Alfred Singer

18.9k total citations · 1 hit paper
185 papers, 13.7k citations indexed

About

Alfred Singer is a scholar working on Immunology, Radiology, Nuclear Medicine and Imaging and Oncology. According to data from OpenAlex, Alfred Singer has authored 185 papers receiving a total of 13.7k indexed citations (citations by other indexed papers that have themselves been cited), including 166 papers in Immunology, 42 papers in Radiology, Nuclear Medicine and Imaging and 36 papers in Oncology. Recurrent topics in Alfred Singer's work include T-cell and B-cell Immunology (152 papers), Immune Cell Function and Interaction (114 papers) and Immunotherapy and Immune Responses (78 papers). Alfred Singer is often cited by papers focused on T-cell and B-cell Immunology (152 papers), Immune Cell Function and Interaction (114 papers) and Immunotherapy and Immune Responses (78 papers). Alfred Singer collaborates with scholars based in United States, Türkiye and Japan. Alfred Singer's co-authors include Lionel Feigenbaum, Jung‐Hyun Park, Batu Erman, Terry I. Guinter, Stanley Adoro, Susan O. Sharrow, Amala Alag, Motoko Y. Kimura, Xuguang Tai and Elizabeth W. Shores and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Alfred Singer

184 papers receiving 13.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 2.9k citations Jung‐Hyun Park, Stanley Adoro et al. Nature Immunology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Alfred Singer United States	64	11.3k	2.5k	2.4k	1.1k	809	185	13.7k
Ronald H. Schwartz United States	50	8.7k 0.8×	2.0k 0.8×	2.7k 1.1×	1.7k 1.5×	947 1.2×	114	11.5k
J A Ledbetter United States	52	9.4k 0.8×	2.0k 0.8×	3.2k 1.4×	2.1k 1.9×	854 1.1×	99	12.7k
Martin E. Dorf United States	55	8.8k 0.8×	2.5k 1.0×	2.6k 1.1×	1.9k 1.7×	908 1.1×	244	12.3k
Nancy H. Ruddle United States	67	9.1k 0.8×	2.9k 1.2×	2.7k 1.1×	823 0.7×	863 1.1×	174	14.2k
Richard A. Kroczek Germany	54	9.2k 0.8×	2.2k 0.9×	2.1k 0.9×	682 0.6×	909 1.1×	103	12.5k
Iqbal S. Grewal United States	56	7.7k 0.7×	2.3k 0.9×	2.0k 0.8×	1.3k 1.2×	873 1.1×	125	10.8k
Eric J. Jenkinson United Kingdom	56	6.6k 0.6×	1.7k 0.7×	2.8k 1.2×	518 0.5×	904 1.1×	170	10.2k
Maureen Howard United States	39	5.7k 0.5×	2.5k 1.0×	1.9k 0.8×	661 0.6×	441 0.5×	87	9.2k
Marie Malissen France	54	7.1k 0.6×	1.9k 0.7×	2.3k 1.0×	1.1k 1.0×	670 0.8×	139	9.2k
Peter J. van den Elsen Netherlands	57	6.3k 0.6×	2.0k 0.8×	3.0k 1.2×	841 0.8×	1.3k 1.6×	193	9.8k

Countries citing papers authored by Alfred Singer

Since Specialization

Citations

This map shows the geographic impact of Alfred Singer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred Singer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred Singer more than expected).

Fields of papers citing papers by Alfred Singer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred Singer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred Singer. The network helps show where Alfred Singer may publish in the future.

Co-authorship network of co-authors of Alfred Singer

This figure shows the co-authorship network connecting the top 25 collaborators of Alfred Singer. A scholar is included among the top collaborators of Alfred Singer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alfred Singer. Alfred Singer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Shinzawa, Miho, E. Ashley Moseman, Selamawit Gossa, et al.. (2022). Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus. Nature Immunology. 23(5). 731–742. 27 indexed citations

Lu, Jinghua, François Van Laethem, Ingrid Saba, et al.. (2020). Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155. The Journal of Immunology. 204(12). 3351–3359. 8 indexed citations

Kadakia, Tejas, Xuguang Tai, Michael J. Kruhlak, et al.. (2019). E-protein–regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex. The Journal of Experimental Medicine. 216(8). 1749–1761. 21 indexed citations

Hong, Jinsung, Chenghao Ge, Prithiviraj Jothikumar, et al.. (2018). A TCR mechanotransduction signaling loop induces negative selection in the thymus. Nature Immunology. 19(12). 1379–1390. 96 indexed citations

