Standout Papers
Citation Impact
Citing Papers
Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response
2015
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Structure of the human TRPM4 ion channel in a lipid nanodisc
2017 StandoutScienceNobel
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Subnuclear Trafficking of Estrogen Receptor-α and Steroid Receptor Coactivator-1
2000
Piezo1 Channels Are Inherently Mechanosensitive
2016 StandoutNobel
Structure and specificity of nuclear receptor–coactivator interactions
1998
The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ
1999
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Selective oestrogen receptor modulators: potential therapeutic applications
1998
Enhancement of Estrogen Receptor Transcriptional Activity by the Coactivator GRIP-1 Highlights the Role of Activation Function 2 in Determining Estrogen Receptor Pharmacology
1998
A comparison of transcriptional activation by ERα and ERβ
1999
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels
2016
Therapeutic potential of selective estrogen receptor modulators
1998
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
2017 Nature
Incorporation of Prior Phase Information Strengthens Maximum-Likelihood Structure Refinement
1998
Spectator no more, the role of the membrane in regulating ion channel function
2016
K2P2.1 (TREK-1)–activator complexes reveal a cryptic selectivity filter binding site
2017 Nature
Dawning of a new era in TRP channel structural biology by cryo-electron microscopy
2018
Potentiation of Human Estrogen Receptor α Transcriptional Activation through Phosphorylation of Serines 104 and 106 by the Cyclin A-CDK2 Complex
1999
The nuclear receptor ligand-binding domain: structure and function
1998
The Protective Effects of Estrogen on the Cardiovascular System
1999 Standout
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
Cloning and Characterization of Human Estrogen Receptor β Isoforms
1998
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Structure of the BTB Domain of Keap1 and Its Interaction with the Triterpenoid Antagonist CDDO
2014
Structures of parasitic CDPK domains point to a common mechanism of activation
2010
The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators
2001
Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase
1999
Nuclear receptor coactivators
1997
Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway
2015
Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2
2018
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
1998
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
1998 StandoutNature
Mechanically Activated Ion Channels
2015 StandoutNobel
Cryo-EM structures of fungal and metazoan mitochondrial calcium uniporters
2018 Nature
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists
1998
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch
2016 StandoutNobel
Molecular determinants of nuclear receptor-corepressor interaction
1999
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
“Force-from-lipids” gating of mechanosensitive channels modulated by PUFAs
2017
Cloning of a Novel Member of the UDP-Galactose:β-N-Acetylglucosamine β1,4-Galactosyltransferase Family, β4Gal-T4, Involved in Glycosphingolipid Biosynthesis
1998
Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
2002
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
1998
Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM
2017
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor
1998
Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels
2019
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Super-resolution biomolecular crystallography with low-resolution data
2010 StandoutNatureNobel
Molecular Cloning of an Estrogen Receptor β Subtype from the Goldfish,Carassius auratus
1999
The fundamentals of protein folding: bringing together theory and experiment
1999
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Transition state in the folding of α‐lactalbumin probed by the 6‐120 disulfide bond
1998
Chk2 Oligomerization Studied by Phosphopeptide Ligation
2008 StandoutNobel
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
1998 Standout
Plant mechanosensitive ion channels: an ocean of possibilities
2017
Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology
2017
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors
1999
Interaction of the Mechanosensitive Channel, MscS, with the Membrane Bilayer through Lipid Intercalation into Grooves and Pockets
2019
Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy
2003
Human TRPML1 channel structures in open and closed conformations
2017 NatureNobel
Secretion systems in Gram-negative bacteria: structural and mechanistic insights
2015
The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine Systems
1998
Production and Actions of Estrogens
2002 Standout
Competition between Thyroid Hormone Receptor-associated Protein (TRAP) 220 and Transcriptional Intermediary Factor (TIF) 2 for Binding to Nuclear Receptors
1999
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors
2000
Hormone-independent Transcriptional Activation and Coactivator Binding by Novel Orphan Nuclear Receptor ERR3
1999
Increasing the Complexity of Coactivation in Nuclear Receptor Signaling
1999
Atomic structure of progesterone complexed with its receptor
1998 Nature
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels
2016
Role of conserved residues in structure and stability: Tryptophans of human serum retinol‐binding protein, a model for the lipocalin superfamily
