William Ruff

3.6k citations

22 papers · 2.3k indexed · 2 hit papers · h-index 16

Impact in

Immunology top 5%
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
Biological Psychiatry top 5%

Papers in ⓘ

Immunology 14
- T-cell and B-cell Immunology 9
- Immune Cell Function and Interaction 6
- Immunotherapy and Immune Responses 6
Molecular Biology 6
- Gut microbiota and health 6

Co-authors: Martin Kriegel (9 shared papers)Teri M. Greiling (5 shared papers)Sílvio M. Vieira (6 shared papers)Carina Dehner (6 shared papers)Daniel F. Zegarra-Ruiz (3 shared papers)Andrew L. Goodman (4 shared papers)Christina Kriegel (3 shared papers)Yuwen Zhu (5 shared papers)
Journals: Cell Host & Microbe (2 papers)Trends in Molecular Medicine (1 paper)Pituitary (1 paper)Immunity (1 paper)Translational research (1 paper)
Partner nations: United States China Belgium

In The Last Decade

William Ruff

21 papers receiving 2.3k citations

Hit Papers

align trajectories log scale

Host–microbiota interactions in immune-mediated diseases 2020 · 311 citations

Peers

Countries citing papers authored by William Ruff

Since Specialization

Citations

This map shows the geographic impact of William Ruff's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William Ruff with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William Ruff more than expected).

Fields of papers citing papers by William Ruff

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William Ruff. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William Ruff. The network helps show where William Ruff may publish in the future.

