpb Cysteine Proteinase Genes ofLeishmania mexicana Encode Isoenzymes That Differ in Their Stage Regulation and Substrate Preferences
1997
Psychrophilic enzymes: molecular basis of cold adaptation
1997
Expression and substrate specificity of a recombinant cysteine proteinase B of Leishmania braziliensis
2008 StandoutNobel
Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay.D-Amino Acid Inhibitors for cruzipain, cathepsin B and cathepsin L
1998 StandoutNobel
Carboxydipeptidase activities of recombinant cysteine peptidases
2004
Proteolytic Activity of Human Osteoclast Cathepsin K
1996
Inference of Macromolecular Assemblies from Crystalline State
2007 Standout
Enzymatic transition states: thermodynamics, dynamics and analogue design
2004
ESKAPEing the labyrinth of antibacterial discovery
2015
Kinetics versus Thermodynamics in Protein Folding
1994 StandoutNobel
Substrate Profiling of Cysteine Proteases Using a Combinatorial Peptide Library Identifies Functionally Unique Specificities
2006
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
2001
Comparison of the specificity, stability and individual rate constants with respective activation parameters for the peptidase activity of cruzipain and its recombinant form, cruzain, from Trypanosoma cruzi
2001
Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action
1999
Discrimination of cruzipain, the major cysteine proteinase of Trypanosoma cruzi, and mammalian cathepsins B and L, by a pH‐inducible fluorogenic substrate of trypanosomal cysteine proteinases
1999
Leishmania major:Molecular Modeling of Cysteine Proteases and Prediction of New Nonpeptide Inhibitors
1997
Dissecting subunit interfaces in homodimeric proteins
2003
Cruzipain, a majorTrypanosoma cruziantigen, conditions the host immune response in favor of parasite
2002
Binding a heparin derived disaccharide to defensin inspired peptides: insights to antimicrobial inhibition from gas-phase measurements
2010 StandoutNobel
Human Cathepsin F
1998
Natural‐Product Sugar Biosynthesis and Enzymatic Glycodiversification
2008
Revised Definition of Substrate Binding Sites of Papain-Like Cysteine Proteases
1998
Characterization of a multi‐copy gene for a major stage‐specific cysteine proteinase of Leishmania mexicana
1992
Degradation of Human IgA by Entamoeba histolytica
1993
Lysosomal cysteine proteases: more than scavengers
2000
Myeloid-derived suppressor cells as regulators of the immune system
2009 Standout
Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes
2004 StandoutNobel
The role of pro regions in protein folding
1993 StandoutNobel
Crystal structure of a caricain D158E mutant in complex with E‐64
1996
The Science of Antibiotic Discovery
2020 Standout
Intermediate metabolism inTrypanosoma cruzi
1994
Structure-based drug screening for G-protein-coupled receptors
2012 StandoutNobel
Computational design of self-assembling cyclic protein homo-oligomers
2016 StandoutNobel
Aggregation-induced emission: phenomenon, mechanism and applications
2009 Standout
A yeast gene (BLH1) encodes a polypeptide with high homology to vertebrate bleomycin hydrolase, a family member of thiol proteinases
1993
Expression of human cathepsin K in Pichia pastoris and preliminary crystallographic studies of an inhibitor complex
1997
Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana
2000 StandoutNobel
Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution
2000 StandoutNobel
Directed evolution study of temperature adaptation in a psychrophilic enzyme 1 1Edited by J. A. Wells
2000 StandoutNobel
The antiamoebic effect of a crude drug formulation of herbal extracts against Entamoeba histolytica in vitro and in vivo
1995
Amoebiasis
2003 Standout
Design and synthesis of dipeptidyl α′,β′-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain
1998
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
Merging homogeneous catalysis with biocatalysis; papain as hydrogenation catalyst
2005 StandoutNobel
Identification of Leishmania major cysteine proteinases as targets of the immune response in humans
2001
Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain
2001
Structural determinants of specificity in the cysteine protease cruzain
1997
Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi Is Composed of 12 Peptides Including a Heterodimeric Ip Subunit
2009 StandoutNobel
Antibacterial drug discovery in the resistance era
2016 StandoutNature
A target within the target: probing cruzain’s P1′ site to define structural determinants for the Chagas’ disease protease
2000
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides
1997 StandoutNobel
Aggresomes: A Cellular Response to Misfolded Proteins
1998 Standout
Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
2016 Standout
Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)
2020 Standout
Vinyl Sulfonate Esters and Vinyl Sulfonamides: Potent, Irreversible Inhibitors of Cysteine Proteases
1998
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Antitumor Antibiotics: Bleomycin, Enediynes, and Mitomycin
2005 Standout
Proteasome activity is required for the stage-specific transformation of a protozoan parasite.
