Citation Impact
Citing Papers
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
Progressive Disruption of Cellular Protein Folding in Models of Polyglutamine Diseases
2006 Science
Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression
2006
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
CRISPR/Cas9 in Genome Editing and Beyond
2016
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
2009
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
The CRISPR tool kit for genome editing and beyond
2018
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
2024 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans
2014 StandoutNobel
Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing
2018
Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans
2010
In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation
2017
Firefly luciferase mutants as sensors of proteome stress
2011
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
2018
Inducible and multiplex gene regulation using CRISPR–Cpf1-based transcription factors
2017
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
2016
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
2017
Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
2018 Nature
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
2017
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Enabling functional genomics with genome engineering
2015
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
2015
Celastrols as Inducers of the Heat Shock Response and Cytoprotection
2004 Standout
Chaperonin TRiC Promotes the Assembly of polyQ Expansion Proteins into Nontoxic Oligomers
2006
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
2017
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage
2017
Small-molecule proteostasis regulators for protein conformational diseases
2011
TCF1 in T cell immunity: a broadened frontier
2021
Diversity and evolution of class 2 CRISPR–Cas systems
2017
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
2016
Mechanism of the eukaryotic chaperonin: protein folding in the chamber of secrets
2004
Hypoxia drives glucose transporter 3 expression through hypoxia-inducible transcription factor (HIF)–mediated induction of the long noncoding RNA NICI
2019 StandoutNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions
2006
Identification of MOAG-4/SERF as a Regulator of Age-Related Proteotoxicity
2010
Deep learning improves prediction of CRISPR–Cpf1 guide RNA activity
2018
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Cellular Strategies of Protein Quality Control
2011
A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
2015
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
2008
Global Functional Analyses of Cellular Responses to Pore-Forming Toxins
2011
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
2020 StandoutNobel
Accessing the Phenotype Gap: Enabling Systematic Investigation of Paralog Functional Complexity with CRISPR
2017
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
2020
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
The next generation of CRISPR–Cas technologies and applications
2019
The Caenorhabditis elegans K10C2.4 Gene Encodes a Member of the Fumarylacetoacetate Hydrolase Family
2008
Finding function in novel targets: C. elegans as a model organism
2006
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity
2011
Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state
2006
The Hallmarks of Aging
2013 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow
2016
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Partial DNA-guided Cas9 enables genome editing with reduced off-target activity
2018
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
Gene drive inhibition by the anti-CRISPR proteins AcrIIA2 and AcrIIA4 in Saccharomyces cerevisiae
2018
CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing
2019
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
2017
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
CRISPR Correction of Duchenne Muscular Dystrophy
2018
ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants
2019 StandoutNobel
Evolution and Ecology of CRISPR
2016
CRISPR-CasΦ from huge phages is a hypercompact genome editor
2020 StandoutScienceNobel
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Genome-wide comprehensive analysis of human helicases
2011
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling
2012 StandoutNobel
Compensatory regulation among ER chaperones in C. elegans
2005
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease
2015
De novo design of protein homodimers containing tunable symmetric protein pockets
2022 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Genome-wide comprehensive analysis of human helicases.
2011
De novo design of protein logic gates
2020 StandoutScienceNobel
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016
Disabling Cas9 by an anti-CRISPR DNA mimic
2017 StandoutNobel
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Alejandro Chavez being referenced
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
2004
Accurate analysis of genuine CRISPR editing events with ampliCan
2019
Comparison of Cas9 activators in multiple species
2016
Highly efficient Cas9-mediated transcriptional programming
2015
Telomeres do the (un)twist: Helicase actions at chromosome termini
2009
Cas9 gRNA engineering for genome editing, activation and repression
2015
An enhanced CRISPR repressor for targeted mammalian gene regulation
2018
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast
2018
A critical role for TCF-1 in T-lineage specification and differentiation
2011 Nature
Safeguarding CRISPR-Cas9 gene drives in yeast
2015
sgRNA Scorer 2.0: A Species-Independent Model To Predict CRISPR/Cas9 Activity
2017