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Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage
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Induction of tolerance in peripheral T cells with monoclonal antibodies
1990
Does T-cell tolerance require a dedicated antigen-presenting cell?
1989 Nature
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Origin of regulatory T cells with known specificity for antigen
2002
Tolerance, Danger, and the Extended Family
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Autoimmune ovarian disease: mechanism of disease induction and prevention
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HIV Infection of Naturally Occurring and Genetically Reprogrammed Human Regulatory T-cells
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2004
Decreasing the threshold for thymocyte activation biases CD4+ T cells toward a regulatory (CD4+CD25+) lineage
2003
CD4: Collaborator in immune recognition and HIV infection
1990 StandoutNobel
CD 69 expression during selection and maturation of CD4+8+ thymocytes
1993
Function and Specificity of T Cell Subsets in the Mouse
1987
T Cell Selection in the Thymus
1988
What is the role of regulatory T cells in transplantation tolerance?
1999
Attenuated T Cell Responses to a High-Potency Ligand In Vivo
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Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
1990
Regulatory T cells
2004
Tumor-Specific Human CD4+ Regulatory T Cells and Their Ligands
2004
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2011
Control of Regulatory T Cell Lineage Commitment and Maintenance
2009
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
1998
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
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Human CD25+ regulatory T cells: two subsets defined by the integrins α4β7 or α4β1 confer distinct suppressive properties upon CD4+ T helper cells
2004
Tolerogenicity of thymic epithelium
1990
Signal transduction by lymphocyte antigen receptors
1994 Standout
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
2007
Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency
1998
Regulatory T cells: how do they suppress immune responses?
2009 StandoutNobel
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
2004 StandoutNobel
How regulatory T cells work
2008 Standout
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
2007
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2005
Induction of FOXP3‐expressing regulatory CD4pos T cells by human mature autologous dendritic cells
2004
Intraclonal competition limits the fate determination of regulatory T cells in the thymus
2009
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2003 StandoutNobel
Foxp3 occupancy and regulation of key target genes during T-cell stimulation
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Idiotypic Regulation of T Cells in Graft‐Versus‐Host Disease and Autoimmunity
1989
Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus
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Biochemical identification of a direct physical interaction between the CD4: p56lck and Ti(TcR)/CD3 complexes
1991
A Two-Step Process for Thymic Regulatory T Cell Development
2008
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2008
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1989
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2005
CD25+CD4+ regulatory T cells exert in vitro suppressive activity independent of CTLA-4
2005
Regulation of Immune Responses by T Cells
2006
FOXP3+ regulatory T cells in the human immune system
2010 StandoutNobel
Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions
2009
An essential role for the IL-2 receptor in Treg cell function
2016
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
2005 Nature
Regulatory T cells in the control of immune pathology
2001
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2008
Thymic development and peripheral homeostasis of regulatory T cells
2007
Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells
2004 StandoutNobel
Compartmentalization of MHC class II gene expression in transgenic mice
1988
Transient expression of FOXP3 in human activated nonregulatory CD4 + T cells
2006
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
2006
Defective B cell development and function in Btk-deficient mice
1995
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Regulatory T cells – a brief history and perspective
2007 StandoutNobel
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
2006
Interleukin-7 receptor expression: intelligent design
2007
First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells
2009
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
2007
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
1998 StandoutNature
Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo
2001
Mechanisms of suppression by suppressor T cells
2005
Functional Analysis of FOXP3
2008
CD4+ regulatory T cells in autoimmunity and allergy
2002
Differential Cytokine Requirements for Regulation of Autoimmune Gastritis and Colitis by CD4+CD25+T Cells
2001