1996 Nobel
Cysteine Proteases and Their Inhibitors
1997
Structure-Based Drug Design: Exploring the Proper Filling of Apolar Pockets at Enzyme Active Sites
2008
Processing and trafficking of cysteine proteases in Leishmania mexicana
2000
Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.
1996
Recent advances in the synthesis of pyrroles by multicomponent reactions
2014 Standout
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
1999
Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites
2005 StandoutNobel
Docking and scoring in virtual screening for drug discovery: methods and applications
2004 Standout
Crystal structure of human cathepsin S
1998
Proteasome Inhibitors Block Development of Plasmodium spp
1998 StandoutNobel
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
2000 StandoutNobel
Small synthetic inhibitors of cysteine proteases
1996
Molecular Docking and High-Throughput Screening for Novel Inhibitors of Protein Tyrosine Phosphatase-1B
2002
Cysteine Proteinases and the Pathogenesis of Amebiasis
2000
Advances in leishmaniasis
2005 Standout
A Formal [3 + 3] Cycloaddition Approach to Natural‐Product Synthesis
2004
Parasite proteinases and amino acid metabolism: possibilities for chemotherapeutic exploitation
1997
Virtual Screening of Combinatorial Libraries across a Gene Family: in Search of Inhibitors of Giardia lamblia Guanine Phosphoribosyltransferase
2001
Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain Inhibitors
2010
Plant Products as Antimicrobial Agents
1999 Standout
Antisense Inhibition of Expression of Cysteine Proteinases Affects Entamoeba histolytica -Induced Formation of Liver Abscess in Hamsters
1999
Design, Synthesis and Evaluation of d-Homophenylalanyl Epoxysuccinate Inhibitors of the Trypanosomal Cysteine Protease Cruzain
2000
THE LYSOSOMAL CYSTEINE PROTEASES
1999
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Enzymes from psychrophilic organisms
1996
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Solid-Phase Library Synthesis, Screening, and Selection of Tight-Binding Reduced Peptide Bond Inhibitors of a RecombinantLeishmaniamexicanaCysteine Protease B
2002 StandoutNobel
Ab Initio Evaluation of the Free Energy Surfaces for the General Base/Acid Catalyzed Thiolysis of Formamide and the Hydrolysis of Methyl Thiolformate: A Reference Solution Reaction for Studies of Cysteine Proteases
2001 StandoutNobel
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy
2010
Review
1997
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase
1999 StandoutNobel
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
2000 StandoutNobel
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors
1998
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Role of the Entamoeba histolytica cysteine proteinase in amebic liver abscess formation in severe combined immunodeficient mice
1995
Cysteine Protease Inhibitors Cure an Experimental Trypanosoma cruzi Infection
1998
Metal-Free Multicomponent Syntheses of Pyridines
2014 Standout
Cysteine Protease B of Leishmania mexicana Inhibits Host Th1 Responses and Protective Immunity
2003
Works of Ann E. Eakin being referenced
Novel Bacterial NAD + -Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo
2010
Structure-based inhibitor design
2000
Purine Phosphoribosyltransferases
2000
Amplification and sequencing of genomic DNA fragments encoding cysteine proteases from protozoan parasites
1990
Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene.
1993
The Crystal Structure of Cruzain: A Therapeutic Target for Chagas' Disease
1995
Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi
2000
Approaching the Transition State in the Crystal Structure of a Phosphoribosyltransferase,
1998
Atlantic cod cDNA encoding a psychrophilic chymotrypsinogen
1994
The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi.
1992
A 1.4 Å Crystal Structure for the Hypoxanthine Phosphoribosyltransferase of Trypanosoma cruzi,
1998
A Cysteine Protease is a Target for the Enzyme Structure-Based Design of Antiparasitic Drugs
1995
Serine proteases from nematode and protozoan parasites: isolation of sequence homologs using generic molecular probes.
1989
Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi.
1993