W.H. Irwin McLean

36.6k total citations · 5 hit papers
250 papers, 19.0k citations indexed

About

W.H. Irwin McLean is a scholar working on Cell Biology, Molecular Biology and Dermatology. According to data from OpenAlex, W.H. Irwin McLean has authored 250 papers receiving a total of 19.0k indexed citations (citations by other indexed papers that have themselves been cited), including 138 papers in Cell Biology, 94 papers in Molecular Biology and 90 papers in Dermatology. Recurrent topics in W.H. Irwin McLean's work include Skin and Cellular Biology Research (134 papers), Dermatology and Skin Diseases (76 papers) and Allergic Rhinitis and Sensitization (56 papers). W.H. Irwin McLean is often cited by papers focused on Skin and Cellular Biology Research (134 papers), Dermatology and Skin Diseases (76 papers) and Allergic Rhinitis and Sensitization (56 papers). W.H. Irwin McLean collaborates with scholars based in United Kingdom, United States and Ireland. W.H. Irwin McLean's co-authors include Alan D. Irvine, Aileen Sandilands, Frances J.D. Smith, Sara Brown, E. Birgitte Lane, Donald Y.M. Leung, Gráinne M. O’Regan, Haihui Liao, Jouni Uitto and Linda Campbell and has published in prestigious journals such as New England Journal of Medicine, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

W.H. Irwin McLean

245 papers receiving 18.4k citations

Hit Papers

Filaggrin Mutations Associated with Skin and Allergic Dis... 2006 2026 2012 2019 2011 2006 2009 2014 2006 250 500 750
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Filaggrin Mutations Associated with Skin and Allergic Diseases
    2011 826 citations Alan D. Irvine, W.H. Irwin McLean et al. New England Journal of Medicine profile →
  2. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
    2006 681 citations Frances J.D. Smith, Alan D. Irvine et al. profile →
  3. Filaggrin in the frontline: role in skin barrier function and disease
    2009 616 citations Aileen Sandilands, Alan D. Irvine et al. profile →
  4. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
    2014 471 citations W.H. Irwin McLean et al. profile →
  5. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations
    2006 453 citations Alan D. Irvine, W.H. Irwin McLean et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
W.H. Irwin McLean United Kingdom 79 9.3k 7.2k 6.4k 4.8k 2.9k 250 19.0k
Alain Taı̈eb France 66 7.4k 0.8× 3.8k 0.5× 5.3k 0.8× 2.7k 0.6× 1.9k 0.7× 399 16.4k
Alan D. Irvine Ireland 58 11.5k 1.2× 8.3k 1.2× 1.9k 0.3× 2.3k 0.5× 3.8k 1.3× 298 17.2k
Hideoki Ogawa Japan 68 4.6k 0.5× 3.5k 0.5× 1.7k 0.3× 4.8k 1.0× 3.5k 1.2× 557 18.8k
Jouni Uitto United States 98 5.7k 0.6× 5.5k 0.8× 16.5k 2.6× 12.0k 2.5× 1.1k 0.4× 812 37.2k
Hiroshi Shimizu Japan 59 2.9k 0.3× 1.5k 0.2× 4.4k 0.7× 3.7k 0.8× 634 0.2× 538 14.2k
Kenji Kabashima Japan 77 10.9k 1.2× 6.8k 0.9× 828 0.1× 3.1k 0.7× 4.6k 1.6× 483 22.4k
Peter M. Steinert United States 84 2.8k 0.3× 1.1k 0.1× 12.8k 2.0× 9.8k 2.0× 791 0.3× 226 21.6k
John P. Sundberg United States 62 3.2k 0.3× 1.0k 0.1× 3.2k 0.5× 7.4k 1.5× 766 0.3× 422 18.4k
Erwin Tschachler Austria 68 3.9k 0.4× 1.1k 0.2× 2.7k 0.4× 5.5k 1.1× 1.6k 0.5× 314 16.6k
Joost Schalkwijk Netherlands 59 3.3k 0.4× 1.3k 0.2× 1.7k 0.3× 3.3k 0.7× 797 0.3× 259 11.2k

Countries citing papers authored by W.H. Irwin McLean

Since Specialization
Citations

This map shows the geographic impact of W.H. Irwin McLean's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by W.H. Irwin McLean with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites W.H. Irwin McLean more than expected).

Fields of papers citing papers by W.H. Irwin McLean

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by W.H. Irwin McLean. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by W.H. Irwin McLean. The network helps show where W.H. Irwin McLean may publish in the future.

