William D. Pennie

4.1k citations

23 papers · 1.8k indexed · 1 hit paper · h-index 17

Molecular Biology top 10%
Computational Theory and Mathematics top 1%
Oncology
Pharmacology top 2%
Genetics

Co-authors: Alex. M. Weir Garry Pairaudeau Owen B. Wallace Andrew R. Leach John Arrowsmith Stephen D. Pickett Robert M. Owen Ji‐Bo Wang
Topics: Gene expression and cancer classification (6 papers)Molecular Biology Techniques and Applications (5 papers)Computational Drug Discovery Methods (3 papers)
Cited by: Computational Theory and Mathematics Pharmacology Molecular Biology
Journals: Journal of Biological Chemistry Molecular and Cellular Biology Nature Reviews Drug Discovery
Partner nations: United States United Kingdom Japan

In The Last Decade

William D. Pennie

22 papers receiving 1.7k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

An analysis of the attrition of drug candidates from four major pharmaceutical companies

2015 955 citations Michael J. Waring, John Arrowsmith et al. Nature Reviews Drug Discovery profile →

Peers

Countries citing papers authored by William D. Pennie

Since Specialization

Citations

This map shows the geographic impact of William D. Pennie's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William D. Pennie with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William D. Pennie more than expected).

Fields of papers citing papers by William D. Pennie

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William D. Pennie. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William D. Pennie. The network helps show where William D. Pennie may publish in the future.

Co-authorship network of co-authors of William D. Pennie

This figure shows the co-authorship network connecting the top 25 collaborators of William D. Pennie. A scholar is included among the top collaborators of William D. Pennie based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William D. Pennie. William D. Pennie is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	An analysis of the attrition of drug candidates from four major pharmaceutical companiesbreakdown → 2015 ·Nature Reviews Drug Discovery ·Michael J. Waring,John Arrowsmith,Andrew R. Leach,Paul D. Leeson,(unknown),Robert M. Owen,Garry Pairaudeau,William D. Pennie,Stephen D. Pickett,Ji‐Bo Wang,Owen B. Wallace,Alex. M. Weir	955
2	A high content screening assay for identifying lysosomotropic compounds 2010 ·Toxicology in Vitro ·Sashi Nadanaciva,Shuyan Lu,David F. Gebhard,Bart Jessen,William D. Pennie,Yvonne Will	158
3	Toxicogenomics in risk assessment: an overview of an HESI collaborative research program. 2004 ·Environmental Health Perspectives ·William D. Pennie,Syril Pettit,Peter G. Lord	84
4	Differential Expression of TIMP-3 During Neoplastic Progression in the Mouse JB6 Model System 2003 ·Humana Press eBooks ·William D. Pennie,Yi Sun,Hyungtae Kim,Nancy H. Colburn	0
5	Toxicogenomics 2003 ·Tohru Inoue,William D. Pennie	5
6	Custom cDNA microarrays; technologies and applications 2002 ·Toxicology ·William D. Pennie	9
7	Use of genomics in toxicology and epidemiology: findings and recommendations of a workshop. 2002 ·Environmental Health Perspectives ·Carol J. Henry,R. T. Phillips,(unknown),J. Christopher Corton,(unknown),Koichi Igarashi,Robert A. LeBœuf,Gary E. Marchant,(unknown),William D. Pennie,Lewis L. Smith,M. Jane Teta,(unknown)	16
8	Application of genomics to the definition of the molecular basis for toxicity 2001 ·Toxicology Letters ·William D. Pennie,N.J Woodyatt,(unknown),George M. Orphanides	36
9	Identification of a possible association between carbon tetrachloride-induced hepatotoxicity and interleukin-8 expression 2000 ·Journal of Biochemical and Molecular Toxicology ·Peter R. Holden,Neil H. James,A. Nigel Brooks,Ruth Roberts,Ian Kimber,William D. Pennie	29
10	Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor 2000 ·Biochemical Pharmacology ·Robert Elsby,John Ashby,John P. Sumpter,A. N. Brooks,William D. Pennie,James L. Maggs,(unknown),J. Odum,Nicola Beresford,David M. Paton,(unknown)	34
11	Use of cDNA microarrays to probe and understand the toxicological consequences of altered gene expression 2000 ·Toxicology Letters ·William D. Pennie	29
12	Transcriptional State of the Mouse Mammary Tumor Virus Promoter Can Affect Topological Domain Size in Vivo 1999 ·Journal of Biological Chemistry ·Phillip R. Kramer,(unknown),William D. Pennie,Han Htun,Gordon L. Hager,Richard R. Sinden	43
13	Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation 1998 ·Oncogene ·Rebecca G. Watts,Chuanshu Huang,Matthew R. Young,Jian Jian Li,Zigang Dong,William D. Pennie,Nancy H. Colburn	108
14	The Position and Length of the Steroid-Dependent Hypersensitive Region in the Mouse Mammary Tumor Virus Long Terminal Repeat Are Invariant despite Multiple Nucleosome B Frames 1998 ·Molecular and Cellular Biology ·Gilberto Fragoso,William D. Pennie,Sam John,Gordon L. Hager	55
15	Differential functional significance of AP-1 binding sites in the promoter of the gene encoding mouse tissue inhibitor of metalloproteinases-3 1997 ·Biochemical Journal ·Hyungtae Kim,William D. Pennie,Yi Sun,Nancy H. Colburn	20
16	Nucleoprotein Structure Influences the Response of the Mouse Mammary Tumor Virus Promoter to Activation of the Cyclic AMP Signalling Pathway 1995 ·Molecular and Cellular Biology ·William D. Pennie,Gordon L. Hager,Catharine L. Smith	43
17	Analysis of the Transforming Functions of Bovine Papillomavirus Type 4 1993 ·Virology ·William D. Pennie,Guillermo Grindlay,Margaret Cairney,M. Saveria Campo	40
18	Synergism between bovine papillomavirus type 4 and the flavonoid quercetin in cell transformation in vitro 1992 ·Virology ·William D. Pennie,M. Saveria Campo	28
19	The B subgroup bovine papillomaviruses lack an identifiable E6 open reading frame 1991 ·Molecular Carcinogenesis ·M. E. Jackson,William D. Pennie,(unknown),Kenneth T. Smith,Guillermo Grindlay,M. Saveria Campo	41
20	<title>Fiber optic based multiprobe system for intraoperative monitoring of brain functions</title> 1991 ·Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE ·Avraham Mayevsky,Eugene S. Flamm,William D. Pennie,Britton Chance	25

About William D. Pennie

William D. Pennie is a scholar working on Immunology, Pharmacology and Computational Theory and Mathematics, having authored 23 papers that have together received 1.8k indexed citations. Recurring topics across this work include Gene expression and cancer classification (6 papers), Molecular Biology Techniques and Applications (5 papers) and Computational Drug Discovery Methods (3 papers). The work is most often cited by research in Computational Theory and Mathematics (440 citations), Pharmacology (185 citations) and Molecular Biology (893 citations). William D. Pennie has collaborated with scholars based in United States, United Kingdom and Japan. Frequent co-authors include Alex. M. Weir, Garry Pairaudeau, Owen B. Wallace, Andrew R. Leach, John Arrowsmith, Stephen D. Pickett, Robert M. Owen, Ji‐Bo Wang, Paul D. Leeson and Michael J. Waring. Their work appears in journals such as Journal of Biological Chemistry, Molecular and Cellular Biology and Nature Reviews Drug Discovery.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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