Extrathymic positive selection of αβ T-cell precursors in nude mice
1992 StandoutNatureNobel
CD4+CD25+ Immunoregulatory T Cells
2002
Deletion of Mls‐reactive T cells in H‐2‐compatible but Mls‐incompatible bone marrow chimeras
1989
The balance between deletion and activation of CD4+8+ thymocytes is controlled by T cell receptor‐antigen interactions and is affected by cyclosporin A
1994
The effect of thymus environment on T cell development and tolerance
1988
CD4, CD8 and tyrosine kinases in thymic selection
1993
Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor
2009
MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8
1992 Nature
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
2002 StandoutNobel
The Immunobiology of Cancer Immunosurveillance and Immunoediting
2004 Standout
Selection of regulatory T cells in the thymus
2012
Control of T cell hyperactivation in IL-2-deficient mice by CD4+CD25- and CD4+CD25+ T cells: evidence for two distinct regulatory mechanisms
2001
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation
2003
Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells
2004
Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood
2001
2013
Positive and Negative Selection of T Cells
2003
IL-2 production by self-reactive CD4 thymocytes scales regulatory T cell generation in the thymus
2019
Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal
2012
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells
2004
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
Protein-Specific Helper T-Lymphocyte Formation Initiated by Dendritic Cells
1985 StandoutScienceNobel
Identity of cells that imprint H–2-restricted T-cell specificity in the thymus
1986 Nature
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells
2006
Signaling Life and Death in the Thymus: Timing Is Everything
2003 Science
The Strength of Persistent Antigenic Stimulation Modulates Adaptive Tolerance in Peripheral CD4+ T Cells
2003
Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells
1996 Science
Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.
1993
Naturally Arising CD4+Regulatory T Cells for Immunologic Self -Tolerance and Negative Control of Immune Responses
2003 StandoutNobel
A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection
1995 Science
CD28 co-stimulation is dispensable for the steady state homeostasis of intestinal regulatory T cells
2018
Autoreactive T Cells in Healthy Individuals
2004
Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells
2017 StandoutNobel
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
2003
Essential Role for STAT5 Signaling in CD25+CD4+ Regulatory T Cell Homeostasis and the Maintenance of Self-Tolerance
2003 Nobel
De novogeneration of antigen-specific CD4+CD25+regulatory T cells from human CD4+CD25–cells
2005
Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression
2002
CD4+CD25high Regulatory Cells in Human Peripheral Blood
2001 Standout
Regulatory T Cells: Mechanisms of Differentiation and Function
2007 Standout
Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity
1999 StandoutNobel
Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen.
1983
Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells
2001
Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts
2002
Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade
2001
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
2003
Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific
2000
A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection
2003
A Nondeletional Mechanism of Thymic Self Tolerance
1989 StandoutScienceNobel
CD4+CD25− T Cells in Aged Mice Are Hyporesponsive and Exhibit Suppressive Activity
2003
Thymic epithelium and the induction of transplantation tolerance in nude mice
1985 Nature
CD4+CD25+ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells
1998
Aire
2009
Thymus and autoimmunity: capacity of the normal thymus to produce pathogenic self-reactive T cells and conditions required for their induction of autoimmune disease.
1990 StandoutNobel
Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex.
1991 StandoutNobel
Evidence from in vitro studies that tolerance to self antigens is MHC-restricted
1984 Nature
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
2009
Induction of classical transplantation tolerance in the adult.
1989
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
2000 StandoutNobel
Tolerance induction by thymic medullary epithelium.
1992 StandoutNobel
Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses
2005
Regulatory T Cells in Autoimmmunity
2000
Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes.
1996
PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
2011 StandoutNobel
Antigen-presenting cells from nonresponder strain 2 guinea pigs are fully competent to present bovine insulin B chain to responder strain 13 T cells. Evidence against a determinant selection model and in favor of a clonal deletion model of immune response gene function.
1983
A dominant-negative transgene defines a role for p56lck in thymopoiesis.
1993
Rescue of thymocytes from glucocorticoid-induced cell death mediated by CD28/CTLA-4 costimulatory interactions with B7-1/B7-2.
