Thomas E. Spratt

2.0k citations

62 papers · 1.7k indexed · h-index 27

Impact in

Geriatrics and Gerontology top 5%
Cancer Research top 5%
- Carcinogens and Genotoxicity Assessment

Papers in ⓘ

Cancer Research 14
- Carcinogens and Genotoxicity Assessment 10
Molecular Biology 53
- DNA Repair Mechanisms 32
- DNA and Nucleic Acid Chemistry 27
- Cancer therapeutics and mechanisms 11
- Polyamine Metabolism and Applications 4

Co-authors: Stephen S. Hecht (8 shared papers)A. S. Prakasha Gowda (13 shared papers)Lisa A. Peterson (7 shared papers)Neil Trushin (3 shared papers)Anthony E. Pegg (5 shared papers)Philip Lazarus (5 shared papers)Shantu Amin (10 shared papers)Scott A. Jones (1 shared paper)
Journals: Chemical Research in Toxicology (18 papers)Biochemistry (12 papers)Journal of the American Chemical Society (2 papers)DNA repair (2 papers)Carcinogenesis (2 papers)
Partner nations: United States India Germany

In The Last Decade

Thomas E. Spratt

62 papers receiving 1.6k citations

Peers

Countries citing papers authored by Thomas E. Spratt

Since Specialization

Citations

This map shows the geographic impact of Thomas E. Spratt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas E. Spratt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas E. Spratt more than expected).

Fields of papers citing papers by Thomas E. Spratt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas E. Spratt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas E. Spratt. The network helps show where Thomas E. Spratt may publish in the future.

