William C. Groutas

4.7k total citations
131 papers, 3.7k citations indexed

About

William C. Groutas is a scholar working on Cancer Research, Molecular Biology and Infectious Diseases. According to data from OpenAlex, William C. Groutas has authored 131 papers receiving a total of 3.7k indexed citations (citations by other indexed papers that have themselves been cited), including 45 papers in Cancer Research, 43 papers in Molecular Biology and 42 papers in Infectious Diseases. Recurrent topics in William C. Groutas's work include Protease and Inhibitor Mechanisms (43 papers), Viral gastroenteritis research and epidemiology (31 papers) and Peptidase Inhibition and Analysis (22 papers). William C. Groutas is often cited by papers focused on Protease and Inhibitor Mechanisms (43 papers), Viral gastroenteritis research and epidemiology (31 papers) and Peptidase Inhibition and Analysis (22 papers). William C. Groutas collaborates with scholars based in United States, China and France. William C. Groutas's co-authors include Yunjeong Kim, Kevin R. Alliston, Kyeong‐Ok Chang, Scott Lovell, Sivakoteswara Rao Mandadapu, Anushka C. Galasiti Kankanamalage, Kyeong-Ok Chang, Dengfeng Dou, K.P. Battaile and R. Venkataraman and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of the American Chemical Society and Biochemistry.

In The Last Decade

William C. Groutas

131 papers receiving 3.7k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
William C. Groutas United States 34 1.5k 1.2k 1.1k 640 436 131 3.7k
Torsten Steinmetzer Germany 33 1.1k 0.7× 454 0.4× 1.5k 1.3× 341 0.5× 369 0.8× 137 3.8k
M.M. Cherney Canada 31 783 0.5× 365 0.3× 1.9k 1.8× 225 0.4× 112 0.3× 75 3.4k
Kiira Ratia United States 24 1.8k 1.2× 233 0.2× 1.3k 1.2× 839 1.3× 67 0.2× 41 3.3k
Cheryl A. Janson United States 43 506 0.3× 1.1k 0.9× 3.1k 2.9× 296 0.5× 374 0.9× 67 5.1k
Michael G. Natchus United States 29 1.0k 0.7× 744 0.6× 879 0.8× 151 0.2× 366 0.8× 69 2.9k
K.P. Battaile United States 34 739 0.5× 232 0.2× 2.1k 1.9× 467 0.7× 95 0.2× 131 3.6k
Donald L. Fine United States 19 500 0.3× 1.1k 0.9× 1.9k 1.8× 109 0.2× 277 0.6× 52 4.5k
Bart L. Staker United States 25 492 0.3× 694 0.6× 2.9k 2.7× 281 0.4× 115 0.3× 99 3.9k
Jeffrey C. Dyason Australia 20 317 0.2× 946 0.8× 1.5k 1.4× 206 0.3× 170 0.4× 39 3.1k
Yongcheng Song United States 42 560 0.4× 1.0k 0.9× 2.9k 2.7× 172 0.3× 250 0.6× 106 4.9k

Countries citing papers authored by William C. Groutas

Since Specialization
Citations

This map shows the geographic impact of William C. Groutas's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William C. Groutas with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William C. Groutas more than expected).

Fields of papers citing papers by William C. Groutas

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William C. Groutas. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William C. Groutas. The network helps show where William C. Groutas may publish in the future.

Co-authorship network of co-authors of William C. Groutas

This figure shows the co-authorship network connecting the top 25 collaborators of William C. Groutas. A scholar is included among the top collaborators of William C. Groutas based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William C. Groutas. William C. Groutas is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Groutas, William C. & Athri D. Rathnayake. (2023). Organic Reaction Mechanisms, Selected Problems, and Solutions. 1 indexed citations
2.
3.
Zheng, Jian, Krishani Dinali Perera, Lok-Yin Roy Wong, et al.. (2021). Postinfection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection. Proceedings of the National Academy of Sciences. 118(29). 57 indexed citations
4.
Rathnayake, Athri D., Jian Zheng, Yunjeong Kim, et al.. (2020). 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice. Science Translational Medicine. 12(557). 169 indexed citations
5.
Kankanamalage, Anushka C. Galasiti, Yunjeong Kim, Vishnu C. Damalanka, et al.. (2018). Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element. European Journal of Medicinal Chemistry. 150. 334–346. 92 indexed citations
6.
Kankanamalage, Anushka C. Galasiti, Yunjeong Kim, Athri D. Rathnayake, et al.. (2016). Structure-based exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design of potent and permeable inhibitors. European Journal of Medicinal Chemistry. 126. 502–516. 18 indexed citations
7.
Dou, Dengfeng, et al.. (2010). Dual function inhibitors of relevance to chronic obstructive pulmonary disease. Bioorganic & Medicinal Chemistry Letters. 21(10). 3177–3180. 6 indexed citations
8.
Dou, Dengfeng, et al.. (2010). Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold. European Journal of Medicinal Chemistry. 45(9). 4280–4287. 7 indexed citations
9.
Yang, Qingliang, Yi Li, Dengfeng Dou, et al.. (2008). Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents. Archives of Biochemistry and Biophysics. 475(2). 115–120. 14 indexed citations
10.
Li, Yi, Qingliang Yang, Dengfeng Dou, Kevin R. Alliston, & William C. Groutas. (2007). Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides. Bioorganic & Medicinal Chemistry. 16(2). 692–698. 11 indexed citations
11.
Wei, Liuqing, Zhong Lai, Kevin R. Alliston, et al.. (2004). Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process. Archives of Biochemistry and Biophysics. 429(1). 60–70. 5 indexed citations
12.
Lai, Zhong, et al.. (2004). Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives. Archives of Biochemistry and Biophysics. 429(2). 191–197. 17 indexed citations
13.
Zhong, Jiaying & William C. Groutas. (2004). Recent Developments in the Design of Mechanism-based and Alternate Substrate Inhibitors of Serine Proteases. Current Topics in Medicinal Chemistry. 4(12). 1203–1216. 34 indexed citations
14.
He, Shu, et al.. (2000). Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide. Bioorganic & Medicinal Chemistry. 8(7). 1713–1717. 32 indexed citations
15.
16.
Groutas, William C., Sumei Ruan, Rongze Kuang, Jerry B. Hook, & Howard Sands. (1997). Inhibition of Human Leukocyte Proteinase 3 by a Novel Recombinant Serine Proteinase Inhibitor (LEX032). Biochemical and Biophysical Research Communications. 233(3). 697–699. 5 indexed citations
17.
Groutas, William C., et al.. (1994). Substituted 3-oxo-1,2,5-Thiadiazolidine 1,1-Dioxides: A New Class of Potential Mechanism-Based Inhibitors of Human Leukocyte Elastase and Cathepsin G. Biochemical and Biophysical Research Communications. 198(1). 341–349. 24 indexed citations
18.
Groutas, William C., et al.. (1992). Inhibitors of human neutrophil cathepsin G: Structural and biochemical studies. Archives of Biochemistry and Biophysics. 294(1). 144–146. 16 indexed citations
19.
20.
Groutas, William C., et al.. (1989). Inhibition of human leukocyte elastase by derivatives of N-hydroxysuccinimide. A structure-activity-relationship study. Journal of Medicinal Chemistry. 32(7). 1607–1611. 57 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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