Alfred Singer

18.9k citations

185 papers · 13.7k indexed · 1 hit paper · h-index 64

Impact in

Immunology top 0.05%
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
Oncology top 1%
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers

Papers in ⓘ

Immunology 166
- T-cell and B-cell Immunology 152
- Immune Cell Function and Interaction 114
- Immunotherapy and Immune Responses 78
- Immune Response and Inflammation 7
Radiology, Nuclear Medicine and Imaging 42
- Monoclonal and Polyclonal Antibodies Research 41

Co-authors: Lionel Feigenbaum (19 shared papers)Jung‐Hyun Park (14 shared papers)Batu Erman (16 shared papers)Terry I. Guinter (24 shared papers)Stanley Adoro (7 shared papers)Susan O. Sharrow (31 shared papers)Motoko Y. Kimura (9 shared papers)Amala Alag (12 shared papers)
Journals: The Journal of Experimental Medicine (42 papers)The Journal of Immunology (35 papers)Nature Immunology (14 papers)Immunity (13 papers)Proceedings of the National Academy of Sciences (11 papers)
Partner nations: United States Türkiye Japan

In The Last Decade

Alfred Singer

184 papers receiving 13.3k citations

Hit Papers

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Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells 2010 · 2.9k citations

Peers

Countries citing papers authored by Alfred Singer

Since Specialization

Citations

This map shows the geographic impact of Alfred Singer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alfred Singer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alfred Singer more than expected).

Fields of papers citing papers by Alfred Singer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alfred Singer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alfred Singer. The network helps show where Alfred Singer may publish in the future.