Co-authors

The 25 scholars most cited alongside Thomas E. Spratt, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas E. Spratt Line = papers co-authored together Thomas E. Spratt links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 62 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress Cell Death and Disease ·Yan Cheng, Xingcong Ren, A SP Gowda, Y. Shan, L. Zhang, Y-S Yuan, Rushang D. Patel, Haibo Wu, Kathryn J. Huber-Keener, Jay W. Yang, D-Y Liu, Thomas E. Spratt, J-M Yang	2013	176
2	Pyridyloxobutyl Adduct O⁶-[4-Oxo-4-(3-pyridyl)butyl]guanine Is Present in 4-(Acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-Treated DNA and Is a Substrate for O⁶-Alkylguanine-DNA Alkyltransferase Chemical Research in Toxicology ·Lijuan Wang, Thomas E. Spratt, Xiao-Keng Liu, Stephen S. Hecht, Anthony E. Pegg, Lisa A. Peterson	1997	91
3	Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-nitrosonornicotine Carcinogenesis ·Stephen S. Hecht, Thomas E. Spratt, Neil Trushin	1988	84
4	In Vitro Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase Journal of Virology ·Scott A. Jones, Rajeev K. Boregowda, Thomas E. Spratt, Jianming Hu	2012	68
5	An unprecedented nucleic acid capture mechanism for excision of DNA damage Nature ·Emily H. Rubinson, A. S. Prakasha Gowda, Thomas E. Spratt, Barry Gold, Brandt F. Eichman	2010	61
6	Identification of Hydrogen Bonds between Escherichia coli DNA Polymerase I (Klenow fragment) and the Minor Groove of DNA by Amino Acid Substitution of the Polymerase and Atomic Substitution of the DNA Biochemistry ·Thomas E. Spratt	2001	61
7	Glucuronidation of Tobacco-Specific Nitrosamines by UGT2B10 Drug Metabolism and Disposition ·Gang Chen, Ryan W. Dellinger, Dongxiao Sun, Thomas E. Spratt, Philip Lazarus	2008	55
8	Evidence for a Watson-Crick Hydrogen Bonding Requirement in DNA Synthesis by Human DNA Polymerase κ Molecular and Cellular Biology ·William T. Wolfle, M. Todd Washington, Eric T. Kool, Thomas E. Spratt, Sandra A. Helquist, Louise Prakash, Satya Prakash	2005	50
9	Different Mechanisms for the Photoinduced Production of Oxidative DNA Damage by Fluoroquinolones Differing in Photostability Chemical Research in Toxicology ·Thomas E. Spratt, Sherri S. Schultz, Douglas E. Levy, Chang Chen, Gerhardt Schlüter, Gary M. Williams	1999	49
10	Solvolysis of model compounds of .alpha.-hydroxylation of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: evidence for a cyclic oxonium ion intermediate in the alkylation of nucleophiles Chemical Research in Toxicology ·Thomas E. Spratt, Lisa A. Peterson, William L. Confer, Stephen S. Hecht	1990	45
11	Escherichia coli DNA Polymerase I (Klenow Fragment) Uses a Hydrogen-bonding Fork from Arg668 to the Primer Terminus and Incoming Deoxynucleotide Triphosphate to Catalyze DNA Replication Journal of Biological Chemistry ·Aviva S. Meyer, Maureen Blandino, Thomas E. Spratt	2004	40
12	Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication Nucleic Acids Research ·Thomas E. Spratt	1997	38
13	Identification of sulfate and glucuronic acid conjugates of the 5-hydroxy derivative as major metabolites of 2-amino-3-methylimidazo[4,5-f]quinoline in rats. PubMed ·Howard Jay Luks, Thomas E. Spratt, Marissa Vavrek, SUZANNE ROLAND, J. H. Weisburger	1989	36
14	Differences in the Rate of Repair of O⁶-Alkylguanines in Different Sequence Contexts by O⁶-Alkylguanine-DNA Alkyltransferase Chemical Research in Toxicology ·R. L. Coulter, Maureen Blandino, Jessica M. Tomlinson, Gary T. Pauly, Magdalena Krajewska, Robert C. Moschel, Lisa A. Peterson, Anthony E. Pegg, Thomas E. Spratt	2007	35
15	Incorporation of Gemcitabine and Cytarabine into DNA by DNA Polymerase β and Ligase III/XRCC1 Biochemistry ·A. S. Prakasha Gowda, Joanna M. Polizzi, Kristin A. Eckert, Thomas E. Spratt	2010	34
16	Reaction and Binding of Oligodeoxynucleotides Containing Analogues of O⁶-Methylguanine with Wild-Type and Mutant Human O⁶-Alkylguanine-DNA Alkyltransferase Biochemistry ·Thomas E. Spratt, Jeffrey D. Wu, Douglas E. Levy, Sreenivas Kanugula, Anthony E. Pegg	1999	33
17	Gastric Carcinogenesis: 2-Chloro-4-methylthiobutanoic Acid, a Novel Mutagen in Salted, Pickled Sanma Hiraki Fish, or Similarly Treated Methionine Chemical Research in Toxicology ·Wei Chen, John H. Weisburger, Emerich S. Fiala, Thomas E. Spratt, Steven G. Carmella, Di Chen, Stephen S. Hecht	1996	32
18	A Fluoroquinolone Antibiotic with a Methoxy Group at the 8 Position Yields Reduced Generation of 8-Oxo-7,8-dihydro- 2′-deoxyguanosine after Ultraviolet-A Irradiation Toxicology and Applied Pharmacology ·Jane Rosen, D. Chen, Agasanur K. Prahalad, Thomas E. Spratt, Gerhard Schlüter, Gary M. Williams	1997	31
19	Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate Proceedings of the National Academy of Sciences ·M. Todd Washington, William T. Wolfle, Thomas E. Spratt, Louise Prakash, Satya Prakash	2003	31
20	Reaction of O6-alkylguanine-DNA alkyltransferase with O6-methylguanine analogs: evidence that the oxygen of O6-methylguanine is protonated by the protein to effect methyl transfer Biochemistry ·Thomas E. Spratt, Hannah De los Santos	1992	30

About Thomas E. Spratt

Thomas E. Spratt is a scholar working on Cancer Research, Molecular Biology, Biochemistry, Toxicology and Aging, having authored 62 papers that have together received 1.7k indexed citations. Recurring topics across this work include DNA Repair Mechanisms (32 papers), DNA and Nucleic Acid Chemistry (27 papers), Cancer therapeutics and mechanisms (11 papers), Carcinogens and Genotoxicity Assessment (10 papers), Synthesis and Biological Evaluation (7 papers), HIV/AIDS drug development and treatment (5 papers), Polyamine Metabolism and Applications (4 papers) and Pharmacogenetics and Drug Metabolism (4 papers). The work is most often cited by research in Geriatrics and Gerontology (90 citations), Cancer Research (344 citations), Molecular Biology (1.2k citations), Pharmacology (104 citations) and Endocrinology (47 citations). Thomas E. Spratt has collaborated with scholars based in United States, India and Germany. Frequent co-authors include Stephen S. Hecht, A. S. Prakasha Gowda, Lisa A. Peterson, Neil Trushin, Anthony E. Pegg, Philip Lazarus, Shantu Amin, Scott A. Jones, Jianming Hu and Dongxiao Sun. Their work appears in journals such as Chemical Research in Toxicology, Biochemistry, Journal of the American Chemical Society, DNA repair and Carcinogenesis.

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