Co-authorship network of co-authors of W.H. Irwin McLean

This figure shows the co-authorship network connecting the top 25 collaborators of W.H. Irwin McLean. A scholar is included among the top collaborators of W.H. Irwin McLean based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with W.H. Irwin McLean. W.H. Irwin McLean is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
McAleer, Maeve A., et al.. (2020). Topical corticosteroids normalize both skin and systemic inflammatory markers in infant atopic dermatitis. British Journal of Dermatology. 185(1). 153–163. 27 indexed citations
2.
Foley, David, C.E. Naylor, G M Wood, et al.. (2019). Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1). ACS Medicinal Chemistry Letters. 10(3). 341–347. 7 indexed citations
3.
Foley, David, C.E. Naylor, Colin Robinson, et al.. (2018). Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1. Bioorganic & Medicinal Chemistry Letters. 28(19). 3255–3259. 19 indexed citations
4.
Martínez‐Fábregas, Jonathan, Alan R. Prescott, Sander van Kasteren, et al.. (2018). Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nature Communications. 9(1). 5343–5343. 57 indexed citations
5.
Gruber, Robert, Peter M. Elias, Debra Crumrine, et al.. (2011). Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function. American Journal Of Pathology. 178(5). 2252–2263. 176 indexed citations
6.
Flohr, Carsten, Kirsty Logan, Tom Marrs, et al.. (2011). Filaggrin loss-of-function mutations and clinical eczema are associated with food sensitization at three months of age. Journal of Investigative Dermatology. 131.
7.
Irvine, Alan D., W.H. Irwin McLean, & Donald Y.M. Leung. (2011). Filaggrin Mutations Associated with Skin and Allergic Diseases. New England Journal of Medicine. 365(14). 1315–1327. 826 indexed citations breakdown →
8.
Flohr, Carsten, Suzana Radulović, W.H. Irwin McLean, et al.. (2010). Filaggrin loss-of-function mutations are associated with early onset eczema, eczema severity, and transepidermal water loss at three months of age. Journal of Investigative Dermatology. 130. 1 indexed citations
9.
Brown, S, Gráinne M. O’Regan, Linda Campbell, et al.. (2010). Replication of eczema susceptibility loci identified from a genome-wide association study. British Journal of Dermatology. 162(4). 925–926. 1 indexed citations
10.
Allen, M H, Yan Zhao, Hong Liao, et al.. (2007). Psoriasis shows no association with filaggrin-null alleles. British Journal of Dermatology. 156(5). 1111–1111.
11.
Steensel, Maurice A. M. Van, Michel van Geel, Peter M. Steijlen, et al.. (2003). Clouston Syndrome Can Mimic Pachyonychia Congenita. Journal of Investigative Dermatology. 121(5). 1035–1038. 27 indexed citations
12.
McLean, W.H. Irwin, Michèle Ramsay, G. C. ASHTON, et al.. (2002). Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene. Journal of Investigative Dermatology. 119(1). 226–226. 4 indexed citations
13.
Porter, Rebecca M., Declan P. Lunny, Neil Wilson, et al.. (2002). Defolliculated (Dfl): A Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles. Journal of Investigative Dermatology. 119(1). 32–37. 45 indexed citations
14.
Smith, Frances J.D., et al.. (2001). Novel Keratin 17 Mutations in Pachyonychia Congenita Type 2. Journal of Investigative Dermatology. 116(5). 806–808. 14 indexed citations
15.
Coleman, Carrie M., et al.. (1999). A novel mutation in the helix termination motif of keratin K12 in a US family with Meesmann corneal dystrophy. American Journal of Ophthalmology. 128(6). 687–691. 51 indexed citations
16.
Smith, et al.. (1998). Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2. British Journal of Dermatology. 139(3). 475–480. 96 indexed citations
17.
Irvine, Alan D., Kevin E. McKenna, Colin S. Munro, et al.. (1998). Mutations in Keratin K9 in Kindreds with Epidermolytic Palmoplantar Keratoderma and Epidemiology in Northern Ireland. Journal of Investigative Dermatology. 111(6). 1207–1209. 30 indexed citations
18.
Pulkkinen, Lea, et al.. (1997). Homozygous  6 Integrin Mutation in Junctional Epidermolysis Bullosa with Congenital Duodenal Atresia. Human Molecular Genetics. 6(5). 669–674. 119 indexed citations
19.
Corden, Laura D., E.L. Rugg, S. Morley, et al.. (1996). Mutations in keratin 17 cause steatocystoma multiplex. Journal of Investigative Dermatology. 106(4). 843. 7 indexed citations
20.
Rugg, E.L., W.H. Irwin McLean, Rosabella T. Pitera, et al.. (1994). Recessive epidermolysis bullosa simplex caused by a functional ‘knockout’ of keratin 14. Journal of Investigative Dermatology. 103(3). 438. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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