Yan Chai

3.7k citations

72 papers · 1.7k indexed · h-index 26

Impact in

Immunology top 5%
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
Infectious Diseases top 5%
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research

Papers in ⓘ

Immunology 30
- Immunotherapy and Immune Responses 16
- T-cell and B-cell Immunology 8
- Immune Cell Function and Interaction 7
Molecular Biology 26
- vaccines and immunoinformatics approaches 6

Co-authors: George F. Gao (44 shared papers)Jianxun Qi (38 shared papers)Shuguang Tan (17 shared papers)Yi Shi (11 shared papers)Jinghua Yan (11 shared papers)Hao Song (12 shared papers)Jianning Zhang (9 shared papers)Xin Chen (8 shared papers)
Journals: The Journal of Immunology (6 papers)Frontiers in Immunology (5 papers)Nature Communications (4 papers)Cell Reports (4 papers)Proceedings of the National Academy of Sciences (4 papers)
Partner nations: China Czechia Macao

In The Last Decade

Yan Chai

70 papers receiving 1.7k citations

Peers

Countries citing papers authored by Yan Chai

Since Specialization

Citations

This map shows the geographic impact of Yan Chai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yan Chai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yan Chai more than expected).

Fields of papers citing papers by Yan Chai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yan Chai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yan Chai. The network helps show where Yan Chai may publish in the future.

