Citation Impact
Citing Papers
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
2009 Standout
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
2013 StandoutNobel
Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?
2009
Determination of diphenhydramine by capillary electrophoresis with tris(2,2′-bipyridyl)ruthenium(II) electrochemiluminescence detection
2003
New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays
2010 Standout
Organoid Models and Applications in Biomedical Research
2015 Standout
Drug-Induced Hepatotoxicity
2003 Standout
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Fluorine in Medicinal Chemistry
2015
HLA-B*5701 Screening for Hypersensitivity to Abacavir
2008 Standout
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice
2007
Identification of sulfation sites of metabolites and prediction of the compounds’ biological effects
2006
Drug discovery for a new generation of covalent drugs
2012
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Complex reactions catalyzed by cytochrome P450 enzymes
2006
The ChEMBL database in 2017
2016 Standout
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Induced pluripotent stem cell–derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice
2010 StandoutNobel
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Mammalian aldehyde oxidases: genetics, evolution and biochemistry
2007
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
Alzheimer's Disease
2004 Standout
Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors
2010
Stem cell-derived polarized hepatocytes
2020 StandoutNobel
The pharmacogenetics of antiretroviral therapy
2006
New atypical antipsychotics for schizophrenia: iloperidone
2010
Ruthenium‐Catalyzed Direct Methylation of Primary and Secondary Aromatic Amines Using Carbon Dioxide and Molecular Hydrogen
2013
Strategies for Discovering and Derisking Covalent, Irreversible Enzyme Inhibitors
2010
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Fluorine in medicinal chemistry
2007 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Enantioselective α-Hydroxylation of 2-Arylacetic Acid Derivatives and Buspirone Catalyzed by Engineered Cytochrome P450 BM-3
2006 StandoutNobel
Targeted Covalent Inhibitors for Drug Design
2016
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Recent Advances in Transition Metal Catalyzed Oxidation of Organic Substrates with Molecular Oxygen
2005 Standout
Covalent Modifiers: An Orthogonal Approach to Drug Design
2009
Applications of Deuterium in Medicinal Chemistry
2019
Heterocycles in drugs and drug discovery
2012
Accessing Drug Metabolites via Transition‐Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration
2016
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Common and Uncommon Cytochrome P450 Reactions Related to Metabolism and Chemical Toxicity
2001
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Metabolism-guided drug design
2012
The Catalytic Asymmetric Intermolecular Prins Reaction
2021 StandoutNobel
Sustainable Conversion of Carbon Dioxide: An Integrated Review of Catalysis and Life Cycle Assessment
2017 Standout
Transition-Metal-Catalyzed C−S, C−Se, and C−Te Bond Formation via Cross-Coupling and Atom-Economic Addition Reactions
2011 Standout
Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification
2018 StandoutNobel
Galantamine in AD
2000
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
The resurgence of covalent drugs
2011
Constituents in Kava Extracts Potentially Involved in Hepatotoxicity: A Review
2011
Synthesis of 2-Aminobenzothiazole via Copper(I)-Catalyzed Tandem Reaction of 2-Iodobenzenamine with Isothiocyanate
2009
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Electrogenerated Chemiluminescence and Its Biorelated Applications
2008 Standout
NADPH-Dependent Covalent Binding of [3H]Paroxetine to Human Liver Microsomes and S-9 Fractions: Identification of an Electrophilic Quinone Metabolite of Paroxetine
2007
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
The Mononuclear Molybdenum Enzymes
2014 Standout
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
2011
Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450 BM3 demethylases
2009 StandoutNobel
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Chemistry: Chemical con artists foil drug discovery
2014 StandoutNature
Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space
2016
Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes
2004 Standout
Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
2011
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Proton-Coupled Electron Transfer
2012 Standout
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Cytochrome P450 and Chemical Toxicology
2007
Structure and Chemistry of Cytochrome P450
2005 Standout
Works of Abdul Mutlib being referenced
Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone.
1995
Application of Liquid Chromatography/Mass Spectrometry in Accelerating the Identification of Human Liver Cytochrome P450 Isoforms Involved in the Metabolism of Iloperidone
1998
A Comprehensive Listing of Bioactivation Pathways of Organic Functional Groups
2005
Characterization of HKI-272 Covalent Binding to Human Serum Albumin
2010
The Species-Dependent Metabolism of Efavirenz Produces a Nephrotoxic Glutathione Conjugate in Rats
2000
Simultaneous analysis of diphenhydramine and a stable isotope analog (2H10)diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewest
1993
Inhibition of Hepatobiliary Transport as a Predictive Method for Clinical Hepatotoxicity of Nefazodone
2006
Bioactivation of Lamotrigine in Vivo in Rat and in Vitro in Human Liver Microsomes, Hepatocytes, and Epidermal Keratinocytes: Characterization of Thioether Conjugates by Liquid Chromatography/Mass Spectrometry and High Field Nuclear Magnetic Resonance Spectroscopy
2009
Pharmacological evaluation of novel Alzheimer's disease therapeutics: acetylcholinesterase inhibitors related to galanthamine.
1996
Identification and Characterization of Efavirenz Metabolites by Liquid Chromatography/Mass Spectrometry and High Field NMR: Species Differences in the Metabolism of Efavirenz
1999
Metabolism-Dependent Mutagenicity of a Compound Containing a Piperazinyl Indazole Motif: Role of a Novel P450-Mediated Metabolic Reaction Involving a Putative Oxaziridine Intermediate
2006
Disposition of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2‘- (methylsulfonyl)-[1,1‘-biphenyl]-4-yl]-3-(trifluoromethyl)- 1H-pyrazole-5-carboxamide (DPC 423) by Novel Metabolic Pathways. Characterization of Unusual Metabolites by Liquid Chromatography/Mass Spectrometry and NMR
2001
Determination of Degradation Pathways and Kinetics of Acyl Glucuronides by NMR Spectroscopy
2007
Alternate Strategies to Obtain Mass Balance without the Use of Radiolabeled Compounds: Application of Quantitative Fluorine (19F) Nuclear Magnetic Resonance (NMR) Spectroscopy in Metabolism Studies
2012
Characterization of Novel Glutathione Adducts of a Non-Nucleoside Reverse Transcriptase Inhibitor, (S)-6-Chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydro-2(1H)-quinazolinone (DPC 961), in Rats. Possible Formation of an Oxirene Metabolic Intermediate from a Disubstituted Alkyne
2000
Metabolism of Capsaicin by Cytochrome P450 Produces Novel Dehydrogenated Metabolites and Decreases Cytotoxicity to Lung and Liver Cells
2003
Application of Stable Isotope-Labeled Compounds in Metabolism and in Metabolism-Mediated Toxicity Studies
2008
A Rational Chemical Intervention Strategy To Circumvent Bioactivation Liabilities Associated with a Nonpeptidyl Thrombopoietin Receptor Agonist Containing a 2-Amino-4-arylthiazole Motif
2007