1996
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
1986 Standout
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Capacity of unprimed CD4+ and CD8+ T cells expressing V beta 11 receptors to respond to I-E alloantigens in vivo.
1989
CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations
2000
Inhibition of Human CD4+CD25+high Regulatory T Cell Function
2002
MHC Class II Expression Identifies Functionally Distinct Human Regulatory T Cells
2006
Developmental regulation of Foxp3 expression during ontogeny
2005
Dendritic cells are critical accessory cells for thymus-dependent antibody responses in mouse and in man.
1983 StandoutNobel
Increased T Cell Autoreactivity in the Absence of CD40-CD40 Ligand Interactions: A Role of CD40 in Regulatory T Cell Development
2001 StandoutNobel
Interleukin‐2 is essential for CD4+CD25+ regulatory T cell function
2004
Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood
2001
Activation of CD25+CD4+ Regulatory T Cells by Oral Antigen Administration
2001
Thymic Requirement for Clonal Deletion During T Cell Development
1989 Science
Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses
2001 StandoutNobel
Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes.
1995
Tyrosine 201 of the cytoplasmic tail of CTLA ‐4 critically affects T regulatory cell suppressive function
2014
THE DYNAMICS OF T CELL RECEPTOR SIGNALING: Complex Orchestration and the Key Roles of Tempo and Cooperation
1999
In Vivo Instruction of Suppressor Commitment in Naive T Cells
2004
Expression of the integrin αEβ7identifies unique subsets of CD25+as well as CD25−regulatory T cells
2002
Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells
2003 StandoutNobel
Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes
1998 StandoutNobel
Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action.
1990
The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
1996
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
2004
Early Events in T-Cell Maturation
1987
Differentiation of regulatory Foxp3+T cells in the thymic cortex
2008
Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells
2000
Human memory FOXP3+Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor RORγt
2009
A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
2005
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
2000 Standout
CTLA-4 Overexpression Inhibits T Cell Responses through a CD28-B7-Dependent Mechanism
2006 StandoutNobel
CD4+CD25+ Immunoregulatory T Cells
2002
Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function
2002
Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells
2005 StandoutNobel
Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
2011
IL-10 Is Required for Regulatory T Cells to Mediate Tolerance to Alloantigens In Vivo
2001
MOUSE CD1-SPECIFIC NK1 T CELLS: Development, Specificity, and Function
1997
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.
1999 StandoutNobel
Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells
2001
Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers
2002
CD4+CD25+T cells responding to serologically defined autoantigens suppress antitumor immune responses
2003
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells
2019
T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses
1988
Maintenance of in Vivo Tolerance by Persistence of Antigen
1992 StandoutScienceNobel
Development of Mature CD8 + Thymocytes: Selection Rather Than Instruction?
1993 Science
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
2010 StandoutNobel
Clonal deletion of self-reactive T cells in irradiation bone marrow chimeras and neonatally tolerant mice. Evidence for intercellular transfer of Mlsa.
1989
Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function
2001
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
T Cell Regulation as a Side Effect of Homeostasis and Competition
2003
CD25+ CD4+ T Cells Regulate the Expansion of Peripheral CD4 T Cells Through the Production of IL-10
2001
T Cell Reactivity to MHC Molecules: Immunity Versus Tolerance
1990 Science
Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells
2001
CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes
2004 StandoutNobel
BALB/c mice have more CD4+CD25+ T regulatory cells and show greater susceptibility to suppression of their CD4+CD25− responder T cells than C57BL/6 mice
2005
Certified Professionals
2001
Altered antigen receptor signaling in anergic T cells from self-tolerant T-cell receptor beta-chain transgenic mice.
1991
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire
2012
TGF-β Requires CTLA-4 Early after T Cell Activation to Induce FoxP3 and Generate Adaptive CD4+CD25+ Regulatory Cells
2006
Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation
1997 StandoutNobel
Self tolerance is H–2-restricted
1984 Nature
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
1996
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
2002
Immunologic effects of whole-body ultraviolet irradiation: selective defect in splenic adherent cell function in vitro.