Co-authors

The 25 scholars most cited alongside Alfred Singer, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alfred Singer Line = papers co-authored together Alfred Singer links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 185 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells Nature Immunology ·Jung‐Hyun Park, Stanley Adoro, Terry I. Guinter, Batu Erman, Amala Alag, Marta Catálfamo, Motoko Y. Kimura, Yongzhi Cui, Philip J. Lucas, Ronald E. Gress, Masato Kubo, Lothar Hennighausen, Lionel Feigenbaum, Alfred Singer Hit paper breakdown →	2010	2928
2	CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 Nature Immunology ·Xuguang Tai, Michelle L. Cowan, Lionel Feigenbaum, Alfred Singer	2005	478
3	Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines Immunity ·Jung‐Hyun Park, Qing Yu, Batu Erman, Jacob Appelbaum, Diego E. Montoya–Durango, H. Leighton Grimes, Alfred Singer	2004	386
4	Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice Nature reviews. Immunology ·Alfred Singer, Stanley Adoro, Jung‐Hyun Park	2008	334
5	Crosstalk in the mouse thymus Immunology Today ·Willem van Ewijk, Elizabeth W. Shores, Alfred Singer	1994	217
6	Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. The Journal of Experimental Medicine ·Jennifer A. Punt, Barbara A. Osborne, Yousuke Takahama, Susan O. Sharrow, Alfred Singer	1994	217
7	Coreceptor Reversal in the Thymus Immunity ·Enrico Brugnera, Avinash Bhandoola, Ricardo Cibotti, Qing Yu, Terry I. Guinter, Yoshio Yamashita, Susan O. Sharrow, Alfred Singer	2000	208
8	Basis of CTLA-4 function in regulatory and conventional CD4+ T cells Blood ·Xuguang Tai, François Van Laethem, Leonid A. Pobezinsky, Terry I. Guinter, Susan O. Sharrow, Anthony J. Adams, Larry Granger, Michael J. Kruhlak, Tullia Lindsten, Craig B. Thompson, Lionel Feigenbaum, Alfred Singer	2012	204
9	T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex Science ·Paul E. Love, Elizabeth W. Shores, Mark D. Johnson, Michel L. Tremblay, Eric J. Lee, Alexander Grinberg, Sing Ping Huang, Alfred Singer, Heiner Westphal	1993	197
10	Foxp3 Transcription Factor Is Proapoptotic and Lethal to Developing Regulatory T Cells unless Counterbalanced by Cytokine Survival Signals Immunity ·Xuguang Tai, Batu Erman, Amala Alag, Jie Mu, Motoko Y. Kimura, Gil Katz, Terry I. Guinter, Tom M. McCaughtry, Ruth Etzensperger, Lionel Feigenbaum, Dinah S. Singer, Alfred Singer	2013	174
11	Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck. The EMBO Journal ·Sarah Anderson, Kristin M. Abraham, Toshinori Nakayama, Alfred Singer, Roger M. Perlmutter	1992	167
12	Phenotype, specificity, and function of T cell subsets and T cell interactions involved in skin allograft rejection. The Journal of Experimental Medicine ·Aaron S. Rosenberg, Toshiaki Mizuochi, S O Sharrow, Alfred Singer	1987	165
13	Disorganization and restoration of thymic medullary epithelial cells in T cell receptor‐negative scid mice: Evidence that receptor‐bearing lymphocytes influence maturation of the thymic microenvironment European Journal of Immunology ·Elizabeth W. Shores, Willem van Ewijk, Alfred Singer	1991	150
14	Deletion of CD4 and CD8 Coreceptors Permits Generation of αβT Cells that Recognize Antigens Independently of the MHC Immunity ·François Van Laethem, Sophia D. Sarafova, Jung‐Hyun Park, Xuguang Tai, Leonid A. Pobezinsky, Terry I. Guinter, Stanley Adoro, Anthony J. Adams, Susan O. Sharrow, Lionel Feigenbaum, Alfred Singer	2007	146
15	Self recognition in allogeneic radiation bone marrow chimeras. A radiation- resistant host element dictates the self specificity and immune response gene phenotype of T-helper cells The Journal of Experimental Medicine ·Alfred Singer, K S Hathcock, R J Hodes	1981	143
16	Clonal deletion and the fate of autoreactive thymocytes that survive negative selection Nature Immunology ·Leonid A. Pobezinsky, Georgi S. Angelov, Xuguang Tai, Susanna Jeurling, François Van Laethem, Lionel Feigenbaum, Jung‐Hyun Park, Alfred Singer	2012	138
17	Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules. The Journal of Experimental Medicine ·David L. Wiest, Lydia C. Yuan, J. Jefferson, Patricia Benveniste, Maria Tsokos, Richard D. Klausner, Laurie H. Glimcher, Lawrence E. Samelson, Alfred Singer	1993	134
18	Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. The Journal of Experimental Medicine ·Joseph L. Roberts, Susan O. Sharrow, Alfred Singer	1990	129
19	'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR Nature Immunology ·Jung‐Hyun Park, Stanley Adoro, Philip J. Lucas, Sophia D. Sarafova, Amala Alag, Loretta L. Doan, Batu Erman, Xiaolong Liu, Wilfried Ellmeier, Rémy Bosselut, Lionel Feigenbaum, Alfred Singer	2007	127
20	Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain Nature ·Toshinori Nakayama, Alfred Singer, Eric D. Hsi, Lawrence E. Samelson	1989	126

About Alfred Singer

Alfred Singer is a scholar working on Immunology, Radiology, Nuclear Medicine and Imaging, Oncology, Immunology and Allergy and Molecular Biology, having authored 185 papers that have together received 13.7k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (152 papers), Immune Cell Function and Interaction (114 papers), Immunotherapy and Immune Responses (78 papers), Monoclonal and Polyclonal Antibodies Research (41 papers), CAR-T cell therapy research (20 papers), Glycosylation and Glycoproteins Research (8 papers), Immune Response and Inflammation (7 papers) and Diabetes and associated disorders (6 papers). The work is most often cited by research in Immunology (11.3k citations), Oncology (2.5k citations), Transplantation (211 citations), Immunology and Allergy (350 citations) and Hematology (536 citations). Alfred Singer has collaborated with scholars based in United States, Türkiye and Japan. Frequent co-authors include Lionel Feigenbaum, Jung‐Hyun Park, Batu Erman, Terry I. Guinter, Stanley Adoro, Susan O. Sharrow, Motoko Y. Kimura, Amala Alag, Xuguang Tai and Elizabeth W. Shores. Their work appears in journals such as The Journal of Experimental Medicine, The Journal of Immunology, Nature Immunology, Immunity and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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