Citation Impact
Citing Papers
Probing mucin-type O-linked glycosylation in living animals
2006 StandoutNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Direct NMR observation of a substrate protein bound to the chaperonin GroEL
2005 Nobel
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
An Overview of Cyclophosphamide and Ifosfamide Pharmacology
1997
Yersinia enterocolitica type III secretion: Evidence for the ability to transport proteins that are folded prior to secretion
2004
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Dynamic personalities of proteins
2007 StandoutNature
Cisplatin resistance in human cancers
1991
Imaging in the era of molecular oncology
2008 StandoutNature
Direct Catalytic Asymmetric Three‐Component Kabachnik–Fields Reaction
2008 StandoutNobel
Molecular Insights into the Biosynthesis of Guadinomine: A Type III Secretion System Inhibitor
2012 StandoutNobel
Protein‐Reactive Natural Products
2005
3 The Medicinal Chemistry of the Azido Group
1994
The 1987 Walter Hubert lecture: Regulation and deficiencies in DNA repair
1987 StandoutNobel
DNA Repair: Enzymatic Mechanisms and Relevance to Drug Response
1996
Cisplatin and Adriamycin Resistance Are Associated with MutLα and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line
1996 StandoutNobel
5-Fluorouracil: mechanisms of action and clinical strategies
2003 Standout
The Limit of Accuracy of Protein Modeling: Influence of Crystal Packing on Protein Structure
2005
10-formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): A potent inhibitor of glycinamide ribonucleotide transformylase
1997
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Clinical Pharmacology of 5-Fluorouracil
1989 Standout
Excision Repair in Mammalian Cells
1995 StandoutNobel
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
Mechanisms of resistance to cisplatin
2001
Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.
1991
Cross-resistance to UV radiation of a cisplatin-resistant human cell line: overexpression of cellular factors that recognize UV-modified DNA.
1991
Resolution of Diols via Catalytic Asymmetric Acetalization
2015 StandoutNobel
Near-native structure refinement using in vacuo energy minimization
2007 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Optimal schedule of methotrexate and 5-fluorouracil in human breast cancer.
1982
The amplified H circle of methotrexate-resistant leishmania tarentolae contains a novel P-glycoprotein gene.
1990
Synthesis of β-Aminophosphonates and -Phosphinates
2005
A Click Chemistry Approach to Pleuromutilin Conjugates with Nucleosides or Acyclic Nucleoside Derivatives and Their Binding to the Bacterial Ribosome
2008
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
1990
Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli damage recognition protein (UvrA) to the major ultraviolet photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T.
1993 StandoutNobel
Self-Assembled Monolayers of Thiolates on Metals as a Form of Nanotechnology
2005 Standout
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
1993 StandoutNobel
Gene-specific formation and repair of cisplatin intrastrand adducts and interstrand cross-links in Chinese hamster ovary cells.
1991 StandoutNobel
All-Catalytic, Efficient, and Asymmetric Synthesis of α,ω-Diheterofunctional Reduced Polypropionates via “One-Pot” Zr-Catalyzed Asymmetric Carboalumination−Pd-Catalyzed Cross-Coupling Tandem Process
2005 StandoutNobel
Identification of a membrane-associated folate-binding protein in human leukemic CCRF-CEM cells with transport-related methotrexate resistance.
1989
Heterogeneity of nitrogen mustard-induced DNA damage and repair at the level of the gene in Chinese hamster ovary cells.
1990 StandoutNobel
Phase I trial of escalating pentoxifylline dose with constant dose thiotepa.
1990
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.
1996 StandoutNobel
DNA amplification is rare in normal human cells.
1990
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase.
1992
Solvent dramatically affects protein structure refinement
2008 StandoutNobel
Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression.
1992 StandoutNobel
Organocatalytic Enantioselective Pictet–Spengler Approach to Biologically Relevant 1-Benzyl-1,2,3,4-Tetrahydroisoquinoline Alkaloids
2015
DNA Repair and Its Pathogenetic Implications
1990
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
Anomeric Configuration-Directed Diastereoselective C−C Bond Formation in Vinyl Sulfone-Modified Carbohydrates: A General Route to Branched-Chain Sugars
2003
The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants.
1990 StandoutNobel
A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis
1989
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
Application of Conformation Design in Acyclic Stereoselection: Total Synthesis of Borrelidin as the Crystalline Benzene Solvate
2003
Solid-Phase Synthesis of Polyamine Toxin Analogues: Potent and Selective Antagonists of Ca2+-Permeable AMPA Receptors
2002
Delivery of drugs, proteins and genes into cells using transferrin as a ligand for receptor-mediated endocytosis
1994
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC).
1995 StandoutNobel
Structural basis for cross-resistance to ribosomal PTC antibiotics
2008 StandoutNobel
Struktur und aromatischer Charakter nichtbenzoider cyclisch konjugierter Systeme
1963
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Identification of a New Endogenous Metabolite and the Characterization of Its Protein Interactions through an Immobilization Approach
2008 StandoutNobel
The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis.