1980 StandoutNobel
Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen
2001
Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus
2005
Essential Roles of CD8+CD122+ Regulatory T Cells in the Maintenance of T Cell Homeostasis
2004
A fail-safe mechanism for maintaining self-tolerance.
1992
Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance
1999 StandoutNobel
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
1998 Standout
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction.
1980 StandoutNobel
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance
2001
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
2009
Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory Cells
2007
CD1 Recognition by Mouse NK1 + T Lymphocytes
1995 StandoutScience
Virus and Autoimmunity: Induction of Autoimmune Disease in Mice by Mouse T Lymphotropic Virus (MTLV) Destroying CD4+ T Cells
1999 StandoutNobel
CD25+CD4+regulatory T cells suppress CD4+T cell‐mediated pulmonary hyperinflammation driven byPneumocystis cariniiin immunodeficient mice
2002
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
2004
Hyper Immunoglobulin E Response in Mice with Monoclonal Populations of B and T Lymphocytes✪
2001
In vitro–expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell–stimulated MLR cultures
2004
Human immunodeficiency virus–driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
2004
Determinants of carboxyl-terminal domain translocation during prion protein biogenesis
1994 StandoutNobel
A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood
2001
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
2007 StandoutNobel
A Role for Endogenous Transforming Growth Factor β1 in Langerhans Cell Biology: The Skin of Transforming Growth Factor β1 Null Mice Is Devoid of Epidermal Langerhans Cells
1996
The role of H-2-linked genes in helper T-cell function. III. Expression of immune response genes for trinitrophenyl conjugates of poly-L(Tyr, Glu)-poly-D,L-Ala--poly-L-Lys in B cells and macrophages.
1978
Works of Alfred Singer being referenced
TCR Activation of ZAP70 Is Impaired in CD4+CD8+ Thymocytes as a Consequence of Intrathymic Interactions that Diminish Available p56lck
1996
Clonal deletion and the fate of autoreactive thymocytes that survive negative selection
2012
Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain
1989 Nature
New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision
2002
Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4
1990 Nature
Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals
2013
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
2010 Standout
CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes
1996
Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines
2004
Crosstalk in the mouse thymus
1994
Positive selection of CD4+T cells by TCR ligation without aggregation even in the absence of MHC
1994 Nature
Coreceptor Reversal in the Thymus
2000
Peripheral Expression of Self-MHC-II Influences the Reactivity and Self-Tolerance of Mature CD4+ T Cells
2002
Positive Selection as a Developmental Progression Initiated by αβTCR Signals that Fix TCR Specificity prior to Lineage Commitment
1999
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
2005
Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment
1991
Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice
2008
Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody.
1989
CORRELATION OF INTRATHYMIC TOLERANCE WITH INTRATHYMIC CHIMERISM IN NEONATALLY TOLERIZED MICE
1985
Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells.
1994
Expression of an unusual T cell receptor (TCR)-V beta repertoire by Ly-6C+ subpopulations of CD4+ and/or CD8+ thymocytes. Evidence for a developmental relationship between Ly-6C+ thymocytes and CD4-CD8-TCR-alpha beta+ thymocytes
1991
Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus.
1982
Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection.
1987
Cytotoxic T lymphocyte responses by chimeric thymocytes. Self-recognition is determined early in T cell development.
1981
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28.
1994
Inhibition of T Cell Receptor Expression and Function in Immature CD4 + cD8 + Cells by CD4
1990 Science
IL-7 Receptor Signals Inhibit Expression of Transcription Factors TCF-1, LEF-1, and RORγt
2004
Analysis of T-cell subsets in rejection of Kb mutant skin allografts differing at class I MHC
1986 Nature
Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys.
1977
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.