Co-authors

The 25 scholars most cited alongside Yan Chai, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Yan Chai Line = papers co-authored together Yan Chai links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 72 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	An unexpected N-terminal loop in PD-1 dominates binding by nivolumab Nature Communications ·Shuguang Tan, Hao Zhang, Yan Chai, Hao Song, Zhou Tong, Qihui Wang, Jianxun Qi, Gary Wong, Xiaodong Zhu, William J. Liu, Shan Gao, Zhongfu Wang, Yi Shi, Fuquan Yang, George F. Gao, Jinghua Yan	2017	195
2	Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein Cell ·Hao Song, Zhennan Zhao, Yan Chai, Xiyue Jin, Changyao Li, Fei Yuan, Sheng Liu, Zhengrong Gao, Haiyuan Wang, Jian Song, Leonardo Vázquez, Yanfang Zhang, Shuguang Tan, Carlos Morel, Jinghua Yan, Yi Shi, Jianxun Qi, Feng Gao, George F. Gao	2019	102
3	The crystal structure of Zika virus NS 5 reveals conserved drug targets The EMBO Journal ·Wenqian Duan, Hao Song, Haiyuan Wang, Yan Chai, Chao Su, Jianxun Qi, Yi Shi, George F. Gao	2017	99
4	Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies Oncotarget ·Mengnan He, Yan Chai, Jianxun Qi, Catherine W.H. Zhang, Zhou Tong, Yi Shi, Jinghua Yan, Shuguang Tan, George F. Gao	2017	69
5	N‐glycosylation of PD‐1 promotes binding of camrelizumab EMBO Reports ·Kefang Liu, Shuguang Tan, Wanjun Jin, Jiawei Guan, Qingling Wang, Huan Sun, Jianxun Qi, Jinghua Yan, Yan Chai, Zhongfu Wang, Chu‐Xia Deng, George F. Gao	2020	66
6	Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures Cell Research ·Ruchao Peng, Ying Xu, Tengfei Zhu, Ningning Li, Jianxun Qi, Yan Chai, Min Wu, Xinzheng Zhang, Yi Shi, Peiyi Wang, Jiawei Wang, Ning Gao, George F. Gao	2017	55
7	Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases Frontiers in Immunology ·Mingming Shi, Yan Chai, Jianning Zhang, Xin Chen	2022	53
8	Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy. PubMed ·Hongchuan Liu, Lijing Guo, Jing Zhang, Yuehua Zhou, Jinwei Zhou, Jian Yao, Hai Wu, Sheng Yao, Bo Chen, Yan Chai, Jianxun Qi, George F. Gao, Shuguang Tan, Hui Feng, Jinghua Yan	2020	52
9	KRAS G12V neoantigen specific T cell receptor for adoptive T cell therapy against tumors Nature Communications ·Dan Lu, Yuan Chen, Min Jiang, Jie Wang, Yiting Li, Keke Ma, Wenqiao Sun, Xing Zheng, Jianxun Qi, Wenjing Jin, Yu Chen, Yan Chai, Catherine W-H Zhang, Hao Liang, Shuguang Tan, George F. Gao	2023	50
10	An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB Cell Reports Medicine ·Qingwen He, Lili Wu, Zepeng Xu, Xiaoyun Wang, Yufeng Xie, Yan Chai, Anqi Zheng, Jianjie Zhou, Shitong Qiao, Min Huang, Guijun Shang, Xin Zhao, Youjun Feng, Jianxun Qi, George F. Gao, Qihui Wang	2023	45
11	Administration of Tauroursodeoxycholic Acid Attenuates Early Brain Injury via Akt Pathway Activation Frontiers in Cellular Neuroscience ·Dongdong Sun, Gang Gu, Jianhao Wang, Yan Chai, Yueshan Fan, Mengchen Yang, Xin Xu, Weiwei Gao, Fēi Li, Dongpei Yin, Shuai Zhou, Xin Chen, Jianning Zhang	2017	42
12	Neutrophil extracellular traps aggravate neuronal endoplasmic reticulum stress and apoptosis via TLR9 after traumatic brain injury Cell Death and Disease ·Liang Mi, Xiaobin Min, Mingming Shi, Liang Liu, Yanfeng Zhang, Yanlin Zhu, Peng Li, Yan Chai, Fanglian Chen, Quanjun Deng, Shu Zhang, Jianning Zhang, Xin Chen	2023	40
13	Protective T Cell Responses Featured by Concordant Recognition of Middle East Respiratory Syndrome Coronavirus–Derived CD8+ T Cell Epitopes and Host MHC The Journal of Immunology ·William J. Liu, Jiaming Lan, Kefang Liu, Yao Deng, Yanfeng Yao, Shaolian Wu, Hong Chen, Lingling Bao, Haifeng Zhang, Min Zhao, Qihui Wang, Lingxia Han, Yan Chai, Jianxun Qi, Jincun Zhao, Songdong Meng, Chuan Qin, George F. Gao, Wenjie Tan	2016	38
14	The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives Proceedings of the National Academy of Sciences ·Ruili Liu, Yeping Sun, Yan Chai, Li Su, Shihua Li, Liang Wang, Jiaqi Su, Shaoxiong Yu, Jinghua Yan, Feng Gao, Gaiping Zhang, Hua-Ji Qiu, George F. Gao, Jianxun Qi, Han Wang	2020	36
15	Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design PLoS Pathogens ·Xiangdong Li, Fanli Yang, Xule Hu, Feifei Tan, Jianxun Qi, Ruchao Peng, Min Wang, Yan Chai, Liying Hao, Junhua Deng, Chenyu Bai, Juan Wang, Hao Song, Shuguang Tan, Guangwen Lu, George F. Gao, Yi Shi, Kegong Tian	2017	35
16	PD-1 N58-Glycosylation-Dependent Binding of Monoclonal Antibody Cemiplimab for Immune Checkpoint Therapy Frontiers in Immunology ·Dan Lü, Zepeng Xu, Ding Zhang, Min Jiang, Kefang Liu, Juanhua He, Dongli Ma, Xiaopeng Ma, Shuguang Tan, George F. Gao, Yan Chai	2022	35
17	The FG Loop of PD-1 Serves as a “Hotspot” for Therapeutic Monoclonal Antibodies in Tumor Immune Checkpoint Therapy iScience ·Danqing Chen, Shuguang Tan, Hao Zhang, Haiyuan Wang, Wei-Wu He, Rui Shi, Zhou Tong, Jianhua Zhu, Hao Cheng, Shan Gao, Yan Chai, Jianxun Qi, Minghui Xiao, Jinghua Yan, George F. Gao	2019	34
18	Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab Cell Reports ·Yan Li, Shuguang Tan, Chang Zhang, Yan Chai, Mengnan He, Catherine W.-H. Zhang, Qihui Wang, Zhou Tong, Kefang Liu, Yifan Lei, William J. Liu, Yingxia Liu, Zhigang Tian, Xuetao Cao, Jinghua Yan, Jianxun Qi, Po Tien, Shan Gao, George F. Gao	2018	34
19	Dysfunctional Endoplasmic Reticulum-Mitochondrion Coupling Is Associated with Endoplasmic Reticulum Stress-Induced Apoptosis and Neurological Deficits in a Rodent Model of Severe Head Injury Journal of Neurotrauma ·Xin Chen, Liang Mi, Gang Gu, Xiangliang Gao, Xiangliang Gao, Mingming Shi, Yan Chai, Fanglian Chen, Weidong Yang, Jianning Zhang	2022	32
20	NLRP1 Inflammasomes: A Potential Target for the Treatment of Several Types of Brain Injury Frontiers in Immunology ·Liang Mi, Xiaobin Min, Yan Chai, Jianning Zhang, Xin Chen	2022	31

About Yan Chai

Yan Chai is a scholar working on Immunology, Molecular Biology, Infectious Diseases, Epidemiology and Oncology, having authored 72 papers that have together received 1.7k indexed citations. Recurring topics across this work include Immunotherapy and Immune Responses (16 papers), T-cell and B-cell Immunology (8 papers), SARS-CoV-2 and COVID-19 Research (8 papers), Immune Cell Function and Interaction (7 papers), Viral Infections and Immunology Research (6 papers), Cancer Immunotherapy and Biomarkers (6 papers), vaccines and immunoinformatics approaches (6 papers) and Mosquito-borne diseases and control (6 papers). The work is most often cited by research in Immunology (504 citations), Infectious Diseases (367 citations), Oncology (444 citations), Virology (57 citations) and Biological Psychiatry (25 citations). Yan Chai has collaborated with scholars based in China, Czechia and Macao. Frequent co-authors include George F. Gao, Jianxun Qi, Shuguang Tan, Yi Shi, Jinghua Yan, Hao Song, Jianning Zhang, Xin Chen, Mingming Shi and Zhou Tong. Their work appears in journals such as The Journal of Immunology, Frontiers in Immunology, Nature Communications, Cell Reports and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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