2001
The Multifaceted Mechanisms of Estradiol and Estrogen Receptor Signaling
2001
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Different positioning of the ligand-binding domain helix 12and the F domain of the estrogen receptor accounts for functional differences between agonists and antagonists
1998
A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors in Vivo
1999
A Novel Isoform of Rat Estrogen Receptor Beta with 18 Amino Acid Insertion in the Ligand Binding Domain as a Putative Dominant Negative Regulator of Estrogen Action
1998
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
1998 Standout
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
2000
Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states
2017
Mechanistic Principles in NR Box-Dependent Interaction between Nuclear Hormone Receptors and the Coactivator TIF2
1998
Antiestrogenic Action of Raloxifene and Tamoxifen: Today and Tomorrow
1998
The ion selectivity filter is not an activation gate in TRPV1-3 channels
2019
Coactivator Peptides Have a Differential Stabilizing Effect on the Binding of Estrogens and Antiestrogens with the Estrogen Receptor
1999
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION
1999
Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors
1998 Science
Orphan Nuclear Receptors: From Gene to Function*
1999
Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms
2020
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Peptide Antagonists of the Human Estrogen Receptor
1999 Science
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells
2016
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
The coregulator exchange in transcriptional functions of nuclear receptors
2000 Standout
Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains
1998
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β
1999
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
1999 Standout
Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway
1999 StandoutNobel
The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions
1999
Direct Visualization of the Human Estrogen Receptor α Reveals a Role for Ligand in the Nuclear Distribution of the Receptor
1999
Bacterial Mechanosensors
2017
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
Mechanisms of Estrogen Action
2001 Standout
Long-range order in the src SH3 folding transition state
2000 StandoutNobel
Connections and Regulation of the Human Estrogen Receptor
2002 Science
The Molecular Pharmacology of SERMs
1999
Molecular Determinants of the Estrogen Receptor-Coactivator Interface
1999
Architecture and function of metallopeptidase catalytic domains
2013
Substrate Binding and Catalysis by Ubiquitin C-Terminal Hydrolases: Identification of Two Active Site Residues
1996
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors
2000
Asymmetric mechanosensitivity in a eukaryotic ion channel
2017
Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS
2019
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Estrogen Receptor Subtype-Selective Ligands: Asymmetric Synthesis and Biological Evaluation of cis- and trans-5,11-Dialkyl- 5,6,11,12-tetrahydrochrysenes
1999
Atomic-Scale Structure and Catalytic Reactivity of the RuO2(110) Surface
2000 StandoutScienceNobel
Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel
2018
Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states
2016
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization
1999
Structural diversity of calmodulin binding to its target sites
2013
Crystallographic study of interaction between adspecies on metal surfaces
1998
The selective oestrogen receptor modulation: evolution and clinical applications
1999
Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β*
1999
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2
2015
Nonnuclear Actions of Estrogen
2002
An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens
1999
P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
1999
Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice
1999 StandoutNobel
Works of A.C.W. Pike being referenced
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
2015 Science
The Structural Basis of ZMPSTE24-Dependent Laminopathies
2013 Science
Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases
2013
Structure and Regulation of the Human Nek2 Centrosomal Kinase
2006
Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
2017
Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
1999 Standout
Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation
2010
Crystal structures of guinea-pig, goat and bovine α-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase
1996
A prominent -hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation
2010
Molecular basis of agonism and antagonism in the oestrogen receptor
1997 StandoutNature
Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor α
2002
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
2016
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2
2017
A structural basis for the interaction of urea with lysozyme
1994
Structural Insights into the Mode of Action of a Pure Antiestrogen
2001
Coverage-dependent Bond Length of Chlorine Adsorbed on Cu{111}
1996
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states
2013
Study by mutagenesis of the roles of two aromatic clusters of alpha-lactalbumin in aspects of its action in the lactose synthase system.
1994