1993
Maturation Versus Death of Developing Double-Positive Thymocytes Reflects Competing Effects on Bcl-2 Expression and Can Be Regulated by the Intensity of CD28 Costimulation
2001
The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymically.
1982
T cells from fully H-2 allogeneic (A replaced by B) radiation bone marrow chimeras are functionally competent and host restricted but are alloreactive against hybrid Ia determinants expressed on (A x B)F1 cells.
1982
Cellular and genetic control of antibody responses in vitro. IV. Expression of Ia antigens on accessory cells required for responses to soluble antigens including a response under Ir gene control.
1978
Major histocompatibility complex-restricted self-recognition in responses to trinitrophenyl-ficoll. Adaptive differentiation and self-recognition by B cells.
1982
Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.
1995
Role of accessory cells in B cell activation. III. Cellular analysis of primary immune response deficits in CBA/N mice: presence of an accessory cell-B cell interaction defect.
1980
Tolerance of thymocytes to allogeneic i region determinants encountered prethymically. Evidence for expression of anti-Ia receptors by T cell precursors before their entry into the thymus
1982
Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus
1996
The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice.
1981
PHENOTYPIC CHARACTERIZATION OF EARLY EVENTS OF THYMUS REPOPULATION IN RADIATION BONE MARROW CHIMERAS
1983
Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection
2006
Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.
1992
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
2012
T cell-accessory cell interactions that initiate allospecific cytotoxic T lymphocyte responses: existence of both Ia-restricted and Ia-unrestricted cellular interaction pathways.
1984
Ia+ murine epidermal Langerhans cells are deficient in surface expression of the class I major histocompatibility complex.
1986
Growth Factor Independence-1B Expression Leads to Defects in T Cell Activation, IL-7 Receptor α Expression, and T Cell Lineage Commitment
2003
In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help.
1990
T cell tolerance to non-H-2-encoded stimulatory alloantigens is induced intrathymically but not prethymically.
1983
Role of CD4 in thymocyte selection and maturation.
1989
Both L3T4+ and Lyt-2+ helper T cells initiate cytotoxic T lymphocyte responses against allogenic major histocompatibility antigens but not against trinitrophenyl-modified self.
1985
T Cell Receptor (TCR)-induced Death of Immature CD4+CD8+ Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus
1997
Cellular and genetic control of antibody responses in vitro 1.cellular requirements for the generation of genetically controlled primary IgM responses to soluble antigens
1977
Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.
1994
Differences in the MHC-restricted self-recognition repertoire of intra-thymic and extra-thymic cytotoxic T lymphocyte precursors.
1983
Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.
1982
Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.
1991
Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras.
1981
T-cell recognition of a chimaeric class II/class I MHC molecule and the role of L3T4
1985 Nature
Relationship among function, phenotype, and specificity in primary allospecific T cell populations: identification of phenotypically identical but functionally distinct primary T cell subsets that differ in their recognition of MHC class I and class II allodeterminants.
1987
Post-Transcriptional Regulation of Early T Cell Development by T Cell Receptor Signals
1992 Science
Role of the H-2 complex in the induction of T cell tolerance to self minor histocompatibility antigens.
1983
In Vivo Calcium Elevations in Thymocytes with T Cell Receptors That Are Specific for Self Ligands
1992 Science
Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.
1990
Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.
1983
Mechanisms of T Cell-B Cell Interaction
1983
Self recognition in allogeneic radiation bone marrow chimeras. A radiation- resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells
1981
Negative Selection of Precursor Thymocytes Before their Differentiation into CD4 + CD8 + Cells
1992 Science
Persistence of glucose residues on core oligosaccharides prevents association of TCR alpha and TCR beta proteins with calnexin and results specifically in accelerated degradation of nascent TCR alpha proteins within the endoplasmic reticulum.
1994
Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways.
1982
Induction of autoimmune disease in CTLA-4−/−mice depends on a specific CD28 motif that is required forin vivocostimulation
2007