Standout Papers

Targeting the DNA repair defect in BRCA mutant cells as a thera... 1995 2026 2005 2015 4.6k
  1. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy (2005)
    Hannah Farmer, Nuala McCabe et al. Nature
  2. Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers (2009)
    Peter C.C. Fong, David S. Boss et al. New England Journal of Medicine
  3. PARP inhibitors: Synthetic lethality in the clinic (2017)
    Christopher J. Lord, Alan Ashworth Science
  4. The DNA damage response and cancer therapy (2012)
    Christopher J. Lord, Alan Ashworth Nature
  5. An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1 (1995)
    Michael F. Olson, Alan Ashworth et al. Science
  6. Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition (2006)
    Nuala McCabe, Nicholas C. Turner et al. Cancer Research
  7. BRCAness revisited (2016)
    Christopher J. Lord, Alan Ashworth Nature reviews. Cancer
  8. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus (1992)
    Neil Brockdorff, Alan Ashworth et al. Cell
  9. Resistance to therapy caused by intragenic deletion in BRCA2 (2008)
    Stacey L. Edwards, Rachel Brough et al. Nature
  10. Poly(ADP)-Ribose Polymerase Inhibition: Frequent Durable Responses in BRCA Carrier Ovarian Cancer Correlating With Platinum-Free Interval (2010)
    Peter C.C. Fong, Timothy A. Yap et al. Journal of Clinical Oncology
  11. A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair (2008)
    Alan Ashworth Journal of Clinical Oncology
  12. Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome (1991)
    Neil Brockdorff, Alan Ashworth et al. Nature
  13. Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function (2018)
    Eric Shifrut, Julia Carnevale et al. Cell
  14. Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence (2022)
    Julia A. Belk, Winnie Yao et al. Cancer Cell

Immediate Impact

4 by Nobel laureates 52 from Science/Nature 96 standout
Sub-graph 1 of 17

Citing Papers

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance
2024 StandoutNature
Transcription–replication conflicts underlie sensitivity to PARP inhibitors
2024 StandoutNature
33 intermediate papers

Works of Alan Ashworth being referenced

PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
and 30 more

Author Peers

Author Last Decade Papers Cites
Alan Ashworth 26118 19056 7266 268 36.8k
Andrew Tutt 14375 15774 5158 161 23.9k
Christopher J. Lord 16571 14756 3892 192 23.8k
Alan D. D’Andrea 24904 11026 4935 310 32.0k
Jos Jonkers 13413 10011 3189 235 20.9k
Myles Brown 35122 10100 11997 285 49.2k
Jorge S. Reis‐Filho 16809 17595 4111 516 36.8k
Jiří Bártek 40971 22942 4563 378 52.8k
Michael J. Birrer 13353 9280 2331 422 24.9k
William C. Hahn 26136 11079 3079 289 40.1k
Thomas Helleday 17550 9992 2115 262 21.6k

All Works

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