Tikhonova, Anastasia N., François Van Laethem, Ken‐ichi Hanada, et al.. (2011). αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities. Immunity. 36(1). 79–91. 82 indexed citations

Park, Jung‐Hyun, Stanley Adoro, Terry I. Guinter, et al.. (2010). Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nature Immunology. 11(3). 257–264. 2928 indexed citations breakdown →

Sarafova, Sophia D., François Van Laethem, Stanley Adoro, et al.. (2009). Upregulation of CD4 Expression during MHC Class II-Specific Positive Selection Is Essential for Error-free Lineage Choice. Immunity. 31(3). 480–490. 16 indexed citations

Graham, Daniel B., Michael P. Bell, Catherine J. Huntoon, et al.. (2006). CD28 Ligation Costimulates Cell Death but Not Maturation of Double-Positive Thymocytes due to Defective ERK MAPK Signaling. The Journal of Immunology. 177(9). 6098–6107. 12 indexed citations

Park, Jung‐Hyun, et al.. (2006). Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection. The Journal of Experimental Medicine. 203(1). 165–175. 73 indexed citations

10.

Doan, Loretta L., Qing Yu, Alfred Singer, et al.. (2003). Growth Factor Independence-1B Expression Leads to Defects in T Cell Activation, IL-7 Receptor α Expression, and T Cell Lineage Commitment. The Journal of Immunology. 170(5). 2356–2366. 47 indexed citations

11.

McKean, D J, Catherine J. Huntoon, Michael P. Bell, et al.. (2001). Maturation Versus Death of Developing Double-Positive Thymocytes Reflects Competing Effects on Bcl-2 Expression and Can Be Regulated by the Intensity of CD28 Costimulation. The Journal of Immunology. 166(5). 3468–3475. 36 indexed citations

12.

Roberts, Joseph L., et al.. (1995). TCRα-CD3δϵ association is the initial step in αβ dimer formation in murine T cells and is limiting in immature CD4+CD8+ thymocytes. Immunity. 2(4). 391–399. 68 indexed citations

13.

McCluskey, James, T I Munitz, Lisa F. Boyd, et al.. (1988). Cell surface expression of the amino-terminal domain of A kappa alpha. Recognition of an isolated MHC antigenic structure by allospecific T cells but not alloantibodies.. The Journal of Immunology. 140(6). 2081–2089. 9 indexed citations

14.

Mizuochi, Toshiaki & Alfred Singer. (1988). Intrathymic differentiation and tolerance induction of lymphokine-secreting Lyt-2+ T helper cells.. The Journal of Immunology. 140(5). 1421–1424. 5 indexed citations

15.

Rosenberg, Aaron S., Toshiaki Mizuochi, & Alfred Singer. (1988). Evidence for involvement of dual-function T cells in rejection of MHC class I disparate skin grafts. Assessment of MHC class I alloantigens as in vivo helper determinants.. The Journal of Experimental Medicine. 168(1). 33–45. 42 indexed citations

16.

Asano, Yoshihiro, Minoru Shigeta, C. Garrison Fathman, Alfred Singer, & Richard J. Hodes. (1982). Role of the major histocompatibility complex in T cell activation of B cell subpopulations. A single monoclonal T helper cell population activates different B cell subpopulations by distinct pathways.. The Journal of Experimental Medicine. 156(2). 350–360. 38 indexed citations

17.

Morrissey, P J, et al.. (1982). Tolerance of thymocytes to allogeneic i region determinants encountered prethymically. Evidence for expression of anti-Ia receptors by T cell precursors before their entry into the thymus. The Journal of Experimental Medicine. 155(6). 1638–1652. 25 indexed citations

18.

Singer, Alfred, P J Morrissey, K S Hathcock, et al.. (1981). Role of the major histocompatibility complex in T cell activation of B cell subpopulations. lyb-5(+) and lyb-5(-) B cell subpopulations differ in their requirement for major histocompatibility complex-restricted T cell recognition. The Journal of Experimental Medicine. 154(2). 501–516. 69 indexed citations

19.

Singer, Alfred, Howard B. Dickler, & Richard J. Hodes. (1977). Cellular and genetic control of antibody responses in vitro. II. Ir gene control of primary IgM responses to trinitrophenyl conjugates of poly-L-(Tyr,Glu)-poly-D,L-Ala--poly-L-Lys and poly-L-(His,Glu)-poly-D,L-Ala--poly-L-Lys.. The Journal of Experimental Medicine. 146(4). 1096–1107. 10 indexed citations

20.

Bregman, David, et al.. (1976). Anomalous origin of the right coronary artery from the pulmonary artery. Journal of Thoracic and Cardiovascular Surgery. 72(4). 626–630. 39 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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