Co-authors

The 25 scholars most cited alongside William Ruff, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William Ruff Line = papers co-authored together William Ruff links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 22 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Translocation of a gut pathobiont drives autoimmunity in mice and humans Science ·Sílvio M. Vieira, Michael Hiltensperger, Varun Kumar, Daniel F. Zegarra-Ruiz, Carina Dehner, Nafeesa Khan, Frederico R. C. Costa, Eleni Tiniakou, Teri M. Greiling, William Ruff, Andrea Barbieri, Christina Kriegel, Sameet Mehta, James Knight, Dhanpat Jain, Andrew L. Goodman, Martin Kriegel Hit paper breakdown →	2018	590
2	Host–microbiota interactions in immune-mediated diseases Nature Reviews Microbiology ·William Ruff, Teri M. Greiling, Martin Kriegel Hit paper breakdown →	2020	311
3	A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity Cell Host & Microbe ·Daniel F. Zegarra-Ruiz, Asmaa El Beidaq, Alonso J. Iñiguez, Martina Lubrano di Ricco, Sílvio M. Vieira, William Ruff, Derek L. Mubiru, Rebecca Fine, John Sterpka, Teri M. Greiling, Carina Dehner, Martin Kriegel	2018	231
4	Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus Science Translational Medicine ·Teri M. Greiling, Carina Dehner, Xinguo Chen, Kevin J. Hughes, Alonso J. Iñiguez, Marco Boccitto, Daniel F. Zegarra-Ruiz, Stephen C. Renfroe, Sílvio M. Vieira, William Ruff, Soyeong Sim, Christina Kriegel, Julia R. Glanternik, Xindi Chen, Michael Girardi, Patrick H. Degnan, Karen H. Costenbader, Andrew L. Goodman, Sandra L. Wolin, Martin Kriegel	2018	219
5	PD-1 on dendritic cells impedes innate immunity against bacterial infection Blood ·Sheng Yao, Shengdian Wang, Yuwen Zhu, Liqun Luo, Gefeng Zhu, Sarah J. Flies, Haiying Xu, William Ruff, Megan Broadwater, In-Hak Choi, Koji Tamada, Lieping Chen	2009	171
6	B7-H5 costimulates human T cells via CD28H Nature Communications ·Yuwen Zhu, Sheng Yao, Bettina P. Iliopoulou, Xue Han, Mathew M. Augustine, Haiying Xu, Ryan Phennicie, Sarah J. Flies, Megan Broadwater, William Ruff, Janis M. Taube, Linghua Zheng, Liqun Luo, Gefeng Zhu, Jianzhu Chen, Lieping Chen	2013	151
7	B7-H2 Is a Costimulatory Ligand for CD28 in Human Immunity ·Sheng Yao, Yuwen Zhu, Gefeng Zhu, Mathew M. Augustine, Linghua Zheng, Diana Goode, Megan Broadwater, William Ruff, Sarah J. Flies, Haiying Xu, Dallas B. Flies, Liqun Luo, Shengdian Wang, Lieping Chen	2011	118
8	Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity Cell Host & Microbe ·William Ruff, Carina Dehner, Woo Jin Kim, Odelya E. Pagovich, Cassyanne L. Aguiar, Andrew Yu, Alexander S. Roth, Sílvio M. Vieira, Christina Kriegel, Olamide Adeniyi, Melissa J. Mulla, Vikki M. Abrahams, William W. Kwok, Ruth Nussinov, Doruk Erkan, Andrew L. Goodman, Martin Kriegel	2019	109
9	B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets PLoS ONE ·Liqun Luo, Gefeng Zhu, Haiying Xu, Sheng Yao, Gang Zhou, Yuwen Zhu, Koji Tamada, Lanqing Huang, Andrew S. Flies, Megan Broadwater, William Ruff, Jan M. A. van Deursen, Ignacio Melero, Zhou Zhu, Lieping Chen	2015	96
10	Autoimmune host–microbiota interactions at barrier sites and beyond Trends in Molecular Medicine ·William Ruff, Martin Kriegel	2015	89
11	Glucose-6–phosphatase Is a Key Metabolic Regulator of Glioblastoma Invasion Molecular Cancer Research ·Sara Abbadi, Julio J. Rodarte, Ameer Abutaleb, Emily Lavell, Christopher L. Smith, William Ruff, Jennifer L. Schiller, Alessandro Olivi, Andre Levchenko, Hugo Guerrero‐Cazares, Alfredo Quiñones‐Hinojosa	2014	64
12	CXCR3+ T cells in multiple sclerosis correlate with reduced diversity of the gut microbiome SHILAP Revista de lepidopterología ·Siobhán Ní Choileáin, Markus Kleinewietfeld, Khadir Raddassi, David A. Hafler, William Ruff, Erin E. Longbrake	2019	42
13	Neuron-specific SALM5 limits inflammation in the CNS via its interaction with HVEM Science Advances ·Yuwen Zhu, Sheng Yao, Mathew M. Augustine, Haiying Xu, Jun Wang, Jingwei Sun, Megan Broadwater, William Ruff, Liqun Luo, Gefeng Zhu, Koji Tamada, Lieping Chen	2016	38
14	The Role of the Gut Microbiota in the Pathogenesis of Antiphospholipid Syndrome Current Rheumatology Reports ·William Ruff, Sílvio M. Vieira, Martin Kriegel	2014	36
15	Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis Journal of Clinical Investigation ·Hiromitsu Asashima, Pierre‐Paul Axisa, Thi Hong Giang Pham, Erin E. Longbrake, William Ruff, Nikhil Lele, Inessa Cohen, Khadir Raddassi, Tomokazu S. Sumida, David A. Hafler	2022	26
16	Influence of immunomodulatory drugs on the gut microbiota Translational research ·Inessa Cohen, William Ruff, Erin E. Longbrake	2021	23
17	Malignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions SHILAP Revista de lepidopterología ·Carina Dehner, William Ruff, Teri M. Greiling, Márcia S. Pereira, Sylvio Redanz, Jennifer M. McNiff, Michael Girardi, Martin Kriegel	2021	12
18	Expression of the pituitary stem/progenitor marker GFRα2 in human pituitary adenomas and normal pituitary Pituitary ·Nestoras Mathioudakis, Ram Sundaresh, Alexandra Giantini-Larsen, William Ruff, Jennifer L. Schiller, Hugo Guerrero‐Cazares, Peter C. Burger, Roberto Salvatori, Alfredo Quiñones‐Hinojosa	2014	9
19	Alterations in Gut Microbiome-Host Relationships After Immune Perturbation in Patients With Multiple Sclerosis Neurology Neuroimmunology & Neuroinflammation ·Vinod K. Gupta, Guneet Janda, Heather K. Pump, Nikhil Lele, Isabella Cruz, Inessa Cohen, William Ruff, David A. Hafler, Jaeyun Sung, Erin E. Longbrake	2025	7
20	Autoantibody cross-reactivity with a microbial protein from a prevalent human gut commensal in antiphospholipid syndrome The Journal of Immunology ·William Ruff, Alexander S. Roth, Carina Dehner, Sílvio M. Vieira, Andrew L. Goodman, Martin Kriegel	2017	1

About William Ruff

William Ruff is a scholar working on Immunology, Molecular Biology, Infectious Diseases, Oncology and Rheumatology, having authored 22 papers that have together received 2.3k indexed citations. Recurring topics across this work include T-cell and B-cell Immunology (9 papers), Gut microbiota and health (6 papers), Immune Cell Function and Interaction (6 papers), Immunotherapy and Immune Responses (6 papers), Clostridium difficile and Clostridium perfringens research (4 papers), Systemic Lupus Erythematosus Research (3 papers), Tryptophan and brain disorders (2 papers) and Diabetes and associated disorders (2 papers). The work is most often cited by research in Immunology (869 citations), Biological Psychiatry (69 citations), Gastroenterology (136 citations), Rheumatology (369 citations) and Infectious Diseases (369 citations). William Ruff has collaborated with scholars based in United States, China and Belgium. Frequent co-authors include Martin Kriegel, Teri M. Greiling, Sílvio M. Vieira, Carina Dehner, Daniel F. Zegarra-Ruiz, Andrew L. Goodman, Christina Kriegel, Yuwen Zhu, Megan Broadwater and Haiying Xu. Their work appears in journals such as Cell Host & Microbe, Trends in Molecular Medicine, Pituitary, Immunity and Translational research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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