1986
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Highly Selective Hydrolytic Kinetic Resolution of Terminal Epoxides Catalyzed by Chiral (salen)CoIIIComplexes. Practical Synthesis of Enantioenriched Terminal Epoxides and 1,2-Diols
2002
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Wolman's disease: Deficiency of E600-resistant acid esterase activity with storage of lipids in lysosomes
1970
Deficient Activity of Hepatic Acid Lipase in Cholesterol Ester Storage Disease
1972 Science
Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction
2016 StandoutNobel
Receptor-Mediated Control of Cholesterol Metabolism
1976 StandoutScienceNobel
New stereospecific synthesis of trisubstituted olefins. Stereospecific synthesis of farnesol
1967 StandoutNobel
Metabolism of oxazaphosphorines
1988
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.
1994
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Synthesis of 4,5-Dianilinophthalimide and Related Analogues for Potential Treatment of Alzheimer's Disease via Palladium-Catalyzed Amination
2005
Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA.
1990
Asymmetric Enamine Catalysis
2007 StandoutNobel
Gene Amplification in a p53-Deficient Cell Line Requires Cell Cycle Progression under Conditions That Generate DNA Breakage
1998
Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase
2004
Enzymatic Methylation of 23-29-kDa Bovine Retinal Rod Outer Segment Membrane Proteins
1989
Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.
1992 StandoutNobel
The Tail Wagging the Dog: Insights into Catalysis in R67 Dihydrofolate Reductase
2010
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line
1992 StandoutScience
Synthesis and Characterization of Dextran−Peptide−Methotrexate Conjugates for Tumor Targeting via Mediation by Matrix Metalloproteinase II and Matrix Metalloproteinase IX
2004
Works of A. Rosowsky being referenced
Structural features of 4-amino antifolates required for substrate activity with mammalian folylpolyglutamate synthetase.
1985
4-amino-3-(2,3,5-tri-O-benzyl-β-d-ribofuranosyl)-5-pyrazolecarbonitrile. Synthesis and conversion into a sugar-blocked 5,7-disubstituted formycin analog
1988
Methotrexate analog. 32. Chain extension, .alpha.-carboxyl deletion, and .gamma. carboxyl replacement by sulfonate and phosphate. Effect on enzyme binding and cell-growth inhibition
1988
Synthesis of new 2,4-Diaminopyrido[2,3-d]pyrimidine and 2,4-Diaminopyrrolo[2,3-d]pyrimidine inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductase
2003
Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response.
1992
Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase
1991
Monensin is obligatory for the cytotoxic action of a disulfide linked methotrexate-anti-transferrin receptor conjugate
1988
Analogues of Nα-(4-Amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l -ornithine (PT523) Modified in the Side Chain: Synthesis and Biological Evaluation
1997
Wild-type and Drug-resistant Leishmania major Hydrolyze Methotrexate to N-10-Methyl-4-deoxy-4-aminopteroate without Accumulation of Methotrexate Polyglutamates
1989
The Chemistry of Fumagillin1
1961
Comparison of Two Independent Crystal Structures of Human Dihydrofolate Reductase Ternary Complexes Reduced with Nicotinamide Adenine Dinucleotide Phosphate and the Very Tight-Binding Inhibitor PT523,
1997
Molecular orbital calculations on some non-classical aromatics
1960
Human thymidylate synthetase—III
1979
Methotrexate analogs. 19. Replacement of the glutamate side-chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity
1984
Methotrexate di-n-butyl ester effects on thymidine metabolism
1979
Alkylating agent resistance: in vitro studies with human cell lines.
1985
NMR Solution Structure of the Antitumor Compound PT523 and NADPH in the Ternary Complex with Human Dihydrofolate Reductase
1997
Collateral methotrexate resistance in cultured human head and neck carcinoma cells selected for resistance to cis-diamminedichloroplatinum(II).
1987
A phase I and pharmacokinetic study of a new camptothecin derivative, 9-aminocamptothecin.
1995
Effects of methotrexate esters and other lipophilic antifolates on methotrexate-resistant human leukemic lymphoblasts
1980
Reduced membrane protein associated with resistance of human squamous carcinoma cells to methotrexate and cis-platinum
1990
Comparison of pharmacokinetics of 5-fluorouracil and 5-fluorouracil with concurrent thymidine infusions in a Phase I trial.
1980
Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture.
1984
Alkylating agents: in vitro studies of cross-resistance patterns in human cell lines.
1986
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
1992
Methotrexate analogs. 14. Synthesis of new .gamma.-substituted derivatives as dihydrofolate reductase inhibitors and potential anticancer agents
1981
Selective expansion of 5,10-methylenetetrahydrofolate pools and modulation of 5-fluorouracil antitumor activity by leucovorin in vivo.
1989
Calorimetric Studies of Ligand Binding in R67 Dihydrofolate Reductase
2005
N.omega.-Alkoxycarbonylation of .alpha.,.omega.-diamino acids with 2-(trimethylsilyl)ethyl 4-nitrophenyl carbonate
1983
A clinical-pharmacological evaluation of hepatic arterial infusions of 5-fluoro-2'-deoxyuridine and 5-fluorouracil.
1978
1 Chemistry and Biological Activity of Antifolates
1989
The use of 1,3-dithiane in a regioselective synthesis of a novel 2-alkyl-2-deoxy-D-arabinofuranose branched-chain sugar
1976
Synthesis of 3′-O-Propargylthymidine as a Candidate Antiretroviral Agent
1989
WOLMAN'S DISEASE: THREE NEW PATIENTS WITH A RECENTLY DESCRIBED LIPIDOSIS
1965
Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).
1987